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Molecular Cell, ISSN 1097-2765, 10/2017, Volume 68, Issue 2, pp. 446 - 455.e3
Journal Article
Journal Article
11/2009
In order to maintain genome stability, DNA damage needs to be detected and repaired in a timely fashion. To cope with damaged DNA, cells have evolved... 
Checkpoint | Rad53 | DNA damage | 0307 | saccharomyces cerevisiae
Dissertation
Developmental Cell, ISSN 1534-5807, 08/2018, Volume 46, Issue 4, pp. 495 - 503.e2
Unlike most checkpoint proteins, Mec1, an ATM/ATR kinase, is essential. We utilized , a missense allele (E2130K) that confers diminished kinase activity, to... 
cycloheximide | amino acid analogue | heat | Mec1 | Rad53 | autophagy | Huntingtin | proteotoxic stress | protein homeostasis | Sml1 | ATM | ATR | REPLICATION | PHOSPHORYLATION | DNA-DAMAGE RESPONSE | PROTEOTOXIC STRESS | DEVELOPMENTAL BIOLOGY | GENOME STABILITY | INHIBITOR | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | CANCER | CELL BIOLOGY | Proteins | Homeostasis | Amino acids | Cell death | Analysis | Cells
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2019, Volume 73, Issue 3, pp. 562 - 573.e3
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 25, pp. 10364 - 10369
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 2014, Volume 34, Issue 17, pp. 3259 - 3271
Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox-active cofactor in many biological processes, including DNA... 
TRANSCRIPTIONAL REGULATOR | SULFUR PROTEIN BIOGENESIS | RAD53 PHOSPHORYLATION | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | SUBCELLULAR-LOCALIZATION | DAMAGE CHECKPOINT PATHWAYS | CLUSTER BIOSYNTHESIS | RNA-BINDING-PROTEINS | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Phosphorylation | Saccharomyces cerevisiae - genetics | Iron-Sulfur Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Aspartic Acid Endopeptidases - genetics | Cell Cycle Proteins - chemistry | Checkpoint Kinase 2 - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Checkpoint Kinase 2 - genetics | Proteolysis | Gene Deletion | Cell Cycle Proteins - genetics | Tristetraprolin - metabolism | Genes, Fungal | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Binding Sites - genetics | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Iron - metabolism | Transcription Factors - metabolism | Tristetraprolin - genetics | Ribonucleotide Reductases - antagonists & inhibitors | Aspartic Acid Endopeptidases - metabolism | Ribonucleotide Reductases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Iron-Sulfur Proteins - metabolism | Protein-Serine-Threonine Kinases - chemistry | Ribonucleotide Reductases - genetics | Deoxyribonucleotides - biosynthesis | Proteasome Endopeptidase Complex - metabolism | Saccharomyces cerevisiae Proteins - chemistry
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 2866 - 2871
The histone chaperone Asf 1 and the checkpoint kinase Rad53 are found in a complex in budding yeast cells in the absence of genotoxic stress. Our data suggest... 
Proteins | Yeasts | Phosphorylation | Chromatin | Histone chaperones | Yeast extract | DNA damage | Histones | Epitopes | Genetic mutation | Checkpoint | NMR | X-ray structure | checkpoint | DOMAIN | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | MECHANISMS | chromatin | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | RAD53 | STRUCTURAL BASIS | STRESS | INSIGHTS | Hydroxyurea - pharmacology | Molecular Chaperones - metabolism | Histone Chaperones - metabolism | Crystallography, X-Ray | Saccharomyces cerevisiae - drug effects | Molecular Chaperones - chemistry | Cell Cycle Proteins - chemistry | Peptides - metabolism | Protein Binding - drug effects | Phosphorylation - drug effects | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Peptides - chemistry | Cell Cycle Proteins - metabolism | Models, Molecular | Mutant Proteins - metabolism | Mutation - genetics | Phosphoserine - metabolism | Phosphothreonine - metabolism | Saccharomyces cerevisiae - cytology | Mutant Proteins - chemistry | Protein Stability - drug effects | Saccharomyces cerevisiae Proteins - metabolism | Checkpoint Kinase 2 | Saccharomyces cerevisiae - enzymology | Protein-Serine-Threonine Kinases - chemistry | DNA Damage | Histones - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Molecular chaperones | Physiological aspects | Biochemistry | Chemical properties | Research | Phosphotransferases | Life Sciences | Biomolecules | Cellular Biology | Biochemistry, Molecular Biology | Cell Behavior | Biological Sciences
Journal Article