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International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2013, Volume 86, Issue 2, pp. 343 - 349
Purpose Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, and radiation is one of the main treatment modalities. However, cure... 
Radiology | Hematology, Oncology and Palliative Medicine | CTLA-4 BLOCKADE | IMMUNITY | MELANOMA | ONCOLOGY | METASTASES | INCREASES | ANTIBODY | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | T-CELLS | IPILIMUMAB | TEMOZOLOMIDE | Immunotherapy - methods | Spleen - immunology | Combined Modality Therapy - mortality | T-Lymphocytes, Regulatory - immunology | Brain Neoplasms - immunology | Time Factors | T-Lymphocytes, Regulatory - cytology | Female | Brain Neoplasms - mortality | Neck | Radiosurgery - methods | T-Lymphocytes, Cytotoxic - immunology | Antigens, Neoplasm - immunology | Mice, Inbred C57BL | Lymph Nodes - immunology | Xenograft Model Antitumor Assays - methods | Glioblastoma - therapy | Immunotherapy - mortality | Animals | B7-H1 Antigen - antagonists & inhibitors | Glioblastoma - immunology | Brain Neoplasms - therapy | Survival Analysis | Cell Line, Tumor | Combined Modality Therapy - methods | Mice | Radiosurgery - mortality | Brain - immunology | Glioblastoma - mortality | T-Lymphocytes, Cytotoxic - cytology | Sects | T cells | Gliomas | Nuclear radiation | Immunotherapy | Radiosurgery | ANTIBODIES | GLIOMAS | SURGERY | LYMPH NODES | ANTIGENS | DEATH | LUCIFERASE | INTERFERON | SPLEEN | INHIBITION | LIGANDS | IMMUNOTHERAPY | RADIOLOGY AND NUCLEAR MEDICINE | MICE | RADIOTHERAPY | RADIOPROTECTIVE SUBSTANCES | RECEPTORS | BRAIN
Journal Article
Cardiovascular and Interventional Radiology, ISSN 0174-1551, 08/2017, Volume 40, Issue 8
BackgroundTo evaluate the course of pro- and anti-inflammatory cytokines after {sup 90}Y-radioembolization (RE) of liver malignancies and to identify... 
PATIENTS | HEPATOMAS | BIOLOGICAL MARKERS | LIVER | RADIOEMBOLIZATION | RADIOLOGY AND NUCLEAR MEDICINE | RADIOPROTECTIVE SUBSTANCES
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2010, Volume 244, Issue 1, pp. 57 - 65
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that positively regulates the basal and inducible expression of a large battery of... 
Toxicokinetics | Oxidative Stress | Nrf2 | Liver | Toxicodynamics | GLUTATHIONE S-TRANSFERASES | HEME OXYGENASE-1 GENE | ERYTHROID 2-RELATED FACTOR-2 | OLEANOLIC ACID PROTECTS | PREGNANE X RECEPTOR | LOCUS-CONTROL REGION | GAMMA-GLUTAMYLCYSTEINE SYNTHETASE | CONSTITUTIVE ANDROSTANE RECEPTOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | MICROSOMAL-ENZYME INDUCERS | TRANSPORTING POLYPEPTIDES OATPS | Chemical and Drug Induced Liver Injury - prevention & control | Antioxidants - metabolism | Humans | Liver - metabolism | Gene Expression Regulation | Chemical and Drug Induced Liver Injury - genetics | Animals | Liver - drug effects | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | NF-E2-Related Factor 2 - metabolism | NF-E2-Related Factor 2 - genetics | Inactivation, Metabolic - genetics | Mice | Multidrug Resistance-Associated Proteins - metabolism | Cytoprotection | Proteins | Physiological aspects | Xenobiotics | Analysis | Quinone | Index Medicus | Drugs | DIGESTIVE SYSTEM | PATHOLOGY | BENZOQUINONES | EXCRETION | COENZYMES | 60 APPLIED LIFE SCIENCES | STRESSES | METABOLISM | GLANDS | KINETICS | ENZYMES | GENES | DRUGS | CHEMICAL REACTIONS | VERTEBRATES | ORGANIC OXYGEN COMPOUNDS | MICE | AROMATICS | RADIOPROTECTIVE SUBSTANCES | MAMMALS | OXIDATION | TRANSCRIPTION FACTORS | ANIMALS | CLEARANCE | RODENTS | QUINONES | RESPONSE MODIFYING FACTORS | ORGANIC COMPOUNDS | TOXICITY | TRANSFERASES | POLYPEPTIDES | NAD | NUCLEOTIDES | ORGANS | XENOBIOTICS | PEPTIDES | GLUTATHIONE | LIVER | PROTEINS | BODY
Journal Article
Journal Article
Russian Journal of Physical Chemistry B, ISSN 1990-7931, 12/2010, Volume 4, Issue 7, pp. 1097 - 1102
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2010, Volume 244, Issue 3, pp. 247 - 253
2,3,3,3-Tetrafluoropropene (HFO-1234yf) is a non-ozone-depleting fluorocarbon replacement with a low global warming potential and is developed as refrigerant.... 
Haloolefins | Rabbits | HFO-1234yf | Biotransformation | 1,1,1,2-TETRAFLUOROETHANE | OXIDATION | RAT | BIOACTIVATION | TOXICITY | METABOLISM | CYTOCHROME-P450 2E1 | KINETICS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | LIVER-MICROSOMES | Fluorocarbons - chemistry | Hazardous Substances - pharmacokinetics | Animals | Hazardous Substances - urine | Liver - metabolism | Female | Fluorocarbons - urine | Fluorocarbons - pharmacokinetics | Inhalation Exposure - analysis | Subcellular Fractions - metabolism | Cysteine | Global warming potential | Global warming | Metabolites | Index Medicus | Epoxidation | BODY FLUIDS | HALIDES | NUCLEAR MAGNETIC RESONANCE | DIGESTIVE SYSTEM | REFRIGERANTS | STABLE ISOTOPES | CHROMATOGRAPHY | FLUORINE COMPOUNDS | 60 APPLIED LIFE SCIENCES | PROPANOLS | FLUORIDES | ORGANIC HALOGEN COMPOUNDS | RABBITS | FLUORINE ISOTOPES | GLANDS | AMINO ACIDS | VERTEBRATES | RADIOPROTECTIVE SUBSTANCES | FLUIDS | METABOLITES | RESPONSE MODIFYING FACTORS | BIOLOGICAL MATERIALS | INTAKE | ORGANIC ACIDS | WASTES | ODD-EVEN NUCLEI | ISOTOPES | EPOXIDES | DOSES | GLUTATHIONE | LIVER | CARBOXYLIC ACIDS | GAS CHROMATOGRAPHY | FLUORINE 19 | BODY | MATERIALS | RATS | MASS SPECTROSCOPY | MAGNETIC RESONANCE | THIOLS | HYDROXY COMPOUNDS | RESONANCE | URINE | DRUGS | ORGANIC SULFUR COMPOUNDS | SEPARATION PROCESSES | ORGANIC OXYGEN COMPOUNDS | LIGHT NUCLEI | WORKING FLUIDS | BIOLOGICAL WASTES | MAMMALS | ANIMALS | RODENTS | ORGANIC FLUORINE COMPOUNDS | ORGANIC COMPOUNDS | INHALATION | CYSTEINE | POLYPEPTIDES | ALCOHOLS | ORGANS | NUCLEI | PEPTIDES | SPECTROSCOPY | HALOGEN COMPOUNDS | EXPOSURE CHAMBERS | PROTEINS
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2010, Volume 244, Issue 1, pp. 66 - 76
Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent... 
Dithiolethiones | NRF2 | Phase 2 enzymes | Chemoprevention | Sulforaphane | KEAP1 | Antioxidant proteins | S-TRANSFERASE POLYMORPHISMS | REPUBLIC-OF-CHINA | HEME OXYGENASE-1 GENE | DNA ADDUCT FORMATION | SMALL MAF PROTEINS | ANTIOXIDANT RESPONSE ELEMENT | CUL3-BASED E3 LIGASE | YA-SUBUNIT GENE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | URINARY-BLADDER CARCINOGENESIS | ABERRANT CRYPT FOCI | Neoplasms - metabolism | Neoplasms - etiology | Humans | Enzyme Induction | Neoplasms - prevention & control | Intracellular Signaling Peptides and Proteins - metabolism | Carcinogens - metabolism | Carcinogens - toxicity | Animals | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Inactivation, Metabolic - genetics | Anticarcinogenic Agents - pharmacology | Kelch-Like ECH-Associated Protein 1 | Cytoprotection | Oxidases | Care and treatment | Biological products | Thiols | Toluene | Sulfates | Drug resistance | Dextran | Antioxidants | Prevention | Phosphatidylinositol | Glutathione transferase | Physiological aspects | Universities and colleges | Ethers | Protein kinases | Cancer | Index Medicus | HYDROCARBONS | ANTIMICROBIAL AGENTS | 60 APPLIED LIFE SCIENCES | CHEMICAL REACTIONS | VERTEBRATES | ANTI-INFECTIVE AGENTS | RADIOPROTECTIVE SUBSTANCES | PYRENE | NEOPLASMS | RESPONSE MODIFYING FACTORS | ANTHRACENE | ANISOLE | ANTIPYRETICS | GLUTATHIONE | CENTRAL NERVOUS SYSTEM DEPRESSANTS | MEN | MAN | MALES | CARBOHYDRATES | PHOSPHORYLATION | ALKYLATED AROMATICS | DEXTRAN | TOLUENE | HEMATOLOGIC AGENTS | PRIMATES | ETHERS | CONDENSED AROMATICS | ENZYMES | GENES | DRUGS | POLYSACCHARIDES | DIMETHYLBENZANTHRACENE | ORGANIC OXYGEN COMPOUNDS | QUININE | AROMATICS | MAMMALS | TRANSCRIPTION FACTORS | ANIMALS | SACCHARIDES | BLOOD SUBSTITUTES | ORGANIC COMPOUNDS | CARCINOGENS | CONFORMATIONAL CHANGES | POLYPEPTIDES | DISEASES | PEPTIDES | PROTEINS | CENTRAL NERVOUS SYSTEM AGENTS | OXIDOREDUCTASES | ALKALOIDS | phase 2 enzymes | antioxidant proteins | dithiolethiones | sulforaphane
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2010, Volume 244, Issue 1, pp. 77 - 83
This review focuses on the emerging evidence that reactive oxygen species (ROS) derived from glucose metabolism, such as H O , act as metabolic signaling... 
Oxidative stress | Nrf2 | Pancreatic beta-cells | ROS | Ucp2 | Antioxidant | Insulin secretion | OXYGEN SPECIES PRODUCTION | GLUTATHIONE-PEROXIDASE | KAPPA-B | STIMULATED INSULIN-SECRETION | UNCOUPLING PROTEIN-2 GENE | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | HYDROGEN-PEROXIDE | TOXICOLOGY | MITOCHONDRIAL SUPEROXIDE | TRANSCRIPTIONAL REGULATION | DEPENDENT ACTIVATION | Reactive Oxygen Species - metabolism | Oxidative Stress | Antioxidants - metabolism | Humans | Diabetes Mellitus, Type 2 - metabolism | Hypoglycemic Agents - pharmacology | Antioxidants - therapeutic use | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Ion Channels - metabolism | Signal Transduction - drug effects | Mitochondrial Proteins - metabolism | NF-E2-Related Factor 2 - metabolism | Glucose - metabolism | Uncoupling Protein 2 | Diabetes Mellitus, Type 2 - drug therapy | Insulin-Secreting Cells - enzymology | Type 2 diabetes | Pancreatic beta cells | Quinone | Superoxide dismutase | Superoxide | Glucose | Thioredoxin | Insulin | Dextrose | Antioxidants | Glucose metabolism | Ligases | Heme | Physiological aspects | Peroxidase | Stress (Psychology) | Public health | Glutathione | APOPTOSIS | OXYGEN COMPOUNDS | SUPEROXIDE DISMUTASE | HYDROGEN COMPOUNDS | DIGESTIVE SYSTEM | PANCREAS | 60 APPLIED LIFE SCIENCES | STRESSES | METABOLISM | GLANDS | HYDROGEN PEROXIDE | GLUCOSE | ENZYMES | DRUGS | CHEMICAL REACTIONS | ENDOCRINE GLANDS | RADIOPROTECTIVE SUBSTANCES | OXIDATION | SACCHARIDES | ANTIOXIDANTS | RESPONSE MODIFYING FACTORS | ORGANIC COMPOUNDS | PEPTIDE HORMONES | ALDEHYDES | DAMAGE | POLYPEPTIDES | INSULIN | HEXOSES | ORGANS | MONOSACCHARIDES | PEPTIDES | PEROXIDES | GLUTATHIONE | PROTEINS | BODY | CARBOHYDRATES | HORMONES | OXIDOREDUCTASES | antioxidant | pancreatic beta-cells | insulin secretion | oxidative stress
Journal Article