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The New England Journal of Medicine, ISSN 0028-4793, 11/2014, Volume 371, Issue 20, pp. 1877 - 1888
Journal Article
Journal Article
Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7326, pp. 973 - 977
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 2, pp. 107 - 114
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2010, Volume 363, Issue 9, pp. 809 - 819
Journal Article
Cell Cycle, ISSN 1538-4101, 12/2010, Volume 9, Issue 24, pp. 4931 - 4940
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2013, Volume 19, Issue 3, pp. 657 - 667
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 01/2013, Volume 26, Issue 1, pp. 136 - 142
To date, there are no effective therapies for tumors bearing NRAS mutations, which are present in 15–20% of human melanomas. Here we extend our earlier studies... 
melanoma | melanoma model | ras/Ink4a | ras | 69A11 | small molecule inhibitor | BI-69A11 | Nras melanoma | Melanoma model | Small molecule inhibitor | Nras/Ink4a | TARGETED THERAPY | CELLS | AKT | Ink4a | MALIGNANT-MELANOMA | CANCER | CHEMOTHERAPY | CELL BIOLOGY | DERMATOLOGY | METASTATIC MELANOMA | REPAIR | Nras | ONCOLOGY | GENETICS | RESISTANCE | Small Molecule Libraries - pharmacology | ras Proteins - genetics | Leukocyte Common Antigens - metabolism | Skin Neoplasms - drug therapy | Humans | Ki-67 Antigen - metabolism | Quinolones - pharmacology | Precancerous Conditions - drug therapy | Benzimidazoles - administration & dosage | Melanoma - genetics | Quinolones - therapeutic use | Precancerous Conditions - pathology | Gene Expression Regulation, Neoplastic - drug effects | Benzimidazoles - therapeutic use | Disease Models, Animal | Skin Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Injections, Intraperitoneal | Small Molecule Libraries - therapeutic use | Melanoma - pathology | Precancerous Conditions - genetics | Xenograft Model Antitumor Assays | Quinolones - administration & dosage | Animals | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Amino Acid Substitution - genetics | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Mice | Prevention | Sarcoma | Analysis | Melanoma | Genetically modified organisms | Models | Biological response modifiers | Gene expression | Cancer | Index Medicus
Journal Article