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SCIENCE, ISSN 0036-8075, 03/2017, Volume 355, Issue 6331, pp. 1306 - 1311
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes activated at the lysosome in response to... 
INSULIN | TRANSPORT | OBESITY | DOMAIN | RAG GTPASES | METABOLISM | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | RAGULATOR | REQUIRES | BINDING
Journal Article
CANCER CELL, ISSN 1535-6108, 03/2019, Volume 35, Issue 3, pp. 385 - 385
Increasingly effective therapies targeting the androgen receptor have paradoxically promoted the incidence of neuroendocrine prostate cancer (NEPC), the most... 
COOPERATE | NETWORK | ONCOLOGY | INFLAMMATION | LINEAGE PLASTICITY | RESISTANCE | RAGULATOR | PROLIFERATION | GENERATION | INCREASED SURVIVAL | TUMORIGENESIS | CELL BIOLOGY
Journal Article
Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6218, pp. 194 - 198
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates environmental and intracellular signals to regulate cell growth. Amino acids... 
COMPLEX | ACTIVATION | RAG GTPASES | MECHANISM | ARF | MULTIDISCIPLINARY SCIENCES | AMINO-ACID SUFFICIENCY | RAGULATOR | PROTEINS | P70 S6 KINASE | REVEALS | Protein research | Rapamycin | Leucine | Research | Glutamate | Health aspects | Protein-protein interactions | Protein expression | Amino acids | Cellular biology | Kinases | Metabolism | Guanosines | Lysosomes | Activation | Detection | Glutamine
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 01/2019, Volume 15, Issue 1, pp. 169 - 171
The Ser/Thr protein kinase MTOR (mechanistic target of rapamycin kinase) regulates cellular metabolism and controls macroautophagy/autophagy. Autophagy has... 
galectin 9 | Rag GTPases | autophagy | galectin 8 | Ragulator | AMPK | APEX2 | SLC38A9 | lysosome | MTOR | CELL BIOLOGY
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2015, Volume 58, Issue 5, pp. 804 - 818
mTORC1 is essential for regulating cell growth and metabolism in response to various environmental stimuli. Heterodimeric Rag GTPases are required for... 
RECRUITMENT | COMPLEX | LYSOSOMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEINS | LIGASES | TFEB | UBIQUITYLATION | TUMOR-SUPPRESSOR | RAGULATOR | AMINO-ACID LEVELS | CELL BIOLOGY | Ubiquitin | Starvation | G proteins | Ligases
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6136, pp. 1100 - 1106
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2019, Volume 75, Issue 1, pp. 26 - 38.e3
Growth factor signaling is initiated at the plasma membrane and propagated through the cytoplasm for eventual relay to intracellular organelles such... 
LOCALIZATION | BORC | ACTIVATION | COMPLEX | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | RAGULATOR | ENDOPLASMIC-RETICULUM | MECHANISMS | PROTEIN-KINASE B | CELL BIOLOGY | Cells | Neurophysiology
Journal Article
Science, ISSN 0036-8075, 06/2017, Volume 356, Issue 6341, pp. 968 - 972
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 08/2019, Volume 15, Issue 8, pp. 776 - 776
Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for... 
SURVIVAL | RAG GTPASES | MECHANISM | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | RAGULATOR | DISTINCT ROLES | LYSOSOME | LIGAND DISCOVERY | MODULATION | REVEALS | H+-transporting ATPase | Profiling | Guanosine | Acidification | Homeostasis | Lysosomes | Kinases | Organelles | Autophagy | Proteins | Signaling | Covalence | Dementia disorders | Inhibition | Frontotemporal dementia | Phagocytosis | Adenosine triphosphatase
Journal Article