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The Journal of immunology (1950), ISSN 1550-6606, 2005, Volume 174, Issue 11, pp. 6686 - 6691
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 12, p. e0168080
Introduction Chronic Periodontitis (CP) is an inflammatory disease of bacterial origin that results in alveolar bone destruction. Porphyromonas gingivalis... 
PORPHYROMONAS-GINGIVALIS INFECTION | EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DISEASE | RECEPTOR | CYTOKINE | PREVALENCE | IL-33 | EXPRESSION | SEVERITY | Up-Regulation | RANK Ligand - metabolism | Porphyromonas gingivalis - pathogenicity | Humans | Middle Aged | Bacteroidaceae Infections - genetics | Male | X-Ray Microtomography | Young Adult | Chronic Periodontitis - microbiology | Chronic Periodontitis - genetics | Adult | Female | Bacteroidaceae Infections - metabolism | Chronic Periodontitis - complications | Disease Models, Animal | Alveolar Bone Loss - metabolism | Genetic Predisposition to Disease | Alveolar Bone Loss - diagnostic imaging | Bacteroidaceae Infections - complications | Cells, Cultured | RANK Ligand - genetics | Interleukin-33 - genetics | Animals | Adolescent | Interleukin-33 - metabolism | Mice | Alveolar Bone Loss - genetics | Chronic Periodontitis - metabolism | Complications and side effects | Care and treatment | Periodontitis | Interleukins | Development and progression | Genetic aspects | Bone diseases | Health aspects | Immunohistochemistry | Disease | Destruction | Epithelial cells | Pathogenesis | Interleukin | Antibodies | Homeostasis | Infections | Arthritis | Kinases | Maxilla | Bone resorption | Interleukin 6 | Biomedical materials | Bacteria | Tumor necrosis factor-TNF | Biocompatibility | TRANCE protein | Bone loss | Immune system | Explants | Cytokines | Alveolar bone | Rheumatology | Hazards | Inflammation | Tumor necrosis factor-α | Gene expression | Dental research | Ligands | Osteoclasts | Gingiva | Life Sciences | Human health and pathology | Rhumatology and musculoskeletal system | Geriatry and gerontology
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 5, pp. 539 - 546
Journal Article
Journal of vascular research, ISSN 1423-0135, 2014, Volume 51, Issue 2, pp. 118 - 131
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 02/2013, Volume 123, Issue 2, pp. 866 - 873
Journal Article
Experimental cell research, ISSN 0014-4827, 2007, Volume 313, Issue 1, pp. 168 - 178
Osteoclast differentiation is tightly regulated by receptor activator of NF-κB ligand (RANKL) signaling. Matrix metalloproteinase-9... 
Osteoclast | Matrix metalloproteinase-9 (MMP-9) | RANK ligand (RANKL) | TRAF6 | NFAT | NFAT FAMILY | CELLS | ALPHA-INDUCED OSTEOCLASTOGENESIS | NECROSIS-FACTOR RECEPTOR | ACTIVATED PROTEIN-KINASE | COLLAGENASE GELATINASE-B | P38 MAPK | CELL BIOLOGY | matrix metalloproteinase-9 (MMP-9) | ONCOLOGY | NUCLEAR-FACTOR | PATHWAY | osteoclast | KAPPA-B LIGAND | RNA, Small Interfering - genetics | RANK Ligand - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Bone Remodeling - physiology | DNA Primers - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Osteoclasts - cytology | RANK Ligand - pharmacology | Gene Expression Regulation, Developmental | Matrix Metalloproteinase 9 - genetics | Base Sequence | Cell Differentiation | TNF Receptor-Associated Factor 6 - genetics | Cell Line | Promoter Regions, Genetic | Signal Transduction | NFATC Transcription Factors - metabolism | Recombinant Proteins - pharmacology | Osteoclasts - metabolism | Gene Expression Regulation, Enzymologic | Animals | TNF Receptor-Associated Factor 6 - metabolism | Mice | Bone Remodeling - genetics | NFATC Transcription Factors - antagonists & inhibitors | NFATC Transcription Factors - genetics | Genetic research | Gene expression | Analysis | Proteins | Enzymes | Signal transduction | Matrix | Peptides | Bones | Binding sites | TRANSCRIPTION FACTORS | PLASMIDS | PEPTIDES | STRUCTURAL CHEMICAL ANALYSIS | LIGANDS | PROMOTERS | GENES | MICE | RECEPTORS | 60 APPLIED LIFE SCIENCES | LUCIFERASE | OLIGONUCLEOTIDES
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2012, Volume 188, Issue 1, pp. 163 - 169
SHIP is an SH2-containing inositol-5-phosphatase expressed in hematopoietic cells. It hydrolyzes the PI3K product PI(3,4,5)P-3 and blunts the PI3K-initiated... 
SURVIVAL | ACTIVATION | COLONY-STIMULATING FACTOR | T-CELLS C1 | NUCLEAR-FACTOR | PHOSPHATIDYLINOSITOL 3-KINASE | GLYCOGEN-SYNTHASE KINASE-3 | SHIP | IMMUNOLOGY | FACTOR RECEPTOR | NEGATIVE REGULATOR | Cell Nucleus - immunology | RANK Ligand - metabolism | Inositol Polyphosphate 5-Phosphatases | Glycogen Synthase Kinase 3 beta | Phosphatidylinositol 3-Kinases - metabolism | Glycogen Synthase Kinase 3 - immunology | Osteoclasts - cytology | Enzyme Activation - immunology | Phosphatidylinositol 3-Kinases - immunology | Proto-Oncogene Proteins c-akt - genetics | RANK Ligand - immunology | Cell Differentiation - genetics | Signal Transduction - immunology | Phosphorylation - genetics | Cell Nucleus - metabolism | NFATC Transcription Factors - immunology | Osteoclasts - immunology | Phosphoric Monoester Hydrolases - immunology | Bone Marrow Cells - immunology | Phosphorylation - immunology | Active Transport, Cell Nucleus | Proto-Oncogene Proteins c-akt - metabolism | Phosphoric Monoester Hydrolases - genetics | NFATC Transcription Factors - metabolism | Signal Transduction - genetics | Glycogen Synthase Kinase 3 - metabolism | Osteoclasts - metabolism | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | RANK Ligand - genetics | Cell Differentiation - immunology | Animals | Proto-Oncogene Proteins c-akt - immunology | Cell Nucleus - genetics | Glycogen Synthase Kinase 3 - genetics | Mice | Enzyme Activation - genetics | Phosphoric Monoester Hydrolases - metabolism | Bone Marrow Cells - metabolism | NFATC Transcription Factors - genetics
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 12, pp. 20113 - 20121
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 8, pp. 933 - 939
Individuals who have mutations in the breast-cancer-susceptibility gene BRCA1 (hereafter referred to as BRCA1-mutation carriers) frequently undergo... 
BRCA2 MUTATION CARRIERS | MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | OVARIAN-CANCER | CELL BIOLOGY | RISK-REDUCING SURGERY | STEM-CELL | MICE | DIFFERENTIAL EXPRESSION ANALYSIS | GLAND | MAMMARY EPITHELIAL-CELLS | Immunohistochemistry | Neoplasm Transplantation | RANK Ligand - metabolism | Humans | Molecular Targeted Therapy | Prophylactic Mastectomy | Stem Cells - metabolism | Breast - metabolism | Breast Neoplasms - metabolism | Denosumab - therapeutic use | Flow Cytometry | Organoids - metabolism | Female | Receptor Activator of Nuclear Factor-kappa B - metabolism | Disease Models, Animal | Carcinogenesis - genetics | Bone Density Conservation Agents - therapeutic use | Reverse Transcriptase Polymerase Chain Reaction | Bone Density Conservation Agents - pharmacology | Breast Neoplasms - prevention & control | Carcinogenesis - drug effects | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Animals | Breast Neoplasms - genetics | RANK Ligand - antagonists & inhibitors | Breast - drug effects | DNA Repair | Organoids - drug effects | Pilocarpine - analogs & derivatives | Stem Cells - drug effects | Heterozygote | Cell Proliferation - drug effects | Mice | Mutation | Denosumab - pharmacology | Tumor Suppressor Proteins | Care and treatment | Cytokines | BRCA mutations | Development and progression | Breast cancer | Genetic aspects | Health aspects | Ligands | Genes
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 06/2006, Volume 116, Issue 6, pp. 1525 - 1534
.... A critical ligand contact site on the TNFR is partly conserved in RANK. Surface plasmon resonance studies showed that a peptide (WP9QY... 
MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | COMPLEX | MECHANISM | CRYSTAL-STRUCTURE | OSTEOCLASTOGENESIS-INHIBITORY FACTOR | EXTRACELLULAR DOMAIN | OSTEOPROTEGERIN | DIFFERENTIATION | DEFICIENCY | FACTOR-ALPHA | Tumor Necrosis Factor-alpha - metabolism | Calcium, Dietary | Receptor Activator of Nuclear Factor-kappa B | Membrane Glycoproteins - metabolism | Membrane Glycoproteins - chemistry | Glycoproteins - metabolism | Peptides - genetics | Molecular Sequence Data | Male | RANK Ligand | Osteoclasts - cytology | Osteoprotegerin | Peptides - metabolism | Receptors, Cytoplasmic and Nuclear - chemistry | Carrier Proteins - chemistry | Female | Osteoclasts - physiology | Glycoproteins - chemistry | Receptors, Tumor Necrosis Factor - genetics | Glycoproteins - genetics | Receptors, Tumor Necrosis Factor - metabolism | Amino Acid Sequence | Cell Line | Bone Resorption | Receptors, Tumor Necrosis Factor - chemistry | Ovariectomy | Peptides - chemistry | Mice, Inbred C57BL | Cells, Cultured | Models, Molecular | Receptors, Cytoplasmic and Nuclear - genetics | Lumbar Vertebrae - anatomy & histology | Mice, Knockout | Sequence Alignment | Animals | Carrier Proteins - metabolism | Protein Conformation | Signal Transduction - physiology | Lumbar Vertebrae - pathology | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Medical research | Peptides | Medicine, Experimental | Bones | Research | Density | Osteoclasts (Biology)
Journal Article
Nature communications, ISSN 2041-1723, 10/2016, Volume 7, Issue 1, p. 13176
Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of SOST... 
CHONDROCYTE HYPERTROPHY | HISTONE DEACETYLASE 4 | TARGETED DISRUPTION | PTH | MULTIDISCIPLINARY SCIENCES | RECEPTOR ACTIVATOR | GENE-EXPRESSION | BONE HOMEOSTASIS | DOWN-REGULATION | SALT-INDUCIBLE KINASES | KAPPA-B LIGAND | Osteocytes - drug effects | RNA, Small Interfering - genetics | RANK Ligand - metabolism | Humans | Glycoproteins - metabolism | Parathyroid Hormone - pharmacology | Bone and Bones - drug effects | Protein Isoforms - metabolism | Parathyroid Hormone - metabolism | Bone and Bones - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Osteogenesis - genetics | Protein-Serine-Threonine Kinases - metabolism | Bone and Bones - cytology | Glycoproteins - genetics | Histone Deacetylases - genetics | Osteocytes - metabolism | Signal Transduction | Intercellular Signaling Peptides and Proteins | Osteocytes - cytology | Osteogenesis - drug effects | Gene Expression Regulation | Glycoproteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Histone Deacetylases - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Mice, Knockout | RANK Ligand - genetics | Transcription Factors - metabolism | Animals | RANK Ligand - antagonists & inhibitors | Active Transport, Cell Nucleus - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 561, Issue 7722, pp. 195 - 200
Journal Article