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Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 4908 - 4927
synGAP is a neuron-specific Ras and Rap GTPase-activating protein (GAP) found in high concentrations in the postsynaptic density (PSD) fraction from the... 
NMDA RECEPTOR | DOMAIN | STIMULATION | INHIBITION | CALPAIN | CLONING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATIONS | HIPPOCAMPAL-NEURONS | PLASTICITY | Oncogene Proteins - genetics | ras Proteins - genetics | Phosphorylation | ras GTPase-Activating Proteins - chemistry | rap1 GTP-Binding Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | ras Proteins - metabolism | Neurons - cytology | GTPase-Activating Proteins - metabolism | Receptors, N-Methyl-D-Aspartate - genetics | Cyclin-Dependent Kinase 5 - chemistry | Cyclin-Dependent Kinase 5 - genetics | ras GTPase-Activating Proteins - genetics | Receptors, N-Methyl-D-Aspartate - chemistry | ras Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | rap1 GTP-Binding Proteins - metabolism | ras GTPase-Activating Proteins - metabolism | Oncogene Proteins - chemistry | Cells, Cultured | Oncogene Proteins - metabolism | Rats | Synapses - enzymology | GTPase-Activating Proteins - chemistry | Cyclin-Dependent Kinase 5 - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Animals | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry | Neurons - enzymology | GTPase-Activating Proteins - genetics | rap1 GTP-Binding Proteins - genetics | rap GTP-Binding Proteins | Index Medicus | Ras Protein | Ras-related Protein 1 (Rap1) | Postsynaptic Density | Ca2 | Synaptic Plasticity | Small GTPase | Neurobiology | Mass Spectrometry (MS) | Cyclin-dependent Kinase 5 (CDK5) | Protein Kinase | Calmodulin-dependent Protein Kinase II (CaMKII) | Synaptic GTPase-activating Protein (synGAP)
Journal Article
The Journal of Pathology, ISSN 0022-3417, 07/2017, Volume 242, Issue 3, pp. 284 - 296
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2007, Volume 104, Issue 49, pp. 19333 - 19338
cAMP is well known to regulate exocytosis in various secretory cells, but the precise mechanism of its action remains unknown. Here, we examine the role of... 
Beta cells | Cell lines | Small interfering RNA | Cultured cells | Cell membranes | Physiological regulation | Islets of Langerhans | Exocytosis | Insulin | Insulin secretion | Total internal reflection fluorescence microscopy | Pancreatic beta cell | PROTEIN-KINASE-A | pancreatic beta cell | EXOCYTOSIS | MULTIDISCIPLINARY SCIENCES | PKA | insulin secretion | CYCLIC-AMP | GLUCAGON-LIKE PEPTIDE-1 | CA2+-INDUCED CA2+ RELEASE | RAP1 | CALCIUM | total internal reflection fluorescence microscopy | PANCREATIC BETA-CELLS | SECRETION | Carrier Proteins - physiology | Cell Line | rap1 GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Guanine Nucleotide Exchange Factors - physiology | Insulin - analysis | Signal Transduction | Cytoplasmic Granules - drug effects | Humans | Glucose - pharmacology | Cytoplasmic Granules - chemistry | Potassium - pharmacology | Exocytosis - drug effects | Mice, Knockout | Cyclic AMP - physiology | Carrier Proteins - genetics | Insulin - metabolism | Animals | Cytoplasmic Granules - metabolism | rap1 GTP-Binding Proteins - analysis | Mice | Insulin Secretion | Pancreatic beta cells | Control | Influence | Cyclic adenylic acid | Properties | Binding proteins | Fluorescence microscopy | Methods | Proteins | Signal transduction | Membranes | Kinases | Cells | Binding sites | Index Medicus | Biological Sciences
Journal Article
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2016, Volume 94, Issue 5, pp. 498 - 507
Hepatic stellate cells (HSCs) activation represents an essential event during alcoholic liver fibrosis (ALF). Previous studies have demonstrated that the rat... 
cellules de Kupffer | hepatic stellate cells | EPAC2 | EPAC1 | Rap1 | acétaldéhyde | acetaldehyde | Hepatic stellate cells | Acetaldehyde | FIBROSIS | PHYSIOLOGY | COLLAGEN | RAT | ALCOHOLIC LIVER-DISEASE | PATHOGENESIS | CYCLIC-AMP | BIOLOGICAL FUNCTIONS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | PROSTAGLANDIN E-2 | CAMP | rap1 GTP-Binding Proteins - antagonists & inhibitors | Actins - metabolism | Cyclic AMP-Dependent Protein Kinases - chemistry | Hepatic Stellate Cells - metabolism | Acetaldehyde - antagonists & inhibitors | Actins - genetics | Collagen Type II - metabolism | Collagen Type I - genetics | Cyclic AMP - analogs & derivatives | RNA Interference | Guanine Nucleotide Exchange Factors - metabolism | Collagen Type II - agonists | rap1 GTP-Binding Proteins - agonists | Actins - agonists | Collagen Type II - antagonists & inhibitors | Cyclic AMP - metabolism | Hepatic Stellate Cells - pathology | Hepatic Stellate Cells - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | rap1 GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Second Messenger Systems - drug effects | Collagen Type I - metabolism | Acetaldehyde - toxicity | Liver Cirrhosis, Alcoholic - pathology | Collagen Type I - antagonists & inhibitors | Rats | Enzyme Activation - drug effects | Guanine Nucleotide Exchange Factors - agonists | Collagen Type II - genetics | Liver Cirrhosis, Alcoholic - prevention & control | Cyclic AMP - pharmacology | Actins - antagonists & inhibitors | Animals | Collagen Type I - agonists | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | Cell Proliferation - drug effects | Cyclic AMP - agonists | Liver Cirrhosis, Alcoholic - metabolism | rap1 GTP-Binding Proteins - genetics | Cell proliferation | Cyclic adenylic acid | Observations | Health aspects | Stem cells | Signal transduction | Protein expression | Cell growth | Collagen | Liver | Index Medicus
Journal Article
03/2013
Cell adhesion and migration play crucial roles in development of multicellular organisms, immune surveillance, wound repair and cancer metastasis. The Gβγ... 
Cell motility | 0379 | Rap1 | Gbetagamma | Radil | 0307 | G protein | Cancer
Dissertation
Developmental Cell, ISSN 1534-5807, 01/2012, Volume 22, Issue 1, pp. 158 - 171
Journal Article