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Drug Design, Development and Therapy, ISSN 1177-8881, 03/2015, Volume 9, pp. 1555 - 1584
Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to... 
ALS | Osteosarcoma | Autophagy | EMT | PI3K/Akt/mTOR pathway | Apoptosis | MASTER | CHEMISTRY, MEDICINAL | autophagy | METASTASIS | CANCER CELLS | apoptosis | SIRTUINS | FAMILY | EMT TRANSCRIPTION FACTORS | METABOLISM | PHARMACOLOGY & PHARMACY | osteosarcoma | PROGRAM | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Structure-Activity Relationship | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Pyrimidines - chemistry | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Azepines - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Azepines - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Screening Assays, Antitumor | Mitogen-Activated Protein Kinases - metabolism | Development and progression | Genetic aspects | Cellular signal transduction | Gene expression | Health aspects | Crosstalk | Nuclear engineering | AKT protein | Aurora kinase | Metastasis | Cancer therapies | Anticancer properties | Proteins | Signal transduction | Mitochondria | N-Cadherin | Surgery | Biocompatibility | Inhibition | Stress response | AMP | Mortality | MAP kinase | Rapamycin | Metabolism | 1-Phosphatidylinositol 3-kinase | Nuclear safety | Chemotherapy | Hospitals | Inhibitors | Phagocytosis | TOR protein | Adolescence | Biotechnology | Oxidative stress | Mesenchyme | Laboratories | Bone tumors | Activation | Kinases | E-cadherin | Cyclin B1 | Cell adhesion & migration | Pathways | Cell cycle | Children | Trends | Inducers | Phenotypes | Signaling | Bone cancer | Cell death | Cell lines | Index Medicus
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2013, Volume 51, Issue 5, pp. 618 - 631
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 2015, Volume 138, Issue 1, pp. 174 - 180
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 06/2017, Volume 329, pp. 166 - 171
Few studies suggest that antidepressants exert their effects by activating some signaling pathways, including the phosphatidylinositol 3-kinase (PI3K).... 
mTOR | Depression | Akt | PI3K | Valproic acid | BEHAVIORAL DESPAIR | BDNF LEVELS | ARACHIDONIC-ACID | NEUROSCIENCES | PREFRONTAL CORTEX | MOOD STABILIZERS LITHIUM | MTOR SIGNALING PATHWAY | SODIUM VALPROATE | BIPOLAR DEPRESSION | GENE-EXPRESSION | BEHAVIORAL SCIENCES | RAT HIPPOCAMPUS | Divalproex | Rapamycin | Antidepressants | Analysis | Depression, Mental
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 7/2007, Volume 178, Issue 3, pp. 437 - 451
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2014, Volume 371, Issue 4, pp. 303 - 312
This study shows that the mTORC pathway is central to the antiphospholipid syndrome. Among patients with kidney transplants and antiphospholipid syndrome, 70%... 
RAPAMYCIN | BETA-GLYCOPROTEIN-I | MEDICINE, GENERAL & INTERNAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ANGIOPLASTY | ANTIBODY-MEDIATED REJECTION | POLYCYSTIC KIDNEY-DISEASE | SMOOTH-MUSCLE-CELLS | ANTI-BETA-GLYCOPROTEIN-I ANTIBODIES | SYNDROME NEPHROPATHY | VASCULOPATHY | Endothelium, Vascular - cytology | Cell Proliferation | Kidney - blood supply | Kidney - pathology | TOR Serine-Threonine Kinases - metabolism | Humans | Immunoglobulin G | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Antiphospholipid Syndrome - complications | TOR Serine-Threonine Kinases - antagonists & inhibitors | Autopsy | Adult | Female | Antiphospholipid Syndrome - metabolism | Immunosuppressive Agents - pharmacology | Kidney Diseases - metabolism | Sirolimus - therapeutic use | Antiphospholipid Syndrome - drug therapy | Kidney Transplantation | Sirolimus - pharmacology | Antibodies, Antiphospholipid - metabolism | Analysis of Variance | Endothelium, Vascular - metabolism | Endothelium, Vascular - pathology | Kidney Diseases - etiology | Metabolic Networks and Pathways - drug effects | Care and treatment | Rapamycin | Health aspects | Antiphospholipid syndrome | TOR protein | Cell proliferation | Lupus | Heart attacks | Kidneys | Transplants & implants | Sirolimus | AKT protein | Antiphospholipid antibodies | Kinases | Thrombosis | Endothelial cells | Endothelium | 1-Phosphatidylinositol 3-kinase | Vascular diseases | Nephropathy | Biopsy | Autoimmune diseases | Kidney transplantation | Index Medicus | Abridged Index Medicus
Journal Article