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ras transformation (374) 374
animals (262) 262
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cell biology (166) 166
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signal transduction (102) 102
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activation (67) 67
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Cancer Research, ISSN 0008-5472, 10/2006, Volume 66, Issue 19, pp. 9535 - 9542
Glial tumors progress to malignant grades by heightened proliferation and relentless dispersion throughout the central nervous system. Understanding genetic... 
SIGNAL-TRANSDUCTION | MIGRATION | GROWTH FACTOR-INDUCIBLE-14 | CDNA MICROARRAY | TWEAK | GENE | ONCOLOGY | TRANSCRIPTION | RAS TRANSFORMATION | PROLIFERATION | RHO-GTPASES
Journal Article
BBA - Reviews on Cancer, ISSN 0304-419X, 12/2009, Volume 1796, Issue 2, pp. 91 - 98
Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding... 
Rho GTPases | DIRECTED MIGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | BREAST-CANCER | LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | BIOPHYSICS | ONCOLOGY | IN-VIVO | SQUAMOUS-CELL CARCINOMA | RAS TRANSFORMATION | ABERRANT SOMATIC HYPERMUTATION | CYCLE PROGRESSION | Proteins | Analysis | Genetically modified organisms | Development and progression | Mice | G proteins | Tumors
Journal Article
CANCER SCIENCE, ISSN 1349-7006, 09/2010, Volume 101, Issue 9, pp. 1997 - 2004
MicroRNAs (miRNAs) are frequently deregulated in human tumors, and play important roles in tumor development and progression. The pathological roles of miRNAs... 
BREAST-CANCER | ACTIVATION | METASTASIS | MESSENGER-RNA | GENE | ONCOLOGY | RAS TRANSFORMATION | NF1 | SCHWANN-CELLS | EXPRESSION | NERVE SHEATH TUMORS
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
CELL LUNG-CANCER | RAS-TRANSFORMATION | OVEREXPRESSION | OXIDATIVE STRESS | HMTH1 | MESSENGER-RNA | GENE | MULTIDISCIPLINARY SCIENCES | HUMAN MUTT HOMOLOG | TUMORIGENESIS | SMALL-MOLECULE INHIBITION | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 11/2012, Volume 72, Issue 22, pp. 5900 - 5911
The tumor suppressor gene deleted in liver cancer-1 (DLC1), which encodes a protein with strong RhoGAP (GTPase activating protein) activity and weak Cdc42GAP... 
SH2 DOMAIN | HEPATOCELLULAR-CARCINOMA | EMBRYONIC-DEVELOPMENT | METASTASIS | ONCOLOGY | RAS TRANSFORMATION | RHO | TUMOR-SUPPRESSOR | GTPASE-ACTIVATING PROTEIN | IDENTIFICATION | CELL CARCINOMA
Journal Article
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 08/2002, Volume 115, Issue 15, pp. 3193 - 3206
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2010, Volume 107, Issue 20, pp. 9446 - 9451
Journal Article
MOLECULAR CELL, ISSN 1097-2765, 10/2003, Volume 12, Issue 4, pp. 841 - 849
The Nf2 tumor suppressor gene codes for merlin, a protein whose function has been elusive. We describe a novel interaction between merlin and p21-activated... 
LOCALIZATION | ACTIVATION | PAXILLIN | GTPASES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | RAS TRANSFORMATION | CELL-ADHESION | RHO FAMILY PROTEINS | NEUROFIBROMATOSIS TYPE-2 | CELL BIOLOGY
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2018, Volume 505, Issue 4, pp. 1022 - 1026
Journal Article
Electrochimica Acta, ISSN 0013-4686, 10/2015, Volume 179, pp. 65 - 73
Cancer cells show an abnormal balance of reduced/oxidised species and the detection of cancer redox balance can be exploited for diagnostic purposes. In... 
Redox balance | Scanning Electrochemical Microscopy | Cancer Diagnostics | Ras transformation | Glutathione | ELECTROCHEMISTRY | OXIDATIVE STRESS | REACTIVE OXYGEN | HELA-CELLS | METABOLISM | VESICULAR EXOCYTOSIS | THIODIONE | SECM | MULTIDRUG-RESISTANCE | LIVING CELLS | Electrochemistry | Lung cancer | Microscope and microscopy | Cancer | Electric properties
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 07/2003, Volume 162, Issue 2, pp. 281 - 291
Activation of the Ras-MAPK signal transduction pathway is necessary for biological responses both to growth factors and ECM. Here, we provide evidence that... 
Src | PHOSPHATIDYLINOSITOL 3-KINASE | adhesion | CROSS-CASCADE ACTIVATION | PROTEIN-TYROSINE KINASE | GROWTH-FACTOR ACTIVATION | RAT-1 FIBROBLASTS | CELL BIOLOGY | SIGNAL-TRANSDUCTION | P21-ACTIVATED KINASE | focal adhesion kinase | CELL-MIGRATION | RAS TRANSFORMATION | integrin | extracellular matrix
Journal Article