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Molecular neurobiology, ISSN 1559-1182, 10/2016, Volume 54, Issue 8, pp. 6287 - 6303
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 12/2015, Volume 89, pp. 668 - 678
Mitochondrial oxidative damage contributes to a wide range of pathologies. One therapeutic strategy to treat these disorders is targeting antioxidants to mitochondria by conjugation to the lipophilic triphenylphosphonium (TPP) cation... 
Mitochondria | MitoC | Mitochondrial targeting | Ascorbic acid | Lipid peroxidation | MitoPerox | Lipophilic cation | MitoPerox MitoC | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Antioxidants - chemistry | Oxidation-Reduction | Rats, Wistar | Mitochondria, Liver - metabolism | Rats | Antioxidants - pharmacology | Chromatography, High Pressure Liquid | Mitochondria, Liver - drug effects | Animals | Ascorbic Acid - pharmacology | Ascorbic Acid - chemistry | Female | Oxidative Stress - drug effects | Drug Delivery Systems - methods | Antioxidants | Superoxide | Mitochondrial DNA | Thioredoxin | Oxidases | Unsaturated fatty acids | Acetic acid | Organic acids | Index Medicus | AO, ascorbate oxidase | RET, reverse electron transport | GSH, glutathione | XO, xanthine oxidase | RLM, rat liver mitochondria | FCS, foetal calf serum | Δψm, mitochondrial membrane potential | FCCP, carbonylcyanide p-(trifluoromethoxy)phenylhydrazone | MitoC, mitochondria-targeted ascorbate | ROS, reactive oxygen species | LAH, linoleic acid hydroperoxide | DTPA, diethylenetriaminepenta-acetic acid | ACR, accumulation ratio | AFR, ascorbyl free radical | MitoDHA, mitochondria-targeted dehydroascorbate | TBARS, thiobarbituric acid reactive species | TPMP, methyltriphenylphosphonium | DHA, dehydroascorbic acid | TPP, triphenylphosphonium | RP-HPLC, reverse-phase HPLC | TFA, trifluoroacetic acid
Journal Article
FEBS letters, ISSN 0014-5793, 11/2010, Volume 584, Issue 22, pp. 4606 - 4610
Journal Article
Biochemical journal, ISSN 0264-6021, 08/2010, Volume 430, Issue 1, pp. 49 - 59
.... We previously developed a MitoSNO (mitochondria-targeted S-nitrosothiol) that selectively S-nitrosates mitochondrial proteins... 
S-nitrosation | Mitochondria | Redox signalling | Difference in gel electrophoresis (DIGE) | Nitric oxide (NO) | S-nitrosylation | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Oxidation-Reduction | Mice, Inbred C57BL | Rats | Electrophoresis, Gel, Two-Dimensional | Male | Myocardium - pathology | S-Nitrosothiols - metabolism | Myocardial Reperfusion Injury - metabolism | Mitochondrial Proteins - pharmacology | Myocardial Reperfusion Injury - pathology | Animals | Mitochondrial Proteins - metabolism | Myocardium - metabolism | Membrane Potential, Mitochondrial | Proteomics | Superoxides - metabolism | Mice | In Vitro Techniques | Mitochondria - physiology | Index Medicus | BVA, biological variance analysis | nitric oxide (NO) | AR, area at risk | RHM, rat heart mitochondria | SA, standardized abundance | DIGE, difference in gel electrophoresis | GSNO, S-nitrosoglutathione | SNO-DIGE, S-nitrosothiol difference in gel electrophoresis | DTT, dithiothreitol | R, ischaemia | redox signalling | RLM, rat liver mitochondria | 2D, two-dimensional | difference in gel electrophoresis (DIGE) | Cy3, indocarbocyanine | ROS, reactive oxygen species | reperfusion | PrSNO, protein S-nitrosothiol | MitoNAP, mito-N-acetylpenicillamine | Cy5, indodicarbocyanine | LAD, left anterior descending coronary artery | NEM, N-ethylmaleimide | LV, left ventricle | SNAP, S-nitroso-N-acetylpenicillamine | mitochondria | MitoSNO, mitochondria-targeted S-nitrosothiol | α-KGDH, α-ketoglutarate dehydrogenase | TPP, triphenylphosphonium | NIH, National Institutes for Health | ALDH2, aldehyde dehydrogenase | MALDI–TOF-TOF, matrix-assisted laser-desorption ionization–time-of-flight time-of-flight
Journal Article