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rat/mouse hemokinin-1 (16) 16
animals (12) 12
mice (11) 11
mammalian tachykinin peptide (10) 10
index medicus (9) 9
male (7) 7
tachykinins - pharmacology (7) 7
peptides (6) 6
pharmacological profile (6) 6
rats (6) 6
substance-p (6) 6
supraspinal level (6) 6
neurosciences (5) 5
dose-response relationship, drug (4) 4
endocrinology & metabolism (4) 4
humans (4) 4
localization (4) 4
pain (4) 4
pharmacology & pharmacy (4) 4
receptors (4) 4
sr140333 and sr48968 (4) 4
tachykinins - administration & dosage (4) 4
advanced basic science (3) 3
analgesia (3) 3
analysis (3) 3
anesthetized rats (3) 3
cardiovascular-responses (3) 3
cells (3) 3
functional expression (3) 3
inflammation (3) 3
injections, intraventricular (3) 3
messenger-rna (3) 3
narcotic antagonists - pharmacology (3) 3
neurokinin-1 receptor antagonists (3) 3
neuropeptides (3) 3
nitric oxide (3) 3
piperidines - pharmacology (3) 3
receptors, neurokinin-1 - metabolism (3) 3
substance p (3) 3
substance p - pharmacology (3) 3
substance-p receptor (3) 3
tachykinins - chemistry (3) 3
tachykinins - metabolism (3) 3
analgesics (2) 2
analgesics - administration & dosage (2) 2
analgesics - pharmacology (2) 2
analgesics, opioid - administration & dosage (2) 2
analysis of variance (2) 2
antinociception (2) 2
benzamides - pharmacology (2) 2
biochemistry & molecular biology (2) 2
biology (2) 2
brain (2) 2
central nervous system (2) 2
chemical properties (2) 2
cloning (2) 2
computer simulation (2) 2
computers (2) 2
conformation (2) 2
drug interactions (2) 2
enzyme inhibitors - pharmacology (2) 2
expression (2) 2
female (2) 2
fluorescent labeled peptides (2) 2
gene expression (2) 2
human hemokinin-1 (2) 2
immune system (2) 2
immunology (2) 2
in-vivo (2) 2
injection (2) 2
knowledge-based systems (2) 2
mechanisms (2) 2
medicine (2) 2
mice, inbred icr (2) 2
molecular-cloning (2) 2
morphine (2) 2
naloxone - pharmacology (2) 2
naltrexone - analogs & derivatives (2) 2
naltrexone - pharmacology (2) 2
neurokinin (2) 2
neuroscience (2) 2
neurotransmitter agents - pharmacology (2) 2
ng-nitroarginine methyl ester - pharmacology (2) 2
nk1 receptor (2) 2
opioid receptor (2) 2
p-like function (2) 2
pain measurement - methods (2) 2
peptide fragments - administration & dosage (2) 2
peptide fragments - pharmacology (2) 2
pharmacology (2) 2
pro-opiomelanocortin - metabolism (2) 2
protein expression (2) 2
protein precursors - pharmacology (2) 2
quinuclidines - pharmacology (2) 2
rat spinal-cord (2) 2
receptors, neurokinin-2 - antagonists & inhibitors (2) 2
research article (2) 2
rna, messenger - metabolism (2) 2
rodents (2) 2
science (2) 2
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1. Full Text Hemokinin-1(4-11)-induced analgesia selectively up- regulates δ-opioid receptor expression in mice
by Fu, Cai-Yun and Xia, Rui-Long and Zhang, Teng-Fei and Lu, Yan and Zhang, Shi-Fu and Yu, Zhi-Qiang and Jin, Tao and Mou, Xiao-Zhou
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e90446
Our previous studies have shown that an active fragment of human tachykinins (hHK-1(4-11)) produced an opioid-independent analgesia after... 
SUPRASPINAL LEVEL | CARDIOVASCULAR-RESPONSES | MESSENGER-RNA | PERIAQUEDUCTAL GRAY | FUNCTIONAL EXPRESSION | MULTIDISCIPLINARY SCIENCES | IN-SITU HYBRIDIZATION | RAT/MOUSE HEMOKININ-1 | PHARMACOLOGICAL PROFILE | MAMMALIAN TACHYKININ PEPTIDE | ANESTHETIZED RATS | Receptors, Opioid, delta - metabolism | Tachykinins - chemistry | Gene Expression - drug effects | Humans | Injections, Intraventricular | Male | Peptide Fragments - pharmacology | Tachykinins - pharmacology | Tachykinins - administration & dosage | Tachykinins - genetics | Receptors, Opioid, delta - genetics | Female | Pro-Opiomelanocortin - genetics | Protein Precursors - genetics | Tachykinins - metabolism | Receptors, Opioid, mu - metabolism | Peptide Fragments - administration & dosage | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Inbred ICR | Protein Precursors - metabolism | Pro-Opiomelanocortin - metabolism | Up-Regulation - drug effects | Analgesia | Animals | Receptors, Opioid, mu - genetics | Brain | Pain perception | Polypeptides | Transcription | Narcotics | Opioid receptors | Cloning | Central nervous system | Pharmacology | Proopiomelanocortin | Injection | Gene expression | Receptors | Analgesics | Rodents | Proteomics | Naltrindole | Life sciences | In vivo methods and tests | Tachykinin | Drug dosages | Combinatorial analysis
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2. Full Text Effects of rat/mouse hemokinin-1, human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on rate and perfusion pressure in the isolated guinea pig heart
by Kong, Zi-Qing and Yang, Wen-Le and Tao, Yan and Shi, Xiao-Mei and Fu, Cai-Yun and Zhao, Rui-Fei and Wang, Rui
Neuropeptides, ISSN 0143-4179, 2010, Volume 44, Issue 5, pp. 437 - 444
Abstract Rat/mouse hemokinin-1 (r/m HK-1), human hemokinin-1 (h HK-1) and human hemokinin-1(4-11) (h HK-1(4-11)) are members of the tachykinin family. In the... 
Endocrinology & Metabolism | Advanced Basic Science | Human hemokinin-1 | Perfusion guinea pig heart | Rat/mouse hemokinin-1 | SR140333 and SR48968 | Human hemokinin-1(4-11) | CARDIOVASCULAR-RESPONSES | LOCALIZATION | INNERVATION | CORONARY-ARTERY | NEUROSCIENCES | ENDOCRINOLOGY & METABOLISM | PHARMACOLOGICAL PROFILE | SUBSTANCE-P | RECEPTORS | NEUROKININ | EXPRESSION | ANESTHETIZED RATS | NG-Nitroarginine Methyl Ester - pharmacology | Guinea Pigs | Heart - physiology | Humans | Enzyme Inhibitors - pharmacology | Rats | Male | Tachykinins - pharmacology | Nitric Oxide | Vasoconstriction - drug effects | Dose-Response Relationship, Drug | Heart Rate - drug effects | Animals | Drug Interactions | Analysis of Variance | Perfusion | Receptors, Tachykinin - antagonists & inhibitors | Heart - drug effects | Mice | Vasodilation - drug effects | Nitrogen oxide | Catecholamines | Neuropeptides | Acetylcholine
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3. Full Text Role of hemokinin-1 in health and disease
by Borbély, Éva and Helyes, Zsuzsanna
Neuropeptides, ISSN 0143-4179, 2016, Volume 64, pp. 9 - 17
Abstract Hemokinin-1 (HK-1), the newest tachykinin encoded by the Tac4 gene was discovered in 2000. Its name differs from that of the other members of this... 
Endocrinology & Metabolism | Advanced Basic Science | Cardiovascular system | Pain | Microbiology | Tachykinins | Inflammation | Endokinins | Immune system | Cancer | CARDIOVASCULAR-RESPONSES | NEUROKININ-1 RECEPTOR | NEUROSCIENCES | SCRATCHING BEHAVIOR | ENDOCRINOLOGY & METABOLISM | RAT/MOUSE HEMOKININ-1 | PHARMACOLOGICAL PROFILE | ENDOKININ A/B | MAMMALIAN TACHYKININ PEPTIDE | SUBSTANCE-P | INFLAMMATORY CYTOKINES | ANESTHETIZED RATS | Inflammation - metabolism | Animals | Tachykinins - metabolism | Humans | Receptors, Neurokinin-1 - metabolism | Signal Transduction - physiology | Substance P - metabolism | Pain - metabolism | Analysis | B cells | Neurosciences
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4. Full Text In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice
by Fu, Cai Y and Zhao, You L and Dong, Li and Chen, Qiang and Ni, Jing M and Wang, Rui
Brain, Behavior, and Immunity, ISSN 0889-1591, 2008, Volume 22, Issue 6, pp. 850 - 860
Abstract Human hemokinin-1 (h HK-1) and its truncated form h HK-1(4-11) are mammalian tachykinin peptides encoded by the recently identified TAC4 gene in... 
Psychiatry | Allergy and Immunology | Opioid receptors antagonists | A competitive antagonist at GABA A receptors | Antinociception | Human HK-1 and its truncated form h HK-1(4-11) | SR140333 and SR48968 | A competitive antagonist at GABA | receptors | SUPRASPINAL LEVEL | RAT SPINAL-CORD | antinociception | PSYCHIATRY | opioid receptors antagonists | MECHANISMS | a competitive antagonist at GABA(A) receptors | IMMUNOLOGY | NEUROSCIENCES | P-LIKE FUNCTION | human HK-1 and its truncated form h HK-1(4-11) | RAT/MOUSE HEMOKININ-1 | NK1 RECEPTOR | GAMMA-AMINOBUTYRIC-ACID | SUBSTANCE-P | EXPRESSION | ANALGESIA | Naltrexone - analogs & derivatives | Receptors, Neurokinin-2 - antagonists & inhibitors | Analgesics - pharmacology | Tachykinins - chemistry | Humans | Injections, Intraventricular | Male | Peptide Fragments - pharmacology | Tachykinins - pharmacology | Tachykinins - administration & dosage | Dose-Response Relationship, Drug | Naltrexone - pharmacology | Piperidines - pharmacology | Benzamides - pharmacology | Neurokinin-1 Receptor Antagonists | Pain - prevention & control | Peptide Fragments - administration & dosage | Tropanes - pharmacology | Analgesics - administration & dosage | Bicuculline - pharmacology | GABA Antagonists - pharmacology | Naloxone - analogs & derivatives | Pain Measurement - methods | Animals | Naloxone - pharmacology | Pain - physiopathology | Narcotic Antagonists - pharmacology | Mice | Care and treatment | Pain | Analgesics | Analysis | GABA | Neuropeptides | Chemical properties
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5. Full Text Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NF-κB and p38 MAPK signaling pathways
by Sakai, Atsushi and Takasu, Kumiko and Sawada, Makoto and Suzuki, Hidenori
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e32268
The mammalian tachykinins, substance P (SP) and hemokinin-1 (HK-1), are widely distributed throughout the nervous system and/or peripheral organs, and function... 
SUPRASPINAL LEVEL | CELLS | PAIN | MESSENGER-RNA | KINASE | BIOLOGY | RAT/MOUSE HEMOKININ-1 | NK1 RECEPTOR | MICE | MAMMALIAN TACHYKININ PEPTIDE | SUBSTANCE-P | Microglia - metabolism | Up-Regulation | Signal Transduction | Tachykinins - metabolism | Gene Expression Regulation | Neurotransmitter Agents - metabolism | Lipopolysaccharides - metabolism | Rats | NF-kappa B - metabolism | RNA, Messenger - metabolism | Rats, Sprague-Dawley | Tachykinins - biosynthesis | Animals | Immune System | Substance P - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Brain | Tachykinin receptors | Peptides | Laboratories | Central nervous system | Intracellular signalling | Nervous system | Neuropeptides | Activation | Kinases | Neuromodulation | Modulators | Medical schools | Proteins | Signal transduction | Pathways | Rodents | Toll-like receptors | Trends | Immune system | NF-κB protein | Substance P | Organs | MAP kinase | Pharmacology | Inflammation | TLR4 protein | Gene expression | Microglia | Neurotransmitters | Brain-derived neurotrophic factor | Protein kinase | Tachykinin
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6. Full Text Study on the distribution sites and the molecular mechanism of analgesia after intracerebroventricular injection of rat/mouse hemokinin-1 in mice
by Xia, Rui-Long and Fu, Cai-Yun and Zhang, Shi-Fu and Jin, Yuan-Ting and Zhao, Fu-Kun
Peptides, ISSN 0196-9781, 05/2013, Volume 43, pp. 113 - 120
► We firstly demonstrated the distribution sites of r/m HK-1 in mouse brain. ► The analgesia of r/m HK-1 is induced by the activation of NK receptor firstly. ►... 
Protein expression | Fluorescent labeled peptides | Intracerebroventricular administration | Rat/mouse hemokinin-1 | Transcriptional expression | SUPRASPINAL LEVEL | SEQUENCE-ANALYSIS | PRECURSOR | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | OPIOID RECEPTOR | CLONING | FUNCTIONAL EXPRESSION | ENDOCRINOLOGY & METABOLISM | PHARMACOLOGICAL PROFILE | PHARMACOLOGY & PHARMACY | MAMMALIAN TACHYKININ PEPTIDE | SUBSTANCE-P | Receptors, Opioid - genetics | Tachykinins - antagonists & inhibitors | RNA, Messenger - genetics | Male | Tachykinins - pharmacology | Tachykinins - administration & dosage | RNA, Messenger - metabolism | Opioid Peptides - metabolism | Tachykinins - pharmacokinetics | Mice, Inbred ICR | Pro-Opiomelanocortin - metabolism | Analgesia | Neurokinin-1 Receptor Antagonists - pharmacology | Animals | Opioid Peptides - genetics | Narcotic Antagonists - pharmacology | Female | Receptors, Neurokinin-1 - metabolism | Mice | Infusions, Intraventricular | Receptors, Neurokinin-1 - genetics | Receptors, Opioid - metabolism | Phosphates | Intermedin | Sugars | Monosaccharides
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7. Full Text Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: Systemic study in anesthetized rats
by Fu, Cai-Yun and Kong, Zi-Qing and Long, Yuan and Chen, Qiang and Wang, Rui
European Journal of Pharmacology, ISSN 0014-2999, 2007, Volume 572, Issue 2, pp. 175 - 181
Rat/mouse hemokinin-1 is a mammalian tachykinin peptide whose biological functions have not been well characterized. In the present study, an attempt has been... 
Rat/mouse hemokinin-1 | Systemic arterial pressure | SR140333 and SR48968 | Substance P | LOCALIZATION | CELLS | rat/mouse hemokinin-1 | METHYL-ESTER | FAMILY | systemic arterial pressure | FUNCTIONAL EXPRESSION | NITRIC-OXIDE | PHARMACOLOGICAL PROFILE | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | substance p | NEUROKININ | SUBSTANCE-P RECEPTOR | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Neurokinin-2 - antagonists & inhibitors | Quinuclidines - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Rats | Atropine - pharmacology | Male | Substance P - pharmacology | Tachykinins - pharmacology | Vagotomy | Protein Precursors - pharmacology | Vagus Nerve - physiology | Animals | Piperidines - pharmacology | Muscarinic Antagonists - pharmacology | Protein Precursors - physiology | Anesthesia | Benzamides - pharmacology | Blood Pressure - drug effects | Mice | Neurokinin-1 Receptor Antagonists | Tachykinins - physiology | Peptides | Gastrointestinal hormones | Knowledge-based systems
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8. Full Text Mechanisms of relaxing response induced by rat/mouse hemokinin-1 in porcine coronary arteries: Roles of potassium ion and nitric oxide
by Long, Yuan and Fu, Cai-Yun and Tian, Xiao-Zhu and Chen, Juan and Han, Min and Wang, Rui
European Journal of Pharmacology, ISSN 0014-2999, 2007, Volume 569, Issue 1, pp. 119 - 125
Rat and mouse hemokinin-1(r/m hemokinin-1) is a recently described member of the tachykinin family whose cardiovascular functions are not fully understood. In... 
Rat/mouse hemokinin-1 | Potassium | Nitric oxide | Coronary artery | nitric oxide | potassium | CAROTID-ARTERY | rat/mouse hemokinin-1 | coronary artery | ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION | CA2+-ACTIVATED K+ CHANNEL | MESENTERIC-ARTERY | INOSITOL 1,4,5-TRISPHOSPHATE | HAMSTER OVARY CELLS | MEMBRANE HYPERPOLARIZATION | PHARMACOLOGY & PHARMACY | MAMMALIAN TACHYKININ PEPTIDE | EPOXYEICOSATRIENOIC ACIDS | SUBSTANCE-P RECEPTOR | Tetraethylammonium - pharmacology | Receptors, Prostaglandin - physiology | Substance P - pharmacology | Tachykinins - pharmacology | Endothelium, Vascular - physiology | Dequalinium - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Piperidines - pharmacology | Oxadiazoles - pharmacology | Swine | Neurotransmitter Agents - pharmacology | Vasodilation - physiology | Neurokinin-1 Receptor Antagonists | Potassium Channel Blockers - pharmacology | Substance P - antagonists & inhibitors | Coronary Vessels - drug effects | Anti-Infective Agents, Local - pharmacology | Coronary Vessels - physiology | Quinuclidines - pharmacology | Clotrimazole - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Nitric Oxide - physiology | Receptors, Neurokinin-1 - physiology | Potassium - pharmacology | Nitroarginine - pharmacology | Protein Precursors - pharmacology | Animals | Mice | Vasodilation - drug effects | In Vitro Techniques
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9. Full Text Effects of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on the antinociceptive activity of pethidine administered at the peripheral and supraspinal level
by Fu, Cai-Yun and Tang, Xiao-Long and Yang, Qi and Chen, Qiang and Wang, Rui
Behavioural Brain Research, ISSN 0166-4328, 2007, Volume 184, Issue 1, pp. 39 - 46
We have recently reported that rat/mouse hemokinin-1 (r/m HK-1), a mammalian tachykinin, produced dose- and time-related antinociceptive effects at the... 
Antinociception | Naloxone | Rat/mouse hemokinin-1 | Pethidine | Tail immersion test | RAT SPINAL-CORD | LOCALIZATION | SUPERFICIAL LAMINAE | antinociception | MORPHINE | MEPERIDINE | rat/mouse hemokinin-1 | NEUROSCIENCES | MU-OPIOID RECEPTORS | pethidine | GAS-CHROMATOGRAPHY | NEURONS | naloxone | BEHAVIORAL SCIENCES | MOLECULAR-CLONING | tail immersion test | SUBSTANCE-P RECEPTOR | Drug Administration Routes | Meperidine - administration & dosage | Male | Tachykinins - administration & dosage | Mice, Inbred Strains | Dose-Response Relationship, Drug | Pain Measurement - methods | Animals | Drug Interactions | Analysis of Variance | Time Factors | Analgesics, Opioid - administration & dosage | Pain - drug therapy | Reaction Time - drug effects | Behavior, Animal - drug effects | Mice | Injections, Intraventricular - methods | Disease Models, Animal | Peptides | Meperidine | Knowledge-based systems
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10. Full Text In vitro characterization of the effects of rat/mouse hemokinin-1 on mouse colonic contractile activity: A comparison with substance P
by Kong, Zi-Qing and Han, Min and Yang, Wen-Le and Zhao, You-Li and Fu, Cai-Yun and Tao, Yan and Chen, Qiang and Wang, Rui
Neuropeptides, ISSN 0143-4179, 2009, Volume 43, Issue 3, pp. 213 - 220
Abstract Rat/mouse hemokinin-1 (r/m HK-1) has been identified as a member of the tachykinin family and its effect in colonic contractile activity remains... 
Endocrinology & Metabolism | Advanced Basic Science | Rat/mouse hemokinin-1 | Neural blocking agents | SR140333 and SR48968 | Substance P | Contractile activity | SUPRASPINAL LEVEL | GUINEA-PIG ILEUM | NITRIC-OXIDE RELEASE | NEUROSCIENCES | INTESTINAL PERISTALSIS | DISTAL COLON | CIRCULAR MUSCLE | NK2 RECEPTORS | ENDOCRINOLOGY & METABOLISM | PHARMACOLOGICAL PROFILE | MAMMALIAN TACHYKININ PEPTIDE | MOTILITY | Animals | Colon - physiology | Muscle Contraction - drug effects | Neurotransmitter Agents - pharmacology | Rats | Receptors, Neurokinin-1 - metabolism | Substance P - pharmacology | Tachykinins - pharmacology | Mice | Receptors, Neurokinin-2 - metabolism | Nitric Oxide - metabolism | Tachykinins | Nitric oxide | Chemical properties
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11. Full Text Murine Monoclonal Antibodies Generated Against Mouse/Rat Hemokinin-1
by Jin, Liang and Jin, Bo-quan and Song, Chao-jun and Zhang, Yu
Hybridoma, ISSN 1554-0014, 08/2009, Volume 28, Issue 4, pp. 259 - 267
The mouse/rat hemokinin-1 (m/rHK-1) was discovered nearly 9 years ago. This molecule is a peptide comprising 11 amino acids. The m/rHK-1 was found to be mainly... 
Original Articles | LOCALIZATION | RAT/MOUSE HEMOKININ-1 | MECHANISMS | MAMMALIAN TACHYKININ PEPTIDE | IMMUNOLOGY | SUBSTANCE-P | IDENTIFICATION | P-LIKE FUNCTION | Tachykinins - chemistry | Enzyme-Linked Immunosorbent Assay | Models, Chemical | Immunologic Techniques | Cross-Linking Reagents - pharmacology | Rats | Inflammation | Tachykinins - immunology | Spinal Cord - immunology | Animals | Microscopy, Fluorescence - methods | Hybridomas - immunology | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal - chemistry | Monoclonal antibodies | Physiological aspects | Poisoning | Peptides | Heterocyclic compounds | Enzyme-linked immunosorbent assay
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12. Molecular dynamics simulation of spatial structure of rat/mouse hemokinin-1
by Agaeva, U.T and Agaeva, G.A and Godjaev, N.M
9th International Conference on Application of Information and Communication Technologies, AICT 2015 - Proceedings, 11/2015, pp. 524 - 526
Molecular dynamics simulations were performed for rat/mouse hemokinin-1, mammalian tachykinin peptide. A single rat/mouse hemokinin-1 was modeled in vacuum as... 
molecular dynamics simulations | rat/mouse hemokinin-1 | insert | flexibility | conformation | Computer simulation | Conferences | Simulation | Molecular dynamics | Amino acids | Boundary conditions | Mammals | Flexibility
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13. Central distribution sites and protein expression of human HK-1 in mice
by Zhou, Han-Wei and Wang, Xi and Chen, Qi and Ge, Chen-Tao and Shi, Yue and Fu, Cai-Yun
International Journal of Clinical and Experimental Pathology, ISSN 1936-2625, 2017, Volume 10, Issue 5, pp. 5875 - 5881
Human hemokinin-1 (human HK-1) is a member of the mammalian tachykinin family encoded by Pptc gene, whose biological activities are needed further... 
Protein expression | Intracerebroventricular injection | Fluorescent labeled peptides | Human HK-1 | SUPRASPINAL LEVEL | CELLS | intracerebroventricular injection | RECEPTOR | PATHOLOGY | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | INJECTION | IN-VIVO | fluorescent labeled peptides | RAT/MOUSE HEMOKININ-1 | MAMMALIAN TACHYKININ PEPTIDE | protein expression
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14. Full Text Supraspinal antinociceptive effect of apelin-13 in a mouse visceral pain model
by Lv, Shuang-Yu and Qin, Yao-Jun and Wang, Ning-Bo and Yang, Yan-Jie and Chen, Qiang
Peptides, ISSN 0196-9781, 09/2012, Volume 37, Issue 1, pp. 165 - 170
► Supraspinal apelin-13 induced antinociceptive effect in the visceral pain model. ► I.t. (not i.p.) injected apelin-13 produced antinociception in the... 
Opioid | Morphine | Apelin-13 | APJ | Writhing | ENDOGENOUS LIGAND APELIN | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED ANALGESIA | MESSENGER-RNA | RENIN-ANGIOTENSIN SYSTEM | OPIOID RECEPTOR | TISSUE DISTRIBUTION | RAT/MOUSE HEMOKININ-1 | PHARMACOLOGY & PHARMACY | MAMMALIAN TACHYKININ PEPTIDE | HUMAN APJ RECEPTOR | Naltrexone - analogs & derivatives | Analgesics - pharmacology | Visceral Pain - chemically induced | Injections, Intraventricular | Analgesics, Opioid - pharmacology | Motor Activity - drug effects | Male | Acetic Acid | Naltrexone - pharmacology | Nociception - drug effects | Visceral Pain - drug therapy | Intercellular Signaling Peptides and Proteins - administration & dosage | Injections, Spinal | Analgesics - therapeutic use | Morphine - pharmacology | Injections, Intraperitoneal | Analgesics - administration & dosage | Drug Synergism | Animals | Analgesics, Opioid - administration & dosage | Intercellular Signaling Peptides and Proteins - pharmacology | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Intercellular Signaling Peptides and Proteins - therapeutic use | Mice | Morphine - administration & dosage | Peptides | Analysis
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