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humans (149) 149
cell biology (120) 120
biochemistry & molecular biology (118) 118
retinoblastoma protein - metabolism (102) 102
animals (93) 93
index medicus (83) 83
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phosphorylation (56) 56
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biological phenomena, cell phenomena, and immunity (25) 25
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histone deacetylase (22) 22
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Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 10/1995, Volume 15, Issue 10, pp. 5444 - 5452
The retinoblastoma-related protein p107 has been shown to be a regulator of the transcription factor E2F. p107 associates with E2F via its pocket region and... 
ADENOVIRUS E1A PROTEIN | ACTIVATION | RB PROTEIN | RETINOBLASTOMA PROTEIN | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLIN-A | CELL-PROLIFERATION | MOLECULAR-CLONING | VIRAL ONCOPROTEINS | BINDING | CELL BIOLOGY
Journal Article
British Journal of Cancer, ISSN 0007-0920, 08/1993, Volume 68, Issue 2, pp. 264 - 268
The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried... 
ADENOVIRUS E1A PROTEINS | CARCINOMA-CELLS | ONCOLOGY | RB GENE | TRANSCRIPTION | C-MYC | SV40 LARGE-T | CELL-CYCLE | SUSCEPTIBILITY GENE-PRODUCT | LARGE T-ANTIGENS | MYC PROMOTER
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/1994, Volume 13, Issue 12, pp. 2897 - 2903
The 86 kDa immediate early IE2 protein of human cytomegalovirus (HCMV) can activate transcription of both viral and cellular genes and can repress... 
HCMV | RB protein | IE2 protein | RB PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN CYTOMEGALOVIRUS | C-MYC | DNA-BINDING PROTEIN | CELL BIOLOGY | ADENOVIRUS E1A PROTEINS | CELLULAR TRANSCRIPTION FACTOR | EARLY PROMOTER | NEGATIVE REGULATION | SEQUENCE | GENE-PRODUCT | IE2 PROTEIN
Journal Article
Archives of Ophthalmology, ISSN 0003-9950, 11/2001, Volume 119, Issue 11, pp. 1699 - 1704
Journal Article
Nature, ISSN 0028-0836, 08/2001, Volume 412, Issue 6846, pp. 561 - 565
In eukaryotic cells the histone methylase SUV39H1 and the methyl-lysine binding protein HP1 functionally interact to repress transcription at heterochromatic... 
cyclin E | SUV39H1 protein | Rb protein | HP1 protein | histone methylase
Journal Article
Journal of molecular biology, ISSN 0022-2836, 1/2014, Volume 426, Issue 1
The retinoblastoma proteinC-terminal domain (RbC) is necessary for the tumor suppressor protein's activities in growth suppression and E2F transcription factor... 
Rb protein | multisite phosphorylation | cyclin-dependent kinases | Cell cycle regulation | protein-protein interactions
Journal Article
Oncogene, ISSN 0950-9232, 01/1994, Volume 9, Issue 5, pp. 1321 - 1326
While familial retinoblastoma has served as the paradigm for the two-hit theory of tumorigenesis and for the concept of the tumor suppressor gene, the etiology... 
tumors | retinoblastoma | retina | Rb-1 gene | RB protein | inactivation | family studies | man
Journal Article
2000, AD-a383 081.
Cancer arises from an accumulation of multiple mutations that may occur in oncogenes, tumor suppressor genes or DNA repair genes. Tumor suppressors control... 
riz | genes | breast cancer | suppressors | x-ray crystallography | crystallography | rb protein | mutations | proteins | deoxyribonucleic acids | crystallization | oncogenic viruses | neoplasms
Government Document
Journal of Cellular Biochemistry, ISSN 0730-2312, 2002, Volume 86, Issue 4, pp. 630 - 641
The retinoblastoma susceptibility gene product, p105Rb (RB), is generally believed to be an important regulator in the control of cell growth, differentiation,... 
cyclosporin A | nuclear factor for activation of T cell | calcineurin | phorbol 12‐myristate 13‐acetate | retinoblastoma susceptibility gene product, RB | cyclophilin A | Nuclear factor for activation of T cell | Retinoblastoma susceptibility gene product, RB | Cyclosporin A | Phorbol 12-myristate 13-acetate | Calcineurin | Cyclophilin A | KINASE-ACTIVITY | phorbol 12-myristate 13-acetate | MOLECULAR CHAPERONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | REPRESSES TRANSCRIPTION | CELL BIOLOGY | TERMINAL REGION | TUMOR-SUPPRESSOR | SUSCEPTIBILITY GENE | SP1-MEDIATED TRANSCRIPTION | TRANSCRIPTION FACTOR | HISTONE DEACETYLASE | Sequence Deletion | Cyclosporine - pharmacology | Jurkat Cells - metabolism | Humans | Substrate Specificity | Recombinant Fusion Proteins - metabolism | Calcineurin Inhibitors | Cyclophilin A - pharmacology | T-Lymphocytes - metabolism | Transcription Factors - pharmacology | Phorbol Esters - pharmacology | Cyclosporine - metabolism | Cyclophilin A - metabolism | Protein Structure, Tertiary | DNA-Binding Proteins - physiology | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Retinoblastoma Protein - metabolism | Glutathione Transferase - metabolism | Transcription Factors - antagonists & inhibitors | NFATC Transcription Factors | Blotting, Western | Precipitin Tests | Nuclear Proteins | Transcription Factors - metabolism | Lymphocyte Activation - drug effects | Plasmids | Ionomycin - pharmacology | Protein Binding | Ionomycin - chemistry | T-Lymphocytes - immunology | Lymphocyte Activation - physiology | Calcineurin - metabolism
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 1997, Volume 1361, Issue 1, pp. 20 - 27
A cDNA clone encoding rat p130, a member of the retinoblastoma (Rb) gene family, was isolated based on the sequence homology of the E1A-binding domain. The... 
Rb family | cDNA | Chromosomal mapping | E1A | Rat p130 | K DA BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | POLYPEPTIDES | chromosomal mapping | ADENOVIRUS E1A PROTEINS | rat p130 | BIOPHYSICS | PRODUCT | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | E2F | CELL-CYCLE | MOLECULAR-CLONING | ElA | DIFFERENTIATION | ASSOCIATION | EXPRESSION
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2005, Volume 24, Issue 1, pp. 160 - 169
Journal Article