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Brain, ISSN 0006-8950, 2012, Volume 135, Issue 11, pp. 3251 - 3264
The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in... 
traumatic brain injury | matrix metalloproteinase-3 | plasminogen activator inhibitor-1 | tissue plasminogen activator | neurovascular unit | MULTIPLE-SCLEROSIS LESIONS | RECEPTOR-RELATED PROTEIN | TPA | FOCAL CEREBRAL-ISCHEMIA | BARRIER BREAKDOWN | NEUROSCIENCES | CLINICAL NEUROLOGY | STROKE | MATRIX METALLOPROTEINASES | CENTRAL-NERVOUS-SYSTEM | EXPRESSION | BLOOD | Capillary Permeability - physiology | Tissue Plasminogen Activator - metabolism | Brain Injuries - drug therapy | Humans | Middle Aged | Injections, Intraventricular | Capillary Permeability - drug effects | Male | Brain Injuries - metabolism | Brain Injuries - physiopathology | Plasminogen Activator Inhibitor 1 - physiology | Matrix Metalloproteinase Inhibitors - therapeutic use | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | Tissue Plasminogen Activator - antagonists & inhibitors | Plasminogen Activator Inhibitor 1 - metabolism | Aged, 80 and over | Recovery of Function - physiology | Adult | Disease Models, Animal | Albumins - metabolism | Mice, Inbred C57BL | Plasminogen Activator Inhibitor 1 - administration & dosage | Tissue Plasminogen Activator - administration & dosage | Tissue Plasminogen Activator - physiology | Animals | Brain Injuries - cerebrospinal fluid | Aged | Mice | Matrix Metalloproteinases - metabolism | Index Medicus | Abridged Index Medicus | Stroke | Central nervous system | Membrane permeability | Albumin | Homeostasis | Cerebrospinal fluid | Matrix metalloproteinase | Permeability | Trauma | Plasmin | t-Plasminogen activator | lipoprotein receptors | neuroserpin | plasminogen | Proteolysis | Plasma membranes | Chromium | Serine proteinase | Brain injury | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e101895 - e101895
Journal Article
Stroke, ISSN 0039-2499, 01/2014, Volume 45, Issue 1, pp. 18 - 23
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 03/2017, Volume 45, Issue 6, pp. 805 - 815
Glutamate phase shifts the circadian clock in the mammalian suprachiasmatic nucleus ( SCN ) by activating NMDA receptors. Tissue‐type plasminogen activator (... 
urokinase‐type plasminogen activator | circadian rhythms | suprachiasmatic nucleus | tissue‐type plasminogen activator | urokinase-type plasminogen activator | tissue-type plasminogen activator | NEURONAL MIGRATION | CELL-ADHESION MOLECULE | NEUROTROPHIC FACTOR | RECEPTOR | NEUROSCIENCES | IN-VITRO | EXTRACELLULAR-MATRIX | BIOLOGICAL CLOCK | BRAIN | GENE-FUNCTION | Brain-Derived Neurotrophic Factor - genetics | Suprachiasmatic Nucleus - drug effects | Tissue Plasminogen Activator - metabolism | Mice, Inbred C57BL | Plasminogen Inactivators - pharmacology | Male | Tissue Plasminogen Activator - genetics | Suprachiasmatic Nucleus - physiology | Animals | Urokinase-Type Plasminogen Activator - metabolism | Proteolysis | Circadian Clocks | Female | Suprachiasmatic Nucleus - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Mice | Urokinase | Glutamate | Tissue plasminogen activator | Laws, regulations and rules | Suprachiasmatic nucleus | Glutamic acid | Brain | Night | Glutamic acid receptors (ionotropic) | Brain slice preparation | Nuclei | Plasmin | t-Plasminogen activator | Receptors | Casein | Rodents | Entrainment | Inhibition | Biological clocks | Circadian rhythms | Phase transformations | Phase shift | Polyamide-imides | N-Methyl-D-aspartic acid receptors | Circadian rhythm | Mammals | U-Plasminogen activator | Brain-derived neurotrophic factor | Inhibitors | Plasminogen activator inhibitors | TrkB receptors | Glutamatergic transmission | Gates | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2005, Volume 280, Issue 43, pp. 36529 - 36540
The invasive ability of tumor cells plays a key role in prostate cancer metastasis and is a major cause of treatment failure. Urokinase plasminogen... 
MIGRATION | VITRO | GROWTH-FACTOR-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | GENE-EXPRESSION | DOWN-REGULATION | UPA PROMOTER | TUMOR-GROWTH | ANTISENSE OLIGONUCLEOTIDES | CATHEPSIN-B | Laminin - pharmacology | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Cell Proliferation | Humans | Extracellular Matrix - metabolism | Collagen - chemistry | Immunoblotting | Male | Proteoglycans - chemistry | Neoplasm Metastasis | Transfection | RNA Interference | Time Factors | Collagen - pharmacology | Prostatic Neoplasms - pathology | Signal Transduction | Cell Survival | Neoplasm Invasiveness | Electrophoresis, Polyacrylamide Gel | Gene Silencing | Tetrazolium Salts - pharmacology | Urokinase-Type Plasminogen Activator - genetics | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Proteoglycans - pharmacology | Urokinase-Type Plasminogen Activator - metabolism | Mice, Nude | Cell Line, Tumor | Laminin - chemistry | Mice | Thiazoles - pharmacology | Neoplasms - pathology | Drug Combinations | Microscopy, Fluorescence | Apoptosis | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Index Medicus | RNAi | uPAR (uPA receptor) | shRNA (small hairpin RNA) | uPA (urokinaseplasminogen activator) | survival | siRNA (small interfering RNA) | prostate cancer | invasion | uPA and uPAR | ANOVA (analysis of variance) | RNAi (RNA interference) | RT (reverse transcription) | TPBS (tween-20 (0.1%) phospate buffered saline) | BSA (bovine serum albumin)
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 2, pp. 203 - 210
PAI-I and PAI-2 (plasminogen-activator inhibitor types I and 2) are inhibitors of cell surface upA (urokinase plasminogen activator). However, tumour... 
Serpin (serine protease inhibitor) | Plasminogen-activator inhibitor type 2 (PAI-2) | Urokinase plasminogen activator (uPA) | Very-low-density lipoprotein receptor (VLDLr) | Plasminogen-activator inhibitor type 1 (PAI-1) | SYSTEM | very-low-density lipoprotein receptor (VLDLr) | PROTEIN | LDL RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | plasminogen-activator inhibitor type 1 (PAI-1) | serpin (serine protease inhibitor) | urokinase plasminogen activator (uPA) | COMPLEX-FORMATION | RAP COMPLEX | plasminogen-activator inhibitor type 2 (PAI-2) | DENSITY-LIPOPROTEIN-RECEPTOR | UROKINASE RECEPTOR | BINDING-SITE | LIGAND | Humans | Receptors, Cell Surface - metabolism | Receptors, LDL - metabolism | Plasminogen Activator Inhibitor 2 - physiology | Plasminogen Activator Inhibitor 1 - physiology | Breast Neoplasms - metabolism | Receptors, Urokinase Plasminogen Activator | Breast Neoplasms - chemistry | Plasminogen Activator Inhibitor 1 - chemistry | Plasminogen Activator Inhibitor 1 - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Breast Neoplasms - pathology | Plasminogen Activator Inhibitor 2 - metabolism | Protein Structure, Secondary - physiology | Signal Transduction - physiology | Urokinase-Type Plasminogen Activator - chemistry | Tumor Cells, Cultured | Plasminogen Activator Inhibitor 2 - chemistry | Protein Binding - physiology | Protein Structure, Tertiary - physiology | Index Medicus | uPA, urokinase plasminogen activator | LDLR, low-density lipoprotein receptor | serpin, serine protease inhibitor | uPAR, urokinase plasminogen activator receptor | VLDLr, very-low-density lipoprotein receptor | PAI, plasminogen-activator inhibitor | RAP, receptor-associated protein | RCL, reactive centre loop | ERK, extracellular-signal-regulated kinase | plasminogen-activator inhibitor type 1 (PAI-1) | LRP, low-density lipoprotein receptor-related protein | SPR, surface plasmon resonance | plasminogen-activator inhibitor type 2 (PAI-2)
Journal Article