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1. Full Text Lack of association between interleukin-1 receptor antagonist gene 86-bp VNTR polymorphism and ischemic stroke: A meta-analysis
by Yang, Yujiao and Wu, Wenhui and Wang, Long and Ding, Yi
Medicine, ISSN 0025-7974, 08/2018, Volume 97, Issue 31, p. e11750
Objective The results of published studies which examined the association between variable number tandem repeat (VNTR) polymorphism of interleukin-1 receptor... 
SUBTYPE | POPULATION | MEDICINE, GENERAL & INTERNAL | NUMBER TANDEM REPEATS | IL-1 | SUSCEPTIBILITY | DISEASE | meta-analysis | variable number tandem repeat | INTRON-2 POLYMORPHISM | interleukin-1 receptor antagonist | ischemic stroke | Asian Continental Ancestry Group | Genetic Predisposition to Disease | Humans | Brain Ischemia - genetics | Interleukin 1 Receptor Antagonist Protein - genetics | Odds Ratio | Stroke - genetics | Minisatellite Repeats | Polymorphism, Genetic | Stroke (Disease) | Care and treatment | Cell receptors | Interleukins | Development and progression | Genetic aspects | Health aspects | Genetic polymorphisms
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2. Full Text Interleukin 1 receptor antagonist (IL1RA) gene polymorphism and levels associated with adverse outcome in severe community‐acquired pneumonia in children: A hospital‐based study in India
by Awasthi, Shally and Yadav, Krishna K and Pandey, Monika and Mahdi, Abbas A and Awasthi, Nidhi
Pediatric Pulmonology, ISSN 8755-6863, 09/2018, Volume 53, Issue 9, pp. 1276 - 1283
Background High morbidity and mortality due to community‐acquired pneumonia (CAP) is seen in children under 5 years of age in India. Besides identified risk... 
IL1RA serum levels | community‐acquired pneumonia | children | Interleukin 1 receptor antagonist (IL1 RA) gene polymorphisms | India | community-acquired pneumonia | MORTALITY | INFECTIONS | IL-1RA | SEPSIS | CYTOKINE PRODUCTION | PLASMA-LEVELS | RESPIRATORY SYSTEM | SEPTIC SHOCK | PEDIATRICS | IL-1-BETA | INTRON-2 | Genes | Septic shock | Congenital heart disease | Genetic aspects | Children | Enzyme-linked immunosorbent assay | Genetic polymorphisms
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3. Full Text Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Disease
by Steven S. Witkin and Stefan Gerber and William J. Ledger
Clinical Infectious Diseases, ISSN 1058-4838, 1/2002, Volume 34, Issue 2, pp. 204 - 209
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring competitive inhibitor of interleukin-1 (IL-1)-induced proinflammatory activity. The IL-1RA... 
Homozygotes | Receptors | Immune response | Cytokines | Review Article | Genes | Alleles | Bones | Autoimmune diseases | Coronary artery disease | Genotypes | RHEUMATOID-ARTHRITIS | INFECTIOUS DISEASES | IL-1RA | RHESUS-MONKEYS | ULCERATIVE-COLITIS | MICROBIOLOGY | INTRAAMNIOTIC INFECTION | IMMUNOLOGY | WOMEN | BONE LOSS | IL-1-BETA | INFLAMMATORY BOWEL-DISEASE | ASSOCIATION | Sialoglycoproteins - genetics | Genetic Predisposition to Disease | Animals | Humans | Interleukin 1 Receptor Antagonist Protein | Polymorphism, Genetic - genetics | Receptors, Interleukin-1 - antagonists & inhibitors | Physiological aspects | Interleukin-1 | Care and treatment | Genetic disorders
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4. Full Text IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort
by Wu, X and Kondragunta, V and Kornman, K.S and Wang, H.Y and Duff, G.W and Renner, J.B and Jordan, J.M
Osteoarthritis and Cartilage, ISSN 1063-4584, 2013, Volume 21, Issue 7, pp. 930 - 938
Summary Objective Within the interleukin-1 (IL-1) cytokine family, IL-1 receptor antagonist ( IL1RN ) gene variants have been associated with radiological... 
Rheumatology | Progression | Genetics | Interleukin-1 | Osteoarthritis | Population stratification | Predictive biomarker | C-REACTIVE PROTEIN | UNITED-STATES | HAPLOTYPES | PREVALENCE | RHEUMATOLOGY | RHEUMATIC CONDITIONS | POLYMORPHISMS | IL1R1 GENE | SUSCEPTIBILITY LOCUS | LINKAGE | ORTHOPEDICS | ASSOCIATION | Body Mass Index | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Interleukin 1 Receptor Antagonist Protein - genetics | Male | Osteoarthritis, Knee - diagnostic imaging | Radiography | Haplotypes - genetics | Osteoarthritis, Knee - genetics | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Genetic research | Interleukins | Genes | population stratification | progression | genetics | predictive biomarker | osteoarthritis
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5. Full Text Positive correlation between interleukin-1 receptor antagonist gene 86bp VNTR polymorphism and colorectal cancer susceptibility: a case-control study
by Ibrahimi, Mostafa and Ibrahimi, Mostafa and Moossavi, Maryam and Moossavi, Maryam and Mojarad, Ehsan Nazemalhosseini and Mojarad, Ehsan Nazemalhosseini and Musavi, Mahsa and Musavi, Mahsa and Mohammadoo-khorasani, Milad and Mohammadoo-khorasani, Milad and Shahsavari, Zahra and Shahsavari, Zahra
Immunologic Research, ISSN 0257-277X, 2/2019, Volume 67, Issue 1, pp. 151 - 156
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Genetic variations in cytokine genes and their receptors lead to the severity of the... 
Allergology | IL1RN | Immunology | Medicine & Public Health | Cytokines | Colorectal cancer | VNTR polymorphism | IL-4 | Internal Medicine | Medicine/Public Health, general | CARCINOGENESIS | INCREASED RISK | IMMUNOLOGY | ASSOCIATION | EPIDEMIOLOGY | Interleukins | Liver | Oncology, Experimental | Genes | Genetic research | Genetic aspects | Disease susceptibility | Research | Genetic polymorphisms | Cancer | Liver diseases | Interleukin 1 receptor antagonist | Interleukin | Colorectal carcinoma | Population studies | Genetic diversity | Inflammation | Gene polymorphism | Receptors | Interleukin 4 | Genotyping | Interleukin 1 | Genotypes | Deoxyribonucleic acid--DNA | Salting | Polymorphism
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6. Full Text IL1 Receptor Antagonist Gene IL1-RN Variable Number of Tandem Repeats Polymorphism and Cancer Risk: A Literature Review and Meta-Analysis
by Zhang, Ying and Liu, Changming and Peng, Huiping and Zhang, Jianzhi and Feng, Quanlin
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e46017
IL1 receptor antagonist (IL1RA) and IL1beta (IL1 beta), members of the pro-inflammatory cytokine interleukin-1 (IL1) family, play a potential role against... 
BREAST-CANCER | IL-1RN POLYMORPHISMS | LUNG-CANCER | GASTRIC-CANCER | INTERLEUKIN-1-BETA GENE | MULTIDISCIPLINARY SCIENCES | CERVICAL-CANCER | HELICOBACTER-PYLORI | HEPATITIS-C | CARCINOMA | CHINESE POPULATION | Stomach Neoplasms - genetics | Interleukin-1 - genetics | Genetic Predisposition to Disease | Humans | Stomach Neoplasms - metabolism | Genotype | Interleukin 1 Receptor Antagonist Protein - genetics | Risk | Interleukin 1 Receptor Antagonist Protein - physiology | Interleukin-1beta - genetics | Models, Statistical | Case-Control Studies | Minisatellite Repeats | Polymorphism, Genetic | Neoplasms - genetics | Interleukin-1beta - metabolism | Models, Genetic | Odds Ratio | Cytokines | Physiological aspects | Development and progression | Genetic aspects | Research | Risk factors | Genetic polymorphisms | Cancer | Pathogenesis | Interleukin | Bladder | Infections | Gene polymorphism | Epidemiology | Stomach cancer | Proteins | Literature reviews | Confidence intervals | Liver cancer | Hepatitis | Urinary bladder | Mathematical analysis | Etiology | Rodents | Interleukin 1 | Gastric cancer | Genotypes | Interleukin 1 receptor antagonist | Health risks | Breast cancer | Inflammation | Gene expression | Meta-analysis | Medicine | Studies | Ethnicity | Hospitals | Binding sites | Polymorphism
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7. Full Text Biscarbamate cross-linked low molecular weight PEI for delivering IL-1 receptor antagonist gene to synoviocytes for arthritis therapy
by Xiang, Shengnan and Su, Jing and Tong, Haijun and Yang, Fei and Tong, Wenxue and Yuan, Weien and Wu, Fei and Wang, Chuandong and Jin, Tuo and Dai, Kerong and Zhang, Xiaoling
Biomaterials, ISSN 0142-9612, 2012, Volume 33, Issue 27, pp. 6520 - 6532
Abstract Cytoxicity is an essential concern for polyethyleneimine 25 kDa (PEI 25 kDa), a widely reported, highly effective transfection agent used in gene... 
Advanced Basic Science | Dentistry | Arthritis | Gene transfer | Cross-linking | Nanoparticle | CELLS | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | POLYETHYLENIMINE | VECTOR | IN-VIVO | OSTEOARTHRITIS | EFFICIENT | CYTOTOXICITY | Genetic Therapy | Synovial Membrane - pathology | Interleukin 1 Receptor Antagonist Protein - genetics | Spectroscopy, Fourier Transform Infrared | Carbamates - chemistry | Drug Delivery Systems | Transfection | Electrophoresis, Agar Gel | Polyethyleneimine - chemistry | Cell Death | Membrane Potential, Mitochondrial | Polyethyleneimine - chemical synthesis | Cross-Linking Reagents - chemistry | Magnetic Resonance Spectroscopy | Arthritis - pathology | Cells, Cultured | Rats | Plasmids - metabolism | Rats, Sprague-Dawley | Microscopy, Confocal | Carbamates - chemical synthesis | Animals | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Intracellular Space - metabolism | Arthritis - therapy
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8. Full Text Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: Results of a phase 1/2 study
by Mease, Philip J and Wei, Nathan and Fudman, Edward J and Kivitz, Alan J and Schechtman, Joy and Trapp, Robert G and Hobbs, Kathryn F and Greenwald, Maria and Hou, Antony and Bookbinder, Stephen A and Graham, Galen E and Wiesenhutter, Craig W and Willis, Larry and Ruderman, Eric M and Forstot, Joseph Z and Maricic, Michael J and Dao, Kathryn H and Pritchard, Charles H and Fiske, Darrell N and Burch, Francis X and Prupas, H. Malin and Anklesaria, Pervin and Heald, Alison E
Journal of Rheumatology, ISSN 0315-162X, 04/2010, Volume 37, Issue 4, pp. 692 - 703
Objective. To assess safety and clinical outcomes in patients with inflammatory arthritis after intraarticular (IA) injection of rAAV2-TNFR:Fc, a recombinant... 
Clinical trials | Biological therapy | Tumor necrosis factor inhibitors | Rheumatoid arthritis | Psoriatic arthritis | RHEUMATOID-ARTHRITIS | HISTOPLASMOSIS | TUMOR NECROSIS FACTOR INHIBITORS | SHOULDER | CLINICAL TRIALS | CONSENSUS | HAND QUESTIONNAIRE | ANKYLOSING-SPONDYLITIS | RHEUMATOLOGY | THERAPY | RHEUMATOID ARTHRITIS | ETANERCEPT | INFLIXIMAB | PSORIATIC ARTHRITIS | MONOARTHRITIS | BIOLOGICAL THERAPY | Adenoviridae | Humans | Tumor Necrosis Factor-alpha - genetics | Antirheumatic Agents - immunology | Male | Patient Selection | Receptors, Tumor Necrosis Factor - therapeutic use | Dose-Response Relationship, Drug | Immunoglobulin G - immunology | Antirheumatic Agents - adverse effects | Arthritis - immunology | Adult | Female | Receptors, Tumor Necrosis Factor - genetics | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Treatment Outcome | Immunoglobulin G - adverse effects | Immunoglobulin G - genetics | Injections, Intra-Articular | Arthritis - therapy | Genetic Vectors | Receptors, Tumor Necrosis Factor - immunology | Immunity, Cellular | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Genetic Therapy - adverse effects
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9. Full Text In Vivo Transfer of Interleukin-1 Receptor Antagonist Gene in Osteoarthritic Rabbit Knee Joints : Prevention of Osteoarthritis Progression
by Fernandes, Julio and Tardif, Ginette and Martel-Pelletier, Johanne and Lascau-Coman, Viorica and Dupuis, Martine and Moldovan, Florina and Sheppard, Mike and Krishnan, B. Rajendra and Pelletier, Jean-Pierre
American Journal of Pathology, ISSN 0002-9440, 04/1999, Volume 154, Issue 4, pp. 1159 - 1169
The goal of this study was to determine the efficacy of local IL-1Ra gene therapy by intra-articular plasmid injections on structural changes in the... 
RHEUMATOID-ARTHRITIS | GROWTH-FACTOR-BETA | INTRAARTICULAR INJECTIONS | SYNOVIAL-MEMBRANE | IN-VIVO | PLASMID DNA | OSTEO-ARTHRITIS | HUMAN ARTICULAR CHONDROCYTES | IL-1 RECEPTOR | PATHOLOGY | EXPRESSION | Immunohistochemistry | Gene Transfer Techniques | Genetic Therapy | Rabbits | Sialoglycoproteins - genetics | Hindlimb | Sialoglycoproteins - metabolism | Synovial Fluid - metabolism | Joints - pathology | Disease Progression | Osteoarthritis - therapy | Plasmids - therapeutic use | Sialoglycoproteins - therapeutic use | Antirheumatic Agents - metabolism | Animals | Dogs | Plasmids - genetics | Polymerase Chain Reaction | Interleukin 1 Receptor Antagonist Protein | Osteoarthritis - pathology | Receptors, Interleukin-1 - antagonists & inhibitors | Joints - metabolism | Antirheumatic Agents - therapeutic use | Regular
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10. Full Text Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease
by Francis, Sheila E and Camp, Nicola J and Dewberry, Rachael M and Gunn, Julian and Syrris, Petros and Carter, Nicholas D and Jeffery, Stephen and Kaski, Juan Carlos and Cumberland, David C and Duff, Gordon W and Crossman, David C
Circulation, ISSN 0009-7322, 02/1999, Volume 99, Issue 7, pp. 861 - 866
Background-Cytokine gene variations are contributory factors in inflammatory pathology. Allele frequencies of interleukin (IL)-1 cluster genes [IL-1A(-889),... 
Interleukins | Coronary artery disease | Genes | coronary artery disease | CARDIAC & CARDIOVASCULAR SYSTEMS | genes | RISK | interleukins | HEART-DISEASE | MEN | PERIPHERAL VASCULAR DISEASE | VASCULAR ENDOTHELIAL-CELLS | HEMATOLOGY | ASSOCIATION | EXPRESSION | SEVERITY | FIBRINOGEN
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11. Full Text Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations
by Attur, Mukundan and Wang, Hwa-Ying and Kraus, Virginia Byers and Bukowski, Jack F and Aziz, Nazneen and Krasnokutsky, Svetlana and Samuels, Jonathan and Greenberg, Jeffrey and McDaniel, Gary and Abramson, Steven B and Kornman, Kenneth S
Annals of the Rheumatic Diseases, ISSN 0003-4967, 05/2010, Volume 69, Issue 5, pp. 856 - 861
Background A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. Objective... 
POLYMORPHISMS | INFLAMMATION | CANDIDATE GENES | HAPLOTYPE | RHEUMATOLOGY | ARTHRITIS | SUPPRESSION | ASSOCIATION | EXPRESSION | IL-10 | PROGRESSION | Haplotypes | Severity of Illness Index | Genetic Predisposition to Disease | Humans | Middle Aged | Genotype | Interleukin 1 Receptor Antagonist Protein - genetics | Male | Genetic Markers | Synovial Fluid - chemistry | Osteoarthritis, Knee - diagnostic imaging | Aging - pathology | Radiography | Aging - genetics | Inflammation Mediators - analysis | Osteoarthritis, Knee - genetics | Adult | Female | Aged | Polymorphism, Single Nucleotide | Osteoarthritis, Knee - metabolism | Interleukin-1 | Genetic markers | Genetic aspects | Research | Osteoarthritis | Risk factors | Genetic polymorphisms | Immunoassay | Disease | Cytokines | Laboratories | Genes | ISO standards | Arthritis | Joint surgery | Patients | Biological activity | Proteins | Studies | Body mass index | Genotype & phenotype | Hospitals | Genetics | Age | Chronic illnesses
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12. Full Text Polymorphisms of the IL1-Receptor Antagonist Gene (IL1RN) Are Associated With Multiple Markers of Systemic Inflammation
by Reiner, Alexander P and Wurfel, Mark M and Lange, Leslie A and Carlson, Christopher S and Nord, Alex S and Carty, Cara L and Rieder, Mark J and Desmarais, Cindy and Jenny, Nancy S and Iribarren, Carlos and Walston, Jeremy D and Williams, O Dale and Nickerson, Deborah A and Jarvik, Gail P
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2008, Volume 28, Issue 7, pp. 1407 - 1412
BACKGROUND—Circulating levels of acute phase reactant proteins such as plasma C-reactive protein (CRP) are likely influenced by multiple genes regulating the... 
Inflammation | C-reactive protein | IL-1 receptor antagonist | Fibrinogen | ACUTE-PHASE PROTEIN | IL-1RA | fibrinogen | INTERLEUKIN-1 RECEPTOR ANTAGONIST | SERUM-AMYLOID-A | COMBINATIONS | inflammation | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | CORONARY-HEART-DISEASE | PROMOTER | HEMATOLOGY | EXPRESSION | Haplotypes | Prospective Studies | United States | Humans | Middle Aged | Interleukin 1 Receptor Antagonist Protein - genetics | Male | Case-Control Studies | Inflammation - blood | Interleukin 1 Receptor Antagonist Protein - blood | C-Reactive Protein - metabolism | Aged, 80 and over | Adult | Female | Genetic Predisposition to Disease | Reproducibility of Results | Gene Frequency | Risk Factors | Inflammation Mediators - blood | Biomarkers - blood | Linkage Disequilibrium | Phenotype | Inflammation - genetics | Aged | Polymorphism, Single Nucleotide | IL-1receptor antagonist
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13. Full Text Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene
by Frisbie, D.D and Ghivizzani, S.C and Robbins, P.D and Evans, C.H and McIlwraith, C.W
Gene Therapy, ISSN 0969-7128, 2002, Volume 9, Issue 1, pp. 12 - 20
Osteoarthritis in horses and in humans is a significant social and economic problem and continued research and improvements in therapy are needed. Because... 
In vivo | Equine | Gene therapy | Osteoarthritis | Interleukin-1 receptor antagonist | interleukin 1 receptor antagonist | interleukin 1 receptors
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14. Full Text Polymorphism in the interleukin-1 receptor antagonist gene is associated with serum interleukin-1 receptor antagonist concentrations and postoperative opioid consumption
by Candiotti, Keith A and Yang, Zongqi and Morris, Richard and Yang, Jinfeng and Crescimone, Nicolas A and Sanchez, Greys C and Bird, Vincent and Leveillee, Raymond and Rodriguez, Yiliam and Liu, Huanliang and Zhang, Yu Dana and Bethea, John R and Gitlin, Melvin C
Anesthesiology, ISSN 0003-3022, 2011, Volume 114, Issue 5, pp. 1162 - 1168
Background: The interleukin-1 receptor antagonist (IL-1Ra) is the principal determinant of IL-1 beta bioactivity within the IL-1 gene cluster, regulating IL-1... 
CYTOKINE PRODUCTION | PAIN | IL-1RA | ANESTHESIOLOGY | IL-1-BETA | TANDEM REPEAT | INTRON-2 | ANALGESIA | Follow-Up Studies | Pain, Postoperative - drug therapy | Humans | Middle Aged | Postoperative Period | Analgesics, Opioid - therapeutic use | Interleukin 1 Receptor Antagonist Protein - genetics | Male | Interleukin 1 Receptor Antagonist Protein - blood | Nephrectomy | Pain, Postoperative - genetics | Analgesics, Opioid - administration & dosage | Polymerase Chain Reaction | Female | Polymorphism, Genetic - genetics | Pain Measurement | Morphine - administration & dosage | Morphine - therapeutic use
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