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NATURE, ISSN 0028-0836, 01/2011, Volume 469, Issue 7329, pp. 241 - 244
beta-adrenergic receptors (beta ARs) are G-protein-coupled receptors (GPCRs) that activate intracellular G proteins upon binding catecholamine agonist ligands... 
CRYSTALLIZATION | AMINO-ACID | ACTIVATION | LIGAND-BINDING | BETA-ADRENERGIC-RECEPTORS | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | CRYSTALLOGRAPHY | HIGH-AFFINITY BINDING | BETA-ADRENERGIC RECEPTOR | Dobutamine - metabolism | Hydroxyquinolines - chemistry | Catecholamines - metabolism | Albuterol - pharmacology | Amphetamines - pharmacology | Adrenergic beta-1 Receptor Antagonists - pharmacology | Crystallography, X-Ray | Adrenergic beta-1 Receptor Agonists - chemistry | Structure-Activity Relationship | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Agonists - pharmacology | Turkeys | Adrenergic beta-1 Receptor Antagonists - chemistry | Drug Design | Adrenergic beta-1 Receptor Antagonists - metabolism | Dobutamine - chemistry | Isoproterenol - chemistry | Binding Sites | Hydroxyquinolines - pharmacology | Amphetamines - chemistry | Drug Partial Agonism | Albuterol - metabolism | Hydroxyquinolines - metabolism | Isoproterenol - metabolism | Models, Molecular | Receptors, Adrenergic, beta-1 - metabolism | Serine - chemistry | Serine - metabolism | Dobutamine - pharmacology | Animals | Hydrogen Bonding | Amphetamines - metabolism | Isoproterenol - pharmacology | Protein Stability - drug effects | Albuterol - chemistry | Ligands | Protein Conformation | Adrenergic beta-1 Receptor Agonists - metabolism
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 04/2013, Volume 38, Issue 5, pp. 729 - 742
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 09/2006, Volume 70, Issue 3, pp. 801 - 805
Varenicline, a new nicotinic ligand based on the structure of cytisine, has recently been approved by the U. S. Food and Drug Administration for use as a... 
SMOKING-CESSATION | ACETYLCHOLINE-RECEPTORS | CYTISINE | SUBTYPES | AFFINITY | ANALOGS | HEK293 CELLS | PHARMACOLOGY | ALPHA | PHARMACOLOGY & PHARMACY | SUBUNIT COMPOSITION
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2005, Volume 48, Issue 10, pp. 3474 - 3477
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified... 
MORTALITY | ACETYLCHOLINE-RECEPTORS | CHEMISTRY, MEDICINAL | CYTISINE | MECAMYLAMINE | LIGANDS | BETA-2 SUBUNIT | MECHANISMS | RAT-BRAIN | DERIVATIVES | ADDICTION
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2007, Volume 104, Issue 30, pp. 12518 - 12523
Alcohol dependence is a disease that impacts millions of individuals worldwide. There has been some progress with pharmacotherapy for alcohol-dependent... 
Ethanol | Water consumption | Agonists | Alcohol drinking | Nicotinic receptors | Dosage | Post hoc | Vehicles | Alcohols | Nicotine dependence | Alcohol | Treatment | Addiction | Dependence | Nicotine | alcohol | Biological Sciences | treatment | dependence | nicotine | addiction
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2014, Volume 349, Issue 3, pp. 427 - 436
Journal Article
Pharmacology Biochemistry and Behavior, ISSN 0091-3057, 08/2018, Volume 171, pp. 46 - 53
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 11/2018, Volume 14, Issue 11, pp. 1059 - 1059
Salmeterol is a partial agonist for the beta(2) adrenergic receptor (beta(2)AR) and the first long-acting beta(2)AR agonist to be widely used clinically for... 
DYNAMIC PROCESS | ACTIVATION | STIMULATION | PROTEIN-COUPLED RECEPTOR | LIGAND EFFICACY | PHOSPHORYLATION | DESENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-ARRESTIN | BETA-ADRENERGIC RECEPTOR | SALMETEROL
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 01/2011, Volume 336, Issue 1, pp. 242 - 253
Neuronal nicotinic alpha 7 acetylcholine receptors (alpha 7nAChRs) are expressed primarily in the brain and are implicated in modulating many cognitive... 
SYSTEM | ACETYLCHOLINE-RECEPTORS | CHANNEL | PREPULSE INHIBITION | 5-HT3 ANTAGONIST | SYNAPTIC-TRANSMISSION | INDUCED DEFICITS | RATS | ONDANSETRON | SCHIZOPHRENIA | PHARMACOLOGY & PHARMACY
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2019, Volume 27, Issue 14, pp. 3128 - 3134
Bexarotene ( ), a retinoid X receptor (RXR) agonist approved for the treatment of cutaneous T cell lymphoma (CTCL), was reported to migrate into baboon brain... 
Retinoids | PET imaging | Nuclear receptors | Pharmacokinetics | RXR | 18F | CHEMISTRY, MEDICINAL | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | CHEMISTRY, ORGANIC | F-18 | NEUTRON-CAPTURE THERAPY | PET | Phosphates | Medical colleges | CT imaging | Phosphatases |