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PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, ISSN 0962-8436, 09/2006, Volume 361, Issue 1473, pp. 1545 - 1564
Neurotrophins are a family of closely related proteins that were identified initially as survival factors for sensory and sympathetic neurons, and have since... 
KAPPA-B ACTIVATION | SCHWANN-CELL MIGRATION | NEURONS IN-VIVO | ACTIVATED PROTEIN-KINASE | INTEGRIN-LINKED KINASE | p75 neurotrophin receptor | DEPENDENT TYROSINE PHOSPHORYLATION | apoptosis | HIGH-AFFINITY BINDING | SENSORY NEURONS | NERVE GROWTH-FACTOR | nerve growth factor | BIOLOGY | neurotrophin | Trk receptor
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 06/2014, Volume 306, Issue 12, pp. E1378 - E1387
Incomplete beta-oxidation of fatty acids in mitochondria is a feature of insulin resistance and type 2 diabetes mellitus (T2DM). Previous studies revealed that... 
Acylcarnitine | β-oxidation | Inflammation | TLR | Pattern recognition receptors | OXIDATION | PHYSIOLOGY | acylcarnitine | SATURATED FATTY-ACIDS | INDUCED INSULIN-RESISTANCE | pattern recognition receptors | TOLL-LIKE RECEPTOR-2 | OBESITY | inflammation | beta-oxidation | ENDOCRINOLOGY & METABOLISM | EXPRESSION | Phosphorylation | Toll-Like Receptor 2 - agonists | Toll-Like Receptor 2 - antagonists & inhibitors | Toll-Like Receptor 2 - genetics | Humans | Carnitine - metabolism | Diabetes Mellitus, Type 2 - metabolism | MAP Kinase Signaling System | Receptors, Pattern Recognition - antagonists & inhibitors | Receptors, Pattern Recognition - metabolism | Macrophages - secretion | Cyclooxygenase 2 - genetics | Diabetes Mellitus, Type 2 - immunology | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Receptors, Pattern Recognition - agonists | Carnitine - analogs & derivatives | Macrophages - immunology | Recombinant Proteins - metabolism | Myristic Acids - metabolism | Cyclooxygenase 2 - chemistry | Cytokines - secretion | Gene Silencing | Myeloid Differentiation Factor 88 - genetics | Enzyme Induction | Recombinant Proteins - chemistry | Toll-Like Receptor 2 - metabolism | Macrophage Activation | Myeloid Differentiation Factor 88 - agonists | Macrophages - metabolism | Animals | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Receptors, Pattern Recognition - genetics | Mice | Protein Processing, Post-Translational | Myeloid Differentiation Factor 88 - metabolism | Cell Line, Transformed | Docosahexaenoic Acids - metabolism | Type 2 diabetes | Physiological aspects | Insulin resistance | Cellular signal transduction | Research | Diabetes | Oxidation | T cell receptors | Cytokines | Index Medicus
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 01/2018, Volume 24, Issue 2, pp. 158 - 170
Journal Article
Diabetes, ISSN 0012-1797, 01/2009, Volume 58, Issue 1, pp. 95 - 103
Hypoxia Decreases Insulin Signaling Pathways in Adipocytes Claire Regazzetti 1 2 , Pascal Peraldi 2 3 , Thierry Grémeaux 1 2 , Rosanna Najem-Lendom 1 2 , Issam... 
KINASE-ACTIVITY | OBESITY | PHOSPHORYLATION | ADIPOSE-TISSUE HYPOXIA | DYSREGULATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | INDUCIBLE FACTOR-2-ALPHA | GROWTH-FACTOR-I | RECEPTOR SUBSTRATE-1 | INFILTRATION | Lipolysis - drug effects | Reactive Oxygen Species - metabolism | Humans | Adipocytes - cytology | Protein Tyrosine Phosphatases - metabolism | Adipocytes - drug effects | Cell Hypoxia | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cobalt - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Interleukin-1beta - metabolism | Biological Transport - drug effects | Phosphorylation - drug effects | Interleukin-6 - metabolism | Cell Line | Insulin - pharmacology | 3T3-L1 Cells | Blotting, Western | Hypoglycemic Agents - pharmacology | Animals | Glycerol - metabolism | Signal Transduction - drug effects | Adipocytes - metabolism | Glucose - metabolism | Receptor, Insulin - metabolism | Mice | Complications and side effects | Fat cells | Receptors | Physiological aspects | Hypoxia | Chemical properties | Insulin | Index Medicus | Abridged Index Medicus | Phosphorylation | Reactive Oxygen Species | Adipocytes | Glucose | Cobalt | Hypoxia-Inducible Factor 1, alpha Subunit | Interleukin-6 | Life Sciences | Hypoglycemic Agents | Biological Transport | Basic Helix-Loop-Helix Transcription Factors | Signal Transduction | Glycerol | Interleukin-1beta | Lipolysis | Receptor, Insulin | Development Biology | Protein Tyrosine Phosphatases
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 04/2013, Volume 38, Issue 5, pp. 872 - 883
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms underlying their effects are unknown. We, therefore,... 
stem cells | Hedgehog signaling | prenatal stress | depression | PROGENITOR CELLS | INDUCED DOWN-REGULATION | ADULT NEUROGENESIS | PSYCHIATRY | MAJOR DEPRESSION | NEUROSCIENCES | MINERALOCORTICOID RECEPTOR | NEURAL STEM-CELLS | GENE | PHARMACOLOGY & PHARMACY | DENTATE GYRUS | EXPRESSION | Microtubule-Associated Proteins - metabolism | Humans | Male | Gene Expression Profiling | Receptors, Glucocorticoid - metabolism | Dose-Response Relationship, Drug | Dexamethasone - pharmacology | Transfection | Glucocorticoids - metabolism | Female | Fetus | Neurogenesis - drug effects | Neurons - metabolism | Hedgehogs - metabolism | Neurons - drug effects | Gene Expression Regulation - genetics | Neural Stem Cells - drug effects | Neural Stem Cells - physiology | Rats | Neuropeptides - metabolism | Hippocampus - cytology | Rats, Sprague-Dawley | Hormone Antagonists - pharmacology | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Neurogenesis - physiology | Receptors, Glucocorticoid - genetics | Signal Transduction - physiology | Cell Proliferation - drug effects | Hydrocortisone - pharmacology | Mifepristone - pharmacology | Index Medicus | Dexamethasone | Glucocorticoids | Astrocytes | Gliogenesis | Hormones | Gene expression | Hydrocortisone | Neurogenesis | Stress | Signal transduction | DNA microarrays | Hedgehog protein | Neuroblasts | Microtubule-associated protein 2 | Mineralocorticoid receptors | Neural stem cells | Notch protein | Differentiation | Hippocampus | stress | Animal models | hippocampus | Neuropharmacology | Receptor Pharmacology | glucocorticoids | Original | Biological Psychiatry | molecular signaling pathways
Journal Article
Cell Reports, ISSN 2211-1247, 05/2017, Volume 19, Issue 6, pp. 1189 - 1201
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 2012, Volume 22, Issue 9, pp. 447 - 456
Endocytosis participates in downregulating incoming signals, but ‘signaling endosomes’ may also serve as physical platforms for crosstalk between signaling... 
Pathology | GROWTH-FACTOR RECEPTOR | NETWORK | ACTIVATION | PROTEIN | DOWN-REGULATION | ENDOCYTIC TRAFFICKING | CELL-SURVIVAL | IDENTIFICATION | CANCER | APPL1 | CELL BIOLOGY | Protein Binding | Animals | Signal Transduction | Humans | Endosomes - metabolism | Protein Engineering | Chromatin | Analysis | Index Medicus | Opinion
Journal Article
SCIENCE, ISSN 0036-8075, 03/2012, Volume 335, Issue 6072, pp. 1106 - 1110
Extracellular ligand binding to G protein-coupled receptors (GPCRs) modulates G protein and beta-arrestin signaling by changing the conformational states of... 
PARTIAL AGONISTS | BETA-2-ADRENERGIC RECEPTOR | BETA ADRENERGIC-RECEPTOR | CONFORMATIONAL-CHANGES | LIGAND-BINDING | PROTEIN-COUPLED RECEPTOR | TRANSMEMBRANE RECEPTORS | CRYSTAL-STRUCTURE | NMR-SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | A(2A) ADENOSINE RECEPTOR
Journal Article