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Biochemical Pharmacology, ISSN 0006-2952, 05/2016, Volume 107, pp. 59 - 66
Gα inhibitor UBO-QIC (FR900359) is becoming an important pharmacological tool, but its selectivity against other G proteins and their subunits, especially βγ,... 
UBO-QIC | Gαq inhibitor | GPCR | FR900359 | Gβγ subunits | G protein | inhibitor | GTP-Binding Protein alpha Subunits, Gi-Go - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Receptor, Muscarinic M2 - agonists | Receptor, Muscarinic M2 - genetics | Cricetulus | Humans | GTP-Binding Protein beta Subunits - antagonists & inhibitors | GTP-Binding Protein gamma Subunits - antagonists & inhibitors | Depsipeptides - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | GTP-Binding Protein gamma Subunits - agonists | HEK293 Cells | Platelet Aggregation Inhibitors - pharmacology | Receptor, Muscarinic M2 - antagonists & inhibitors | GTP-Binding Protein beta Subunits - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Adenosine A1 - genetics | CHO Cells | Pertussis Toxin - pharmacology | Recombinant Proteins - metabolism | GTP-Binding Protein gamma Subunits - metabolism | Receptor, Muscarinic M2 - metabolism | Enzyme Inhibitors - pharmacology | GTP-Binding Protein beta Subunits - agonists | Recombinant Proteins - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Receptor, Adenosine A1 - chemistry | Receptor, Adenosine A1 - metabolism | Animals | MAP Kinase Signaling System - drug effects | GTP-Binding Protein alpha Subunits, Gi-Go - antagonists & inhibitors | Signal Transduction - drug effects | Models, Biological | Proto-Oncogene Proteins c-akt - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Gβγsubunits
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 9, pp. 6763 - 6776
Journal Article
1993, Neuroscience perspectives., ISBN 0122826302, xiv, 281 p., [4] p. of plates
Book
Current Opinion in Pharmacology, ISSN 1471-4892, 2006, Volume 7, Issue 1, pp. 39 - 47
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key roles in excitatory... 
Internal Medicine | Medical Education | LIGAND-BINDING CORE | CORTICAL-NEURONS | TERMINAL DOMAIN | NR2B SUBUNIT | D-ASPARTATE RECEPTORS | ION-CHANNEL | CRYSTAL-STRUCTURES | ZINC INHIBITION | PHARMACOLOGY & PHARMACY | DRUG TARGETS | NR1 SUBUNIT | Life Sciences | Neurons and Cognition
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2017, Volume 114, Issue 33, pp. E6942 - E6951
NMDA-type glutamate receptors are ligand-gated ion channels that contribute to excitatory neurotransmission in the central nervous system (CNS). Most NMDA... 
X-ray crystallography | Schild analysis | Kinetic modeling | PEAQX | Synaptic transmission | GLUTAMATE BINDING-SITE | DETERMINANTS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MECHANISMS | D-ASPARTATE RECEPTOR | kinetic modeling | INHIBITION | KINETICS | POSITIVE ALLOSTERIC MODULATORS | AMINO-ACID-RESIDUES | synaptic transmission | AGENTS | Excitatory Amino Acid Antagonists - metabolism | Xenopus | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Humans | Protein Multimerization | Receptors, N-Methyl-D-Aspartate - metabolism | Crystallography, X-Ray | Protein Subunits - metabolism | Quinoxalines - pharmacology | Receptors, N-Methyl-D-Aspartate - chemistry | Protein Domains | Female | Excitatory Amino Acid Antagonists - chemistry | Binding, Competitive | Glutamic Acid - pharmacology | Oocytes - metabolism | Models, Molecular | Quinoxalines - chemistry | Rats | Excitatory Amino Acid Antagonists - pharmacology | Quinoxalines - metabolism | Patch-Clamp Techniques | Animals | Oocytes - physiology | Glutamic Acid - metabolism | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Glutamic Acid - chemistry | Neural transmission | Cell receptors | Models | Molecular structure | Properties | Testing | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | Biological Sciences | PNAS Plus
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 3, pp. 387 - 400
Journal Article
Journal Article
17.