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British Journal of Pharmacology, ISSN 0007-1188, 02/2014, Volume 171, Issue 3, pp. 772 - 788
Background and PurposeReceptor activity-modifying proteins (RAMPs) define the pharmacology of the calcitonin receptor-like receptor (CLR). The interactions of... 
GPCR | adrenomedullin | RAMP | CGRP | receptor activity‐modifying protein | receptor activity-modifying protein | CRYSTAL-STRUCTURE | EXTRACELLULAR DOMAIN | N-TERMINUS | FAMILY | CORTICOTROPIN-RELEASING-FACTOR | STRUCTURAL BASIS | MOLECULAR RECOGNITION | PHARMACOLOGY & PHARMACY | CLASS-B GPCR | COUPLED-RECEPTOR | BINDING | Receptors, Adrenomedullin - chemistry | Humans | Adrenomedullin - chemistry | Cercopithecus aethiops | Receptor Activity-Modifying Protein 1 - chemistry | Receptor Activity-Modifying Protein 2 - chemistry | Receptor Activity-Modifying Protein 3 - genetics | Calcitonin Gene-Related Peptide - chemistry | Receptors, Calcitonin Gene-Related Peptide - metabolism | Recombinant Fusion Proteins - metabolism | Peptide Hormones - metabolism | Receptors, Calcitonin Gene-Related Peptide - chemistry | Peptide Hormones - chemistry | Protein Interaction Domains and Motifs | Calcitonin Gene-Related Peptide - metabolism | Cyclic AMP - metabolism | Peptide Fragments - genetics | Second Messenger Systems | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Receptors, Adrenomedullin - metabolism | Calcitonin Receptor-Like Protein - chemistry | Models, Molecular | Rats | Receptor Activity-Modifying Protein 1 - metabolism | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Receptor Activity-Modifying Protein 2 - metabolism | Adrenomedullin - metabolism | Receptor Activity-Modifying Protein 1 - genetics | Recombinant Fusion Proteins - chemistry | Calcitonin Receptor-Like Protein - metabolism | Peptide Fragments - chemistry | Animals | Receptor Activity-Modifying Protein 3 - chemistry | Calcitonin Receptor-Like Protein - genetics | Mutant Proteins - chemistry | Receptor Activity-Modifying Protein 3 - metabolism | Receptor Activity-Modifying Protein 2 - genetics | COS Cells | Proteins | Genetic research | Pharmacology | Genetic aspects | Algorithms | Analysis | Peptides | Mutation | Index Medicus | Research Papers
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 09/2015, Volume 412, Issue C, pp. 26 - 35
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2018, Volume 293, Issue 41, pp. 15840 - 15854
The cardioprotective vasodilator peptide adrenomedullin 2/intermedin (AM2/IMD) and the related adrenomedullin (AM) and calcitonin gene-related peptide (CGRP)... 
OXIDATIVE STRESS | GENE-RELATED PEPTIDE | receptor activity-modifying protein | signal transduction | vasodilation | BIOCHEMISTRY & MOLECULAR BIOLOGY | molecular pharmacology | EXTRACELLULAR DOMAIN | peptide hormone | N-GLYCOSYLATION | class B GPCR | receptor structure-function | X-ray crystallography | protein engineering | CALCITONIN-RECEPTOR | ACTIVITY-MODIFYING PROTEINS | fluorescence anisotropy | G protein-coupled receptor (GPCR) | cardioprotection | ECTODOMAIN COMPLEX | CLASS-B GPCR | CRYO-EM STRUCTURE | COUPLED-RECEPTOR | Humans | Calcitonin Gene-Related Peptide - isolation & purification | Receptor Activity-Modifying Protein 3 - isolation & purification | Peptide Hormones - genetics | Peptide Hormones - metabolism | Drug Design | HEK293 Cells | Protein Engineering | Receptor Activity-Modifying Proteins - isolation & purification | Receptor Activity-Modifying Protein 2 - isolation & purification | Adrenomedullin - isolation & purification | Calcitonin Gene-Related Peptide - metabolism | Receptors, Adrenomedullin - isolation & purification | Receptor Activity-Modifying Proteins - metabolism | Mutagenesis, Site-Directed | Peptide Hormones - isolation & purification | Receptors, Adrenomedullin - metabolism | Receptor Activity-Modifying Protein 1 - metabolism | Receptor Activity-Modifying Protein 2 - metabolism | Adrenomedullin - metabolism | Calcitonin Receptor-Like Protein - metabolism | Receptor Activity-Modifying Protein 1 - isolation & purification | Peptide Hormones - antagonists & inhibitors | Receptor Activity-Modifying Protein 3 - metabolism | Protein Binding | Ligands | Protein Conformation | Calcitonin Receptor-Like Protein - isolation & purification | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7572, pp. 263 - 267
Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients diagnosed annually. In late-stage colorectal cancer, the most commonly... 
PANITUMUMAB | THERAPY | MULTIDISCIPLINARY SCIENCES | SEQUENCE | ACQUIRED-RESISTANCE | SOMATIC MUTATION | IDENTIFICATION | GENE COPY NUMBER | ACTIVATING MUTATIONS | BREAST | INSIGHTS | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Genomics | Humans | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Cetuximab - therapeutic use | Molecular Targeted Therapy | Receptor, Fibroblast Growth Factor, Type 1 - genetics | MAP Kinase Kinase 1 - genetics | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Insulin Receptor Substrate Proteins - genetics | Colorectal Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Cetuximab - pharmacology | DNA Copy Number Variations - genetics | Mutation - genetics | Genome, Human - genetics | Receptor, Epidermal Growth Factor - chemistry | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Exome - genetics | Animals | Receptor, Platelet-Derived Growth Factor alpha - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Colorectal cancer | Drug metabolism | Genetic aspects | Identification and classification | Health aspects | Proteins | Epidermal growth factor | Genes | Clinical trials | Mutation | Kinases | Cancer therapies | Tumors | Index Medicus
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 10/2018, Volume 470, Issue 10, pp. 1521 - 1542
The ventral medial prefrontal cortex (vMPFC) facilitates the cardiac baroreflex response through N-methyl-d-aspartate (NMDA) receptor activation and nitric... 
Medial prefrontal cortex | Neurosciences | Receptors | Biomedicine | Human Physiology | Baroreflex | Nitric oxide | CB 1 receptors | TRPV 1 receptors | Molecular Medicine | NMDA receptors | Cell Biology | TRPV | receptors | POSTTRAUMATIC-STRESS-DISORDER | CARDIOVASCULAR-RESPONSES | PHYSIOLOGY | AUTONOMIC DYSFUNCTION | ENDOCANNABINOID SYSTEM | CANNABINOID RECEPTOR | TRPV1 receptors | MULTIPLE-SCLEROSIS | HEART-RATE-VARIABILITY | CB1 receptors | VANILLOID RECEPTORS | NITRIC-OXIDE | MAJOR DEPRESSIVE DISORDER | Heart Rate | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Rats, Wistar | Heart - physiology | TRPV Cation Channels - agonists | Enzyme Inhibitors - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Rats | Male | Excitatory Amino Acid Antagonists - pharmacology | Guanylate Cyclase - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - metabolism | TRPV Cation Channels - metabolism | Animals | Prefrontal Cortex - drug effects | Nitric Oxide Synthase Type I - antagonists & inhibitors | Prefrontal Cortex - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Nitric Oxide - metabolism | Prefrontal Cortex - physiology | Methyl aspartate | Medical colleges | Glutamate | Neurons | Heart | Baroreceptors | Cortex (prefrontal) | Femoral artery | Femur | Glutamic acid receptors (ionotropic) | N-Methyl-D-aspartic acid receptors | Capsaicin receptors | Glutamic acid receptors | Cannabinoid CB1 receptors | Guanylate cyclase | Nitric-oxide synthase | Transient receptor potential proteins | Microinjection | Stainless steel | Rodents | Glutamatergic transmission | Receptor mechanisms | Heart diseases | Reflexes | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 58 - 71
Activation of the PI3K-AKT pathway in tumors is modulated by negative feedback, including mTORC1-mediated inhibition of upstream signaling. We now show that... 
RAPAMYCIN | TARGET | FORKHEAD TRANSCRIPTION FACTOR | CELLS | INSULIN-RECEPTOR | ACTIVATION | ONCOLOGY | SIGNALING PATHWAY | PHOSPHORYLATION | UPSTREAM | HUMAN CANCER | CELL BIOLOGY | RNA, Small Interfering - genetics | Receptor, IGF Type 1 - metabolism | Protein Binding - genetics | Receptor, ErbB-3 - metabolism | Humans | Forkhead Transcription Factors - metabolism | Protein Binding - drug effects | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Receptor, ErbB-2 - antagonists & inhibitors | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Quinoxalines - therapeutic use | Carcinoma, Non-Small-Cell Lung - metabolism | Receptor, ErbB-3 - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Breast Neoplasms - drug therapy | Receptor, IGF Type 1 - genetics | Signal Transduction - drug effects | Mice, Nude | Models, Biological | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | Feedback, Physiological - physiology | Quinazolines - pharmacology | Proteins - antagonists & inhibitors | Neoplasms - metabolism | Gene Expression - drug effects | Multiprotein Complexes | Receptor, ErbB-2 - metabolism | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Quinoxalines - pharmacology | Receptor, Insulin - genetics | Female | Forkhead Transcription Factors - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Drug Therapy, Combination | Gene Expression Regulation, Neoplastic - physiology | Carcinoma, Non-Small-Cell Lung - pathology | Up-Regulation - genetics | Forkhead Transcription Factors - genetics | Xenograft Model Antitumor Assays | Animals | Receptor Protein-Tyrosine Kinases - genetics | Breast Neoplasms - pathology | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Feedback, Physiological - drug effects | Receptor, Insulin - metabolism | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Benzylamines - pharmacology | Benzylamines - therapeutic use | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus
Journal Article
1993, Methods in neurosciences, ISBN 0121852717, Volume 11, xv, 440
Book
Journal of Neuroimmunology, ISSN 0165-5728, 2006, Volume 181, Issue 1, pp. 46 - 56
In a mouse model of neurocysticercosis, the expression and distribution of Toll‐like receptors (TLRs) was investigated by using both gene array analyses and in... 
Parasite | Helminth | CNS | Neurocysticercosis | Toll‐like receptors | Toll-like receptors | CELL-WALL COMPONENTS | toll-like receptors | DENDRITIC CELLS | INNATE IMMUNE-RESPONSE | DELTA T-CELLS | IMMUNOLOGY | NEUROSCIENCES | parasite | STREPTOCOCCUS-PNEUMONIAE | LEUKOCYTE MIGRATION | neurocysticercosis | CENTRAL-NERVOUS-SYSTEM | STAPHYLOCOCCUS-AUREUS | helminth | NEURAL STEM-CELL | MISSING LINK | Toll-Like Receptor 5 - genetics | Toll-Like Receptor 9 - genetics | Neurocysticercosis - physiopathology | Mesocestoides | RNA, Messenger - metabolism | Gene Expression - immunology | Cestode Infections - physiopathology | Female | Toll-Like Receptor 3 - genetics | Toll-Like Receptors - metabolism | Cestode Infections - immunology | Brain - parasitology | Disease Models, Animal | Toll-Like Receptor 7 - genetics | Toll-Like Receptor 5 - metabolism | Toll-Like Receptor 7 - metabolism | Cestode Infections - metabolism | Neurocysticercosis - immunology | Toll-Like Receptor 1 - metabolism | Toll-Like Receptor 4 - genetics | Neurocysticercosis - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Toll-Like Receptor 1 - genetics | Animals | Toll-Like Receptors - genetics | Toll-Like Receptor 8 - genetics | Mice | Mice, Inbred BALB C | Toll-Like Receptor 9 - metabolism | Brain - immunology | Toll-Like Receptor 8 - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2011, Volume 108, Issue 20, pp. 8485 - 8490
The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and β-phenylethylamine, has... 
Receptors | Neurons | Serotonin receptors | Trace amines | Agonists | Inurement | Autoreceptors | Antipsychotic agents | Cocaine | Dosage | Schizophrenia | Depression | Anxiety | Drug discovery | Serotonin | AMINE-ASSOCIATED RECEPTOR-1 | MULTIDISCIPLINARY SCIENCES | TRACE AMINES | PROTEIN-COUPLED RECEPTORS | schizophrenia | DOPAMINE TRANSPORTER | FAMILY | anxiety | serotonin | BETA-PHENYLETHYLAMINE | drug discovery | ANIMAL-MODEL | depression | AMPHETAMINE | STRESS-INDUCED HYPERTHERMIA | Synaptic Transmission - physiology | Receptors, G-Protein-Coupled - metabolism | Humans | Glutamine - metabolism | Receptors, G-Protein-Coupled - agonists | Phenylpropionates - pharmacology | Animals | Receptors, G-Protein-Coupled - deficiency | Mental Disorders | HEK293 Cells | Mice | Biogenic Monoamines - metabolism | Benzodioxoles - pharmacology | Dopamine - metabolism | Physiological aspects | Neural transmission | Cell receptors | Research | Dopaminergic mechanisms | Health aspects | Proteins | Brain | Rodents | Amino acids | Mutation | Gene expression | Cells | Neuroleptics | Mental disorders | Glutamic acid receptors (ionotropic) | Hyperactivity | Brain slice preparation | Firing rate | amines | N-Methyl-D-aspartic acid receptors | Neuromodulation | Serotonin S1 receptors | dorsal raphe nucleus | Metabolites | Dopamine transporter | Norepinephrine | Neurotransmission | Index Medicus | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2016, Volume 291, Issue 22, pp. 11657 - 11675
Journal Article