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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
Science, ISSN 0036-8075, 3/2009, Volume 323, Issue 5920, pp. 1485 - 1488
The YODA (YDA) mitogen-activated protein kinase pathway promotes elongation of the Arabidopsis zygote and development of its basal daughter cell into the... 
Proteins | Zygotes | Phenotypes | Spermatozoa | Fertilization | Fluorescence | Reports | Pollen | Endosperm | Plants | Embryos | ELEMENTS | MAPKK KINASE | STOMATAL DEVELOPMENT | MULTIDISCIPLINARY SCIENCES | RECEPTOR-LIKE KINASES | SEED DEVELOPMENT | PLANTS | PROTEIN-KINASES | Genomic Imprinting | Interleukin-1 Receptor-Associated Kinases - metabolism | Pollen - metabolism | Interleukin-1 Receptor-Associated Kinases - genetics | Arabidopsis - embryology | RNA, Messenger - metabolism | Recombinant Fusion Proteins | MAP Kinase Signaling System | Arabidopsis Proteins - metabolism | Seeds - growth & development | Cell Division | Interleukin-1 Receptor-Associated Kinases - chemistry | Plants, Genetically Modified | Gene Expression Regulation, Plant | Transcription, Genetic | Protein Structure, Tertiary | Catalytic Domain | Biocatalysis | Seeds - metabolism | RNA, Messenger - genetics | MAP Kinase Kinase Kinases - metabolism | Amino Acid Motifs | Arabidopsis - metabolism | Arabidopsis - genetics | Protein Binding | Mutation | Crosses, Genetic | Arabidopsis thaliana | Physiological aspects | Embryonic development | Research | Genetics | Cellular biology | Kinases | Developmental biology | Botany | MAP Kinase Kinase Kinases | Seeds | Arabidopsis | Interleukin-1 Receptor-Associated Kinases | Life Sciences | Arabidopsis Proteins | Vegetal Biology | RNA, Messenger
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2012, Volume 318, Issue 16, pp. 2105 - 2115
The activation of transforming growth factor-β1(TGF-β1)/Smad signaling pathway and increased expression of connective tissue growth factor (CTGF) induced by... 
TGFβ1 | Angiotensin II | Atrial fibroblasts | TRAF6 | CTGF | MAPKs | TGFΒ1 | Heart Atria - pathology | Gene Expression - drug effects | Heart Atria - drug effects | Transforming Growth Factor beta1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Fibrosis - metabolism | MAP Kinase Kinase 4 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | MAP Kinase Kinase 4 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | TNF Receptor-Associated Factor 6 - genetics | MAP Kinase Kinase Kinases - antagonists & inhibitors | Fibroblasts - metabolism | Angiotensin II - pharmacology | Fibrosis - genetics | Mitogen-Activated Protein Kinase 3 - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Losartan - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Heart Atria - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | TNF Receptor-Associated Factor 6 - metabolism | MAP Kinase Kinase 4 - genetics | Connective Tissue Growth Factor - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Angiotensin II - physiology | Connective Tissue Growth Factor - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2014, Volume 461, Issue 3, pp. 531 - 537
IKK beta {I kappa B [inhibitor of NF-kappa B (nuclear factor kappa B)] kinase beta} is required to activate the transcription factor NF-kappa B, but how IKK... 
Inhibitor of nuclear factor κB kinase (IKK) | Linear ubiquitin chain assembly complex (LUBAC) | Nuclear factor κB(NF-κB) | Transforming growth factor β-activated kinase-1 (TAK1) | Interleukin-1 (IL-1) | nuclear factor kappa B (NF-kappa B) | linear ubiquitin chain assembly complex (LUBAC) | SIGNALING PATHWAYS | PROTEIN | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | interleukin-1 (IL-1) | KINASE COMPLEX | transforming growth factor beta-activated kinase-1 (TAK1) | UBIQUITIN CHAINS | INFLAMMATION | inhibitor of nuclear factor kappa B kinase (IKK) | POLYUBIQUITIN CHAINS | NF-KAPPA-B | NEMO | BINDING | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | I-kappa B Kinase - antagonists & inhibitors | HEK293 Cells | Protein Interaction Domains and Motifs | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Mutant Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cells, Cultured | Mutant Proteins - genetics | Recombinant Proteins - chemistry | Mice, Transgenic | Mutant Proteins - metabolism | MAP Kinase Kinase Kinases - metabolism | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Serine - metabolism | Gene Knock-In Techniques | Animals | Embryo, Mammalian - cytology | Mutant Proteins - chemistry | Mice | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Amino Acid Substitution | Index Medicus | NEMO, NF-κB essential modulator | TLR, Toll-like receptor | IKK, IκB kinase | TNF, tumour necrosis factor | transforming growth factor β-activated kinase-1 (TAK1) | HEK, human embryonic kidney | IL-1, interleukin-1 | JNK, c-Jun N-terminal kinase | PP1γ, protein phosphatase 1γ | TRAF, TNF receptor-associated factor | inhibitor of nuclear factor κB kinase (IKK) | LUBAC, linear ubiquitin chain assembly complex | HOIP, HOIL1 [haem-oxidized IRP2 (iron regulatory protein 2) ubiquitin ligase 1]-interacting protein | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | TAK1, transforming growth factor β-activated kinase-1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | M-CSF, macrophage colony-stimulating factor | MKK, MAPK kinase | Accelerated Publication | E, embryonic day | MEF, mouse embryonic fibroblast | HA, haemaglutinnin | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2004, Volume 382, Issue 2, pp. 393 - 409
Two members of the NF-kappaB (nuclear factor kappaB)/Rel transcription factor family, NF-kappaB1 and NF-kappaB2, are produced as precursor proteins, NF-kappaB1... 
IκB kinase (IKK) | p100 | Tumour progression locus-2 (TPL-2) | Nuclear factor κB (NF-κB) | p105 | Toll-like receptor (TLR) | nuclear factor kappa B (NF-kappa B) | TRCP UBIQUITIN LIGASE | I kappa B kinase (IKK) | BIOCHEMISTRY & MOLECULAR BIOLOGY | P105 REQUIRES PHOSPHORYLATION | ALLERGIC AIRWAY INFLAMMATION | KINASE KINASE KINASE | P50 SUBUNIT | GLYCINE-RICH REGION | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | tumour progression locus-2 (TPL-2) | NF-KAPPA-B | SIGNAL-TRANSDUCTION PATHWAY | TNF, tumour necrosis factor | GC, germinal centre | NEMO, nuclear factor κB essential modulator | MAP 3-kinase, MAP kinase kinase kinase | BAFF, B-cell activating factor | ERK, extracellular-signal-regulated kinase | Fn14, fibroblast-growth-factor-inducible 14 | ABIN, A20-binding inhibitor of nuclear factor κB | GM-CSF, granulocyte–macrophage colony-stimulating factor | GSK, glycogen synthase kinase | Dif, Dorsal-related immunity factor | EBNA1, EBV nuclear antigen 1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | SCF, Skp1 | Imd, immune deficiency | F-box | IL, interleukin | MAP kinase, mitogen-activated protein kinase | EBV, Epstein–Barr virus | LPS, lipopolysaccharide | IFNβ, interferon-β | IκB, inhibitor of nuclear factor κB | TRAF, TNF-receptor-associated factor | TLR, Toll-like receptor | DC, dendritic cell | IKK, IκB kinase | GRR, glycine-rich region | Review | JNK, c-Jun N-terminal kinase | PGRP-LC, peptidoglycan recognition protein LC | ERK kinase | RANKL, receptor activator of NF-κB ligand | LTβR, lymphotoxin-β receptor | MIP, macrophage inflammatory protein | DD, death domain | HTLV-1, human T-cell leukaemia virus type 1 | MEK, MAP kinase | COX-2, cyclo-oxygenase-2 | TH2, T-helper 2 | TH1, T-helper 1 | LMP1, latent membrane protein 1 | TPL-2, tumour progression locus-2 | TWEAK, TNF-like weak inducer of apoptosis | Cul1 | PEST region, polypeptide sequence enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) | RHD, Rel homology domain | nuclear factor κB (NF-κB) | NIK, NF-κB-inducing kinase | MEF, mouse embryo fibroblast | βTrCP, β-transducin repeat-containing protein
Journal Article
Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 11/2014, Volume 10, Issue 11, pp. 3270 - 3285
Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs... 
IFI16, interferon, gamma-inducible protein 16 | IRF, interferon regulatory factor | CDNs, cyclic dinucleotides | AIM2, absent in melanoma 2 | LT, lethal toxin | MIB, mind bomb | ALRs, AIM2-like receptors | MDP, muramyl dipeptide | LUBAC, linear ubiquitin assembly complex | innate immunity | TRIF, TIR domain-containing adaptor inducing IFN-b | DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | IKK, IkB kinase | MyD88, myeloid differentiation factor 88 | TRAILR, tumor-necrosis factor-related apoptosis-inducing ligand receptor | AMPK, AMP activated protein kinase | LBP, LPS-binding protein | NEMO, NF-kB essential modulator | TRIMs, tripartite motif containing proteins | IKKi, inducible IkB kinase | PKC-d, protein kinase C delta | LRR, leucine-rich repeat | TAK1, TGF-b-activating kinase 1 | RIP, receptor-interacting protein | TBK1, TANK binding kinase 1 | TRIP, TRAF-interacting protein | TLRs, Toll-like receptors | LGP 2, laboratory of genetics and physiology 2 | PKR, dsRNA-dependent protein kinase | PRRs, pathogen recognition receptors | STING, stimulator of interferon gene | GBP5, guanylate-binding protein 5 | RLRs, RIG-I-like receptors | ULK1, autophagy related serine threonine UNC-51- like kinase | TIR, Toll IL-1 receptor | LPS, lipopolysaccharide | TRAF, TNFR-associated factor | Atg16L, autophagy related 16-like | cDC, conventional dendritic cell | MDA5, melanoma differentiation-associated protein 5 | DCs, dendritic cells | CARD, caspase recruitment domain | PRRs | KSHV, Kaposi's sarcoma-associated herpesvirus | RAUL, RTA-associated E3 ligase | CLRs, C-type lectin receptors | pDC, plasmacytoid dendritic cell | MAVS, mitochondrial antiviral signaling protein | inflammation | NAIPs, neuronal apoptosis inhibitory proteins | CYLD, the familial cylindromatosis tumor suppressor gene | SIGIRR, single Ig IL-1-related receptor | ROS, reactive oxygen species | RIG-I, retinoic acid-inducible gene 1 | TANK, TRAF family-member-associated NF-kB activator | ASC, apoptosis-associated speck-like protein containing a CARD | DAMPs, danger-associated molecular patterns | IFN, interferon | TRAM, TRIF-related adaptor molecule | TIRAP, TIR domain-containing adapter protein | iE-DAP, g-D-glutamyl-meso-diaminopimelic acid | PAMPs, pathogen-associated molecular patterns | cGAS, cyclic GMP-AMP synthase | cIAP, cellular inhibitor of apoptosis protein | GSK3β, Glycogen synthase kinase 3β | NOD, nucleotide-binding oligomerization domain | IRAK, interleukin-1 receptor-associated kinase | BMM, bone marrow-derived macrophage | type I interferon | RACK1, receptor for activated C kinase 1 | SARM, sterile a- and armadillo motif-containing protein | SOCS, suppressor of cytokine signaling | CMV, cytomegalovirus | cancer | NLRs, Nod- like receptors | Nrdp1, neuregulin receptor degradation protein 1 | HCC, hepatocellular carcinoma | ER, endoplasmic reticulum | Innate immunity | Inflammation | Type I interferon | Cancer | linear ubiquitin assembly complex | C-type lectin receptors | IKKi | TRIP | TRAF | apoptosis-associated speck-like protein containing a CARD | I INTERFERON INDUCTION | neuregulin receptor degradation protein 1 | RIG-I | TRAM | CARD | TRIF-related adaptor molecule | dendritic cells | TBK1 | cytomegalovirus | cyclic dinucleotides | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | cellular inhibitor of apoptosis protein | GSK3 | PAMPs | retinoic acid-inducible gene 1 | CDNs | hepatocellular carcinoma | TANK binding kinase 1 | RAUL | GBP5 | Toll IL-1 receptor | cDC | MIB | protein kinase C delta | iE-DAP | CMV | SARM | SIGIRR | IRAK | sterile a- and armadillo motif-containing protein | cyclic GMP-AMP synthase | TNFR-associated factor | autophagy related serine threonine UNC-51-like kinase | AMPK | ULK1 | lipopolysaccharide | TRIF | IRF | RLRs | Nrdp1 | receptor-interacting protein | LPS-binding protein | plasmacytoid dendritic cell | tripartite motif containing proteins | LPS | ANTIVIRAL SIGNAL-TRANSDUCTION | DAMPs | melanoma differentiation-associated protein 5 | ASC | TAK1 | KSHV | LGP 2 | neuronal apoptosis inhibitory proteins | TRIMs | danger-associated molecular patterns | cGAS | RIG-I-like receptors | lethal toxin | OXYGEN SPECIES PRODUCTION | BMM | muramyl dipeptide | interleukin-1 receptor-associated kinase | IKK | AMP activated protein kinase | absent in melanoma 2 | IkB kinase | CYLD | dsRNA-dependent protein kinase | MAVS | Kaposi's sarcoma-associated herpesvirus | TIR domain-containing adaptor inducing IFN-b | STING | TIR | TOLL-LIKE-RECEPTORS | AIM2-like receptors | laboratory of genetics and physiology 2 | DDX41 | IMMUNOLOGY | LRR | MyD88 | nucleotide-binding oligomerization domain | CLRs | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | myeloid differentiation factor 88 | MDP | RACK1 | LBP | TRAF-interacting protein | bone marrow-derived macrophage | NF-KAPPA-B | NOD-LIKE RECEPTOR | NOD | conventional dendritic cell | NLRP3 INFLAMMASOME ACTIVATION | HCC | TGF-b-activating kinase 1 | inducible IkB kinase | TIRAP | Atg16L | mind bomb | pathogen-associated molecular patterns | AIM2 | PKR | TRAF family-member-associated NF-kB activator | ROS | interferon regulatory factor | g-D-glutamyl-meso-diaminopimelic acid | pathogen recognition receptors | NLRs | UBIQUITIN-DEPENDENT KINASE | DEUBIQUITINATING ENZYME CYLD | NEMO | stimulator of interferon gene | RTA-associated E3 ligase | Nod- like receptors | the familial cylindromatosis tumor suppressor gene | tumor-necrosis factor-related apoptosis-inducing ligand receptor | TANK | MDA5 | IFN | mitochondrial antiviral signaling protein | ALRs | IFI16 | DCs | TRAILR | reactive oxygen species | Toll-like receptors | cIAP | TIR domain-containing adapter protein | PATTERN-RECOGNITION RECEPTORS | single Ig IL-1-related receptor | guanylate-binding protein 5 | suppressor of cytokine signaling | autophagy related 16-like | leucine-rich repeat | NF-kB essential modulator | Glycogen synthase kinase 3 | SOCS | interferon | LUBAC | caspase recruitment domain | pDC | NAIPs | receptor for activated C kinase 1 | PKC-d | RIP | gamma-inducible protein 16 | TLRs | endoplasmic reticulum | Immunity, Innate - immunology | Signal Transduction - immunology | Neoplasms - immunology | Humans | Inflammasomes - immunology | RNA Viruses - immunology | Toll-Like Receptors - immunology | Interferon Type I - immunology | DNA Viruses - immunology
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 1937 - 1952
Lipopolysaccharide (LPS)-induced activation of TLR4 (toll-like receptor 4) is followed by a subsequent overwhelming inflammatory response, a hallmark of the... 
ACTB, actin, beta | MYD88, myeloid differentiation primary response 88 | PELI3 | CHX, cycloheximide | BECN1, Beclin 1, autophagy related | TICAM1, toll-like receptor adaptor molecule 1 | LPS | RIPK1, receptor (TNFRSF)-interacting serine-threonine kinase 1 | TUBB, tubulin, beta class I | PRRs, pattern recognition receptors | UBB, ubiquitin B | IRAKs, interleukin-1 receptor-associated kinases | HBSS, Hank's balanced salt solution | ATG7, autophagy-related 7 | MAP1LC3B, microtubule-associated protein 1 light chain 3 beta | TLRs, toll-like receptors | Baf A1, bafilomycin A | WT, wildtype | autophagy | TNF, tumor necrosis factor | MAPK14, mitogen-activated protein kinase 14 | NFKB, nuclear factor of kappa light polypeptide gene enhancer in B-cells | MAPK1/3, mitogen-activated protein kinase 1/3 | Epoxo, epoxomycin | TRAF6, TNF receptor-associated factor 6, E3 ubiquitin protein ligase | IL1B, interleukin 1, beta | MTOR, mechanistic target of rapamycin (serine/threonine kinase) | TABs, TGF-beta activated kinase 1/MAP3K7 binding protein 1/2/3 | Wortm, wortmannin | 1 | PELI3, pellino E3 ubiquitin protein ligase family member 3 | MAPK8/9, mitogen-activated protein kinase 8/9 | SQSTM1, sequestosome 1 | NFE2L2, nuclear factor, erythroid 2-like 2 | NLRP3, NLR family, pyrin domain containing 3 | LAMP2, lysosomal-associated membrane protein 2 | LPS, lipopolysaccharide | MAP3K14, mitogen-activated protein kinase kinase kinase 14 | MΦ, macrophages | Rapa, rapamycin | SQSTM1 | TBK1, TANK-binding kinase 1 | Torin2 | MAP3K7, mitogen-activated protein kinase kinase kinase 7 | Autophagy | TOLL-LIKE-RECEPTORS | ACTIVATION | BECLIN 1 | RECOGNITION | SELECTIVE AUTOPHAGY | CELL BIOLOGY | UBIQUITINATION | IL-1-BETA PRODUCTION | INFLAMMASOME | SCAFFOLD PROTEINS | INNATE IMMUNITY | Cell Line | Cytokines - metabolism | Signal Transduction | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Lipopolysaccharides - metabolism | Inflammation | Immunity, Innate | RNA, Messenger - metabolism | Toll-Like Receptor 4 - metabolism | Point Mutation | Macrophages - metabolism | Animals | Interleukin-1beta - metabolism | Sepsis - metabolism | Mice | Naphthyridines - metabolism | RNA, Small Interfering - metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 50, pp. 36223 - 36229
The Rip2 kinase contains a caspase recruitment domain and has been implicated in the activation of the transcriptional factor NF-κB downstream of Toll-like... 
PEPTIDOGLYCAN | PROTEIN | INNATE IMMUNE-RESPONSES | HOST RECOGNITION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTOR | SYSTEMS | NF-KAPPA-B | TLR4 | MYD88 | Mycobacterium tuberculosis - immunology | Ubiquitin - metabolism | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Ubiquitination - drug effects | TNF Receptor-Associated Factor 6 - genetics | Toll-Like Receptors - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Macrophages - microbiology | MAP Kinase Kinase Kinases - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Protein Ligases - metabolism | Nod2 Signaling Adaptor Protein - immunology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ubiquitin - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Macrophages - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Toll-Like Receptors - genetics | I-kappa B Kinase - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Adjuvants, Immunologic - pharmacology | NF-kappa B - immunology | TNF Receptor-Associated Factor 6 - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Enzyme Activation - immunology | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | I-kappa B Kinase - metabolism | Myeloid Differentiation Factor 88 - immunology | Ubiquitin-Conjugating Enzymes - immunology | Tuberculosis - metabolism | Macrophages - immunology | Cells, Cultured | Ubiquitination - immunology | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Tuberculosis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | NF-kappa B - genetics | Tuberculosis - genetics | TNF Receptor-Associated Factor 6 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Ubiquitin - immunology
Journal Article