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Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | FORMYL PEPTIDE RECEPTORS | HIGH-AFFINITY RECEPTOR | NOD-LIKE RECEPTORS | BETA-GAMMA-SUBUNIT | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 10/2011, Volume 1813, Issue 10, pp. 1893 - 1905
The endoplasmic reticulum (ER) is the biggest organelle in most cell types, but its characterization as an organelle with a continuous membrane belies the fact... 
Endoplasmic reticulum (ER) | Plasma membrane-associated membrane (PAM) | Mitochondria-associated membrane (MAM) | Lipid droplet | Russell bodies | GOLGI INTERMEDIATE COMPARTMENT | CELL TERMINAL DIFFERENTIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNER NUCLEAR-MEMBRANE | STRESS-INDUCED APOPTOSIS | ACTIVATES CRAC CHANNELS | PLASMA-MEMBRANE | CELL BIOLOGY | MITOCHONDRIA-ASSOCIATED MEMBRANES | SIGNAL RECOGNITION PARTICLE | PANCREATIC BETA-CELL | LIPID DROPLETS | Animals | Membrane Proteins - physiology | Mitochondrial Membranes - physiology | Models, Biological | Humans | Endoplasmic Reticulum - physiology | Endoplasmic Reticulum - metabolism | Protein Transport - physiology | Signal Transduction - physiology | Cell Membrane - metabolism | Membrane Proteins - metabolism | Mitochondrial Membranes - metabolism | Phosphates | Niacinamide | Immunoglobulins | Inositol | Transferases | Leukemia | Low density lipoproteins | Fluorescence | Protein C | Glucose | Dextrose | Physiological aspects | Adenosine triphosphatase | Protein binding | NADPH, reduced nicotinamide adenine dinucleotide phosphate | SNARE, soluble N-ethylmaleimide sensitive fusion protein attachment protein receptor | GRP, glucose regulated protein | AMFR, autocrine motility factor receptor | DGAT acyl-CoA, diacylglycerol acyltransferase | ACAT | ERQC, endoplasmic reticulum quality control compartment | TIP47, tail-interacting protein of 47 kDa (TIP47) | SRP, signal recognition particle | PDI, protein disulfide isomerase | SREBP, sterol-regulatory element binding protein 2 | ERMES, endoplasmic reticulum-mitochondria encounter structure | ERES, endoplasmic reticulum exit sites | LRP6, low-density lipoprotein receptor-related protein 6 | RFP, red fluorescent protein | TRAP, translocon-associated protein | enhancer binding protein (C | COP, coat protein complex | CHOP, CCAAT | XBP1, X-box binding protein 1 | GFP, green fluorescent protein | PAM, plasma membrane-associated membrane | PERK, protein kinase (PKR)-like endoplasmic reticulum kinase | BAP31, B-cell receptor-associated protein of 31 kDa | VAPB, vesicle-associated membrane, protein-associated protein B | KDEL, lys-asp-glu-leu | IP3R, inositol 1,4,5-trisphosphate receptor | MAM, mitochondria-associated membrane | EBP) homologous protein | Climp63, cytoskeleton-linking membrane protein of 63 kDa | FACL4, acyl-CoA synthase 4 | endoplasmic reticulum Ca2+-ATPase | STIM1, stromal interaction molecule 1 | TRAM, translocating chain-associated membrane protein | ERK, extracellular signal-regulated kinase | OST, oligosaccharyl transferases | SOAT, acyl-CoA cholesteryl acyl transferase | BiP, immunoglobulin binding protein | SERCA, sarco | ACS4 | ER, endoplasmic reticulum | PACS-2, phospho-furin acidic cluster sorting protein 2 | ERAD, endoplasmic reticulum associated degradation
Journal Article
Redox Biology, ISSN 2213-2317, 04/2015, Volume 4, Issue C, pp. 184 - 192
Cancer formation is a complex and highly regulated multi-step process which is highly dependent of its environment, from the tissue to the patient. This... 
Mitochondria | Antioxidant | Mitophagy | Autophagy | ROS | Cancer | KAPPA-B ACTIVATION | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | HYPOXIA | FIBROBLASTS | METABOLISM | STROMA COEVOLUTION | GROWTH | Neoplasms - metabolism | AMP-Activated Protein Kinases - metabolism | Autophagy-Related Proteins | Reactive Oxygen Species - metabolism | Humans | Gene Expression Regulation, Neoplastic | Tumor Microenvironment | Antineoplastic Agents - therapeutic use | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy-Related Protein-1 Homolog | Mitochondrial Degradation - genetics | Cysteine Endopeptidases - metabolism | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Autophagy - genetics | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Protein-Serine-Threonine Kinases - metabolism | Beclin-1 | Signal Transduction | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Lymphatic Metastasis | Mitochondria - metabolism | Mitochondria - pathology | Cell Transformation, Neoplastic - metabolism | Apoptosis Regulatory Proteins - metabolism | Neoplasms - drug therapy | Cysteine Endopeptidases - genetics | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | AMP-Activated Protein Kinases - genetics
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 523 - 540
Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they are signalling... 
Mitochondrion | Oxidative stress | Redox signalling | Neurodegeneration | Autophagy | Nitrative stress | autophagy | CHAPERONE-MEDIATED AUTOPHAGY | ANTIOXIDANT RESPONSIVE ELEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOFUSCINOSES BATTEN-DISEASE | neurodegeneration | AMYOTROPHIC-LATERAL-SCLEROSIS | mitochondrion | redox signalling | MOTOR-NEURON DEGENERATION | MANGANESE SUPEROXIDE-DISMUTASE | nitrative stress | SMOOTH-MUSCLE-CELLS | PATHOGENIC DJ-1 MUTATIONS | HYPOXIA-INDUCED AUTOPHAGY | oxidative stress | COMPLEX-I DEFICIENCY | Protein Kinases - metabolism | Transcription, Genetic - drug effects | Cardiovascular Diseases - physiopathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Humans | Oxidative Stress - physiology | Hydrogen Peroxide - pharmacology | Oncogene Proteins - metabolism | Nitric Oxide - physiology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Parkinson Disease - physiopathology | Lysosomes - physiology | Protein Deglycase DJ-1 | Animals | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Neoplasms - physiopathology | AMPK, 5′-AMP-activated protein kinase | NBR1, neighbour of BRCA1 (breast cancer early-onset 1) | NGF, nerve growth factor | LC3, light chain 3 | NOX, NADPH oxidase | EM, electron microscopy | TOR, target of rapamycin | ULK, unc (unco-ordinated family member)-51-like kinase | mtDNA, mitochondrial DNA | mTOR, mammalian target of rapamycin | IKKβ, IκB kinase β | LRRK2, leucine-rich repeat kinase 2 | NAC, N-acetyl-L-cysteine | Nrf2, nuclear factor-erythroid 2-related factor 2 | PI3P, phosphatidylinositol 3-phosphate | ECH, enoyl-CoA hydratase | BNIP3L, BNIP3-like | Drp1, dynamin-related protein 1 | tfLC3, tandem fluorescently tagged LC3 | NF-κB, nuclear factor κB | BAG, Bcl-2-associated athanogene | Keap1, Kelch-like ECH-associated protein 1 | PE, phosphatidylethanolamine | 3-MA, 3-methyladenine | UCP, uncoupling protein | IκB, inhibitor of nuclear factor κB | FIP200, focal adhesion kinase family-interacting protein of 200 kDa | PI3K, phosphoinositide 3-kinase | HNE, 4-hydroxynonenal | Review | ALS, amyotrophic lateral sclerosis | ATG, AuTophaGy-related | adenovirus E18 19-kDa-interacting protein | Tzb, trastuzumab | mETC, mitochondrial electron-transport chain | Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein | VDAC, voltage-dependent anion channel | IP3, inositol 1,4,5-trisphosphate | RFP, red fluorescent protein | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1 | GFP, green fluorescent protein | LAMP, lysosome-associated membrane protein | JNK1, c-Jun N-terminal kinase 1 | TAC, transverse aortic constriction | GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein | HIF-1, hypoxia-inducible factor 1 | NOS, nitric oxide synthase | siRNA, small interfering RNA | SOD, superoxide dismutase | RLS, reactive lipid species | RNS, reactive nitrogen species | ER, endoplasmic reticulum | TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator | Vps34, vacuolar protein sorting 34 | BNIP, Bcl-2
Journal Article