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Cell death and differentiation, ISSN 1476-5403, 06/2014, Volume 21, Issue 10, pp. 1511 - 1521
Necroptosis is a form of programmed cell death that depends on the activation of receptor interacting protein kinase-1 (RIPK1... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Protein Structure, Tertiary | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Cell Line | Phosphorylation | Protein Kinases - genetics | Cell Survival | Humans | Protein Multimerization | Receptors, Tumor Necrosis Factor, Type I | Caspase 8 - metabolism | Imidazoles - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Necrosis - physiopathology | RNA Interference | Indoles - pharmacology | RNA, Small Interfering | Apoptosis - physiology | Enzyme Activation | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | Receptor-Interacting Protein Serine-Threonine Kinases/genetics | Protein Kinases/genetics | Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & inhibitors | Caspase 8/metabolism | Receptor-Interacting Protein Serine-Threonine Kinases/metabolism | Tumor Necrosis Factor-alpha/antagonists & inhibitors | Indoles/pharmacology | Life Sciences | Tumor Necrosis Factor-alpha/metabolism | Imidazoles/pharmacology | Immunology | Apoptosis/physiology | Protein Kinases/metabolism | Necrosis/physiopathology | Original Paper
Journal Article
Cell host & microbe, ISSN 1931-3128, 11/2018, Volume 24, Issue 5, pp. 689 - 702.e7
... (FADD, RIPK1, RIPK3, and caspase 8) and autophagy (ATG5, ATG7, and SQSTM1) proteins. Genetic or pharmacological inhibition of autophagy induction, but not autophagy-mediated... 
caspase 8 | autophagy | HIV | CD4+ T cell | SMAC mimetics | apoptosis | XIAP | Fas | RIPK1 | BIRC2 | CD4+ T cell | Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | HIV-1 - pathogenicity | Apoptosis - drug effects | Autophagy-Related Protein 7 - metabolism | Cyclohexanes - pharmacology | Humans | Caspase 8 - metabolism | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy - drug effects | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV-1 - physiology | Mitochondrial Proteins - metabolism | Baculoviral IAP Repeat-Containing 3 Protein - metabolism | Cell Death | Indoles - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Sequestosome-1 Protein - metabolism | Cell Line | HIV-1 - drug effects | Dipeptides - pharmacology | Fas-Associated Death Domain Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Benzoquinones - pharmacology | Pyrroles - pharmacology | Apoptosis Regulatory Proteins | X-Linked Inhibitor of Apoptosis Protein - metabolism | Autophagy-Related Protein 5 - metabolism | Apoptosis - physiology | Beclin-1 - metabolism | Proteins | Medical colleges | Trout | Communicable diseases | T cells | HIV (Viruses) | Health aspects | HIV infection | Apoptosis | Index Medicus
Journal Article
Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical journal, ISSN 1470-8728, 06/2004, Volume 381, Issue 1, pp. 213 - 219
Proteins of the NACHT [NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E... 
CLAN | Caspase 1 | Nod2 | Nod1 | Nuclear factor κB (NF-κB) | Interleukin-1β | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neuronal Apoptosis-Inhibitory Protein | Peptidoglycan - metabolism | Protein Kinases - metabolism | Kidney - embryology | Humans | DNA, Complementary - genetics | Molecular Sequence Data | Monocytes - metabolism | NF-kappa B - metabolism | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Protein Isoforms - metabolism | Cloning, Molecular | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Cell Line | NF-kappa B - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins | Nod2 Signaling Adaptor Protein | Immunity, Innate | Macromolecular Substances | Nerve Tissue Proteins - metabolism | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | CARD Signaling Adaptor Proteins | Nod1 Signaling Adaptor Protein | Interleukin-1 - secretion | Nucleoside-Phosphate Kinase - metabolism | Index Medicus | NB-ARC domain, nucleotide-binding domain shared by Apaf-1, certain R gene products and CED-4 | NACHT, NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TP1 (telomerase-associated protein) | TLR, Toll-like receptor | CARDIAK, CARD-containing interleukin-1β-converting-enzyme-associated kinase | Apaf-1, apoptotic protease-activating factor 1 | RICK, RIP-like interacting CLARP kinase | caspase 1 | CLAN, CARD, LRR and NACHT domain-containing protein | interleukin-1β | ECL®, enhanced chemiluminescence | NAC, nucleotide-binding domain and CARD-containing protein | CARD, caspase-recruitment domain | NALP, NACHT, LRR and PYRIN protein 1 | PAN, PAAD- and NACHT-containing protein | NF-κB, nuclear factor κB | ORF, open reading frame | RIP2, receptor-interacting protein | LRR, leucine-rich repeat | IKK, inhibitory κB kinase | PAAD, pyrin, AIM (absent-in-melanoma), ASC (apoptosis-associated speck-like protein containing a CARD) and death-domain-like | PGN, peptidoglycan | LPS, lipopolysaccharide | RACE, rapid amplification of cDNA ends | nuclear factor κB (NF-κB) | PAMP, pathogen-associated molecular pattern | HEK-293T, human embryonic kidney
Journal Article
Nature (London), ISSN 1476-4687, 03/2002, Volume 416, Issue 6877, pp. 194 - 199
The immune system consists of two evolutionarily different but closely related responses, innate immunity and adaptive immunity. Each of these responses has... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein-Serine-Threonine Kinases - deficiency | Toll-Like Receptor 2 | Membrane Glycoproteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases | NF-kappa B - metabolism | Listeria monocytogenes - immunology | Receptors, Interleukin - metabolism | Toll-Like Receptors | T-Lymphocytes - metabolism | Gene Deletion | Interleukins - immunology | Listeriosis - immunology | Tumor Necrosis Factor-alpha - immunology | Killer Cells, Natural - immunology | Receptors, Antigen, T-Cell - immunology | Cell Differentiation | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Interleukins - biosynthesis | Listeria monocytogenes - physiology | Macrophages - immunology | Macrophages - microbiology | Protein-Serine-Threonine Kinases - metabolism | Drosophila Proteins | Listeriosis - metabolism | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Lymphocyte Activation | Receptors, Cytokine - biosynthesis | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Receptors, Cell Surface - metabolism | Nod2 Signaling Adaptor Protein | Mice, Knockout | Immunity, Innate - immunology | Adaptor Proteins, Signal Transducing | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | T-Lymphocytes - cytology | Listeriosis - pathology | T-Lymphocytes - immunology | Mice | Nod1 Signaling Adaptor Protein | Killer Cells, Natural - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Molecules | Bacteria | Genes | Cells | Immune system | Rip2 protein | TLR2 protein | Toll-like receptors | TLR4 protein | TLR3 protein | TLR9 protein | CARDIAK protein | RICK protein | Index Medicus
Journal Article
International immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
.... Those include G-protein-coupled chemokine and chemoattractant receptors, Fc-receptors, adhesion receptors such as selectins/selectin ligands and integrins, various cytokine receptors, as well... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | Pharmacology & Pharmacy | Immunology | Life Sciences & Biomedicine | Science & Technology | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | Index Medicus | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article