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Journal Article
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 01/2018, Volume 43, Issue 1, pp. 44 - 60
Despite its name, signalling induced by the tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is versatile. Besides eliciting cell death... 
cytokine | TRAIL | death | inflammation | LUBAC | ubiquitin | INDUCED CELL-DEATH | SPATA2 LINKS CYLD | APOPTOSIS-INDUCING LIGAND | MEDIATED GENE INDUCTION | FADD-DEPENDENT APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR-SELECTIVE MUTANTS | NECROSIS-FACTOR-ALPHA | NF-KAPPA-B | AUGMENTS ANTITUMOR-ACTIVITY | DEATH DOMAIN PROTEIN | Ubiquitin
Journal Article
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 383, Issue 2, pp. 250 - 260
Abstract During the last years, a great effort has been invested into developing new TRAIL formulations with increased bioactivity, trying to overcome the... 
Hematology, Oncology and Palliative Medicine | TRAIL | Immunotherapy | Lipid nanoparticles | Colorectal cancer | DR5 cross-linking | APO2L/TRAIL | ANTIBODIES | DEATH RECEPTORS | FAS LIGAND | CELLS | ACTIVATION | LIPOSOME-BOUND TRAIL | IN-VITRO | APOPTOSIS-INDUCING LIGAND | ONCOLOGY | RECEPTOR-SELECTIVE MUTANTS | Colonic Neoplasms - genetics | Apoptosis - drug effects | Receptors, TNF-Related Apoptosis-Inducing Ligand - agonists | Colonic Neoplasms - drug therapy | Humans | Drug Resistance, Neoplasm | Male | Antineoplastic Agents - administration & dosage | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Colonic Neoplasms - metabolism | Drug Carriers | Dose-Response Relationship, Drug | Nanoparticles | Lipids - chemistry | Time Factors | Drug Compounding | Inhibitory Concentration 50 | bcl-2-Associated X Protein - genetics | Caco-2 Cells | Cell Survival - drug effects | TNF-Related Apoptosis-Inducing Ligand - administration & dosage | TNF-Related Apoptosis-Inducing Ligand - chemistry | Cross-Linking Reagents - chemistry | HCT116 Cells | bcl-2-Associated X Protein - metabolism | Antineoplastic Agents - chemistry | Cross-Linking Reagents - administration & dosage | HT29 Cells | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Colonic Neoplasms - pathology | Protein Conformation | Oligomers | Colon cancer | T cells | Analysis | Medical research | Medicine, Experimental | Biotechnology | Toxicity | Xenotransplantation | Clinical trials | Cytotoxicity | Lipids | Lymphocytes T | Exosomes | Cancer therapies | Cell surface | Anticancer properties | Coating effects | Xenografts | Conflicts of interest | Tumor necrosis factor-TNF | Biocompatibility | Colon | Formulations | Hematology | Crosslinking | Tumor cell lines | Clustering | Biological activity | Cell lines | Ligands | Tumors | Cancer | Apoptosis
Journal Article
Current Drug Targets, ISSN 1389-4501, 12/2011, Volume 12, Issue 14, pp. 2079 - 2090
Tumor necrosis factor-related apoptosis-inducing ligand or Apo2 ligand (TRAIL/Apo2L) is a member of the tumor necrosis factor (TNF) superfamily that induces... 
DR5 | DR4 | TRAIL and clinical trials | DcR1 | Apoptosis | Cancer | DcR2 | DEATH RECEPTORS | HUMAN-BREAST-CANCER | FADD-DEPENDENT APOPTOSIS | DECOY RECEPTOR | HUMAN MONOCLONAL-ANTIBODY | APOPTOSIS-INDUCING LIGAND | DIFFERENTIAL ACTIVATION | RECEPTOR-SELECTIVE MUTANTS | PHARMACOLOGY & PHARMACY | cancer | NF-KAPPA-B | PHASE-I
Journal Article
Oncogene, ISSN 0950-9232, 2008, Volume 27, Issue 22, pp. 3211 - 3220
Journal Article
British Journal of Haematology, ISSN 0007-1048, 11/2007, Volume 139, Issue 4, pp. 568 - 577
Journal Article
Journal Article