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Pharmaceutical Research, ISSN 0724-8741, 10/2011, Volume 28, Issue 10, pp. 2393 - 2402
To study the effect of oxidation on the structure of recombinant human interferon beta-1a (rhIFNβ-1a) and its immunogenicity in wild-type and immune-tolerant... 
Biomedical Engineering | Biochemistry, general | Biomedicine | Pharmacy | recombinant human interferon beta | oxidation | Medical Law | antibodies | protein aggregates | Pharmacology/Toxicology | immunogenicity | QUANTIFICATION | STABILITY | RECEPTOR | IMMUNE-TOLERANT | CHEMISTRY, MULTIDISCIPLINARY | MULTIPLE-SCLEROSIS | THERAPEUTIC PROTEINS | MOUSE MODEL | PHARMACOLOGY & PHARMACY | Protein Structure, Tertiary | Antibody Formation - immunology | Chromatography, High Pressure Liquid - methods | Interferon-beta - chemistry | Interferon-beta - immunology | Guanidine - chemistry | Oxidation-Reduction | Humans | Mice, Inbred C57BL | Recombinant Proteins - chemistry | Mice, Transgenic | Recombinant Proteins - pharmacology | Protein Binding - immunology | Protein Folding | Hydrogen Peroxide - chemistry | Antibodies, Neutralizing - immunology | Animals | Interferon beta-1a | Interferon-beta - pharmacology | Recombinant Proteins - immunology | Immune Tolerance - immunology | Mice | Drugs | Oligomers | Viral antibodies | Drug delivery systems | Immune response | Interferon beta | Antibodies | Genetic engineering | Biological response modifiers | Vehicles | Beer | Interferon | Immunology | Transgenic animals | Rodents | Pharmaceutical sciences | beta -Interferon | Immunogenicity | Transgenic mice | Oxidation | Protein structure | Index Medicus
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2012, Volume 101, Issue 1, pp. 187 - 199
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2017, Volume 61, Issue 6
Journal Article
ANALYTICAL CHEMISTRY, ISSN 0003-2700, 01/2016, Volume 88, Issue 2, pp. 1138 - 1146
New and improved methods are required for the enhanced characterization of complex biopharmaceuticals, especially those with charge and glycan heterogeneity.... 
TOP-DOWN CHARACTERIZATION | RECOMBINANT ANTIBODY | CHEMISTRY, ANALYTICAL | IONIZATION-MASS-SPECTROMETRY | HISTONE H3 | ZONE ELECTROPHORESIS | COMBINATORIAL MODIFICATION | CAPILLARY-ELECTROPHORESIS | MONOCLONAL-ANTIBODY | DEAMIDATION | BETA | Proteins | High resolution | Separation | Charge | Isomers | Glycan | Columns (structural) | Quantitative analysis
Journal Article
Science Signaling, ISSN 1945-0877, 05/2012, Volume 5, Issue 225, pp. ra38 - ra38
Interferon-beta (IFN-beta) is widely used to treat multiple sclerosis (MS), and its efficacy was demonstrated in the setting of experimental autoimmune... 
RESPONSES | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | MECHANISM | CASPASE-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CENTRAL-NERVOUS-SYSTEM | EXPRESSION | NALP3 INFLAMMASOME | CELL BIOLOGY | Recombinant Proteins - therapeutic use | Proto-Oncogene Proteins c-vav - antagonists & inhibitors | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Encephalomyelitis, Autoimmune, Experimental - immunology | Suppressor of Cytokine Signaling 1 Protein | Male | Receptor, Interferon alpha-beta - physiology | Interleukin-1beta - genetics | Neuropeptides - physiology | Proto-Oncogene Proteins c-vav - physiology | Cytoskeletal Proteins - deficiency | Interferon-beta - therapeutic use | rac GTP-Binding Proteins - antagonists & inhibitors | Interleukin-1beta - biosynthesis | Caspase 1 - physiology | rac GTP-Binding Proteins - physiology | Disease Models, Animal | Carrier Proteins - physiology | Macrophages - physiology | Encephalomyelitis, Autoimmune, Experimental - physiopathology | Receptor, Interferon alpha-beta - deficiency | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Mice, Transgenic | Mice, Knockout | Gene Expression Regulation - drug effects | Carrier Proteins - genetics | Inflammasomes - physiology | Animals | Apoptosis Regulatory Proteins | Interferon beta-1b | CD4-Positive T-Lymphocytes - transplantation | CARD Signaling Adaptor Proteins | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Suppressor of Cytokine Signaling Proteins - physiology | Mice | Enzyme Activation | rac1 GTP-Binding Protein | Neuropeptides - antagonists & inhibitors | Index Medicus
Journal Article
Gene Therapy, ISSN 0969-7128, 11/2008, Volume 15, Issue 21, pp. 1446 - 1453
Journal Article