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1. Full Text Leptin and leptin receptor expression in asthma
by Bruno, Andreina, PhD and Pace, Elisabetta, MD and Chanez, Pascal, MD and Gras, Delphine, PhD and Vachier, Isabelle, PhD and Chiappara, Giuseppina, PhD and La Guardia, Maurizio, MD and Gerbino, Stefania, PhD and Profita, Mirella, PhD and Gjomarkaj, Mark, MD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2009, Volume 124, Issue 2, pp. 230 - 237.e4
Allergy and Immunology | severe asthma | TGF-β | remodeling | epithelium | Leptin | leptin receptor | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Immunopathology | Biological and medical sciences | Medical sciences | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Receptors, Leptin - antagonists & inhibitors | Asthma - metabolism | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Male | Receptors, Leptin - biosynthesis | Fluticasone | Receptors, Leptin - agonists | Respiratory Mucosa - pathology | Bronchi - metabolism | Adult | Female | Leptin - biosynthesis | Leptin - pharmacology | Chromones - pharmacology | Bronchi - pathology | Transforming Growth Factor beta1 - pharmacology | Cell Line | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Imidazoles - pharmacology | Recombinant Proteins - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Androstadienes - pharmacology | Cell Proliferation - drug effects | Pyridines - pharmacology | Respiratory Mucosa - metabolism | Asthma - pathology | Transforming growth factors | Peptide hormones | Propionates | Asthma | Studies | Cell growth | Kinases | Rodents | Polyclonal antibodies | Methods | Index Medicus | Abridged Index Medicus
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2. Full Text Pegylated Human Leptin D23L Mutant-Preparation and Biological Activity In Vitro and In Vivo in Male ob/ob Mice
by Gertler, Arieh and Solomon, Gili
Endocrinology (Philadelphia), ISSN 0013-7227, 04/2019, Volume 160, Issue 4, pp. 891 - 898
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Polyethylene Glycols - metabolism | Glucose Tolerance Test | Leptin - metabolism | Body Weight - drug effects | Male | Eating - drug effects | Animals | Leptin - analogs & derivatives | Mice, Obese | Leptin - pharmacology | Mice | Mutation | Receptors, Leptin - metabolism | Blood Glucose - metabolism | Polyethylene Glycols - pharmacology | Obesity | Care and treatment | Gene mutations | Leptin | Physiological aspects | Genetic aspects | Models | Health aspects | Recombinant proteins | Size exclusion chromatography | Animal models | Sodium lauryl sulfate | Cytokines | Gel electrophoresis | Body weight | Fuel consumption | Glucose | Secondary structure | Biological activity | Circular dichroism | Mutants | Glucose tolerance | E coli | N-Terminus | Reagents | Dichroism | In vivo methods and tests | Food consumption | Protein structure | Food | Index Medicus | Abridged Index Medicus
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3. Full Text Leptin antagonist ameliorates chronic colitis in IL-10−/− mice
by Singh, Udai P and Singh, Narendra P and Guan, Hongbing and Busbee, Brandon and Price, Robert L and Taub, Dennis D and Mishra, Manoj K and Fayad, Raja and Nagarkatti, Mitzi and Nagarkatti, Prakash S
Immunobiology (1979), ISSN 0171-2985, 2013, Volume 218, Issue 12, pp. 1439 - 1451
Allergy and Immunology | Advanced Basic Science | Pegylated | Inflammatory bowel disease (IBD) | Leptin | Inflammation | Crohn's disease (CD) | Antagonist | Ulcerative colitis (UC) | Life Sciences & Biomedicine | Immunology | Science & Technology | Body Weight - drug effects | Polyethylene Glycols - chemistry | Intestinal Mucosa - drug effects | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | STAT1 Transcription Factor - metabolism | Intestinal Mucosa - immunology | Leptin - analogs & derivatives | Female | Leptin - administration & dosage | Colitis - drug therapy | Colitis - immunology | Smad7 Protein - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Smad7 Protein - metabolism | Leptin - chemistry | Mice, Inbred C57BL | Apyrase - metabolism | Recombinant Proteins - chemistry | Down-Regulation - drug effects | STAT1 Transcription Factor - genetics | Recombinant Proteins - administration & dosage | Mice, Knockout | Insulin - metabolism | T-Lymphocytes, Regulatory - drug effects | Animals | Signal Transduction - drug effects | Interleukin-10 - genetics | Mice | Chronic Disease | Transforming Growth Factor beta - metabolism | Index Medicus | Crohn’s Disease (CD) | Ulcerative Colitis (UC)
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4. Full Text Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3Î’/Î’-catenin signaling
by Garza, J.C and Guo, M and Zhang, W and Lu, X.-Y
Molecular psychiatry, ISSN 1359-4184, 08/2012, Volume 17, Issue 8, pp. 790 - 808
glycogen synthase kinase-3β | neurogenesis | β-catenin | chronic unpredictable stress | glucocorticoids | leptin | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Psychopathology. Psychiatry | Mood disorders | Biological and medical sciences | Depression | Medical sciences | Recombinant Proteins - therapeutic use | Dexamethasone - antagonists & inhibitors | Glycogen Synthase Kinase 3 beta | Male | Hippocampus - drug effects | Cranial Irradiation - methods | Depression - drug therapy | Depression - metabolism | Dexamethasone - pharmacology | Stress, Psychological - metabolism | Neurogenesis - radiation effects | Depression - complications | Leptin - pharmacology | Neurogenesis - drug effects | Phosphorylation - drug effects | Disease Models, Animal | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Stress, Psychological - drug therapy | Cells, Cultured | Leptin - therapeutic use | Rats | Recombinant Proteins - pharmacology | Glycogen Synthase Kinase 3 - metabolism | Rats, Sprague-Dawley | beta Catenin - metabolism | Hippocampus - metabolism | Animals | Signal Transduction - drug effects | Neurogenesis - physiology | beta Catenin - antagonists & inhibitors | Hippocampus - radiation effects | Cell Proliferation - drug effects | Stress, Psychological - complications | Cell Proliferation - radiation effects | Index Medicus | Cell proliferation | Animal models | Phosphorylation | Dexamethasone | Glucocorticoids | catenin | Glycogen synthase kinase 3 | Glucocorticoid receptors | Hormones | Neurogenesis | Behavioral despair | Nuclear transport | Stress | Signal transduction | Antidepressants | Neural stem cells | X radiation | Hippocampus
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5. Full Text Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial
by Heymsfield, Steven B and Greenberg, Andrew S and Fujioka, Ken and Dixon, Russell M and Kushner, Robert and Hunt, Thomas and Lubina, John A and Patane, Janet and Self, Barbara and Hunt, Pam and McCamish, Mark
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 10/1999, Volume 282, Issue 16, pp. 1568 - 1575
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Medical sciences | General and cellular metabolism. Vitamins | Pharmacology. Drug treatments | Body Composition | Body Mass Index | Recombinant Proteins - therapeutic use | Double-Blind Method | Drug Administration Schedule | Obesity - drug therapy | Humans | Leptin - therapeutic use | Linear Models | Male | Energy Intake | Weight Loss | Leptin - analogs & derivatives | Adult | Antibodies - blood | Female | Leptin - administration & dosage | Leptin - immunology | Leptin - pharmacokinetics | Obesity | Care and treatment | Health aspects | Leptin | Drug therapy | Weight control | Hormones | Index Medicus | Abridged Index Medicus
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6. Full Text Structural and Mechanistic Paradigm of Leptin Receptor Activation Revealed by Complexes with Wild-Type and Antagonist Leptins
by Moharana, Kedar and Zabeau, Lennart and Peelman, Frank and Ringler, Philippe and Stahlberg, Henning and Tavernier, Jan and Savvides, Savvas N
Structure (London), ISSN 0969-2126, 06/2014, Volume 22, Issue 6, pp. 866 - 877
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Recombinant Proteins - metabolism | Biophysical Phenomena | Leptin - chemistry | Receptors, Leptin - genetics | Humans | Leptin - metabolism | Protein Multimerization | Models, Molecular | Recombinant Proteins - chemistry | Scattering, Small Angle | Recombinant Proteins - genetics | Cysteine - chemistry | Receptors, Leptin - chemistry | Multiprotein Complexes - metabolism | Multiprotein Complexes - chemistry | X-Ray Diffraction | Protein Structure, Quaternary | Protein Interaction Domains and Motifs | Receptors, Leptin - metabolism | Acetates | Leptin | Index Medicus | Binding | Cysteine | Receptors | Reproduction | Cytokines | Breast | Activation | Binding sites
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7. Full Text Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
by Sadaf Farooqi, I and Matarese, Giuseppe and Lord, Graham M and Keogh, Julia M and Lawrence, Elizabeth and Agwu, Chizo and Sanna, Veronica and Jebb, Susan A and Perna, Francesco and Fontana, Silvia and Lechler, Robert I and Depaoli, Alex M and O'Rahilly, Stephen
The Journal of clinical investigation, ISSN 0021-9738, 2002, Volume 110, Issue 8, pp. 1093 - 1103
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Recombinant Proteins - therapeutic use | Obesity - drug therapy | Humans | Child, Preschool | Leptin - therapeutic use | Obesity - physiopathology | Leptin - genetics | Weight Loss - drug effects | Obesity - genetics | Obesity - pathology | Phenotype | Animals | Lymphocyte Activation - drug effects | T-Lymphocytes - drug effects | Female | Neurosecretory Systems - drug effects | T-Lymphocytes - immunology | Mice | Leptin - deficiency | Child | Energy Metabolism - drug effects | Neurosecretory Systems - physiopathology | Index Medicus | Abridged Index Medicus
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8. Full Text Early leptin blockade predisposes fat-fed rats to overweight and modifies hypothalamic microRNAs
by Benoit, Charlotte and Ould-Hamouda, Hassina and Crepin, Delphine and Gertler, Arieh and Amar, Laurence and Taouis, Mohammed
Journal of endocrinology, ISSN 0022-0795, 7/2013, Volume 218, Issue 1, pp. 35 - 47
Insulin resistance | MicroRNA | High-fat diet | Postnatal leptin | Leptin resistance | Overweight | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Leptin - antagonists & inhibitors | Receptors, Leptin - antagonists & inhibitors | Leptin - metabolism | Diet, High-Fat - adverse effects | Male | MicroRNAs - metabolism | Gene Expression Profiling | Overweight - metabolism | Liver - drug effects | Leptin - analogs & derivatives | Hypothalamus - drug effects | Animals, Newborn | Liver - metabolism | Insulin Resistance | Rats | Random Allocation | Down-Regulation - drug effects | Up-Regulation - drug effects | Animals | Hypothalamus - metabolism | Overweight - etiology | Signal Transduction - drug effects | Hormone Antagonists - toxicity | Recombinant Proteins - toxicity | Overweight - chemically induced | Receptors, Leptin - metabolism | Energy Metabolism - drug effects | Index Medicus | Up-Regulation | Liver | Neurons and Cognition | Neurobiology | Recombinant Proteins | Hypothalamus | Life Sciences | Diet, High-Fat | Hormone Antagonists | Receptors, Leptin | Signal Transduction | Down-Regulation | Psychology and behavior | Energy Metabolism | Leptin | MicroRNAs | Cognitive Sciences
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