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Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 01/2016, Volume 31, Issue 1, pp. 52 - 64
Journal Article
BMC Genomics, ISSN 1471-2164, 06/2013, Volume 14, Issue 1, pp. 408 - 408
Journal Article
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2007, Volume 92, Issue 6, pp. 2292 - 2299
Aim/Hypothesis: Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is... 
3T3-L1 ADIPOCYTES | SUBCUTANEOUS FAT-CELLS | BETA-ADRENERGIC STIMULATION | WEIGHT-REDUCTION | TISSUE | ENDOCRINOLOGY & METABOLISM | UPPER-BODY OBESITY | PPAR-GAMMA | SKELETAL-MUSCLE METABOLISM | TNF-ALPHA | LIPOPROTEIN-LIPASE | Hyperinsulinism - metabolism | Obesity - diet therapy | Humans | Middle Aged | Sterol Esterase - metabolism | Adipose Tissue - pathology | Male | Lipase - metabolism | RNA, Messenger - metabolism | Diet, Reducing | Obesity - metabolism | Obesity - pathology | Gene Expression Regulation, Enzymologic | Hyperinsulinism - pathology | Regression Analysis | Sterol Esterase - genetics | Biopsy | Insulin Resistance - physiology | Weight Loss - physiology | Adult | Female | Adipose Tissue - enzymology | Hyperinsulinism - diet therapy | Lipase - genetics | Obesity | Sterol Esterase | Biochemistry, Molecular Biology | Insulin Resistance | Lipase | Life Sciences | Weight Loss | Adipose Tissue | RNA, Messenger | Hyperinsulinism | Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is mediated by hormone-sensitive lipase (HSL) and the recently discovered adipose triglyceride lipase (ATGL). The aim of the present study was to examine whether ATGL and HSL mRNA and protein expression are altered in insulin-resistant conditions. In addition | gender | indicating a tight coregulation and transcriptional control. CONCLUSIONS: In obese subjects | Medical and Health Sciences | Medicin och hälsovetenskap | before and just after a 10-wk hypocaloric diet. ATGL and HSL protein and mRNA expression was determined by Western blot and quantitative RT-PCR | and body composition. Both mRNA and protein levels of ATGL and HSL were reduced in insulin-resistant compared with insulin-sensitive subjects (P < 0.05). Weight reduction significantly decreased ATGL and HSL mRNA and protein expression. A positive correlation between the decrease in leptin and the decrease in ATGL protein level after weight reduction was observed. Finally | we investigated whether a possible impaired expression could be reversed by a period of weight reduction. METHODS: Adipose tissue biopsies were taken from obese subjects (n = 44) with a wide range of insulin resistance | respectively. RESULTS: Fasting insulin levels and the degree of insulin resistance (using the homeostasis model assessment index for insulin resistance) were negatively correlated with ATGL and HSL protein expression | Klinisk medicin | independent of fat mass. Data on weight reduction indicated that also other factors (e.g. leptin) relate to ATGL and HSL protein expression | Clinical Medicine | Endokrinologi och diabetes | ATGL and HSL mRNA and protein levels seem to be highly correlated | independent of age | insulin resistance and hyperinsulinemia are strongly associated with ATGL and HSL mRNA and protein expression | fat cell size | Endocrinology and Diabetes
Journal Article
Journal Article
Carcinogenesis, ISSN 0143-3334, 11/2008, Volume 29, Issue 11, pp. 2073 - 2077
microRNAs (miRNA) are small, endogenously expressed non-coding RNAs that are sequentially processed by Drosha and Dicer from primary transcripts, by negatively... 
REPRESSES | ONCOGENE | HUMAN LUNG CANCERS | ONCOLOGY | MYC | MIR-17-92 | CELL-PROLIFERATION | MICRORNAS | TUMORIGENESIS | REDUCED EXPRESSION | Cell Line | Ribonuclease III - genetics | Cell Division | Humans | RNA, Messenger - genetics | Gene Expression Profiling | HeLa Cells | MicroRNAs - physiology | Reverse Transcriptase Polymerase Chain Reaction | Index Medicus
Journal Article
Journal Article