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Brain, ISSN 0006-8950, 08/2015, Volume 138, Issue 8, pp. 2191 - 2205
Journal Article
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 9/2012, Volume 35, Issue 5, pp. 761 - 776
Journal Article
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 2011, Volume 34, Issue 4, pp. 907 - 916
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2003, Volume 65, Issue 9, pp. 1427 - 1433
Journal Article
Nature Genetics, ISSN 1061-4036, 09/2009, Volume 41, Issue 9, pp. 1016 - 1021
Journal Article
Blood, ISSN 0006-4971, 04/2006, Volume 107, Issue 8, pp. 3288 - 94
The reduced folate carrier (RFC) is the dominant route for the uptake of various antifolates including PT523, a potent dihydrofolate reductase inhibitor (Ki =... 
Down-Regulation/drug effects | Loss of Heterozygosity/genetics | Response Elements/drug effects | Humans | Tetrahydrofolate Dehydrogenase/genetics | Biological Transport/drug effects | Drug Resistance, Neoplasm/drug effects | Transcription Factors/genetics | Gene Silencing/drug effects | Enzyme Inhibitors/pharmacology | Reduced Folate Carrier Protein | Membrane Transport Proteins/genetics | Leukemia/drug therapy | Alleles | Cell Line, Tumor | Gene Expression Regulation, Leukemic/drug effects | Ornithine/analogs & derivatives | Methotrexate/pharmacology | Pterins/pharmacology | ANTIFOLATE RESISTANCE | METHYLATION | GENE | ANALOGS | PHOSPHORYLATION | METHOTREXATE TRANSPORT | DIHYDROFOLATE-REDUCTASE | DOWN-REGULATION | HEMATOLOGY | FOLIC-ACID | LINES | Methotrexate - pharmacology | Gene Silencing - drug effects | Pterins - therapeutic use | Ornithine - analogs & derivatives | Ornithine - therapeutic use | Leukemia - metabolism | Gene Expression Regulation, Leukemic - genetics | Loss of Heterozygosity - genetics | Membrane Transport Proteins - genetics | Membrane Transport Proteins - metabolism | Biological Transport - drug effects | Biological Transport - genetics | Response Elements - genetics | Leukemia - genetics | Enzyme Inhibitors - pharmacology | Ornithine - pharmacology | Gene Expression Regulation, Leukemic - drug effects | Leukemia - drug therapy | Transcription Factors - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Tetrahydrofolate Dehydrogenase - metabolism | Response Elements - drug effects | Transcription Factors - metabolism | Drug Resistance, Neoplasm - genetics | Pterins - pharmacology | Drug Resistance, Neoplasm - drug effects | Tetrahydrofolate Dehydrogenase - genetics
Journal Article