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fosfomycin - analogs & derivatives (8) 8
isoprenoid biosynthesis (8) 8
index medicus (7) 7
1-deoxy-d-xylulose 5-phosphate reductoisomerase (6) 6
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Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2012, Volume 51, pp. 277 - 285
Since sets up several multiple anti-tuberculosis drug resistance mechanisms, development of new drugs with innovative target is urgent. The methylerythritol... 
Prodrug synthesis | Mycobacterium | Isoprenoid biosynthesis | Deoxyxylulose 5-phosphate reducto-isomerase | VIVO ANTIMALARIAL ACTIVITY | CHEMISTRY, MEDICINAL | PHOSPHONIC ACID ANTIBIOTICS | ESTER PRODRUGS | TUBERCULOSIS | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | ESCHERICHIA-COLI | DRUG-RESISTANCE | FOSMIDOMYCIN RESISTANCE | CELL-WALL | Oxidoreductases - antagonists & inhibitors | Mycobacterium smegmatis - metabolism | Multienzyme Complexes - metabolism | Organophosphonates - metabolism | Prodrugs - chemistry | Fosfomycin - metabolism | Prodrugs - metabolism | Organophosphonates - chemical synthesis | Oxazines - metabolism | Xanthenes - metabolism | Anti-Bacterial Agents - chemistry | Mycobacterium smegmatis - enzymology | Aldose-Ketose Isomerases - metabolism | Fosfomycin - analogs & derivatives | Mycobacterium smegmatis - growth & development | Enzyme Inhibitors - metabolism | Microbial Viability - drug effects | Oxidoreductases - metabolism | Anti-Bacterial Agents - metabolism | Multienzyme Complexes - antagonists & inhibitors | Anti-Bacterial Agents - chemical synthesis | Organophosphonates - pharmacology | Mycobacterium smegmatis - drug effects | Organophosphonates - chemistry | Hydrophobic and Hydrophilic Interactions | Prodrugs - chemical synthesis | Anti-Bacterial Agents - pharmacology | Kinetics | Aldose-Ketose Isomerases - antagonists & inhibitors | Prodrugs - pharmacology | Phosphates | Drug resistance in microorganisms | Metabolites | Growth | Phosphonates | Physiological aspects | Drug resistance
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2013, Volume 23, Issue 6, pp. 1643 - 1647
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2005, Volume 386, Issue 1, pp. 127 - 135
Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against pathogenic bacteria and the malaria parasite Plasniodium falciparum.... 
Malaria | Antibacterial drug | 2-C-methyl-D-erythritol 4-phosphate | Isoprenoid biosynthesis | 1-deoxy-D-xylulose 5-phosphate | 1-deoxy-D-xylulose 5-phosphate reducto-isomerase | isoprenoid biosynthesis | VIVO ANTIMALARIAL ACTIVITY | 1-deoxy-D-Xylulose 5-phosphate reducto-isomerase | ESTER PRODRUGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | ESCHERICHIA-COLI | TERPENOID BIOSYNTHESIS | malaria | antibacterial drug | REACTION-INTERMEDIATE ANALOGS | HIGHER-PLANTS | HISTONE DEACETYLASE | NONMEVALONATE PATHWAY | Oxidoreductases - antagonists & inhibitors | Butyrates - pharmacology | Escherichia coli - drug effects | Enzyme Inhibitors - chemical synthesis | Microbial Sensitivity Tests | Organophosphonates - chemical synthesis | Terpenes - metabolism | Drug Resistance, Multiple, Bacterial | Drug Design | Escherichia coli Proteins - antagonists & inhibitors | NADP - metabolism | Hydroxamic Acids - pharmacology | Antimalarials - chemical synthesis | Fosfomycin - analogs & derivatives | Escherichia coli - enzymology | Fosfomycin - pharmacology | Enzyme Inhibitors - pharmacology | Multienzyme Complexes - antagonists & inhibitors | Antimalarials - pharmacology | Butyrates - chemical synthesis | Anti-Bacterial Agents - chemical synthesis | Organophosphonates - pharmacology | Anti-Bacterial Agents - pharmacology | Aldose-Ketose Isomerases - antagonists & inhibitors | Hydroxamic Acids - chemical synthesis | H-DXR, His6-tagged DXR | THF, tetrahydrofuran | MEP, 2-C-methyl-D-erythritol 4-phosphate | HRMS, high-resolution MS | LB, Luria–Bertani | FAB, fast atom bombardment | DTT, dithiothreitol | DXR, 1-deoxy-D-xylulose 5-phosphate reducto-isomerase | DXP, 1-deoxy-D-xylulose 5-phosphate
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Journal Article
Journal Article
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