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science & technology (165) 165
regulated intramembrane proteolysis (162) 162
life sciences & biomedicine (149) 149
humans (121) 121
animals (101) 101
proteolysis (73) 73
biochemistry & molecular biology (68) 68
cell biology (67) 67
signal transduction (64) 64
membrane proteins - metabolism (54) 54
proteins (48) 48
presenilin (36) 36
alzheimer's disease (34) 34
membrane proteins - genetics (33) 33
mice (33) 33
proteases (33) 33
amyloid precursor protein secretases - metabolism (30) 30
cell line (30) 30
neurosciences (30) 30
amino acid sequence (28) 28
molecular sequence data (28) 28
neurosciences & neurology (28) 28
cell membrane - metabolism (23) 23
gene expression (23) 23
γ-secretase (23) 23
endopeptidases - metabolism (22) 22
protein structure, tertiary (22) 22
substrate specificity (21) 21
research (20) 20
biology (19) 19
biophysics (19) 19
membrane proteins (19) 19
mutation (19) 19
physiological aspects (19) 19
amyloid beta-protein precursor - metabolism (18) 18
biochemistry (18) 18
signal transduction - physiology (18) 18
binding sites (17) 17
kinases (17) 17
ligands (17) 17
research article (17) 17
site-2 protease (17) 17
biological and medical sciences (16) 16
membrane proteins - chemistry (16) 16
models, biological (16) 16
multidisciplinary sciences (16) 16
peptide hydrolases - metabolism (16) 16
protein binding (16) 16
science & technology - other topics (16) 16
amyloid precursor protein secretases (15) 15
cancer (15) 15
cell nucleus - metabolism (15) 15
phosphorylation (15) 15
endoplasmic reticulum (14) 14
enzymes (14) 14
extracellular signal-regulated kinase (14) 14
hek293 cells (14) 14
alzheimer disease - metabolism (13) 13
apoptosis (13) 13
developmental biology (13) 13
peptides (13) 13
transcription factors (13) 13
biological sciences (12) 12
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endopeptidases - genetics (12) 12
fundamental and applied biological sciences. psychology (12) 12
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neurology (12) 12
notch (12) 12
signaling (12) 12
amyloid beta-protein precursor - genetics (11) 11
amyloid precursor protein secretases - genetics (11) 11
analysis (11) 11
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extracellular signal-regulated map kinases - metabolism (11) 11
health aspects (11) 11
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microbiology (11) 11
protease (11) 11
transcription factors - metabolism (11) 11
unfolded protein response (11) 11
alzheimer disease - genetics (10) 10
amyloid precursor protein (10) 10
aspartic acid endopeptidases - metabolism (10) 10
cells, cultured (10) 10
cercopithecus aethiops (10) 10
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escherichia coli proteins - metabolism (10) 10
gene expression regulation (10) 10
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rip (10) 10
signal peptide peptidase (10) 10
transcription (10) 10
amyloid beta-protein (9) 9
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presenilin-1 (9) 9
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1. Full Text Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity
by McCarthy, J.V and Twomey, C and Wujek, P
Cellular and Molecular Life Sciences, ISSN 1420-682X, 01/2009, Volume 66, Issue 9, pp. 1534 - 1555
Presenilin | Signal transduction | Regulated intramembrane proteolysis | Alzheimer's disease | γ-secretase complexes | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Presenilins - physiology | Amyloid Precursor Protein Secretases - genetics | Amyloid Precursor Protein Secretases - metabolism | Animals | Amyloid Precursor Protein Secretases - physiology | Models, Biological | Presenilins - metabolism | Substrate Specificity | Signal Transduction - physiology | Presenilins - chemistry | Index Medicus
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2. Full Text Production of BBF2H7‐derived small peptide fragments via endoplasmic reticulum stress‐dependent regulated intramembrane proteolysis
by Matsuhisa, Koji and Saito, Atsushi and Cai, Longjie and Kaneko, Masayuki and Okamoto, Takumi and Sakaue, Fumika and Asada, Rie and Urano, Fumihiko and Yanagida, Kanta and Okochi, Masayasu and Kudo, Yukitsuka and Matsumoto, Masaki and Nakayama, Keiichi I and Imaizumi, Kazunori
The FASEB journal, ISSN 0892-6638, 01/2020, Volume 34, Issue 1, pp. 865 - 880
site‐2 protease | regulated intramembrane proteolysis | transmembrane transcription factor | endoplasmic reticulum stress | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
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3. Full Text EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes
by Mani, Saravana Kumar Kailasam and Zhang, Hao and Diab, Ahmed and Pascuzzi, Pete E and Lefrançois, Lydie and Fares, Nadim and Bancel, Brigitte and Merle, Philippe and Andrisani, Ourania
Journal of hepatology, ISSN 0168-8278, 2016, Volume 65, Issue 5, pp. 888 - 898
Gastroenterology and Hepatology | SUZ12/polycomb repressive complex 2 | Wnt signaling | BAMBI | Hepatocellular carcinoma | Hepatitis B virus | EpCAM-regulated intramembrane proteolysis | Pluripotency genes (NANOG, OCT4 and SOX2) | CD44 | CD133 | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Animals | Hepatocytes | Proteolysis | Humans | Mice | Neoplastic Stem Cells | Carcinoma, Hepatocellular | Liver Neoplasms | Epithelial Cell Adhesion Molecule | Hepatitis B | Genetic aspects | Stem cells | Cancer | Flow cytometry | Chromatin | Wnt protein | Epithelial cells | Oct-4 protein | c-Myc protein | Chronic infection | Stem cell transplantation | Immunoblotting | Myc protein | Cell adhesion & migration | Cell adhesion molecules | Hepatitis | Liver cancer | Transfection | CD44 antigen | Therapeutic applications | Gene expression | Cisplatin | Polycomb group proteins | Green fluorescent protein | Pluripotency | Tumors | Index Medicus | SUZ12 | polycomb repressive complex 2
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4. Full Text Trafficking, a key player in regulated intramembrane proteolysis
by Sannerud, Ragna and Annaert, Wim
Seminars in cell & developmental biology, ISSN 1084-9521, 2009, Volume 20, Issue 2, pp. 183 - 190
Presenilin | Regulated intramembrane proteolysis | Alzheimer's disease | γ-Secretase | Amyloid precursor protein | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Amyloid Precursor Protein Secretases - metabolism | Signal Transduction | Humans | Amyloid beta-Protein Precursor - metabolism | Protein Transport | Peptides | Proteolysis | Proteases | Amyloid beta-protein | Index Medicus
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5. Full Text Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
by Brown, Michael S and Ye, Jin and Rawson, Robert B and Goldstein, Joseph L
Cell (Cambridge), ISSN 0092-8674, 02/2000, Volume 100, Issue 4, pp. 391 - 398
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Endopeptidases - metabolism | Humans | Nuclear Proteins - metabolism | Protein Folding | CCAAT-Enhancer-Binding Proteins | Endoribonucleases | DNA-Binding Proteins - metabolism | Animals | Amyloid beta-Protein Precursor - metabolism | Bacteria - enzymology | Membrane Proteins - metabolism | Transcription Factors | Sterol Regulatory Element Binding Protein 1 | Protein-Serine-Threonine Kinases - metabolism | Proteolysis | Plasma membranes | Cellular control mechanisms | Physiological aspects | Homology (Biology) | Cellular signal transduction | Research | Cytochemistry | Endoplasmic reticulum | Membrane proteins | ATF6 protein | sterols | regulated intramembrane proteolysis | Ire1 protein | sterol regulatory element-binding protein | Index Medicus
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6. Full Text Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function
by Cho, Youngkyung and Kim, Sang Bum and Kim, Jiyoon and An Vuong Quynh Pham and Yoon, Min Ji and Park, Jeong Hwan and Hwang, Ki-Tae and Park, Dongeun and Cho, Yongcheol and Kim, Moon Gyo and Kim, Chungho
BMC biology, ISSN 1741-7007, 06/2020, Volume 18, Issue 1, pp. 1 - 60
Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Care and treatment | Peptides | Serine | Estrogen | Antibodies | Development and progression | Thrombin | Metastasis | Gene expression | Viral antibodies | Proteolysis | Analysis | Health aspects | Cancer | Plasma | Shedding | Membranes | Estrogens | Estrogen receptors | Metastases | Proteins | Functionals | Protease | Signal peptide peptidase | Bioinformatics | Peptidase | Invasiveness | Breast cancer | Ribonucleic acid--RNA | Membrane proteins | Medical prognosis | Serine proteinase | Intracellular | Chemokines | Index Medicus | Regulated intramembrane proteolysis | Transcriptional regulation | Epithin/PRSS14
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7. Full Text Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes
by Craessaerts, Katleen and Müller, Ulrike and De Strooper, Bart and Derks, Carmen and Filippov, Mikhail A and Hébert, Sébastien S and Serneels, Lutgarde and Tolia, Alexandra
EMBO reports, ISSN 1469-221X, 07/2006, Volume 7, Issue 7, pp. 739 - 745
secretase | regulated intramembrane proteolysis | amyloid precursor protein | Alzheimer's disease | Regulated intramembrane proteolysis | Amyloid precursor protein | Secretase | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Structure, Tertiary | Amyloid beta-Protein Precursor - deficiency | Cell Line | Endopeptidases - metabolism | Amyloid beta-Protein Precursor - chemistry | Humans | Gene Expression Regulation | Cercopithecus aethiops | Membranes - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Aspartic Acid Endopeptidases | Alzheimer Disease - metabolism | Amyloid Precursor Protein Secretases | Amyloid beta-Protein Precursor - metabolism | Mice | Protein Processing, Post-Translational | HeLa Cells | Alzheimer Disease - genetics | COS Cells | Peptide Hydrolases - metabolism | Proteins | Membranes | Gene expression | Proteomics | Index Medicus | Scientific Report
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8. Full Text The Metastable XBP1u Transmembrane Domain Defines Determinants for Intramembrane Proteolysis by Signal Peptide Peptidase
by Yücel, Sara Suna and Stelzer, Walter and Lorenzoni, Alessandra and Wozny, Manfred and Langosch, Dieter and Lemberg, Marius K
Cell reports (Cambridge), ISSN 2211-1247, 03/2019, Volume 26, Issue 11, pp. 3087 - 3099.e11
ERAD | GxGD aspartic intramembrane protease | SPP | transmembrane helix dynamics | subsite | HO1 | regulated intramembrane proteolysis | XBP1u | exosite | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Heme Oxygenase-1 - metabolism | Humans | Endoplasmic Reticulum - metabolism | X-Box Binding Protein 1 - chemistry | Proteolysis | X-Box Binding Protein 1 - metabolism | Aspartic Acid Endopeptidases - metabolism | HEK293 Cells | Protein Domains | Mutation | X-Box Binding Protein 1 - genetics | Intracellular Membranes - metabolism | SEC Translocation Channels - metabolism | Index Medicus
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