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science & technology (165) 165
regulated intramembrane proteolysis (162) 162
life sciences & biomedicine (149) 149
humans (121) 121
animals (101) 101
proteolysis (73) 73
biochemistry & molecular biology (68) 68
cell biology (67) 67
signal transduction (64) 64
membrane proteins - metabolism (54) 54
proteins (48) 48
presenilin (36) 36
alzheimer's disease (34) 34
membrane proteins - genetics (33) 33
mice (33) 33
proteases (33) 33
amyloid precursor protein secretases - metabolism (30) 30
cell line (30) 30
neurosciences (30) 30
amino acid sequence (28) 28
molecular sequence data (28) 28
neurosciences & neurology (28) 28
cell membrane - metabolism (23) 23
gene expression (23) 23
γ-secretase (23) 23
endopeptidases - metabolism (22) 22
protein structure, tertiary (22) 22
substrate specificity (21) 21
research (20) 20
biology (19) 19
biophysics (19) 19
membrane proteins (19) 19
mutation (19) 19
physiological aspects (19) 19
amyloid beta-protein precursor - metabolism (18) 18
biochemistry (18) 18
signal transduction - physiology (18) 18
binding sites (17) 17
kinases (17) 17
ligands (17) 17
research article (17) 17
site-2 protease (17) 17
biological and medical sciences (16) 16
membrane proteins - chemistry (16) 16
models, biological (16) 16
multidisciplinary sciences (16) 16
peptide hydrolases - metabolism (16) 16
protein binding (16) 16
science & technology - other topics (16) 16
amyloid precursor protein secretases (15) 15
cancer (15) 15
cell nucleus - metabolism (15) 15
phosphorylation (15) 15
endoplasmic reticulum (14) 14
enzymes (14) 14
extracellular signal-regulated kinase (14) 14
hek293 cells (14) 14
alzheimer disease - metabolism (13) 13
apoptosis (13) 13
developmental biology (13) 13
peptides (13) 13
transcription factors (13) 13
biological sciences (12) 12
cell line, tumor (12) 12
endopeptidases - genetics (12) 12
fundamental and applied biological sciences. psychology (12) 12
molecular biology (12) 12
neurology (12) 12
notch (12) 12
signaling (12) 12
amyloid beta-protein precursor - genetics (11) 11
amyloid precursor protein secretases - genetics (11) 11
analysis (11) 11
aspartic acid endopeptidases (11) 11
extracellular signal-regulated map kinases - metabolism (11) 11
health aspects (11) 11
membranes (11) 11
microbiology (11) 11
protease (11) 11
transcription factors - metabolism (11) 11
unfolded protein response (11) 11
alzheimer disease - genetics (10) 10
amyloid precursor protein (10) 10
aspartic acid endopeptidases - metabolism (10) 10
cells, cultured (10) 10
cercopithecus aethiops (10) 10
endoplasmic reticulum - metabolism (10) 10
escherichia coli proteins - metabolism (10) 10
gene expression regulation (10) 10
genes (10) 10
medical sciences (10) 10
models, molecular (10) 10
rip (10) 10
signal peptide peptidase (10) 10
transcription (10) 10
amyloid beta-protein (9) 9
bacterial proteins - genetics (9) 9
genetic aspects (9) 9
physiology (9) 9
presenilin-1 (9) 9
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