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Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 07/2017, Volume 102, Issue 1, pp. 19 - 29
TNF‐α stimulates exocytosis of secretory vesicles and gelatinase granules, and primes specific and azurophilic granule exocytosis that depend on p38 MAPK and... 
actin cytoskeleton | mass spectrometry | phosphorylation | p38 MAPK | P38 MAPK | Phosphorylation | Actin cytoskeleton | Mass spectrometry | RESPIRATORY BURST | ACTIVATED PROTEIN-KINASE | SECRETORY VESICLES | PLATELET SECRETION | REGULATED EXOCYTOSIS | MAST-CELLS | POLYMORPHONUCLEAR LEUKOCYTE | IMMUNOLOGY | BINDING PROTEIN | CELL BIOLOGY | DEGRANULATION | HEMATOLOGY | Gelatinases - immunology | Neutrophil Activation | Humans | Lipoylation - drug effects | Neutrophils - immunology | Protein Kinase C - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Proto-Oncogene Proteins c-raf - immunology | Actin Cytoskeleton - immunology | Exocytosis - drug effects | Secretory Vesicles - immunology | Tumor Necrosis Factor-alpha - pharmacology | Exocytosis - immunology | alpha-Defensins - immunology | Tumor Necrosis Factor-alpha - immunology | Lipoylation - immunology | Proto-Oncogene Proteins c-abl - immunology | Protein kinase C | Leukemia | Stimulation | Kinases | Exocytosis | Proteins | Secretory vesicles | Vesicles | Actin | Phosphoproteins | Myosin | Tumor necrosis factor-TNF | Alanine | Immune response | Neutrophils | MAP kinase | Priming | Mass spectroscopy | Pharmacology | Gelatinase | Tumor necrosis factor-α | Substrates | Granular materials | Cytoskeleton | Granules | MARCKS protein | Index Medicus | Spotlight on Leading Edge Research
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 45, pp. 32343 - 32356
Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown efficacy in a phase 2 clinical trial, development of resistance to TRAIL by... 
Reactive Oxygen Species (ROS) | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | MEDIATED APOPTOSIS | Limonoid | ANTITUMOR-ACTIVITY | Cancer Therapy | MAP Kinases (MAPKs) | Death Receptor | Trail | MELIA-AZADIRACHTA L | CHOP | CHOLANGIOCARCINOMA CELLS | SURVIVAL PROTEINS | NF-KAPPA-B | UP-REGULATION | APO2L/TRAIL-INDUCED APOPTOSIS | Anticancer Drug | COLON-CARCINOMA | Apoptosis | Neoplasms - metabolism | Transcription Factor CHOP - genetics | Reactive Oxygen Species - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Neoplasms - genetics | Antineoplastic Agents - pharmacology | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | Gene Expression Regulation, Neoplastic - drug effects | Apoptosis Regulatory Proteins - biosynthesis | Response Elements | Cell Survival | Tumor Suppressor Protein p53 - metabolism | Down-Regulation - drug effects | Neoplasms - drug therapy | Up-Regulation - drug effects | Limonins - pharmacology | MAP Kinase Signaling System - drug effects | Cell Line, Tumor | Neoplasms - pathology | Transcription Factor CHOP - metabolism | Signal Transduction
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1365 - 13
Despite anti-TNF therapy advancements for inflammatory diseases such as rheumatoid arthritis, the burden of diseases remains high. An 11-mer TNF peptide,... 
RHEUMATOID-ARTHRITIS | ACTIVATION | POLYUNSATURATED FATTY-ACID | HUMAN NEUTROPHILS | P38 | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | HOST-DEFENSE | TNF-ALPHA | LONG-CHAIN | RESPIRATORY SYNCYTIAL VIRUS | Neutrophils - cytology | Arthritis, Experimental - drug therapy | Arthritis, Experimental - genetics | Humans | Pneumonia, Viral - drug therapy | Respiratory Syncytial Viruses - immunology | Tumor Necrosis Factor-alpha - genetics | Lipopolysaccharides - antagonists & inhibitors | Anti-Inflammatory Agents - metabolism | Peritonitis - pathology | Pneumonia, Viral - genetics | Peritonitis - genetics | Tumor Necrosis Factor-alpha - immunology | Pneumonia - immunology | Peptide Fragments - genetics | Disease Models, Animal | Pneumonia - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Neutrophils - drug effects | p38 Mitogen-Activated Protein Kinases - immunology | Peptide Fragments - biosynthesis | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Platelet Glycoprotein GPIb-IX Complex - genetics | Mice | Mice, Inbred BALB C | Peritonitis - drug therapy | Respiratory Syncytial Viruses - pathogenicity | Pneumonia - pathology | Peptide Fragments - pharmacology | Respiratory Burst - drug effects | Arthritis, Experimental - pathology | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | Female | Receptors, Tumor Necrosis Factor - genetics | Pneumonia, Viral - pathology | Gene Expression Regulation | Neutrophils - immunology | p38 Mitogen-Activated Protein Kinases - genetics | Arthritis, Experimental - immunology | Peritonitis - immunology | Pneumonia, Viral - immunology | Animals | Anti-Inflammatory Agents - chemistry | Pneumonia - drug therapy | Protein Binding | Receptors, Tumor Necrosis Factor - immunology | Platelet Glycoprotein GPIb-IX Complex - immunology | Tumor necrosis factor receptors | NF-κB protein | Peptides | Extracellular signal-regulated kinase | MAP kinase | Viruses | JNK protein | Activation | Leukocytes (neutrophilic) | Inflammation | T cell receptors | Arthritis | Inflammatory diseases | Mutants | Signal transduction | Signaling | Lungs | Tumor necrosis factor | Rheumatoid arthritis | Tumor necrosis factor-TNF | Respiratory burst | Carrageenan | Peritonitis | Tumors
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2011, Volume 31, Issue 8, pp. 1890 - 1897
Journal Article
Cardiovascular Research, ISSN 0008-6363, 11/2009, Volume 84, Issue 2, pp. 201 - 208
Aims Ischaemic postconditioning (IPostC) is a powerful protective phenomenon that activates prosurvival intrinsic signalling cascades to limit reperfusion... 
Ischaemia | Infarction | Reperfusion | Postconditioning | Preconditioning | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | NECROSIS-FACTOR-ALPHA | CARDIAC MYOCYTE | MURINE MODEL | ISOLATED MOUSE HEARTS | INDUCED CARDIOPROTECTION | ACUTE MYOCARDIAL-INFARCTION | TNF-ALPHA | PROSURVIVAL KINASES | SIGNAL TRANSDUCER | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Tumor Necrosis Factor-alpha - genetics | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Glycogen Synthase Kinase 3 beta | Male | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Tumor Necrosis Factor-alpha - deficiency | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Myocardial Reperfusion Injury - pathology | Receptors, Tumor Necrosis Factor, Type II - metabolism | Myocardial Infarction - pathology | Myocardium - metabolism | STAT3 Transcription Factor - deficiency | Flavonoids - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Mice, Inbred C57BL | Myocardium - pathology | Tyrphostins - pharmacology | Myocardial Infarction - metabolism | Glycogen Synthase Kinase 3 - metabolism | Receptors, Tumor Necrosis Factor, Type I - genetics | Receptors, Tumor Necrosis Factor, Type II - genetics | Mice, Knockout | Receptors, Tumor Necrosis Factor, Type II - deficiency | Myocardial Reperfusion Injury - metabolism | Animals | Androstadienes - pharmacology | Signal Transduction - drug effects | Mice | Myocardial Infarction - prevention & control | Protein Kinase Inhibitors - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Myocardial Reperfusion Injury - prevention & control | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Journal Article