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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2006, Volume 103, Issue 37, pp. 13759 - 13764
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e46269 - e46269
Regulating transgene expression in vivo by delivering oral drugs has been a long-time goal for the gene therapy field. A novel gene regulating system based on... 
SYSTEM | CELLS | PROTEIN STABILITY | THERAPY | REGULATED GENE-EXPRESSION | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | TETRACYCLINE | LENTIVIRAL VECTORS | PARKINSONS-DISEASE | DELIVERY | Parkinson Disease - therapy | Genetic Therapy | Trimethoprim - pharmacology | Anti-Infective Agents - pharmacology | Humans | Injections, Intraventricular | Molecular Targeted Therapy | Recombinant Fusion Proteins - metabolism | Brain - metabolism | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Female | Lentivirus - genetics | Models, Animal | Parkinson Disease - metabolism | Transgenes | Recombinant Fusion Proteins - administration & dosage | Protein Structure, Tertiary | Gene Expression | Bacterial Proteins - genetics | Glial Cell Line-Derived Neurotrophic Factor - genetics | Rats | Parkinson Disease - genetics | Escherichia coli - chemistry | Rats, Sprague-Dawley | Tetrahydrofolate Dehydrogenase - metabolism | Brain - drug effects | Animals | Escherichia coli - genetics | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Genetic Vectors | Luminescent Proteins - metabolism | Tetrahydrofolate Dehydrogenase - genetics | Physiological aspects | Research | Gene therapy | Gene expression | Drugs | Brain | Drug delivery systems | Parkinson's disease | Escherichia coli | Parkinsons disease | Nervous system | Drug delivery | Joint surgery | Proteins | Biological effects | Blood-brain barrier | Rodents | Dihydrofolate reductase | Movement disorders | Glial cell line-derived neurotrophic factor | Dopamine | Neurodegenerative diseases | Vectors (Biology) | Biological activity | Antibiotics | Stem cells | Proteasomes | Genetic engineering | Reductase | Index Medicus | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Journal Article
Journal Article
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 2013, Volume 2, Issue 7, pp. e106 - e106
Gene therapy, in its current configuration, is irreversible and does not allow control over transgene expression in case of side effects. Only few regulated... 
regulated expression | Gene Switch | AAV | Regulated expression | SYSTEM | MEDICINE, RESEARCH & EXPERIMENTAL | RAT | NEUROTROPHIC FACTOR | DELIVERY | CONDITIONAL GENE-EXPRESSION | AAV VECTOR | THERAPY | IN-VIVO | TETRACYCLINE | PARKINSONS-DISEASE | Methods - Original
Journal Article
Gene Therapy, ISSN 0969-7128, 12/2007, Volume 14, Issue 23, pp. 1668 - 1673
Journal Article
Experimental Neurology, ISSN 0014-4886, 2010, Volume 222, Issue 1, pp. 70 - 85
Viral vector-mediated gene transfer has emerged as a powerful means to target transgene expression in the central nervous system. Here we characterized the... 
Striatum | Neonate | Rat | Swine | In vivo gene transfer | Adeno-associated viral vectors | Cortex | Confocal microscopy | Stereology | Pig | MOUSE-BRAIN | HUMAN ALPHA-SYNUCLEIN | DOMESTIC PIG | BASAL GANGLIA | MEDIATED GENE-TRANSFER | NEUROSCIENCES | GOTTINGEN MINIPIG BRAIN | GREEN FLUORESCENT PROTEIN | CENTRAL-NERVOUS-SYSTEM | CONVECTION-ENHANCED DELIVERY | VIRUS VECTOR | Dependovirus - genetics | Microscopy, Electron, Transmission - methods | Humans | Corpus Striatum - growth & development | Dopamine and cAMP-Regulated Phosphoprotein 32 - genetics | Neurons - cytology | Phosphopyruvate Hydratase - metabolism | Green Fluorescent Proteins - genetics | Corpus Striatum - cytology | Corpus Striatum - metabolism | Neurons - ultrastructure | Transfection - methods | Time Factors | Neurons - metabolism | Prosencephalon - metabolism | Transduction, Genetic - methods | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Rats | Dependovirus - classification | Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism | Microscopy, Confocal - methods | Rats, Sprague-Dawley | Genetic Vectors - genetics | Animals | Prosencephalon - cytology | Genetic Vectors - physiology | Cell Line, Transformed | Virus diseases | Immunohistochemistry | Brain | Neurosciences | Neurons | Genetic research | Fluorescence | Gene expression | Index Medicus | Atlases | Neurologi | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Clinical Medicine | Neurology
Journal Article