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1. Full Text Interferon-β-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF
by Zhang, Jun and Zhao, Hongying and Chen, Jinping and Xia, Bing and Jin, Yongming and Wei, Wei and Shen, Jianjian and Huang, Yazeng
FEBS Letters, ISSN 0014-5793, 09/2012, Volume 586, Issue 19, pp. 3255 - 3262
â–º IFN-β induced miR-155 during osteoclast differentiation. â–º miR-155 mediated the suppression effect of IFN-β on osteoclast differentiation. â–º miR-155... 
Osteoclast differentiation | microRNA | MITF | IFN-β | SOCS1 | miR-155 | 3′UTRs | RANKL | interferon-β | TRAP | tartrate-resistant acid phosphatase | BMMs | 3′untranslated regions | microphthalmia-associated transcription factor | suppressor of cytokine signaling1 | bone marrow-derived macrophages | receptor activator of NF-κB ligand | miRNA | IFN-beta | C-FOS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOKINE | KAPPA-B | MICRORNA-155 | CELL BIOLOGY | BONE LOSS | BIOPHYSICS | GENE | REGULATE OSTEOCLASTOGENESIS | OSTEOPROTEGERIN LIGAND | RECEPTOR ACTIVATOR | T-CELLS | RANK Ligand - metabolism | Humans | Suppressor of Cytokine Signaling 1 Protein | Osteoclasts - cytology | Cell Differentiation - genetics | Bone Resorption - genetics | Base Sequence | HEK293 Cells | Bone Resorption - metabolism | Interferon-beta - genetics | 3' Untranslated Regions | Cell Differentiation - physiology | Cell Line | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Down-Regulation | Mice, Inbred C57BL | Suppressor of Cytokine Signaling Proteins - genetics | MicroRNAs - biosynthesis | Recombinant Proteins - pharmacology | Osteoclasts - metabolism | Sequence Homology, Nucleic Acid | Mice, Knockout | Animals | Interferon-beta - pharmacology | Cell Differentiation - drug effects | Bone Resorption - pathology | Mice | MicroRNAs - genetics | Suppressor of Cytokine Signaling Proteins - metabolism | Microphthalmia-Associated Transcription Factor - genetics | Interferon-beta - deficiency | Osteoclasts - drug effects
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2. Full Text PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation
by de la Rica, Lorenzo and Rodríguez-Ubreva, Javier and García, Mireia and Islam, Abul B.M.M.K and Urquiza, José M and Hernando, Henar and Christensen, Jesper and Helin, Kristian and Gómez-Vaquero, Carmen and Ballestar, Esteban
Genome Biology, ISSN 1474-760X, 09/2013, Volume 14, Issue 9, pp. R99 - R99
Background: DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-fate decisions. Local deposition and removal of DNA methylation are... 
STIMULATING FACTOR | CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROBE LEVEL | GENETICS & HEREDITY | REGULATES OSTEOCLASTOGENESIS | PERIPHERAL-BLOOD | NFATC1 | ACTIVE DNA DEMETHYLATION | BONE | EXPRESSION | 5-METHYLCYTOSINE OXIDATION | Cytosine - analogs & derivatives | RNA, Small Interfering - genetics | Monocytes - cytology | Transcription Factor AP-1 - genetics | 5-Methylcytosine - analogs & derivatives | Epigenesis, Genetic | Humans | Monocytes - metabolism | NF-kappa B - metabolism | Osteoclasts - cytology | Transcription Factor AP-1 - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | DNA Methylation | Cytosine - metabolism | Trans-Activators - genetics | Cell Differentiation | Protein Interaction Domains and Motifs | Binding Sites | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Osteoclasts - metabolism | DNA (Cytosine-5-)-Methyltransferases - genetics | NF-kappa B - genetics | CpG Islands | Protein Binding | Trans-Activators - metabolism | Trans-Activators - antagonists & inhibitors | RNA, Small Interfering - metabolism | Activator protein 1 | Metabolisme | RNA no missatgers | Proteïnes | Transcripció genètica | Research
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3. Full Text Retinoic acid increases proliferation of human osteoclast progenitors and inhibits RANKL-stimulated osteoclast differentiation by suppressing RANK
by Hu, Lijuan and Lind, Thomas and Sundqvist, Anders and Jacobson, Annica and Melhus, Håkan and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 10, p. e13305
It has been shown that high vitamin A intake is associated with bone fragility and fractures in both animals and humans. However, the mechanism by which... 
IN-VITRO | RESORPTION | BONE-MINERAL DENSITY | BIOLOGY | RECEPTOR ACTIVATOR | REGULATES RANKL | PRECURSOR CELLS | VITAMIN-A | ACUTE PROMYELOCYTIC LEUKEMIA | KAPPA-B LIGAND | ALL-TRANS | Cell Line | Receptor Activator of Nuclear Factor-kappa B - antagonists & inhibitors | Humans | RNA, Messenger - genetics | Osteoclasts - cytology | Animals | RANK Ligand - antagonists & inhibitors | Cell Differentiation - drug effects | RANK Ligand - physiology | Receptor Activator of Nuclear Factor-kappa B - genetics | Stem Cells - drug effects | Cell Proliferation - drug effects | Mice | Cell Differentiation - physiology | Osteoclasts - drug effects | Tretinoin - pharmacology | Vitamin A | Rankings | Interferon | Phosphatases | B cells | RNA | Osteoprogenitor cells | Cell culture | Transcription factors | Retinoic acid receptors | Kinases | CD14 antigen | Osteoprotegerin | Bone resorption | Receptors | Biomedical materials | Granulocytes | Rodents | Acid resistance | Peripheral blood | Bones | Biocompatibility | Physiology | Inhibition | TRANCE protein | Growth factors | Immune system | Gene expression | Fragility | Osteoclastogenesis | Monocytes | Fractures | Acids | Osteoclasts | Acid phosphatase (tartrate-resistant) | Bone | Differentiation | Plastics | Acid phosphatase | Retinoic acid | Interferon regulatory factor | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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4. Full Text Roles of Cyclic AMP Response Element Binding Activation in the ERK1/2 and p38 MAPK Signalling Pathway in Central Nervous System, Cardiovascular System, Osteoclast Differentiation and Mucin and Cytokine Production
by Koga, Y and Tsurumaki, H and Aoki-Saito, H and Sato, M and Yatomi, M and Takehara, K and Hisada, T
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 03/2019, Volume 20, Issue 6, p. 1346
There are many downstream targets of mitogen-activated protein kinase (MAPK) signalling that are involved in neuronal development, cellular differentiation,... 
PROTEIN-KINASE-A | COLONY-STIMULATING FACTOR | periostin | LIGHT-CHAIN PHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | steroidogenesis | HUMAN LUNG FIBROBLASTS | osteoclast differentiation | p38 MAPK | CHEMISTRY, MULTIDISCIPLINARY | MUC5AC | GM-CSF PRODUCTION | GROWTH-FACTOR RECEPTOR | ERK1 | CREB | GM-CSF | RENIN-ANGIOTENSIN SYSTEM | mucin | REGULATES TNF-ALPHA | migration | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | ERK1/2
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5. Full Text 3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells
by GuezGuez, Amel and Prod'Homme, Virginie and Mouska, Xavier and Baudot, Alice and Blin-Wakkach, Claudine and Rottapel, Robert and Deckert, Marcel
Journal of Biological Chemistry, ISSN 0021-9258, 07/2010, Volume 285, Issue 27, pp. 20952 - 20963
The adapter protein 3BP2 (also known as SH3BP2 and Abl SH3-binding protein 2) has been involved in leukocyte signaling and activation downstream... 
CHERUBISM | SYK | SIGNALING PATHWAY | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATES OSTEOCLASTOGENESIS | BONE HOMEOSTASIS | MICE | ANTIGEN RECEPTOR | T-CELLS | C-SRC | Macrophages - physiology | Cell Line | Monocytes - cytology | Humans | Macrophages - cytology | DNA Primers | Osteoclasts - cytology | Genetic Complementation Test | Adaptor Proteins, Signal Transducing - physiology | Animals | Transfection | RANK Ligand - physiology | Adaptor Proteins, Signal Transducing - deficiency | Base Sequence | Adaptor Proteins, Signal Transducing - genetics | Polymerase Chain Reaction | Mice | Osteoclasts - physiology | Monocytes - physiology | Cell Differentiation - physiology | RNA, Antisense - genetics | NFAT Transcription Factor | RANKL | Signal Transduction | Src | Cytokine Action | Cytoskeleton | Cell Differentiation | Osteoclast | Adaptor Proteins | Cell Biology | Macrophage
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6. Full Text Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
by Takayanagi, Hiroshi
Nature Reviews Immunology, ISSN 1474-1733, 04/2007, Volume 7, Issue 4, pp. 292 - 304
Osteoimmunology is an interdisciplinary research field focused on the molecular understanding of the interplay between the immune and skeletal systems.... 
LYMPH-NODE ORGANOGENESIS | NECROSIS-FACTOR RECEPTOR | REGULATES OSTEOCLAST DIFFERENTIATION | COLONY-STIMULATING FACTOR | NUCLEAR-FACTOR | OSTEOPROTEGERIN-LIGAND | FACTOR FAMILY-MEMBER | STEM-CELL NICHE | IMMUNOLOGY | NF-KAPPA-B | T-CELLS | Bone Remodeling - immunology | Cell Communication - immunology | Immune System - physiology | Humans | Osteoblasts - immunology | Bone Resorption - immunology | Osteoclasts - cytology | Cell Differentiation - immunology | Signal Transduction - immunology | Animals | Lymphocytes - immunology | Osteoclasts - immunology | Bone Development - immunology | Bone and Bones - immunology | Osteoblasts - cytology | Cell interaction | Immune response | Growth | Bones | Regulation | Research | Immune system
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7. Full Text Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis
by Bellavia, D and De Luca, A and Carina, V and Costa, V and Raimondi, L and Salamanna, F and Alessandro, R and Fini, M and Giavaresi, G
Bone, ISSN 8756-3282, 05/2019, Volume 122, pp. 52 - 75
MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of... 
Osteoblast | Osteoporosis | miRNA | Osteoclast | Osteogenesis | LINEAGE PROGRESSION | INHIBITED OSTEOGENIC DIFFERENTIATION | REGULATES OSTEOCLAST DIFFERENTIATION | CIRCULATING MIRNAS | MESENCHYMAL STEM-CELLS | POSTMENOPAUSAL OSTEOPOROSIS | ENDOCRINOLOGY & METABOLISM | PROMOTES OSTEOBLAST DIFFERENTIATION | MICRORNA EXPRESSION | ADIPOGENIC DIFFERENTIATION | TARGETING RUNX2 | Epigenetic inheritance | MicroRNA | Tissue engineering | Analysis | Development and progression | Cell differentiation
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8. Full Text Immunology and bone
by Danks, Lynett and Takayanagi, Hiroshi
Journal of Biochemistry, ISSN 0021-924X, 07/2013, Volume 154, Issue 1, pp. 29 - 39
It is now well acknowledged that the immune and skeletal systems interact and affect one another during developmental physiology and pathology. With the aid of... 
RANKL | osteoblast | osteoclast | T cell | haematopoietic stem cell | RHEUMATOID-ARTHRITIS | NECROSIS-FACTOR RECEPTOR | REGULATES OSTEOCLAST DIFFERENTIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCE OSTEOCLASTOGENESIS | IMMUNE-SYSTEM | MARROW NICHE | NUCLEAR-FACTOR | HEMATOPOIETIC STEM-CELLS | NF-KAPPA-B | T-CELLS | T-Lymphocyte Subsets - immunology | Stem Cell Niche - immunology | RANK Ligand - metabolism | Humans | Male | RANK Ligand - immunology | Arthritis, Rheumatoid - metabolism | NFATC Transcription Factors - immunology | Osteoclasts - immunology | Bone and Bones - metabolism | Osteoprotegerin - genetics | Female | Receptor Activator of Nuclear Factor-kappa B - metabolism | Calcium Signaling | Signal Transduction | NFATC Transcription Factors - metabolism | Osteoprotegerin - immunology | Osteoclasts - metabolism | RANK Ligand - genetics | Animals | Models, Biological | Receptor Activator of Nuclear Factor-kappa B - genetics | Mice | Bone and Bones - immunology | Osteoprotegerin - metabolism | Arthritis, Rheumatoid - immunology | Receptor Activator of Nuclear Factor-kappa B - immunology
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9. Full Text Osteoimmunology: Interplay between the immune system and bone metabolism
by Walsh, Matthew C and Kim, Nacksung and Kadono, Yuho and Rho, Jaerang and Lee, Soo Young and Lorenzo, Joseph and Choi, Yongwon
Annual Review of Immunology, ISSN 0732-0582, 2006, Volume 24, Issue 1, pp. 33 - 63
Studies of bone and the immune system have converged in recent years under the banner of osteoimmunology. The immune system is spawned in the bone marrow... 
Osteoblast | Dendritic cell | TRANCE-RANK | Osteoclast | T lymphocyte | Costimulation | REGULATES OSTEOCLAST DIFFERENTIATION | ACTIVATION-INDUCED CYTOKINE | DENDRITIC CELL-INTERACTIONS | osteoblast | IMMUNOLOGY | LYMPH-NODE ORGANOGENESIS | TUMOR-NECROSIS-FACTOR | costimulation | FACTOR FAMILY-MEMBER | TOLL-LIKE RECEPTORS | LIVED PLASMA-CELLS | RECEPTOR-RELATED PROTEIN-5 | osteoclast | NF-KAPPA-B | dendritic cell | Autoimmunity | Receptors, Tumor Necrosis Factor - metabolism | Receptor Activator of Nuclear Factor-kappa B | Cytokines - metabolism | Membrane Glycoproteins - metabolism | Signal Transduction | Humans | Gene Expression Regulation | Glycoproteins - metabolism | RANK Ligand | Bone Development | Osteoprotegerin | Models, Immunological | Animals | Carrier Proteins - metabolism | Models, Biological | Bone and Bones - metabolism | Bone and Bones - immunology | Toll-Like Receptors - metabolism | Bone Remodeling | Bone and Bones - cytology | Receptors, Cytoplasmic and Nuclear - metabolism
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10. Full Text The cell biology of bone metabolism
by Datta, H K and Ng, W F and Walker, J A and Tuck, S P and Varanasi, S S
Journal of Clinical Pathology, ISSN 0021-9746, 05/2008, Volume 61, Issue 5, pp. 577 - 587
Contrary to the commonly held misconception, bone is a relatively dynamic organ that undergoes significant turnover as compared to other organs in the body.... 
SIGNAL-TRANSDUCTION PATHWAYS | DENTIN MATRIX PROTEIN-1 | TUMOR-NECROSIS-FACTOR | REGULATES OSTEOCLAST DIFFERENTIATION | OSTEOBLAST DIFFERENTIATION | RECEPTOR-RELATED PROTEIN-5 | PATHOLOGY | ALDRICH-SYNDROME PROTEIN | TRANSCRIPTION FACTOR | VAN-BUCHEM-DISEASE | T-CELLS | Energy Metabolism | Bone and Bones - metabolism | Humans | Osteoblasts - physiology | Signal Transduction - physiology | Bone Remodeling - physiology | Bone and Bones - immunology | Osteoclasts - physiology | Cell Differentiation - physiology | Osteocytes - physiology | Bone and Bones - cytology | Physiological aspects | Bone cells | Research | Cytology | Cytokines | Vertebra | Glucose | Proteins | Collagen | Stem cells | Bones | Growth hormones | Regulation | Growth factors | Metabolic disorders | Immune system | Apoptosis
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