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PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, p. e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2012, Volume 188, Issue 7, pp. 2967 - 2971
The host response to Chikungunya virus is dependent on the direct action of type I IFN on infected nonhematopoietic cells. Prior studies have demonstrated that... 
PATHOGENESIS | VIRUS | PROTEIN | MODEL | IMMUNOLOGY | DISTINCT | Age Factors | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Interferon Regulatory Factor-7 - physiology | Interferon-alpha - genetics | Bone Marrow Transplantation | Hematopoietic Stem Cells - virology | Fibroblasts - metabolism | Animals, Newborn | Chikungunya Fever | Fibroblasts - virology | Toll-Like Receptor 7 - genetics | Interferon-alpha - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 7 - deficiency | Hematopoietic Stem Cells - metabolism | Radiation Chimera | Alphavirus Infections - immunology | Chikungunya virus - growth & development | Chikungunya virus - immunology | Interferon Regulatory Factor-3 - physiology | Membrane Glycoproteins - genetics | Mice, Knockout | Host-Pathogen Interactions | Adaptor Proteins, Signal Transducing - physiology | Animals | Interferon Regulatory Factor-3 - deficiency | Myeloid Differentiation Factor 88 - deficiency | Interferon Regulatory Factor-7 - deficiency | Mice | Membrane Glycoproteins - deficiency | Interferon Regulatory Factor-7/deficiency | Toll-Like Receptor 7/genetics | Membrane Glycoproteins/genetics | Hematopoietic Stem Cells/metabolism | Myeloid Differentiation Factor 88/genetics | Life Sciences | Alphavirus Infections/immunology | Immunology | Fibroblasts/metabolism | Chikungunya virus/growth & development | Myeloid Differentiation Factor 88/deficiency | Toll-Like Receptor 7/deficiency | Interferon Regulatory Factor-3/physiology | Interferon Regulatory Factor-3/genetics | Interferon-alpha/biosynthesis | Adaptor Proteins, Signal Transducing/physiology | Hematopoietic Stem Cells/virology | Membrane Glycoproteins/deficiency | Interferon Regulatory Factor-3/deficiency | Chikungunya virus/immunology
Journal Article
Science, ISSN 0036-8075, 5/2003, Volume 300, Issue 5622, pp. 1145 - 1148
Journal Article
03/2012
Cardiovascular disease, and myocardial infarction (MI) in particular, remains a major burden in the developed world today. In fact, the remodeling process,... 
Interferon Regulatory Factor-3 | Myocardial Infarction | Innate Immunity | 0719 | Cardiac Remodeling
Dissertation
Journal of Immunology, ISSN 0022-1767, 10/2003, Volume 171, Issue 8, pp. 4304 - 4310
We previously reported a new Toll/IL-1R (TIR)-containing molecule, named TIR domain-containing adaptor inducing IFN-beta (TRIF). Although initial study... 
TBK1 | IKK-EPSILON | RECOGNITION | PATHWAY | MOLECULE | ENDOTOXIN | INNATE | COMPONENTS | INDUCTION | IMMUNOLOGY | TIRAP | Membrane Glycoproteins - metabolism | Humans | NF-kappa B - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | DNA-Binding Proteins - metabolism | Interferon Regulatory Factor-3 | Signal Transduction - immunology | Toll-Like Receptors | Membrane Glycoproteins - physiology | Interferon-beta - genetics | Receptors, Cell Surface - physiology | Binding, Competitive - immunology | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Proteins - physiology | NF-kappa B - antagonists & inhibitors | Peptide Fragments - metabolism | Adaptor Proteins, Vesicular Transport - physiology | Gene Expression Regulation - immunology | Adaptor Proteins, Vesicular Transport - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Interferon-beta - biosynthesis | Receptors, Cell Surface - metabolism | I-kappa B Kinase | Protein Binding - immunology | Interferon-beta - antagonists & inhibitors | Receptors, Interleukin-1 - metabolism | Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | TNF Receptor-Associated Factor 6 | Animals | Proteins - metabolism | Amino Acid Motifs - immunology | Receptors, Interleukin-1 - physiology | Mice | Promoter Regions, Genetic - immunology | Protein Structure, Tertiary - physiology
Journal Article
Genes and Development, ISSN 0890-9369, 07/1998, Volume 12, Issue 13, pp. 2061 - 2072
Interferon regulatory factor-3 (IRF-3) was found to specifically interact with HPV16 E6 in a yeast two-hybrid screen. IRF-3 is activated by the presence of... 
IRF-3 | Transcription | Protein-protein interactions | Oncoprotein | HPV16 | CARCINOMA CELL-LINES | FACTOR FAMILY | PROTEIN | transcription | DNA-DAMAGE | HPV-16 E6 | DEVELOPMENTAL BIOLOGY | HUMAN KERATINOCYTES | protein-protein interactions | FULL-LENGTH E6 | IFN-BETA | EPITHELIAL-CELLS | GENETICS & HEREDITY | GENE-EXPRESSION | oncoprotein
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 387 - 399.e5
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry,... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | DEFENSE | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SENSOR | POLYMERASE-II | 7SK RNA | BINDING | GMP-AMP SYNTHASE | P-TEFB | CELL BIOLOGY | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article
Journal Article