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relevant g-quadruplex (29) 29
index medicus (23) 23
dna (17) 17
g-quadruplexes (16) 16
humans (16) 16
biochemistry & molecular biology (13) 13
base sequence (10) 10
c-myc promoter (10) 10
g-quadruplex (10) 10
heterocyclic compounds (10) 10
dna - chemistry (9) 9
article (8) 8
telomeric g-quadruplex (8) 8
c-myc (7) 7
cancer (7) 7
chemistry, multidisciplinary (7) 7
circular dichroism (7) 7
gene (7) 7
small-molecule (7) 7
analysis (6) 6
binding (6) 6
deoxyribonucleic acid--dna (6) 6
gene-expression (6) 6
nuclease hypersensitive element (6) 6
nucleic acid conformation (6) 6
promoter region (6) 6
research (6) 6
structure (6) 6
deoxyribonucleic acid (5) 5
dna - genetics (5) 5
medicine (5) 5
multidisciplinary sciences (5) 5
potassium - chemistry (5) 5
promoter regions, genetic - genetics (5) 5
proto-oncogene proteins c-myc - genetics (5) 5
region (5) 5
science (5) 5
transcription (5) 5
animals (4) 4
biochemistry (4) 4
chemical properties (4) 4
dna - metabolism (4) 4
dna g-quadruplexes (4) 4
gene expression (4) 4
genetic aspects (4) 4
intramolecular g-quadruplex (4) 4
k+ solution (4) 4
models, molecular (4) 4
nmr (4) 4
potassium solution (4) 4
protein binding (4) 4
thermodynamics (4) 4
biophysics (3) 3
breast-cancer (3) 3
chemistry (3) 3
chemistry, medicinal (3) 3
circular-dichroism (3) 3
crystal-structure (3) 3
down-regulation (3) 3
drug design (3) 3
fluorescence (3) 3
g-quadruplex dna (3) 3
genetic transcription (3) 3
genetics (3) 3
human telomeric sequence (3) 3
i-motif structures (3) 3
kinetics (3) 3
magnetic resonance spectroscopy (3) 3
mass spectrometry (3) 3
molecular biology (3) 3
molecular sequence data (3) 3
myc protein (3) 3
nucleic acids (3) 3
promoter (3) 3
promoter regions, genetic (3) 3
research article (3) 3
rna g-quadruplex (3) 3
spectroscopy (3) 3
stability (3) 3
stabilization (3) 3
telomere - genetics (3) 3
virtual screening (3) 3
alkaloids (2) 2
amplification (2) 2
berberine (2) 2
berberine derivatives (2) 2
binding sites (2) 2
biologically relevant (2) 2
biology (2) 2
biology and life sciences (2) 2
burkitt-lymphoma (2) 2
c-myc protein (2) 2
cell-growth (2) 2
cells (2) 2
cytosine (2) 2
diagnosis (2) 2
dna mutational analysis (2) 2
dna structure-selective (2) 2
dna, single-stranded - chemistry (2) 2
dynamics (2) 2
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1. Full Text Folding Landscape of a Parallel G-Quadruplex
by Gray, Robert D and Trent, John O and Arumugam, Sengodagounder and Chaires, Jonathan B
Journal of Physical Chemistry Letters, ISSN 1948-7185, 03/2019, Volume 10, Issue 5, pp. 1146 - 1151
Circular dichroism and stopped-flow UV spectroscopies were used to investigate the thermodynamic stability and the folding pathway of... 
RELEVANT G-QUADRUPLEX | PATHWAYS | TELOMERIC G-QUADRUPLEX | STABILITY | MATERIALS SCIENCE, MULTIDISCIPLINARY | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | SINGLE-MOLECULE FRET | KINETICS | DNA | DYNAMICS | CONFORMATIONAL-ANALYSIS | PROMOTER
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2. Full Text Identification and Characterization of Nucleolin as a c-myc G-quadruplex-binding Protein
by Verónica González and Kexiao Guo and Laurence Hurley and Daekyu Sun
Journal of Biological Chemistry, ISSN 0021-9258, 08/2009, Volume 284, Issue 35, pp. 23622 - 23635
myc is a proto-oncogene that plays an important role in the promotion of cellular growth and proliferation. Understanding the regulation of c- myc is important... 
PROXIMAL PROMOTER REGION | RELEVANT G-QUADRUPLEX | HUMAN TELOMERIC DNA | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYMERASE-I TRANSCRIPTION | REMODELING COMPLEX NORC | GENE-EXPRESSION | NUCLEASE HYPERSENSITIVE ELEMENT | INTRAMOLECULAR G-QUADRUPLEX | PRE-RIBOSOMAL-RNA | Promoter Regions, Genetic | RNA-Binding Proteins - genetics | Humans | RNA-Binding Proteins - chemistry | Molecular Sequence Data | Phosphoproteins - genetics | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Phosphoproteins - chemistry | Base Sequence | Protein Binding | G-Quadruplexes | Proto-Oncogene Proteins c-myc - genetics | HeLa Cells | Proto-Oncogene Proteins c-myc - chemistry | RNA-Binding Proteins - metabolism | Transcription, Chromatin, and Epigenetics
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3. Full Text Ethyl-substitutive Thioflavin T as a highly-specific fluorescence probe for detecting G-quadruplex structure
by Guan, Ai-Jiao and Zhang, Xiu-Feng and Sun, Xin and Li, Qian and Xiang, Jun-Feng and Wang, Li-Xia and Lan, Ling and Yang, Feng-Min and Xu, Shu-Juan and Guo, Xiao-Meng and Tang, Ya-Lin
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 2666 - 12
G-quadruplex has attracted considerable attention due to their prevalent distribution in functional genomic regions and transcripts, which can importantly... 
RELEVANT G-QUADRUPLEX | TELOMERIC DNA | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | SEQUENCE | SELECTIVE RECOGNITION | LIGAND | PROMOTER | RNA G-QUADRUPLEX | BINDING | REGION | Fluorescent indicators | Diagnosis | Transcription | U.V. radiation | Deoxyribonucleic acid--DNA
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4. Full Text Spectroscopic studies of Thioflavin-T binding to c-Myc G-quadruplex DNA
by Verma, Smita and Ghuge, Sandip A and Ravichandiran, V and Ranjan, Nihar
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, 04/2019, Volume 212, pp. 388 - 395
G-quadruplexes are well-known DNA secondary structures which can be formed both within the DNA and the RNA sequences of the human genome. While many functions... 
Thioflavin T | G-Quadruplex | c-Myc | DNA | CD spectroscopy | RELEVANT G-QUADRUPLEX | TELOMERIC G-QUADRUPLEX | DISPLACEMENT ASSAY | DUAL RECOGNITION | SMALL-MOLECULE | LIGHT-UP PROBE | CIRCULAR-DICHROISM | FORMING SEQUENCES | SPECTROSCOPY | PROMOTER REGION | FLUORESCENT-PROBE | Genetic research | Fluorescence | Nucleotide sequencing | Genomics | DNA sequencing
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5. Full Text Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence
by Dai, Jixun and Carver, Megan and Punchihewa, Chandanamali and Jones, Roger A and Yang, Danzhou
Nucleic Acids Research, ISSN 0305-1048, 8/2007, Volume 35, Issue 15, pp. 4927 - 4940
Formation of the G-quadruplex in the human telomeric sequence can inhibit the activity of telomerase, thus the intramolecular telomeric G-quadruplexes have... 
RELEVANT G-QUADRUPLEX | HUMAN-CHROMOSOMES | THERMODYNAMIC PROPERTIES | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTICANCER DRUG | TARGETS | C-MYC PROMOTER | POTASSIUM SOLUTION | CANCER | REGION | Protons | Humans | Models, Molecular | Potassium - chemistry | Telomere - chemistry | DNA - chemistry | Solutions | DNA Mutational Analysis | Base Sequence | Nuclear Magnetic Resonance, Biomolecular | G-Quadruplexes | Guanine - chemistry | Nucleic Acid Conformation | Structural Biology
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6. Full Text The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements
by Kendrick, Samantha and Hurley, Laurence H
Pure and Applied Chemistry, ISSN 0033-4545, 06/2010, Volume 82, Issue 8, pp. 1609 - 1621
The nature of DNA has captivated scientists for more than 50 years. The discovery of the double-helix model of DNA by Watson and Crick in 1953 not only... 
transcription | G-quadruplex | i-motif | supercoiling | Supercoiling | C-myc | Transcription | I-motif | RELEVANT G-QUADRUPLEX | c-myc | SMALL-MOLECULE | RESONANCE ENERGY-TRANSFER | NUCLEASE HYPERSENSITIVE ELEMENT | CHEMISTRY, MULTIDISCIPLINARY | HUMAN KRAS PROMOTER | FORMING REGION UPSTREAM | DNA G-QUADRUPLEXES | GENE-EXPRESSION | C-MYC PROMOTER | Biochemistry | Chemical properties | Research | G proteins | DNA
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7. Full Text Effects of Salt on the Stability of a G-Quadruplex from the Human c-MYC Promoter
by Kim, Byul G and Evans, Heather M and Dubins, David N and Chalikian, Tigran V
Biochemistry, ISSN 0006-2960, 06/2015, Volume 54, Issue 22, pp. 3420 - 3430
In an atmosphere of potassium ions, a modified c-WYC NHE III1 sequence with: two G-to-T mutations (MYC22-G14T/G23T) forms a highly stable parallel-stranded... 
RELEVANT G-QUADRUPLEX | DNA STRUCTURES | TELOMERIC G-QUADRUPLEX | EQUILIBRIUM MELTING CURVES | COUNTERION CONDENSATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROWDING CONDITIONS | GENE-EXPRESSION | EXTRACTING THERMODYNAMIC DATA | NUCLEASE HYPERSENSITIVE ELEMENT | ORDER-DISORDER TRANSITIONS | Promoter Regions, Genetic | DNA - chemistry | Proto-Oncogene Proteins c-myc | Humans | Cesium - chemistry | Nucleic Acid Conformation | Potassium - chemistry | Structure | DNA
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8. Full Text Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations
by Rocca, Roberta and Moraca, Federica and Costa, Giosuè and Alcaro, Stefano and Distinto, Simona and Maccioni, Elias and Ortuso, Francesco and Artese, Anna and Parrotta, Lucia
Molecules, ISSN 1420-3049, 01/2015, Volume 20, Issue 1, pp. 206 - 223
Several ligands can bind to the non-canonical G-quadruplex DNA structures thereby stabilizing them. These molecules can act as effective anticancer agents by... 
Alkaloids | Berberine | H-telo | DNA | G-quadruplex | Molecular dynamics | Virtual screening | Docking | C-myc | RELEVANT G-QUADRUPLEX | TELOMERIC G-QUADRUPLEX | MOLECULAR-DYNAMICS | c-myc | virtual screening | BIOCHEMISTRY & MOLECULAR BIOLOGY | alkaloids | DOWN-REGULATION | molecular dynamics | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | berberine | NUCLEIC-ACIDS | h-telo | docking | ONCOGENE | BERBERINE DERIVATIVES | PROMOTER REGION | BINDING | Alkaloids - pharmacology | Telomerase - genetics | Humans | G-Quadruplexes | Molecular Structure | Genes, myc | Alkaloids - chemistry | Molecular Dynamics Simulation
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9. Full Text Fluorescence Methods for Probing G‑Quadruplex Structure in Single- and Double-Stranded DNA
by Stevens, Aaron J and Kennedy, Hannah L and Kennedy, Martin A
Biochemistry, ISSN 0006-2960, 07/2016, Volume 55, Issue 26, pp. 3714 - 3725
Interest in exploring G-quadruplex (G4) structures in nucleic acids is growing as it becomes more widely recognized that these structures have many interesting... 
RELEVANT G-QUADRUPLEX | PROXIMAL PROMOTER | HUMAN GENOME | STABILIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | GENE-EXPRESSION | TETRAPLEX FORMATION | C-MYC PROMOTER | I-MOTIF STRUCTURES | REGION | Fluorescent Dyes - chemistry | DNA - chemistry | DNA - analysis | DNA, Single-Stranded - analysis | Humans | Fluorescence | G-Quadruplexes | Proto-Oncogene Proteins c-myc - genetics | Circular Dichroism | DNA, Single-Stranded - chemistry | DNA sequencers | Nucleic acids | Structure | Analysis | Methods
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10. Full Text Analysis of G‐quadruplex conformations using Raman and polarized Raman spectroscopy
by Friedman, Samantha J and Terentis, Andrew C
Journal of Raman Spectroscopy, ISSN 0377-0486, 03/2016, Volume 47, Issue 3, pp. 259 - 268
G‐quadruplexes (G4s) are four‐stranded DNA structures formed within nucleic acid sequences that are rich in guanines. G4 formation within DNA strands is... 
G‐quadruplex | depolarization ratio | c‐MYC | DNA | thrombin binding aptamer | telomere | c-MYC | G-quadruplex | RELEVANT G-QUADRUPLEX | DIRECTED DNA-STRUCTURE | TO-Z TRANSITION | CRYSTAL-STRUCTURE | STRUCTURAL POLYMORPHISM | TELOMERE BINDING-PROTEIN | NUCLEIC-ACIDS | SPECTROSCOPY | G-TETRAPLEX | VIBRATIONAL SPECTROSCOPY | C-MYC PROMOTER | Raman spectroscopy | Thrombin | Analysis | Backbone | Depolarization | Bands | Heat treatment | Biological effects | Deoxyribonucleic acid | Spectra
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11. Full Text Allelic dropout during polymerase chain reaction due to G-quadruplex structures and DNA methylation is widespread at imprinted human loci
by Stevens, Aaron J and Taylor, Millie G and Pearce, Frederick Grant and Kennedy, Martin A
G3: Genes, Genomes, Genetics, ISSN 2160-1836, 2017, Volume 7, Issue 3, pp. 1019 - 1025
Loss of one allele during polymerase chain reaction (PCR) amplification of DNA, known as allelic dropout, can be caused by a variety of mechanisms. Allelic... 
Polymerase chain reaction | Allelic dropout | Methylation | PCR | G-quadruplex | RELEVANT G-QUADRUPLEX | DIAGNOSIS | ASSAY | SEQUENCES | MOTIF | allelic dropout | AMPLIFICATION | GENE | methylation | GENETICS & HEREDITY | BINDING | polymerase chain reaction | DNA - genetics | Genomic Imprinting | Base Sequence | Humans | Alleles | Templates, Genetic | G-Quadruplexes | DNA Methylation - genetics | Genetic Loci | Genome, Human | Circular Dichroism | Polymerase Chain Reaction - methods
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12. Full Text Thermodynamic Stability and Folding Kinetics of the Major G-Quadruplex and Its Loop Isomers Formed in the Nuclease Hypersensitive Element in the Human c-Myc Promoter: Effect of Loops and Flanking Segments on the Stability of Parallel-Stranded Intramolecular G-Quadruplexes
by Hatzakis, Emmanuel and Okamoto, Keika and Yang, Danzhou
Biochemistry, ISSN 0006-2960, 11/2010, Volume 49, Issue 43, pp. 9152 - 9160
Overexpression of the c-Myc proto-oncogene is associated with a broad spectrum of human cancers. Nuclease hypersensitivity element III1 (NHE III1) of the c-Myc... 
RELEVANT G-QUADRUPLEX | BREAST-CANCER | BURKITT-LYMPHOMA | AMPLIFICATION | GENE | DNA G-QUADRUPLEXES | STABILIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | OLIGONUCLEOTIDE | REGION | Promoter Regions, Genetic | Thermodynamics | Endonucleases - genetics | Humans | Regulatory Sequences, Nucleic Acid | G-Quadruplexes | Proto-Oncogene Proteins c-myc - genetics | Kinetics | Nucleic Acid Conformation | Transition Temperature | Drugs | Drug delivery systems | Research | Genetic transcription | Vehicles | Thermal properties | Protein folding | Analysis | Genetic aspects | G proteins | Chemical properties | Structure | Cancer | thermodynamic stability | folding kinetics | parallel-stranded G-quadruplex | c-Myc promoter G-quadruplex | loop-isomers
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13. Full Text The formation and stabilization of a novel G-quadruplex in the 5′-flanking region of the relaxin gene
by Lin, Sen and Gu, Huiping and Xu, Ming and Cui, Xiaojie and Zhang, Youyi and Gao, Wei and Yuan, Gu
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31201
It has been reported that binding of STAT3 protein to the 5'-flanking region of the relaxin gene may result in downregulation of the relaxin expression. There... 
RELEVANT G-QUADRUPLEX | TARGET | TELOMERIC G-QUADRUPLEX | CIRCULAR-DICHROISM | RECOGNITION | DNA | MULTIDISCIPLINARY SCIENCES | BERBERINE DERIVATIVES | AUTOMATED DOCKING | PROMOTER | BINDING | Berberine - chemistry | Luciferases - metabolism | Magnetic Resonance Spectroscopy | Humans | Models, Molecular | Molecular Sequence Data | Rats | Up-Regulation - genetics | Enzyme Assays | Berberine - metabolism | 5' Flanking Region - genetics | Animals | Relaxin - genetics | Base Sequence | HEK293 Cells | G-Quadruplexes | Circular Dichroism | Transition Temperature | Alkaloids | Telomeres | Genes | Nuclear magnetic resonance spectroscopy | Genetic aspects | Gene expression | Mass spectrometry | Protein binding | Nuclear magnetic resonance--NMR | Peptides | Experiments | Guanine | Programming languages | Magnetic resonance spectroscopy | Engineering | Education | Vascular endothelial growth factor | Pharmaceutical sciences | Deoxyribonucleic acid--DNA | Berberine | Spectroscopy | Stat3 protein | Mass spectroscopy | Relaxin | Medicine | Chemistry | Hospitals | Molecular modelling | Ligands | Molecular biology | Laboratory animals | NMR spectroscopy | Binding sites | Deoxyribonucleic acid | Nuclear magnetic resonance | NMR
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14. Full Text Quadruplex Nucleic Acids as Novel Therapeutic Targets
by Neidle, Stephen
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2016, Volume 59, Issue 13, pp. 5987 - 6011
Quadruplex-forming sequences are widely prevalent in human and other genomes, including bacterial ones. These sequences are over-represented in eukaryotic... 
DNA SECONDARY STRUCTURES | RELEVANT G-QUADRUPLEX | TELOMERIC G-QUADRUPLEX | CHEMISTRY, MEDICINAL | REPEAT-CONTAINING RNA | SMALL-MOLECULE | HUMAN CANCER-CELLS | INTRAMOLECULAR G-QUADRUPLEX | RNA G-QUADRUPLEX | C-KIT PROMOTER | K+ SOLUTION | Small Molecule Libraries - pharmacology | G-Quadruplexes - drug effects | Apoptosis - drug effects | Humans | Models, Molecular | Drug Discovery - methods | Telomere - drug effects | Promoter Regions, Genetic - drug effects | Small Molecule Libraries - chemistry | Telomere - chemistry | Animals | Nucleic Acids - chemistry | Telomerase - metabolism | Cell Proliferation - drug effects | Nucleic Acids - genetics | Telomerase - antagonists & inhibitors | Molecular Targeted Therapy - methods | Telomere - genetics
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15. Structure of G-Quadruplex in the Oncogene c-myc Promoter and Small Ligands Targeting the G-Quadruplex
by Tian, MY and Zhang, XF and Pan, R and Zhao, CQ and Tang, YL
PROGRESS IN CHEMISTRY, ISSN 1005-281X, 05/2010, Volume 22, Issue 5, pp. 983 - 992
The revealing of the relationship between the G-quadruplex and cancer by modern molecular biology techniques provides a new opportunity to the anti-cancer... 
RELEVANT G-QUADRUPLEX | small ligands | SMALL-MOLECULE | SILENCER ELEMENT | G-quadruplex | DOWN-REGULATION | DRUG DESIGN | CHEMISTRY, MULTIDISCIPLINARY | KIT ONCOGENE | NMR | NUCLEASE-HYPERSENSITIVE ELEMENT | NMR METHODS | DNA G-QUADRUPLEXES | oncogene c-myc | IN-VIVO
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16. Full Text Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions
by Qin, Yong and Hurley, Laurence H
Biochimie, ISSN 0300-9084, 08/2008, Volume 90, Issue 8, pp. 1149 - 1171
In its simplest form, a DNA G-quadruplex is a four-stranded DNA structure that is composed of stacked guanine tetrads. G-quadruplex-forming sequences have been... 
Promoter element | Transcriptional control | G-quadruplex | RELEVANT G-QUADRUPLEX | TRIPLET REPEAT DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SINGLE-STRANDED-DNA | RET PROTOONCOGENE | promoter element | NUCLEASE-HYPERSENSITIVE ELEMENT | transcriptional control | HUMAN GENOME | A-CHAIN GENE | C-MYC PROMOTER | ENDOTHELIAL GROWTH-FACTOR | I-MOTIF STRUCTURES | DNA - genetics | DNA - chemistry | Animals | Base Sequence | Humans | Eukaryotic Cells - metabolism | G-Quadruplexes | DNA - metabolism | Promoter Regions, Genetic - genetics | Genetic research | Purines | Genetic transcription | Genes | DNA
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