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PloS one, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, pp. e0157487 - e0157487
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 05/2003, Volume 284, Issue 5, pp. 885 - 892
.... A unique feature of the mammalian peptide transporters is the capability of proton-dependent electrogenic cotransport of all substrates, regardless of their charge... 
Functional analysis | Localization | PEPT2 | Renal physiology | PEPT1 | Physiology | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Tissue Distribution | Amino Acids - metabolism | Kidney - metabolism | Animals | Carrier Proteins - metabolism | Peptide Transporter 1 | Homeostasis | Substrate Specificity | Kidney Tubules - metabolism | Symporters - metabolism | Index Medicus
Journal Article
Diabetes & vascular disease research, ISSN 1752-8984, 02/2015, Volume 12, Issue 2, pp. 101 - 110
The sodium-dependent glucose transporter 2 (SGLT2) inhibitors are an important emerging class for the treatment of diabetes... 
sotagliflozin | type 1 | glucagon-like peptide 1 | sodium-glucose transporter 2 | diabetes mellitus | LX4211 | sodium-glucose transporter 1 | diabetes mellitus type 2 | Endocrinology & Metabolism | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Humans | Molecular Targeted Therapy | Renal Reabsorption - drug effects | Sodium-Glucose Transporter 1 - metabolism | Hypoglycemic Agents - therapeutic use | Kidney Tubules, Proximal - physiopathology | Sodium-Glucose Transporter 1 - antagonists & inhibitors | Sodium-Glucose Transporter 2 - metabolism | Diabetes Mellitus, Type 1 - physiopathology | Renal Elimination - drug effects | Treatment Outcome | Clinical Trials as Topic | Drug Discovery | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Diabetes Mellitus, Type 1 - drug therapy | Blood Glucose - drug effects | Diabetes Mellitus, Type 1 - diagnosis | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Animals | Diabetes Mellitus, Type 2 - physiopathology | Diabetes Mellitus, Type 1 - blood | Kidney Tubules, Proximal - metabolism | Glycosides - adverse effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Glycosides - therapeutic use | Kidney Tubules, Proximal - drug effects | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 3/2004, Volume 101, Issue 10, pp. 3569 - 3574
Journal Article
Diabetes care, ISSN 1935-5548, 06/2017, Volume 40, Issue 6, pp. 771 - 776
OBJECTIVE Pharmacologically induced glycosuria elicits adaptive responses in glucose homeostasis and hormone release, including decrements in plasma glucose... 
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | 3-Hydroxybutyric Acid - urine | Humans | Middle Aged | Male | Erythropoietin - blood | Kidney - metabolism | Sodium - urine | Glycosuria - blood | Peptide Fragments - blood | Female | Glucosides - therapeutic use | Benzhydryl Compounds - therapeutic use | Glycosuria - urine | Natriuretic Peptide, Brain - blood | Body Mass Index | Hypoglycemic Agents - therapeutic use | Lactic Acid - urine | Glomerular Filtration Rate | Kidney - drug effects | Sodium-Glucose Transporter 2 - metabolism | Blood Glucose | Diabetes Mellitus, Type 2 - urine | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Glucagon - metabolism | Natriuresis | Diabetes Mellitus, Type 2 - drug therapy | Ketones - metabolism | Type 2 diabetes | Care and treatment | Usage | Research | Ketones | Insulin | Normalizing | Renal function | Erythropoietin | Ketogenesis | Glucagon | Homeostasis | Stimulation | Hormones | Glucose | Hormone release | Body mass index | Measurement methods | Inhibition | Creatinine | Brain natriuretic peptide | Excretion | Fasting | Kidneys | Medical treatment | Diabetes mellitus | Reabsorption | Pharmacology | Metabolism | Patients | Lipolysis | Glomerular filtration rate | Sodium | Research design | Diabetes | Lactic acid | Kidney transplantation | Plasmas (physics) | Index Medicus
Journal Article
Analytical chemistry (Washington), ISSN 0003-2700, 05/2018, Volume 90, Issue 9, pp. 5788 - 5794
...), a prototypic 12-transmembrane-domains transporter. In a first assay step, complex samples are enzymatically fragmented into peptides as routinely done for mass spectrometry... 
Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Immunoassay | Usage | Peptides | Biological transport | Analysis | Glycoproteins | Genetic aspects | Research | Carcinoma, Renal cell | Gene expression | Proteins | Corrosion resistance | Domains | Spectroscopy | Reproducibility | Antibodies | Drug resistance | Cost analysis | Mass spectrometry | Transporter | Index Medicus
Journal Article
Diabetes (New York, N.Y.), ISSN 1939-327X, 05/2016, Volume 65, Issue 5, pp. 1190 - 1195
Pharmacologically induced glycosuria elicits adaptive responses in glucose homeostasis and hormone release. In type 2 diabetes (T2D), along with decrements in... 
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Glucose Intolerance - metabolism | Glycosuria - chemically induced | Carbohydrate Metabolism - drug effects | Lipolysis - drug effects | Benzhydryl Compounds - administration & dosage | Humans | Glucagon-Like Peptide 1 - blood | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Glucagon - blood | Glucose Intolerance - blood | Glucose Intolerance - drug therapy | Benzhydryl Compounds - adverse effects | Hypoglycemic Agents - administration & dosage | Time Factors | Glucosides - therapeutic use | C-Reactive Protein - analysis | Benzhydryl Compounds - therapeutic use | Insulin Secretion | Glucosides - adverse effects | Hypoglycemic Agents - therapeutic use | 3-Hydroxybutyric Acid - blood | Sodium-Glucose Transporter 2 - metabolism | Glucose Intolerance - urine | 3-Hydroxybutyric Acid - agonists | Renal Elimination - drug effects | Sodium-Glucose Transporter 2 Inhibitors | Membrane Transport Modulators - administration & dosage | Diabetes Mellitus, Type 2 - urine | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Algorithms | Glucosides - administration & dosage | 3-Hydroxybutyric Acid - metabolism | Lipid Metabolism - drug effects | Membrane Transport Modulators - therapeutic use | Glucagon - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Membrane Transport Modulators - adverse effects | Hypoglycemic Agents - adverse effects | Energy Metabolism - drug effects | Type 2 diabetes | Care and treatment | Glucagon | Dosage and administration | Triglycerides | Research | Insulin | Homeostasis | Glucose | Hormones | Diabetes | Substrates | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Acta pharmaceutica Sinica. B, ISSN 2211-3835, 2016, Volume 6, Issue 5, pp. 363 - 373
The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites.Renal drug transporters,which are primarily located in the renal... 
anions;Nephrotoxicity | transporters;Drug–drug | interactions;Organic | cations;Organic | Renal | drug | Organic cations | Organic anions | Drug-drug interactions | Nephrotoxicity | Renal drug transporters | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Physiological aspects | Models | Kidneys | Health aspects | Drug interactions | Biological transport | NSAID, non-steroidal anti-inflammatory drugs | CHO, Chinese hamster ovary | URAT, urate transporter | P-gp, P-glycoprotein | GSH, glutathione | DDIs, drug–drug interactions | HEK, human embryonic kidney | IC50, half maximal inhibitory concentration | SNP, single-nucleotide polymorphism | Review | Cmax, maximum plasma concentration | MPP+, 1-methyl-4-phenylpyridimium | OCTN, Organic zwitterions | SLC, solute carrier | TEA, tetraethylammonium | ABC, ATP-binding cassette | AUC, area under the plasma concentration curve | MRP, multidrug resistance-associated protein | NBD, nucleotide-binding domain | Drug–drug interactions | ITC, International Transporter Consortium | OA, organic anion | OAT or Oat, organic anion transporters | OC, organic cation | ATP, adenosine triphosphate | TMD, transmembrane domain | CL, plasma clearance | FDA, U.S. Food and Drug Administration | MSD, membrane-spanning domain | MW, molecular weight | NME, new molecular entity | BBB, blood–brain barrier | cation transporters | PAH, p-aminohippurate | Ki, inhibitory constant | OATP or Oatp, organic anion-transporting peptide | fe, fraction of the absorbed dose excreted unchanged in urine | MATE, multidrug and toxin extrusion protein | CLR, renal clearance | OCT or Oct, organic cation transporter
Journal Article