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SCIENCE, ISSN 0036-8075, 03/2017, Volume 355, Issue 6331, pp. 1306 - 1311
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes activated at the lysosome in response to... 
INSULIN | TRANSPORT | OBESITY | DOMAIN | RAG GTPASES | METABOLISM | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | RAGULATOR | REQUIRES | BINDING
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2009, Volume 11, Issue 2, pp. 123 - 132
Nuclear factor-kappa B (NF-kappa B) is a key transcription factor in inflammatory, anti-apoptotic and immune processes. The ubiquitin pathway is crucial in... 
CHAIN | SITE | PROTEIN-KINASE-C | UBIQUITIN-CONJUGATING ENZYME | CANCER DEVELOPMENT | REQUIRES | LIGASE COMPLEX | IDENTIFICATION | BINDING | DEUBIQUITINATING ENZYMES | CELL BIOLOGY
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 01/2015, Volume 5
Collective cell migration plays a crucial role in several biological processes, such as embryonic development, wound healing, and cancer metastasis. Here, we... 
POLARITY | MULTIDISCIPLINARY SCIENCES | LEADING CELLS | MOVEMENT | DYNAMICS | REQUIRES | NEUTROPHIL CHEMOTAXIS | GUIDANCE | TISSUE MIGRATION | CANCER | POLARIZATION
Journal Article
SCIENCE, ISSN 0036-8075, 02/2010, Volume 327, Issue 5969, pp. 1135 - 1139
A20 negatively regulates inflammation by inhibiting the nuclear factor kappa B (NF-kappa B) transcription factor in the tumor necrosis factor receptor (TNFR)... 
RESPONSES | ACTIVATION | UBC13 | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | CONJUGATING ENZYME | REQUIRES | TNFAIP3 | TERMINATION | REGION
Journal Article
BLOOD, ISSN 0006-4971, 03/2017, Volume 129, Issue 13, pp. 1768 - 1778
Weidentified apilimod as an antiproliferative compound by high-throughput screening of clinical-stage drugs. Apilimod exhibits exquisite specificity for... 
ACTIVATION | TRANSPORT | COMPLEX | ORAL INTERLEUKIN-12/23 INHIBITOR | STA-5326 | TRANSCRIPTIONAL CONTROL | REQUIRES | AUTOPHAGY | LYSOSOME | MATURATION | HEMATOLOGY
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 02/2013, Volume 110, Issue 7, pp. 2623 - 2628
Type VI protein secretion system (T6SS) is important for bacterial competition through contact-dependent killing of competitors. T6SS delivers effectors to... 
MUTAGENESIS | actin cross-linking | DETERMINANTS | TARGET-CELLS | MULTIDISCIPLINARY SCIENCES | lipase | ESCHERICHIA-COLI | VIRULENCE | VgrG | Dictyostelium discoideum | LIBRARIES | REQUIRES | T6SS assembly | VI-SECRETION-SYSTEM | CHITOSANASE | REVEALS
Journal Article
Cell, ISSN 0092-8674, 08/2013, Volume 154, Issue 3, pp. 651 - 663
Journal Article
NATURE METHODS, ISSN 1548-7091, 01/2006, Volume 3, Issue 1, pp. 17 - 21
Transcription regulation in higher eukaryotes is controlled by regulatory elements such as enhancers that are recognized by transcription factors. In many... 
ELEMENTS | TRANSCRIPTION | BIOCHEMICAL RESEARCH METHODS | SITES | REQUIRES | SPATIAL-ORGANIZATION | BETA-GLOBIN LOCUS
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 08/2019, Volume 62, Issue 16, pp. 7431 - 7444
A series of 2-amino-2,3-dihydro-1H-indene-5-carboxamides were designed and synthesized as new selective discoidin domain receptor 1 (DDR1) inhibitors. One of... 
TRKC | CHEMISTRY, MEDICINAL | KINASE | DIFFRACTION | REQUIRES | UP-REGULATION | DISCOVERY | N-CADHERIN | Index Medicus
Journal Article
NATURE REVIEWS IMMUNOLOGY, ISSN 1474-1733, 06/2006, Volume 6, Issue 6, pp. 476 - 483
A common view supposes that dendritic cells (DCs) exist in two basic functional states: immature DCs induce tolerance to self, whereas mature DCs induce... 
ADAPTIVE IMMUNITY | EPIDERMAL LANGERHANS CELLS | REGULATE ANTIGEN PRESENTATION | TUMOR-NECROSIS-FACTOR | IN-VIVO REQUIRES | LYMPH-NODE | PERIPHERAL TOLERANCE | STEADY-STATE | IMMUNOLOGY | PRESENT SELF-ANTIGENS | CD8 T-CELLS
Journal Article
Journal of Engineering and Applied Sciences, ISSN 1816-949X, 2017, Volume 12, Issue 12, pp. 3142 - 3146
Journal Article
by Hou, WJ and Sun, H and Ma, YF and Liu, CY and Zhang, ZY
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 06/2019, Volume 62, Issue 12, pp. 5901 - 5919
In the course of developing the biochemistry to chemistry activity-based protein profiling (BTC-ABPP) method, we herein unexpectedly discovered that the... 
ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | SERINE PROTEASES | DIPEPTIDYL PEPTIDASE-I | REQUIRES | GENERATION | DISCOVERY
Journal Article
Cell, ISSN 0092-8674, 2009, Volume 136, Issue 6, pp. 1098 - 1109
Activation of nuclear factor-κB (NF-κB), a key mediator of inducible transcription in immunity, requires binding of NF-κB essential modulator (NEMO) to... 
PROTEINS | SIGNALING | BINDING DOMAINS | COMPLEX | IKK-GAMMA | TURNOVER | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANHIDROTIC ECTODERMAL DYSPLASIA | CONJUGATING ENZYME | REQUIRES | POLYUBIQUITIN CHAINS | IMMUNODEFICIENCY | REVEALS | CELL BIOLOGY
Journal Article
Science, ISSN 0036-8075, 03/2016, Volume 351, Issue 6279, pp. 1266 - 1267
  The S-adenosylmethionine (SAM) radical enzyme superfamily plays a central role in the biosynthesis of many vitamins, cofactors, and antibiotics. Radical SAM... 
TRYPTOPHAN | TYROSINE | BIOSYNTHESIS | SUBSTRATE | MULTIDISCIPLINARY SCIENCES | INTERMEDIATE | REQUIRES
Journal Article
BLOOD, ISSN 0006-4971, 03/2017, Volume 129, Issue 10, pp. 1296 - 1307
Two subsets of blood monocytes are commonly described in mice and humans: the classical inflammatory monocytes, which are rapidly mobilized upon inflammation... 
EMIGRATION | CELLS | RECRUITMENT | BONE-MARROW | CHEMOKINE RECEPTOR | DYNAMICS | REQUIRES | INFECTION | HEMATOLOGY | EXPRESSION | ADHERENCE
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2019, Volume 202, Issue 3, pp. 736 - 746
Adoptive transfer of allogeneic NK cells holds great promise for cancer immunotherapy. There is a variety of protocols to expand NK cells in vitro, most of... 
NATURAL-KILLER-CELLS | ACTIVATION | MEMORY | REQUIRES | GENERATION | IMMUNOLOGY | BCL-2 FAMILY | EXPRESSION | ANTITUMOR | PROMOTES | T-CELLS
Journal Article
HUMAN MOLECULAR GENETICS, ISSN 0964-6906, 05/2013, Volume 22, Issue 9, pp. 1746 - 1754
Several known or putative glycosyltransferases are required for the synthesis of laminin-binding glycans on alpha-dystroglycan (DG), including POMT1, POMT2,... 
ALPHA-DYSTROGLYCAN | CONGENITAL MUSCULAR-DYSTROPHY | COMPLEX | ABNORMAL GLYCOSYLATION | LAMININ | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | WALKER-WARBURG-SYNDROME | GLYCOPROTEINS | REQUIRES | RECEPTOR | EXTRACELLULAR-MATRIX
Journal Article
Development, ISSN 0950-1991, 09/2009, Volume 136, Issue 22, pp. 3691 - 3697
Advances in our understanding of the many levels of regulation of TGF beta and BMP signaling were reported at the recent FASEB Summer Conference entitled 'The... 
RECEPTOR COMPLEXES | CELLS | ACTIVATION | GROWTH | PRODOMAIN | REQUIRES | DEVELOPMENTAL BIOLOGY | DORSOVENTRAL AXIS | PROTEINS | SMAD1/5 PHOSPHORYLATION | DROSOPHILA
Journal Article
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