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1. Full Text Effects of homocysteine-lowering with folic acid plus vitamin B 12 vs placebo on mortality and major morbidity in myocardial infarction survivors: A randomized trial
by Armitage, Jane M and Bowman, Louise and Clarke, Robert J and Wallendszus, Karl and Bulbulia, Richard and Rahimi, Kazem and Haynes, Richard and Parish, Sarah and Sleight, Peter and Peto, Richard and Collins, Rory and SEARCH Collaborative Grp
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 06/2010, Volume 303, Issue 24, pp. 2486 - 2494
Context Blood homocysteine levels are positively associated with cardiovascular disease, but it is uncertain whether the association is causal. Objective To... 
SUPPLEMENTATION | HIP FRACTURE | MEDICINE, GENERAL & INTERNAL | REQUIRING PROLONGED OBSERVATION | RISK-FACTOR | STROKE PREVENTION | CARDIOVASCULAR EVENTS | PLASMA HOMOCYSTEINE | B-VITAMINS | VASCULAR-DISEASE | FORTIFICATION
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2. Full Text Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies
by Beral, V and Bull, D and Pirie, K and Reeves, G and Peto, R and Skegg, D and LaVecchia, C and Magnusson, C and Pike, M. C and Thomas, D and Hamajima, N and Hirose, K and Tajima, K and Rohan, T and Friedenreich, C. M and Calle, E. E and Gapstur, S. M and Patel, A. V and Coates, R. J and Liff, J. M and Talamini, R and Chantarakul, N and Koetsawang, S and Rachawat, D and Marcou, Y and Kakouri, E and Duffy, S. W and Morabia, A and Schuman, L and Stewart, W and Szklo, M and Coogan, P. F and Palmer, J. R and Rosenberg, L and Band, P and Coldman, A. J and Gallagher, R. P and Hislop, T. G and Yang, P and Cummings, S. R and Canfell, K and Sitas, F and Chao, P and Lissowska, J and Horn-Ross, P. L and John, E. M and Kolonel, L. M and Nomura, A. M. Y and Ghiasvand, R and Hu, J and Johnson, K. C and Mao, Y and Callaghan, K and Crossley, B and Goodill, A and Green, J and Hermon, C and Key, T and Lindgard, I and Liu, B and Collins, R and Doll, R and Bishop, T and Fentiman, I. S and De Sanjose, S and Gonzaler, C. A and Lee, N and Marchbanks, P and Ory, H. W and Peterson, H. B and Wingo, P and Ebeling, K and Kunde, D and Nishan, P and Hopper, J. L and Eliassen, H and Gajalakshmi, V and Martin, N and Pardthaisong, T and Silpisornkosol, S and Theetranont, C and Boosiri, B and Chutivongse, S and Jimakorn, P and Virutamasen, P and Wongsrichanalai, C and Neugut, A and Santella, R and Baines, C. J and Kreiger, N and Miller, A. B and Wall, C and Tjonneland, A and Jorgensen, T and Stahlberg, C and Pedersen, A. Tonnes and Flesch-Janys, D and Hakansson, N and Cauley, J and Heuch, I and ... and S Hankinson Nurses Hlth Study I II Res Grp and Collaborative Grp Hormonal Factors and Collaborative Group on Hormonal Factors in Breast Cancer and Onkologi och Patologi, MV and Oncology and Pathology, Kamprad Lab and Lund University and Oncology and Pathology, MV and EpiHealth: Epidemiology for Health and BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation and Lunds universitet and Onkologi och Patologi, Kampradlab
Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 11, pp. 1141 - 1151
Summary Background Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast... 
Hematology, Oncology and Palliative Medicine | DESIGN | REQUIRING PROLONGED OBSERVATION | ONCOLOGY | RECALL | PATIENT | VALIDITY | REPRODUCIBILITY | AGE | Receptors, Estrogen - metabolism | Age Factors | Premenopause | Neoplasm Invasiveness | Humans | Menopause | Middle Aged | Risk Factors | Menarche | Neoplasms, Hormone-Dependent - epidemiology | Hormone Replacement Therapy | Reproduction | Breast Neoplasms - pathology | Neoplasms, Hormone-Dependent - pathology | Aged, 80 and over | Adult | Female | Aged | Estrogens - metabolism | Breast Neoplasms - epidemiology | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
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3. Full Text Embedding patient- and public health-oriented research in a national health service: the GISSI experience
by Tognoni, Gianni and Franzosi, Maria Grazia and Garattini, Silvio
Journal of the Royal Society of Medicine, ISSN 0141-0768, 5/2019, Volume 112, Issue 5, pp. 200 - 204
TRIAL | MEDICINE, GENERAL & INTERNAL | POLYUNSATURATED FATTY-ACIDS | DESIGN | REQUIRING PROLONGED OBSERVATION | ATTITUDES
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4. Full Text The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
by Baigent, Colin, Prof and Landray, Martin J, FRCP and Reith, Christina, MRCP and Emberson, Jonathan, PhD and Wheeler, David C, FRCP and Tomson, Charles, DM and Wanner, Christoph, Prof and Krane, Vera, MD and Cass, Alan, Prof and Craig, Jonathan, Prof and Neal, Bruce, Prof and Jiang, Lixin, MD and Hooi, Lai Seong, FRCP and Levin, Adeera, Prof and Agodoa, Lawrence, Prof and Gaziano, Mike, Prof and Kasiske, Bertram, Prof and Walker, Robert, Prof and Massy, Ziad A, Prof and Feldt-Rasmussen, Bo, Prof and Krairittichai, Udom, MD and Ophascharoensuk, Vuddidhej, MD and Fellström, Bengt, Prof and Holdaas, Hallvard, MD and Tesar, Vladimir, Prof and Wiecek, Andrzej, Prof and Grobbee, Diederick, Prof and de Zeeuw, Dick, Prof and Grönhagen-Riska, Carola, Prof and Dasgupta, Tanaji, MRCP and Lewis, David, MRCP and Herrington, William, MRCP and Mafham, Marion, MD and Majoni, William, FRACP and Wallendszus, Karl, MSc and Grimm, Richard, Prof and Pedersen, Terje, Prof and Tobert, Jonathan, PhD and Armitage, Jane, Prof and Baxter, Alex, BA and Bray, Christopher, PhD and Chen, Yiping, DPhil and Chen, Zhengming, Prof and Hill, Michael, DPhil and Knott, Carol, MSc and Parish, Sarah, DPhil and Simpson, David and Sleight, Peter, Prof and Young, Alan, DPhil and Collins, Rory, Prof and SHARP Investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper
Lancet, The, ISSN 0140-6736, 2011, Volume 377, Issue 9784, pp. 2181 - 2192
Summary Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | UNITED-KINGDOM HEART | DESIGN | REQUIRING PROLONGED OBSERVATION | EFFICACY | CARDIOVASCULAR EVENTS | SAFETY | OUTCOMES | Confidence Intervals | Simvastatin - adverse effects | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Ezetimibe | Renal Dialysis - methods | Male | Reference Values | Cholesterol, LDL - analysis | Kidney Function Tests | Renal Insufficiency, Chronic - drug therapy | Dose-Response Relationship, Drug | Renal Insufficiency, Chronic - therapy | Renal Dialysis - mortality | Time Factors | Renal Insufficiency, Chronic - mortality | Adult | Female | Renal Insufficiency, Chronic - diagnosis | Drug Therapy, Combination | Severity of Illness Index | Hypolipidemic Agents - adverse effects | Double-Blind Method | Drug Administration Schedule | Risk Assessment | Simvastatin - administration & dosage | Cholesterol, LDL - drug effects | Treatment Outcome | Azetidines - administration & dosage | Hypolipidemic Agents - administration & dosage | Survival Analysis | Aged | Simvastatin | Low density lipoproteins | Physiological aspects | Drug therapy, Combination | Research | Kidney diseases | Diagnosis | Drug therapy | Health aspects | Studies | Heart failure | Cardiac arrhythmia | Medical imaging | Hospitals | Compliance | Cardiovascular disease | Blood pressure | Family medical history | Cholesterol | Cancer | Mortality | myocardial infarction | cholesterol | councils | Dialysis | medical research | stroke | Kidney | Fast track | Pharmaceutical Sciences | Basic Medicine | PHARMACY | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | FARMACI | Farmaceutiska vetenskaper
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5. Full Text Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99–06): a randomised trial
by Facon, Thierry, Prof and Mary, Jean Yves, PhD and Hulin, Cyrille, MD and Benboubker, Lotfi, MD and Attal, Michel, Prof and Pegourie, Brigitte, MD and Renaud, Marc, MD and Harousseau, Jean Luc, Prof and Guillerm, Gaëlle, MD and Chaleteix, Carine, MD and Dib, Mamoun, MD and Voillat, Laurent, MD and Maisonneuve, Hervé, MD and Troncy, Jacques, MD and Dorvaux, Véronique, MD and Monconduit, Mathieu, Prof and Martin, Claude, MD and Casassus, Philippe, Prof and Jaubert, Jérôme, MD and Jardel, Henry, MD and Doyen, Chantal, Prof and Kolb, Brigitte, MD and Anglaret, Bruno, MD and Grosbois, Bernard, Prof and Yakoub-Agha, Ibrahim, MD and Mathiot, Claire, MD and Avet-Loiseau, Hervé, Prof and Intergroupe Francophone Mye and Intergroupe Francophone du Myélome
Lancet, The, ISSN 0140-6736, 2007, Volume 370, Issue 9594, pp. 1209 - 1218
Summary Background In multiple myeloma, combination chemotherapy with melphalan plus prednisone is still regarded as the standard of care in elderly patients.... 
Internal Medicine | STAGING SYSTEM | MEDICINE, GENERAL & INTERNAL | DEXAMETHASONE | DESIGN | REQUIRING PROLONGED OBSERVATION | IMPROVES SURVIVAL | CHEMOTHERAPY | Prednisone - administration & dosage | Multiple Myeloma - mortality | Humans | Male | Survival Rate | Antineoplastic Agents, Alkylating - administration & dosage | Thalidomide - administration & dosage | Stem Cell Transplantation | Melphalan - administration & dosage | Multiple Myeloma - drug therapy | Multiple Myeloma - therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Female | Aged | Immunosuppressive Agents - administration & dosage | Chemotherapy | Hospitals | Transplants & implants | Medical treatment | Clinical trials | Radiation therapy | Drug therapy
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6. Full Text Reflections on the design and analysis of clinical trials and meta-analyses in the 1970s and 1980s
by Peto, Richard
Journal of the Royal Society of Medicine, ISSN 0141-0768, 2/2019, Volume 112, Issue 2, pp. 78 - 80
ACUTE MYOCARDIAL-INFARCTION | MEDICINE, GENERAL & INTERNAL | PATIENT | REQUIRING PROLONGED OBSERVATION
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7. Full Text Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study
by Merchant, Thomas E, Prof and Li, Chenghong, PhD and Xiong, Xiaoping, Prof and Kun, Larry E, Prof and Boop, Frederic A, MD and Sanford, Robert A, MD
Lancet Oncology, The, ISSN 1470-2045, 2009, Volume 10, Issue 3, pp. 258 - 266
Summary Background Therapy for ependymoma includes aggressive surgical intervention and radiotherapy administered by use of methods that keep the risk of... 
Hematology, Oncology and Palliative Medicine | LOCALIZED EPENDYMOMA | POSTOPERATIVE CHEMOTHERAPY | REQUIRING PROLONGED OBSERVATION | PROGNOSTIC-FACTORS | ONCOLOGY | CHILDHOOD EPENDYMOMA | COMPETING RISK | INTRACRANIAL EPENDYMOMA | RADIATION-THERAPY | BRAIN-TUMORS | CHILDREN | Prospective Studies | Humans | Child, Preschool | Infant | Male | Combined Modality Therapy | Ependymoma - therapy | Ependymoma - mortality | Treatment Failure | Adolescent | Brain Neoplasms - therapy | Adult | Female | Radiotherapy, Conformal - adverse effects | Brain Neoplasms - mortality | Child | Radiotherapy, Conformal - methods | Radiotherapy | Pediatrics
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