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science & technology (13) 13
life sciences & biomedicine (12) 12
humans (10) 10
adult (5) 5
aged (5) 5
animals (5) 5
biological and medical sciences (5) 5
male (5) 5
middle aged (5) 5
unfolded protein response (5) 5
endoplasmic reticulum (4) 4
er, endoplasmic reticulum (4) 4
female (4) 4
health aspects (4) 4
medical research (4) 4
research (4) 4
risk factors (4) 4
treatment outcome (4) 4
upr, unfolded protein response (4) 4
abridged index medicus (3) 3
analysis (3) 3
apoptosis (3) 3
atf, activating transcription factor (3) 3
double-blind method (3) 3
drug therapy (3) 3
endocrinology & metabolism (3) 3
follow-up studies (3) 3
general & internal medicine (3) 3
medical sciences (3) 3
medicine, experimental (3) 3
metaanalysis (3) 3
protein-serine-threonine kinases - metabolism (3) 3
proteins (3) 3
requiring prolonged observation (3) 3
risk assessment (3) 3
signal transduction (3) 3
time factors (3) 3
activating transcription factor 6 (2) 2
animal models (2) 2
autophagy (2) 2
azetidines - administration & dosage (2) 2
biochemistry & molecular biology (2) 2
cardiovascular diseases (2) 2
children (2) 2
cholesterol (2) 2
cholesterol, ldl - drug effects (2) 2
chop, c (2) 2
chop, ccaat (2) 2
design (2) 2
dose-response relationship, drug (2) 2
drug administration schedule (2) 2
drug therapy, combination (2) 2
efficacy (2) 2
eif-2 kinase - metabolism (2) 2
endoribonucleases - metabolism (2) 2
ezetimibe (2) 2
gastroenterology and hepatology (2) 2
general aspects (2) 2
homeostasis (2) 2
inositol (2) 2
inositol-requiring enzyme 1 (2) 2
internal medicine (2) 2
ire1, inositol-requiring enzyme 1 (2) 2
kidneys (2) 2
kinases (2) 2
low density lipoproteins (2) 2
medicine (2) 2
medicine, general & internal (2) 2
membrane proteins - genetics (2) 2
membrane proteins - metabolism (2) 2
nephrology. urinary tract diseases (2) 2
nephropathies. renovascular diseases. renal failure (2) 2
nervous system diseases (2) 2
original research (2) 2
pain management (2) 2
perk, protein kinase rna-like endoplasmic reticulum kinase (2) 2
physiological aspects (2) 2
prevalence (2) 2
renal dialysis (2) 2
renal failure (2) 2
retrospective studies (2) 2
ribonucleic acid--rna (2) 2
ros, reactive oxygen species (2) 2
safety (2) 2
simvastatin (2) 2
simvastatin - administration & dosage (2) 2
sirna, small interfering rna (2) 2
stress (2) 2
stroke (2) 2
umcg approved (2) 2
unfolded protein response - genetics (2) 2
unfolded protein response - physiology (2) 2
united-kingdom heart (2) 2
urinary system involvement in other diseases. miscellaneous (2) 2
usage (2) 2
xbp1, x-box binding protein 1 (2) 2
'enteropathy'- disease of the intestine (1) 1
'gluten intolerance'- adverse responses to gluten, with immune system not involved (1) 1
11 medical and health sciences (1) 1
1107 immunology (1) 1
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1. Full Text The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
by Baigent, Colin, Prof and Landray, Martin J, FRCP and Reith, Christina, MRCP and Emberson, Jonathan, PhD and Wheeler, David C, FRCP and Tomson, Charles, DM and Wanner, Christoph, Prof and Krane, Vera, MD and Cass, Alan, Prof and Craig, Jonathan, Prof and Neal, Bruce, Prof and Jiang, Lixin, MD and Hooi, Lai Seong, FRCP and Levin, Adeera, Prof and Agodoa, Lawrence, Prof and Gaziano, Mike, Prof and Kasiske, Bertram, Prof and Walker, Robert, Prof and Massy, Ziad A, Prof and Feldt-Rasmussen, Bo, Prof and Krairittichai, Udom, MD and Ophascharoensuk, Vuddidhej, MD and Fellström, Bengt, Prof and Holdaas, Hallvard, MD and Tesar, Vladimir, Prof and Wiecek, Andrzej, Prof and Grobbee, Diederick, Prof and de Zeeuw, Dick, Prof and Grönhagen-Riska, Carola, Prof and Dasgupta, Tanaji, MRCP and Lewis, David, MRCP and Herrington, William, MRCP and Mafham, Marion, MD and Majoni, William, FRACP and Wallendszus, Karl, MSc and Grimm, Richard, Prof and Pedersen, Terje, Prof and Tobert, Jonathan, PhD and Armitage, Jane, Prof and Baxter, Alex, BA and Bray, Christopher, PhD and Chen, Yiping, DPhil and Chen, Zhengming, Prof and Hill, Michael, DPhil and Knott, Carol, MSc and Parish, Sarah, DPhil and Simpson, David and Sleight, Peter, Prof and Young, Alan, DPhil and Collins, Rory, Prof and on behalf of the SHARP Investigators and SHARP Investigators
The Lancet (British edition), ISSN 0140-6736, 2011, Volume 377, Issue 9784, pp. 2181 - 2192
Internal Medicine | UNITED-KINGDOM HEART | DESIGN | METAANALYSIS | REQUIRING PROLONGED OBSERVATION | EFFICACY | CARDIOVASCULAR EVENTS | SAFETY | HEMODIALYSIS | OUTCOMES | UMCG Approved | PARTICIPANTS | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | General aspects | Kidneys | Urinary system involvement in other diseases. Miscellaneous | Nephropathies. Renovascular diseases. Renal failure | Renal failure | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Confidence Intervals | Simvastatin - adverse effects | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Ezetimibe | Renal Dialysis - methods | Male | Reference Values | Cholesterol, LDL - analysis | Kidney Function Tests | Renal Insufficiency, Chronic - drug therapy | Dose-Response Relationship, Drug | Renal Insufficiency, Chronic - therapy | Renal Dialysis - mortality | Time Factors | Renal Insufficiency, Chronic - mortality | Adult | Female | Renal Insufficiency, Chronic - diagnosis | Drug Therapy, Combination | Severity of Illness Index | Hypolipidemic Agents - adverse effects | Double-Blind Method | Drug Administration Schedule | Risk Assessment | Simvastatin - administration & dosage | Cholesterol, LDL - drug effects | Treatment Outcome | Azetidines - administration & dosage | Hypolipidemic Agents - administration & dosage | Survival Analysis | Aged | Simvastatin | Low density lipoproteins | Physiological aspects | Drug therapy, Combination | Research | Kidney diseases | Diagnosis | Drug therapy | Health aspects | Studies | Heart failure | Cardiac arrhythmia | Medical imaging | Hospitals | Compliance | Cardiovascular disease | Blood pressure | Family medical history | Cholesterol | Cancer | Index Medicus | Abridged Index Medicus | Mortality | myocardial infarction | cholesterol | councils | Dialysis | medical research | stroke | Kidney | Fast track
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2. Full Text Study of Heart and Renal Protection (SHARP): Randomized trial to assess the effects of lowering low-density lipoprotein cholesterol among 9,438 patients with chronic kidney disease
by SHARP Collaborative Group and SHARP Collaborative Grp
The American heart journal, ISSN 0002-8703, 2010, Volume 160, Issue 5, pp. 785 - 794.e10
Cardiovascular | UNITED-KINGDOM HEART | METAANALYSIS | REQUIRING PROLONGED OBSERVATION | EFFICACY | CARDIOVASCULAR OUTCOMES | SAFETY | CLINICAL-TRIALS | SIMVASTATIN | EZETIMIBE | STATINS | UMCG Approved | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Kidneys | Urinary system involvement in other diseases. Miscellaneous | Nephropathies. Renovascular diseases. Renal failure | Renal failure | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Simvastatin - therapeutic use | Follow-Up Studies | Humans | Middle Aged | Ezetimibe | Male | Incidence | Dose-Response Relationship, Drug | Atherosclerosis - etiology | Adult | Cholesterol, LDL - blood | Female | Retrospective Studies | Drug Therapy, Combination | Double-Blind Method | Simvastatin - administration & dosage | Cholesterol, LDL - drug effects | Treatment Outcome | Atherosclerosis - blood | Kidney Failure, Chronic - therapy | Anticholesteremic Agents - therapeutic use | Azetidines - administration & dosage | Azetidines - therapeutic use | Kidney Failure, Chronic - blood | Anticholesteremic Agents - administration & dosage | Kidney Failure, Chronic - complications | Aged | Atherosclerosis - prevention & control | Renal Dialysis | Medicine, Experimental | Medical research | Chronic kidney failure | Analysis | Low density lipoproteins | Cholesterol | Lipids | Heart attacks | Drug therapy | Low density lipoprotein | Index Medicus | Abridged Index Medicus
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3. Full Text The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: Statistical analysis plan for a randomised controlled trial
by Al-Shahi Salman, Rustam and Murray, Gordon D and Dennis, Martin S and Newby, David E and Sandercock, Peter A. G and Sprigg, Nikola and Sudlow, Cathie L. M and Werring, David J and White, Philip M and Whiteley, William N
Trials, ISSN 1745-6215, 03/2019, Volume 20, Issue 1, pp. 183 - 183
Secondary prevention | randomised controlled trial | intracerebral haemorrhage | antiplatelet therapy | statistical analysis plan | stroke | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cerebral Hemorrhage - chemically induced | Recurrence | Cerebral Hemorrhage - drug therapy | Data Interpretation, Statistical | Anticoagulants - administration & dosage | Drug Administration Schedule | Risk Assessment | Stroke - diagnostic imaging | Humans | Risk Factors | Treatment Outcome | Stroke - drug therapy | Anticoagulants - adverse effects | Secondary Prevention - methods | Cerebral Hemorrhage - diagnostic imaging | Randomized Controlled Trials as Topic | Secondary Prevention - statistics & numerical data | Fibrinolytic Agents - adverse effects | Stroke - chemically induced | Time Factors | Platelet Aggregation Inhibitors - administration & dosage | Fibrinolytic Agents - administration & dosage | Platelet Aggregation Inhibitors - adverse effects | Blood circulation disorders | Medical research | Usage | Analysis | Clinical trials | Medicine, Experimental | Thrombolytic drugs | Stroke patients | Health aspects | Risk factors | Index Medicus
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4. Full Text Clinical trials: a summary
by Wilhelmsen, L and Held, P and Wedel, H and Hjärt-kärlinstitutionen and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Cardiovascular Institute and Sahlgrenska Academy
Journal of internal medicine, ISSN 0954-6820, 10/2004, Volume 256, Issue 4, pp. 284 - 287
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Publishing - trends | Sample Size | Randomized Controlled Trials as Topic - methods | Humans | Statistics as Topic - methods | Research Design | Practice Guidelines as Topic | Randomized Controlled Trials as Topic - standards | Index Medicus | requiring prolonged observation | Dermatologi och venereologi | Dermatology and Venereal Diseases | patient | design | evolution | issues
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5. Full Text Breast cancer and hormonal contraceptives: Further results
by Calle, EE and Heath, CW and MiracleMcMahill, HL and Coates, RJ and Liff, JM and Franceschi, S and Talamini, R and Chantarakul, N and Koetsawang, S and Rachawat, D and Morabia, A and Schuman, I and Stewart, W and Szklo, M and Bain, C and Schofield, F and Siskind, V and Band, P and Coldman, AJ and Gallagher, RP and Hislop, TG and Yang, P and D
1996, Volume 54, Issue 3
REQUIRING PROLONGED OBSERVATION; ORAL-CONTRACEPTIVES; RISK-FACTORS; FINAL REPORT; PREMENOPAUSAL WOMEN; YOUNG-WOMEN; AGE; POPULATION; ESTROGEN; PATTERNS
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6. Full Text The dynamic plasticity of insulin production in β-cells
by Boland, Brandon B and Rhodes, Christopher J and Grimsby, Joseph S
Molecular metabolism (Germany), ISSN 2212-8778, 2017, Volume 6, Issue 9, pp. 958 - 973
Endocrinology & Metabolism | β-cell rest | T2DM | Insulin production | Life Sciences & Biomedicine | Science & Technology | Insulin-Secreting Cells - physiology | Insulin - metabolism | Insulin Secretion - physiology | Insulin-Secreting Cells - metabolism | Animals | Signal Transduction | Humans | Glucose - metabolism | Diabetes Mellitus, Type 2 - metabolism | Insulin - biosynthesis | Cell Plasticity - physiology | Index Medicus
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7. Full Text Progression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high-risk haplotypes
by Pietropaolo, M and Becker, D. J and LaPorte, R. E and Dorman, J. S and Riboni, S and Rudert, W. A and Mazumdar, S and Trucco, M
Diabetologia, ISSN 0012-186X, 1/2002, Volume 45, Issue 1, pp. 66 - 76
2 HLA-DQ high-risk haplotypes | autoantibodies | islet cell autoimmunity | Seronegative insulin-requiring diabetes | Autoantibodies | Islet cell autoimmunity | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Diabetes Mellitus, Type 1 - epidemiology | Haplotypes | Demography | Prediabetic State - genetics | Prevalence | Age Factors | Follow-Up Studies | Autoantibodies - blood | Humans | Middle Aged | Isoenzymes - immunology | Time Factors | Prediabetic State - immunology | Adult | Registries | Insulin Antibodies - blood | Diabetes Mellitus, Type 1 - immunology | Glutamate Decarboxylase - immunology | Child | Pennsylvania - epidemiology | Prediabetic State - epidemiology | Risk Assessment | Diabetes Mellitus, Type 1 - genetics | Islets of Langerhans - immunology | HLA-DQ Antigens - genetics | Adolescent | Aged | Autoimmunity | Diabetics | Medical colleges | HLA histocompatibility antigens | Development and progression | Autoantigens | Insulin | Risk factors | Immunogenetics | Histocompatibility antigens | Prediabetic state | Public health | Index Medicus
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8. Full Text Endoplasmic Reticulum Stress as a Target of Therapy Against Oxidative Stress and Hypoxia
by Inagi, Reiko
11/2010, Oxidative Stress in Applied Basic Research and Clinical Practice, ISBN 9781607618560
Glucose-regulated protein 78 | Double-stranded RNA-activated-protein kinase-like ER kinase | Activating transcription factor 6 | Acute kidney injury | Hypoxia-inducible factor | Inositol-requiring enzyme 1 | Inflammatory response | Chronic kidney disease | Oxidative stress-inducible pathway | Unfolded protein response
Book Chapter
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9. Full Text Adaptive preconditioning in neurological diseases – Therapeutic insights from proteostatic perturbations
by Mollereau, B and Rzechorzek, N.M and Roussel, B.D and Sedru, M and Van den Brink, D and Bailly-Maitre, B and Palladino, F and Medinas, D.B and Domingos, P.M and Hunot, S and Chandran, S and Birman, S and Baron, T and Vivien, D and Duarte, C.B and Ryoo, H.D and Steller, H and Urano, F and Chevet, E and Kroemer, G and Ciechanover, A and Calabrese, E.J and Kaufman, R.J and Hetz, C
Brain research, ISSN 0006-8993, 2016, Volume 1648, Issue Pt B, pp. 603 - 616
Neurology | Wolfram syndrome | Ischemia | Glioblastoma | ER stress | Hormesis | Parkinson׳s disease | Autophagy | Proteasome | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology