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Journal of Hepatology, ISSN 0168-8278, 12/2018, Volume 69, Issue 6, pp. 1221 - 1230
Journal Article
Journal of Medical Virology, ISSN 0146-6615, 03/2018, Volume 90, Issue 3, pp. 532 - 536
Oral DAA have demonstrated high efficacy as treatment of hepatitis C. However, the presence of resistance‐associated substitutions (RAS) at baseline has... 
NS5A | resistance associated substitutions | direct‐acting antivirals | direct-acting antivirals | VIRUS-INFECTION | LEDIPASVIR-SOFOSBUVIR | SIMEPREVIR | COMBINATION | POLYMORPHISMS | VIROLOGY | DRUGS | GENOTYPE 1 INFECTION | HCV | MUTATIONS | Hepatitis C virus | Hepatitis C | Therapy | Liver | Viruses | Cures | Patients | Gene sequencing | Hepatitis | Inhibitors | Human immunodeficiency virus--HIV | Fibrosis | Genotypes
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2015, Volume 112, Issue 11, pp. 3511 - 3516
The incidence of multidrug-resistant bacterial infections is increasing globally and the need to understand the underlying mechanisms is paramount to discover... 
Efflux | Antimicrobial resistance | Whole genome sequencing | AcrB | MOLECULAR-DYNAMICS | ENTERICA SEROVAR TYPHIMURIUM | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | MULTIDRUG TRANSPORTER ACRB | efflux | CIPROFLOXACIN RESISTANCE | whole genome sequencing | EFFLUX PUMP | antimicrobial resistance | PSEUDOMONAS-AERUGINOSA | SALMONELLA-TYPHIMURIUM | STAPHYLOCOCCUS-AUREUS | MULTIPLE ANTIBIOTIC-RESISTANCE | Minocycline - pharmacology | Escherichia coli - drug effects | Humans | Salmonella enterica - genetics | Doxorubicin - chemistry | Microbial Sensitivity Tests | Salmonella enterica - drug effects | Membrane Transport Proteins - genetics | Water - chemistry | Salmonella enterica - isolation & purification | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | Doxorubicin - metabolism | Binding Sites | Genome, Bacterial | Bacterial Proteins - genetics | Ciprofloxacin - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Mutation - genetics | Genetic Fitness | Substrate Specificity - drug effects | Escherichia coli - genetics | Escherichia coli - isolation & purification | Escherichia coli Proteins - genetics | Polymorphism, Single Nucleotide - genetics | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - drug effects | Multidrug Resistance-Associated Proteins - metabolism | Amino Acid Substitution | Drug resistance in microorganisms | Usage | Gene mutations | Genetic aspects | Ciprofloxacin | Identification and classification | Health aspects | Biological Sciences
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2016, Volume 17, Issue 9, pp. 1416 - 1416
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 8818 - 12
To evaluate the effects of HCV NS5B amino acid substitutions on treatment outcome in Ledipasvir (LDV)/Sofosbuvir (SOF) for Japanese patients with genotype 1b... 
PROTEIN SIDE-CHAIN | BASE-LINE | RESISTANCE-ASSOCIATED VARIANTS | TREATMENT-NAIVE | DACLATASVIR/ASUNAPREVIR THERAPY | NONNUCLEOSIDE INHIBITOR | SOFOSBUVIR | MULTIDISCIPLINARY SCIENCES | POLYMERASE | MOLECULAR-DYNAMICS SIMULATIONS | JAPANESE PATIENTS
Journal Article
Journal of Clinical Virology, ISSN 1386-6532, 11/2019, Volume 120, pp. 84 - 87
Direct-acting antivirals (DAA) have revolutionised hepatitis C virus (HCV) treatment, and most regimens include an NS5A inhibitor. Certain amino-acid... 
Resistance associated substitutions | Resistance associated substitution | Hepatitis C | Virological relapse | C VIRUS-RESISTANCE | POLYMORPHISMS | VIROLOGY | ELBASVIR | RIBAVIRIN | COMBINATION | Antiviral agents | Genetic aspects | Hepatitis C virus | Health aspects
Journal Article
Journal of Gastroenterology, ISSN 0944-1174, 7/2017, Volume 52, Issue 7, pp. 855 - 867
Journal Article
by Lu, J and Feng, YP and Chen, LC and Zeng, ZY and Liu, XL and Cai, W and Wang, H and Guo, XL and Zhou, HJ and Tao, WY and Xie, Q
FRONTIERS IN MICROBIOLOGY, ISSN 1664-302X, 03/2019, Volume 10, p. 535
Resistance associated substitutions (RASs) can reduce the efficacy of direct-acting antiviral agents (DAAs) targeting hepatitis C virus (HCV) and lead to... 
POPULATION | resistance associated substitutions | MICROBIOLOGY | HCV INFECTION | direct-acting antivirals | prevalence | POLYMORPHISMS | NS5A | GENOTYPE 1B | HCV | DACLATASVIR | AGENTS | GLOBAL EPIDEMIOLOGY | INHIBITOR
Journal Article
Viruses, ISSN 1999-4915, 02/2019, Volume 11, Issue 2, p. 148
Background: Little is known about the frequency or geographic distributions of naturally occurring resistance-associated substitutions (RASs) in the... 
geographic distribution | resistance-associated substitutions (RASs) | natural polymorphisms | NS5A replication complex inhibitors | HCV genotype 3 subtypes | SOFOSBUVIR | VELPATASVIR | VIROLOGY | HEPATITIS-C VIRUS | NS5A | GENOTYPE 3 | HCV | INFECTION | GLOBAL EPIDEMIOLOGY | ANTIVIRAL DRUGS
Journal Article
Microbial Pathogenesis, ISSN 0882-4010, 11/2019, Volume 136, p. 103694
The backbone of current treatment for chronic Hepatitis C virus (HCV) infection are direct-acting antivirals targeting viral nonstructural proteins (NS3, NS4A,... 
Genotype 1 | Hepatitis C virus | Resistance-associated substitutions | Population-based sequencing | Direct-acting antivirals | VARIANTS | SUBTYPES | MICROBIOLOGY | MECHANISMS | PREVALENCE | IMMUNOLOGY | POLYMORPHISMS | INHIBITORS | TREATMENT-NAIVE PATIENTS | EPIDEMIOLOGY
Journal Article