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Journal of Molecular Biology, ISSN 0022-2836, 05/2019, Volume 431, Issue 10, pp. 1981 - 1992
Interactions between mutations play a central role in shaping the fitness landscape, but a clear picture of intragenic epistasis has yet to emerge. To further... 
antibiotic resistance protein | fitness landscapes | epistasis | protein evolution
Journal Article
Chinese Journal of Cancer, ISSN 1000-467X, 2012, Volume 31, Issue 2, pp. 58 - 72
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2013, Volume 56, Issue 1, pp. 2 - 12
This Perspective provides important concepts about the blood-brain barrier (BBB) in drug discovery and how they should be applied effectively in designing... 
CHEMISTRY, MEDICINAL | POSITRON-EMISSION-TOMOGRAPHY | PERMEABILITY ASSAY | IN-VIVO | LEAD OPTIMIZATION | UNBOUND CONCENTRATION | P-GLYCOPROTEIN EXPRESSION | RECEPTOR OCCUPANCY | PERFUSION TECHNIQUE | CACO-2 CELLS | CANCER RESISTANCE PROTEIN
Journal Article
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 06/2015, Volume 56, Issue 6, pp. 1085 - 1099
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 10/2019, Volume 108, Issue 10, pp. 3434 - 3442
Small-molecule tyrosine kinase inhibitors (TKIs) are novel anticancer agents with enhanced selectivity and superior safety profiles than conventional... 
tyrosine kinase inhibitors | P-glycoprotein | pharmacokinetics | combination therapy | breast cancer resistance protein | efflux pumps
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2019, Volume 62, Issue 6, pp. 3122 - 3134
Imatinib mesylate, la, inhibits production of beta-amyloid (A beta) peptides both in cells and in animal models. It reduces both the beta-secretase and... 
SECRETASE | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | INHIBITORS | MODEL | IMATINIB MESYLATE | BRAIN | CANCER RESISTANCE PROTEIN | ABCG2
Journal Article
11/2012
Mother's milk provides multiple benefits to the offspring. However, xenobiotics transferred into breast milk may pose a risk to the nursing infant. The breast... 
Toxicology | Lactation | Cimetidine | Riboflavin | 0383 | Pharmacology | Breast cancer resistance protein (BCRP) | 0419 | Mammary Gland | Riboflavin transporters | Breast milk
Dissertation
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2015, Volume 58, Issue 6, pp. 2584 - 2608
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 03/2013, Volume 344, Issue 3, pp. 655 - 664
Brain metastases are a common cause of death in stage IV metastatic melanoma. Dabrafenib is a BRAF (gene encoding serine/threonine-protein kinase B-Raf)... 
BREAST-CANCER | SURVIVAL | EFFLUX | TRANSPORTERS | PHARMACOLOGY & PHARMACY | OPEN-LABEL | P-GLYCOPROTEIN ABCB1 | CANCER RESISTANCE PROTEIN | PHASE-2 TRIAL | VEMURAFENIB | ABCG2
Journal Article
Cancers, ISSN 2072-6694, 09/2019, Volume 11, Issue 9, p. 1330
Our recent publications showed that multidrug resistance protein 2 (MRP2, encoded by the ABCC2 gene) conferred oxaliplatin resistance in human liver cancer... 
multidrug resistance protein 2 (MRP2) | oxaliplatin | gastrointestinal cancer
Journal Article
BLOOD, ISSN 0006-4971, 07/2006, Volume 108, Issue 2, pp. 697 - 704
Intrinsic sensitivity of newly diagnosed chronic myeloid leukemia (CML) patients to imatinib (IC50(imatinib)) correlates with molecular response. IC50imatinib... 
CHRONIC MYELOGENOUS LEUKEMIA | ORGANIC CATION TRANSPORTERS | ABCG2 BCRP | TYROSINE KINASE | BCR-ABL | P-GLYCOPROTEIN EXPRESSION | FUNCTIONAL-CHARACTERIZATION | MULTIDRUG-RESISTANCE | HEMATOLOGY | CHRONIC MYELOID-LEUKEMIA | CANCER RESISTANCE PROTEIN
Journal Article
Chemical Reviews, ISSN 0009-2665, 04/2017, Volume 117, Issue 8, pp. 5704 - 5783
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 03/2010, Volume 9, Issue 3, pp. 215 - 236
Journal Article