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Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 06/2019, Volume 105, Issue 6, pp. 1501 - 1512
This study investigated the impact of SLCO1B1 genotype on pravastatin systemic exposure in children and adolescents with hypercholesterolemia. Participants... 
PHARMACOKINETIC INTERACTION | ANION TRANSPORTING POLYPEPTIDE | FAMILIAL HYPERCHOLESTEROLEMIA | COA REDUCTASE INHIBITORS | CARDIAC TRANSPLANT RECIPIENTS | STATIN THERAPY | DRUG-INTERACTIONS | PHARMACOLOGY & PHARMACY | RESTORES ENDOTHELIAL FUNCTION | SIMVASTATIN | OATP-C
Journal Article
Journal Article
TRENDS IN PHARMACOLOGICAL SCIENCES, ISSN 0165-6147, 01/2009, Volume 30, Issue 1, pp. 48 - 54
Tetrahydrobiopterin (BH4) is an essential cofactor required for the activity of endothelial nitric oxide (NO) synthase. Suboptimal concentrations of BH4 in the... 
OXIDATIVE STRESS | DEPENDENT VASODILATION | SUPEROXIDE-PRODUCTION | NITRIC-OXIDE SYNTHASE | TETRAHYDROBIOPTERIN SYNTHESIS | GTP-CYCLOHYDROLASE-I | PHARMACOLOGY & PHARMACY | RESTORES ENDOTHELIAL FUNCTION | DOSE FOLIC-ACID | ASCORBIC-ACID | CORONARY-ARTERY-DISEASE
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 2014, Volume 13, Issue 6, pp. 445 - 464
Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol (HDL-C) are inversely associated with cardiovascular outcome, it... 
CHOLESTERYL-ESTER-TRANSFER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ANTISENSE OLIGONUCLEOTIDE INHIBITION | TRANSFER PROTEIN CETP | PHARMACOLOGY & PHARMACY | RESTORES ENDOTHELIAL FUNCTION | APOA-I | CORONARY-HEART-DISEASE | PRE-BETA | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-A-I | ARTERY-DISEASE | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Recombinant Proteins - therapeutic use | Drugs, Investigational - adverse effects | Lipoproteins, HDL - agonists | Hypolipidemic Agents - metabolism | Lipoproteins, HDL - blood | Cardiovascular Diseases - prevention & control | Humans | Lipoproteins, HDL - metabolism | Drugs, Investigational - therapeutic use | Drugs, Investigational - metabolism | Recombinant Proteins - adverse effects | Phosphatidylcholine-Sterol O-Acyltransferase - genetics | Apolipoprotein A-I - genetics | Niacin - therapeutic use | Cardiovascular Diseases - blood | Lipoproteins, HDL - therapeutic use | Niacin - adverse effects | Recombinant Proteins - metabolism | Hypolipidemic Agents - adverse effects | Molecular Targeted Therapy - adverse effects | Cardiovascular Diseases - metabolism | Clinical Trials as Topic | Apolipoprotein A-I - metabolism | Apolipoprotein A-I - agonists | Niacin - metabolism | Up-Regulation - drug effects | Phosphatidylcholine-Sterol O-Acyltransferase - adverse effects | Animals | Models, Biological | Phosphatidylcholine-Sterol O-Acyltransferase - therapeutic use | Hypolipidemic Agents - therapeutic use | Cholesterol Ester Transfer Proteins - metabolism | Phosphatidylcholine-Sterol O-Acyltransferase - metabolism | Care and treatment | High density lipoproteins | Patient outcomes | Development and progression | Research | Cardiovascular diseases | Risk factors
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 12/2010, Volume 17, Issue 34, pp. 4256 - 4269
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 02/2018, Volume 820, pp. 130 - 137
It has been reported that metformin reduces blood pressure although the mechanisms have not been described. Indeed, several mechanisms could be implicated... 
LIPID-METABOLISM | Cardiovascular | AORTA | RESTORES ENDOTHELIAL FUNCTION | SYMPATHETIC OUTFLOW | Hypotension | REDUCES BLOOD-PRESSURE | GLUCOSE | alpha(1/2)-adrenoceptors | PHARMACOLOGY & PHARMACY | Blood pressure | Metformin | HYPERTENSION
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2009, Volume 53, Issue 11, pp. 962 - 971
Journal Article
Circulation, ISSN 0009-7322, 04/2009, Volume 119, Issue 15, pp. 2103 - U134
Background-Low plasma high-density lipoprotein (HDL) is associated with elevated cardiovascular risk and aspects of the metabolic syndrome. We hypothesized... 
glucose | APOLIPOPROTEIN AL | ACTIVATED PROTEIN-KINASE | insulin | RESTORES ENDOTHELIAL FUNCTION | RANDOMIZED CONTROLLED-TRIAL | HUMAN SKELETAL-MUSCLE | muscles | FATTY-ACID OXIDATION | CORONARY ATHEROSCLEROSIS | HYPERCHOLESTEROLEMIC MEN | INSULIN-RESISTANCE | metabolism | NO SYNTHASE | lipoproteins | Muscles | Lipoproteins | Glucose | Metabolism | Insulin | CARDIAC & CARDIOVASCULAR SYSTEMS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Apolipoprotein A-I - pharmacology | Islets of Langerhans - drug effects | AMP-Activated Protein Kinases - metabolism | Humans | Middle Aged | Muscle Cells - drug effects | Male | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | ATP-Binding Cassette Transporters - physiology | Apolipoprotein A-I - therapeutic use | Lipoproteins, HDL - pharmacology | Islets of Langerhans - metabolism | Lipoproteins, HDL - therapeutic use | Female | ATP Binding Cassette Transporter 1 | Fatty Acids - metabolism | Insulin Secretion | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Insulin - pharmacology | Lipoproteins, HDL - administration & dosage | Cells, Cultured - drug effects | Double-Blind Method | Muscle Cells - metabolism | Lipoproteins, LDL - pharmacology | Phenformin - pharmacology | Cross-Over Studies | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Animals | Signal Transduction - drug effects | Calcium Signaling - drug effects | Glucose - metabolism | Cells, Cultured - metabolism | Mice | Infusions, Intravenous | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Glucose metabolism | High density lipoproteins | Physiological aspects | Development and progression | Research | Protein kinases
Journal Article