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Molecular Vision, ISSN 1090-0535, 09/2016, Volume 22, pp. 1077 - 1094
Purpose: The generation of three-dimensional (3D) organoids with optic cup-like structures from pluripotent stem cells has created opportunities for... 
MORPHOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OPHTHALMOLOGY | NRL | GENE-THERAPY | GENERATION | MICE | PRECURSORS | CULTURE | EXPRESSION | TRANSPLANTATION | RETINOGENESIS
Journal Article
Nature protocols, ISSN 1754-2189, 10/2016, Volume 11, Issue 10, pp. 1955 - 1976
Postmitotic differentiated neurons are among the most difficult cells to reprogram into induced pluripotent stem cells (iPSCs) because they have poor viability... 
reprogramming | STEM-RET | 3D culture | induced pluripotent stem cell | retinal differentiation | Retina | retinal development | retinogenesis
Journal Article
Neuron, ISSN 0896-6273, 05/2017, Volume 94, Issue 3, pp. 550 - 568.e10
In the developing retina, multipotent neural progenitors undergo unidirectional differentiation in a precise spatiotemporal order. Here we profile the... 
iPSCs | retinoblastoma | rod photoreceptors | DNA methylation | retinal development | epigenetics | epigenetic memory | TRANSCRIPTION FACTORS | SEQ REVEALS | RETINOBLASTOMA | SUPER-ENHANCERS | CHROMATIN | DNA | CELL IDENTITY | GENE-EXPRESSION | DIFFERENTIATION | CANCER | NEUROSCIENCES | Retina - metabolism | Retinoblastoma - genetics | Animals, Genetically Modified | Epigenesis, Genetic | Humans | Carcinogenesis - genetics | Mouse Embryonic Stem Cells - cytology | DNA Methylation - genetics | Retina - embryology | Mouse Embryonic Stem Cells - metabolism | Cell Differentiation - genetics | Animals | Retinoblastoma Protein - genetics | Retinal Rod Photoreceptor Cells - cytology | Mice | Induced Pluripotent Stem Cells - cytology | Cellular Reprogramming - genetics | Histone Code - genetics | Disease Models, Animal | Induced Pluripotent Stem Cells - metabolism | Cytogenetics | Epigenetic inheritance | Stem cells | Neurophysiology | Tumors | Analysis | Genomics | Methylation | Brain | Transcription factors | Regulators | Adrenal glands | Central nervous system | Retina | Rods | Nuclei | Proteins | Bone growth | Developmental stages | Biocompatibility | Bioinformatics | Deoxyribonucleic acid--DNA | Gene expression | Embryos | Retinogenesis | Studies | Gene silencing | Amacrine cells | Neural stem cells | Genes | Genomes | Neurogenesis | Biomedical materials | Cell cycle | Children | Assemblies | Adolescents | Origins | Data analysis | Nucleotide sequence | Neurons | Sympathetic nervous system | Clustering | Ribonucleic acid--RNA | Computer programs | Dynamic tests | Cell death | Cells (biology) | Epigenetics | Photoreceptors | Differentiation | Pluripotency | Cancer | Inhibitory postsynaptic potentials
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2019, Volume 166, Issue 22, pp. 10824 - 10833
Rod and cone photoreceptors are light-sensing cells in the human retina. Rods are dominant in the peripheral retina, whereas cones are enriched in the macula,... 
Retinal differentiation | Single cell | Cone and rod photoreceptor | Retinal organoid | RNA-seq | AMACRINE CELLS | ROD | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | retinal differentiation | ISOFORM | INNER SEGMENT | single cell | retinal organoid | cone and rod photoreceptor | GENE-EXPRESSION | NEURAL RETINA | CHANNELS | REEP6 | PHOTORECEPTORS | Organoids - physiology | Cell Line | Retina - metabolism | Humans | Organoids - chemistry | RNA, Messenger - genetics | Organoids - cytology | Retinal Cone Photoreceptor Cells - physiology | RNA, Messenger - analysis | Transcriptome - genetics | RNA, Messenger - metabolism | Retina - chemistry | Retina - physiology | Retina - cytology | Organoids - metabolism | Retinal Cone Photoreceptor Cells - chemistry | Retinal Cone Photoreceptor Cells - cytology | Embryonic Stem Cells | Single-Cell Analysis | Cell Differentiation - physiology | Retinal Cone Photoreceptor Cells - metabolism | Macular degeneration | RNA | Cell differentiation | Genes | Self assembly | Cell culture | Alternative splicing | Profiling | Epithelial cells | Differentiation (biology) | Retina | Rods | Gene sequencing | Acuity | Cell fate | Organoids | Extracellular matrix | Splicing | Retinal cells | Visual acuity | Ribonucleic acid--RNA | Electron microscopy | Gene expression | Epithelium | Progenitor cells | Retinogenesis | Cysts | Cones | Microscopy | Vision | Stem cells | Cells (biology) | Neural stem cells | Photoreceptors | Biological Sciences | PNAS Plus
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 08/2018, Volume 59, Issue 10, pp. 3869 - 3878
Journal Article
Molecular Therapy, ISSN 1525-0016, 03/2017, Volume 25, Issue 3, pp. 634 - 653
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 6823 - 13
The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling... 
PLURIPOTENT STEM-CELLS | TRANSCRIPTION FACTORS | SONIC HEDGEHOG | EMBRYONIC MOUSE RETINA | COMPETENCE STATE | MATH5 | MULTIDISCIPLINARY SCIENCES | NEUROGENESIS | DIFFERENTIATION | MAMMALIAN RETINA | ZEBRAFISH RETINA | Retinal ganglion cells | Territory | Organoids | Cell death | Stem cells | Cell cycle | Retina | Photoreceptors | Superior colliculus | Helix-loop-helix proteins | Retinogenesis
Journal Article