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Journal Article
Journal Article
Cell, ISSN 0092-8674, 06/2019, Volume 178, Issue 1, pp. 152 - 159.e11
Intrinsic and acquired drug resistance and induction of secondary malignancies limit successful chemotherapy. Because mutagenic translesion synthesis (TLS)... 
REV7 | chemoresistance | REV1 | cisplatin | chemotherapy | translesion synthesis | POL ζ | COMPLEX | REPAIR | DNA-POLYMERASE DELTA | RECOGNITION | CISPLATIN | POL-ZETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | INHIBITOR | ACCESSORY SUBUNITS | CELL BIOLOGY | DNA polymerases | Development and progression | Chemotherapy | Drug resistance | Melanoma | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 16, pp. 12299 - 12307
DNA polymerase ζ (Polζ) is an error-prone DNA polymerase involved in translesion DNA synthesis. Polζ consists of two subunits: the catalytic REV3, which... 
Protein Structure and Folding | Crystal Structure | DNA and Chromosomes | DNA Polymerase ζ | REV7 | X-ray Crystallography | REV3 | REV1 | DNA Replication | Protein Structure | Translesion DNA Synthesis | Protein-Protein Interactions
Journal Article
EMBO reports, ISSN 1469-221X, 05/2019, Volume 20, Issue 5, p. n/a
Journal Article
Nature, ISSN 0028-0836, 08/2018, Volume 560, Issue 7716, pp. 122 - 127
53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1... 
CELLS | REV7 | RESECTION | TRANSLOCATIONS | POL-ZETA | MULTIDISCIPLINARY SCIENCES | BRCA1 DEFICIENCY | CLASS-SWITCH RECOMBINATION | MECHANISMS | POLYMERASE-ZETA | GENE-FUNCTION | Mad2 Proteins - metabolism | Humans | Male | Tumor Suppressor p53-Binding Protein 1 - deficiency | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | DNA End-Joining Repair | Female | Mad2 Proteins - deficiency | Tumor Suppressor p53-Binding Protein 1 - metabolism | Cell Line | DNA, Single-Stranded - metabolism | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | DNA - metabolism | DNA, Single-Stranded - chemistry | V(D)J Recombination - genetics | DNA - chemistry | Multiprotein Complexes - chemistry | Animals | Mad2 Proteins - genetics | Mice | Mutation | Immunoglobulin Class Switching - genetics | Genetic research | Genetic recombination | Recombinant proteins | Analysis | DNA structure | Chromatin | Animal models | Single-stranded DNA | DNA damage | Homology | DNA repair | Genomic instability | Proteins | Immunology | Lymphocytes | Cooperation | Bone marrow | Tumorigenesis | Repair | Deoxyribonucleic acid--DNA | Stability | V(D)J recombination | Immunodeficiency | Crosslinking | Double-strand break repair | Substrates | Class switching | Telomeres | Non-homologous end joining | Instability | Tumors
Journal Article
by Zhang, H and He, XQ and Yu, WF and Yue, BQ and Yu, ZT and Qin, Y
ONCOLOGY RESEARCH, ISSN 0965-0407, 2019, Volume 27, Issue 8, pp. 859 - 869
As the noncatalytic subunit of mammalian DNA polymerase, mitotic arrest-deficient protein 2B (MAD2B) has been reported to play a role in cell cycle regulation,... 
CELLS | COMPLEX | STATISTICS | Lung cancer | Slug | MESENCHYMAL TRANSITION | CUL4A | ADHESION | Epithelial-mesenchymal transition (EMT) | REV7 | DNA-POLYMERASE-ZETA | ONCOLOGY | MAD2B | ADENOMAS
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/2018, Volume 37, Issue 18, p. n/a
Journal Article
by Bhat, A and Qin, ZS and Wang, GF and Chen, WY and Xiao, W
FEBS JOURNAL, ISSN 1742-464X, 06/2017, Volume 284, Issue 12, pp. 1790 - 1803
In eukaryotic cells, Rev7 interacts with Rev3 and functions as a regulatory subunit of Pol zeta, a translesion DNA synthesis (TLS) polymerase. In addition to... 
translesion DNA synthesis | PCNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSLESION SYNTHESIS | DNA-SYNTHESIS | NUCLEOTIDE EXCISION-REPAIR | XPC PROTEIN | Rev7 | ubiquitination | UBIQUITYLATION | S-PHASE | Cul4 | HPOL-ZETA | nucleotide excision repair | POLYMERASE-ZETA | LIGASE
Journal Article
Cancer Science, ISSN 1347-9032, 03/2019, Volume 110, Issue 3, pp. 962 - 972
Radiotherapy has been widely used for the clinical management of esophageal squamous cell carcinoma. However, radioresistance remains a serious concern that... 
PRDX2 | REV7 | DNA double‐strand breaks | radioresistance | reactive oxygen species | DNA double-strand breaks | PROTEIN | PEROXIREDOXIN | CHEMORADIOTHERAPY | KINASE INHIBITOR | RADIATION | DAMAGE | INACTIVATION | BREAST-CANCER CELLS | DNA-POLYMERASE-ZETA | ONCOLOGY | EXPRESSION | Proteins | Squamous cell carcinoma | DNA damage | Analysis | Cells | Esophageal cancer | Original
Journal Article
DNA Repair, ISSN 1568-7864, 2008, Volume 7, Issue 4, pp. 597 - 604
Translesion synthesis (TLS) refers to mechanisms by which specialized DNA polymerases incorporate nucleotides opposite fork-blocking lesions and extend... 
Rev7 | Ultraviolet radiation | Polymerase zeta | MAD2B | Translesion synthesis | Rev3
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2015, Volume 34, Issue 12, pp. 1609 - 1611
REV7/MAD2L2 plays important roles in translesion DNA synthesis and mitotic control. Two new papers extend its gamut by revealing its unexpected participation... 
REV7 | REPAIR | RESECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA BREAKS | CELL BIOLOGY | Recombinational DNA Repair | Animals | Mad2 Proteins - metabolism | DNA End-Joining Repair | Humans | Telomere - metabolism | DNA Breaks, Double-Stranded | Poly(ADP-ribose) Polymerase Inhibitors | Cell division | Chemotherapy | Drug resistance | DNA repair | Tumors | Have You Seen?
Journal Article
by Ye, J and Chu, T and Li, R and Niu, Y and Jin, B and Xia, J and Shao, M and Han, B
Neoplasma, ISSN 0028-2685, 2015, Volume 62, Issue 5, pp. 833 - 839
Lung cancer is the greatest contributor to tumor-derived death. Traditionally, platinum-based chemotherapies are the primary treatment for most patients.... 
Pol ζ | REV7 | Toxicity | Translesion synthesis | REV3 | Platinum-based chemotherapies
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2016, Volume 24, Issue 18, pp. 4339 - 4346
Journal Article