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Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 37, pp. 15205 - 15215
Transcriptional activation of the human telomerase reverse transcriptase (hTERT) gene, which remains repressed in adult somatic cells, is critical during... 
CELLS | ACTIVATION | NM23-H2 | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | TRANSCRIPTION | GENE-EXPRESSION | HUMAN CANCERS | PROMOTER | GENOME | Epigenetic Repression | Humans | Protein Multimerization | Neoplasm Proteins - antagonists & inhibitors | Fibrosarcoma - metabolism | Neoplasm Proteins - metabolism | NM23 Nucleoside Diphosphate Kinases - genetics | NM23 Nucleoside Diphosphate Kinases - metabolism | Repressor Proteins - antagonists & inhibitors | Fibrosarcoma - pathology | Telomerase - genetics | Chromatin Immunoprecipitation | RNA Interference | Carcinoma - enzymology | G-Quadruplexes | Telomerase - metabolism | Carcinoma - pathology | Neoplasm Proteins - genetics | Genes, Reporter | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | NM23 Nucleoside Diphosphate Kinases - chemistry | Promoter Regions, Genetic | Repressor Proteins - chemistry | Mutagenesis, Site-Directed | Histone Demethylases - chemistry | NM23 Nucleoside Diphosphate Kinases - antagonists & inhibitors | Cells, Cultured | Recombinant Proteins - chemistry | Repressor Proteins - genetics | Neoplasm Proteins - chemistry | Histone Demethylases - metabolism | Point Mutation | Cell Line, Tumor | Carcinoma - metabolism | Telomerase - antagonists & inhibitors | Fibrosarcoma - enzymology | Amino Acid Substitution | Gene Regulation | transcription regulation | chromatin modification | G-quadruplex | telomerase reverse transcriptase (TERT) | NME2 | REST repressor complex | epigenetics
Journal Article
Medicine, ISSN 0025-7974, 08/2018, Volume 97, Issue 35, p. e11794
Journal Article
Journal of Bioscience and Bioengineering, ISSN 1389-1723, 03/2015, Volume 119, Issue 3, pp. 351 - 357
Cordycepin is an adenosine analog originally extracted from that possesses many pharmacological effects including immune activation and antioxidant and... 
Phosphoinositide-3-kinase/Akt | Telomerase | Cordycepin | Apoptosis | Human telomerase reverse transcriptase | PROTEIN | PHOSPHORYLATION | FOOD SCIENCE & TECHNOLOGY | TRANSCRIPTION | DOWN-REGULATION | ALPHA | BREAST-CANCER CELLS | INHIBITION | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TELOMERASE ACTIVITY | NF-KAPPA-B | Transcription, Genetic - drug effects | Leukemia - pathology | Apoptosis - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Nucleus - metabolism | Telomerase - genetics | Telomerase - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Leukemia - genetics | Cordyceps - chemistry | Leukemia - enzymology | Adenosine - pharmacology | Down-Regulation - drug effects | Telomerase - biosynthesis | Signal Transduction - drug effects | Sp1 Transcription Factor - genetics | Active Transport, Cell Nucleus - drug effects | Adenosine - analogs & derivatives | Cell Line, Tumor | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-myc - genetics | Telomerase - antagonists & inhibitors | Transcription, Genetic - genetics | Cell Nucleus - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Antioxidants | International trade | Pharmacy | Leukemia | Drugstores | Marine biology | International economic relations | Acupuncture | Exports | Medical colleges | DNA binding proteins | Genetic transcription
Journal Article
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 6/2011, Volume 60, Issue 6, pp. 809 - 818
Immunotherapy targeting the hTERT subunit of telomerase has been shown to induce robust immune responses in cancer patients after vaccination with single hTERT... 
Immunology | Medicine & Public Health | Epitope identification | Pancreas cancer | Cancer Research | Oncology | Telomerase (hTERT) | Dendritic cell vaccination | CD8(+) | PHASE-I/II | INDUCTION | IMMUNOLOGY | IDENTIFICATION | TUMOR-ANTIGEN | MELANOMA | ONCOLOGY | GENERATION | TELOMERASE PEPTIDE VACCINATION | T-CELLS | CROSS-PRESENTATION | Cell Growth Processes - immunology | RNA, Messenger - immunology | Dendritic Cells - immunology | Humans | Middle Aged | Telomerase - immunology | Carcinoma, Pancreatic Ductal - genetics | Cancer Vaccines - genetics | Epitopes - immunology | Cancer Vaccines - therapeutic use | Telomerase - genetics | Transfection | Female | Carcinoma, Pancreatic Ductal - immunology | T-Lymphocytes, Cytotoxic - immunology | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - therapy | Epitopes - genetics | Carcinoma, Pancreatic Ductal - pathology | Cancer Vaccines - immunology | T-Lymphocytes, Cytotoxic - metabolism | Pancreatic Neoplasms - immunology | Cell Line, Tumor | Pancreatic Neoplasms - therapy | Care and treatment | Peptides | Dendritic cells | Vaccination | Oncology, Experimental | Research | T cells | Pets | Chemotherapy | Messenger RNA | Analysis | Pancreatic cancer | Telomerase | Antigenic determinants | Cancer | Adenocarcinoma | Immune response | Cytotoxicity | Lymphocytes T | mRNA | Epitopes | Vaccines | Radicals | Computed tomography | Immunotherapy | Surgery | Remission | gemcitabine | telomerase reverse transcriptase | Neutropenia | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7, p. e11457
Background: Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is a common dietary component that has histone deacetylase inhibition... 
APOPTOSIS | HISTONE DEACETYLASE INHIBITOR | DNA METHYLATION | ACETYLATION | MULTIDISCIPLINARY SCIENCES | GROWTH | GENE-EXPRESSION | PROMOTER | TELOMERASE REVERSE-TRANSCRIPTASE | MODULATION | TRICHOSTATIN | Humans | Apoptosis - genetics | Promoter Regions, Genetic - genetics | DNA (Cytosine-5-)-Methyltransferases - metabolism | Repressor Proteins - physiology | DNA Methylation | Telomerase - genetics | Chromatin Immunoprecipitation | Female | Telomerase - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Isothiocyanates | Gene Expression Regulation, Neoplastic - genetics | Thiocyanates - therapeutic use | DNA (Cytosine-5-)-Methyltransferase 1 | Electrophoresis, Polyacrylamide Gel | Repressor Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Breast Neoplasms - prevention & control | DNA (Cytosine-5-)-Methyltransferases - genetics | Acetylation - drug effects | Breast Neoplasms - genetics | CCCTC-Binding Factor | Cell Line, Tumor | Cell Proliferation - drug effects | RNA, Small Interfering | Apoptosis - physiology | Prevention | Epigenetic inheritance | Chromatin | Vegetables | Methyltransferases | RNA | Analysis | Genes | Breast cancer | Telomerase | Protein binding | Cancer | Cell proliferation | Histone deacetylase | Regulations | Telomerase reverse transcriptase | Immunoprecipitation | RNA-directed DNA polymerase | Transcription | Disease | Leukemia | Gene regulation | Colorectal cancer | Biology | Proteins | Demethylation | Penicillin | Cell cycle | DNA methylation | Tumorigenesis | Inhibition | Catalysis | Deoxyribonucleic acid--DNA | CpG islands | Sulforafan | Binding | Markers | DNMT1 protein | Isothiocyanate | siRNA | Tumor cell lines | Low level | Studies | Diet | Epigenetics | Breast | Viability | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e97114
Journal Article