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1. Full Text Treatment outcomes of integrase inhibitors, boosted protease inhibitors and nonnucleoside reverse transcriptase inhibitors in antiretroviral‐naïve persons starting treatment
by Mocroft, A and Neesgard, B and Zangerle, R and Rieger, A and Castagna, A and Spagnuolo, V and Antinori, A and Lampe, FC and Youle, M and Vehreschild, JJ and Mussini, C and Borghi, V and Begovac, J and Duvivier, C and Gunthard, HF and Rauch, A and Tiraboschi, J and Chkhartishvili, N and Bolokadze, N and Wit, F and Wasmuth, JC and De Wit, S and Necsoi, C and Pradier, C and Svedhem, V and Stephan, C and Petoumenos, K and Garges, H and Rogatto, F and Peters, L and Ryom, L and RESPOND Study Grp and the RESPOND study group
HIV medicine, ISSN 1464-2662, 10/2020, Volume 21, Issue 9, pp. 599 - 606
protease inhibitors | integrase inhibitors | antiretroviral naïve | nonnucleoside reverse transcriptase inhibitors | Life Sciences & Biomedicine | Infectious Diseases | Science & Technology | Integrase | Subpopulations | RNA-directed DNA polymerase | Health services | Clinical trials | Proteinase inhibitors | Ribonucleic acid--RNA | Success | Antiretroviral therapy | CD4 antigen | Consortia | Infectious diseases | Immunology | Non-nucleoside reverse transcriptase inhibitors | Protease inhibitors | Acquired immune deficiency syndrome--AIDS | Protease | Antiretroviral agents | Human immunodeficiency virus--HIV | Age | Index Medicus
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2. Full Text Cancer risk and use of protease inhibitor or nonnucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy: the D: A: D study
by Bruyand, Mathias and Ryom, Lene and Shepherd, Leah and Fatkenheuer, Gerd and Grulich, Anew and Reiss, Peter and de Wit, Stéphane and D Arminio Monforte, Antonella and Furrer, Hansjakob and Pradier, Christian and Lundgren, Jens and Sabin, Caroline and Powderly, B and Shortman, N and Moecklinghoff, C and Reilly, G and Franquet, X and Ryom, L and Sabin, C. A and Kamara, D and Smith, C and Phillips, A and Mocroft, A and Tverland, J and Mansfeld, M and Nielsen, J and Raben, D and Lundgren, J. D and Salbøl Brandt, R and Rickenbach, M and Fanti, I and Krum, E and Prins, J. M and Kuijpers, T. W and Scherpbier, H. J and van der Meer, J. T. M and Wit, F. W. M. N and Godfried, M. H and van der Poll, T and Nellen, F. J. B and Lange, J. M. A and Geerlings, S. E and van Vugt, M and Pajkrt, D and Bos, J. C and van der Valk, M and Grijsen, M. L and Wiersinga, W. J and Goorhuis, A and Hovius, J. W. R and DAD Study Grp and D:A:D study group
Journal of acquired immune deficiency syndromes (1999), ISSN 1525-4135, 2015, Volume 68, Issue 5, pp. 568 - 577
no | cancer | risk | HIV | antiretroviral therapy | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Prospective Studies | Follow-Up Studies | Risk Assessment | Humans | Middle Aged | Antiretroviral Therapy, Highly Active - adverse effects | Male | Incidence | Reverse Transcriptase Inhibitors - adverse effects | Protease Inhibitors - adverse effects | Adult | Female | HIV Infections - drug therapy | Antiretroviral Therapy, Highly Active - methods | Neoplasms - epidemiology | Antiretroviral drugs | Regression analysis | Protease inhibitors | Risk assessment | Cancer | Index Medicus | AIDS/HIV
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3. Full Text Greater Tenofovir-Associated Renal Function Decline with Protease Inhibitor-Based versus Nonnucleoside Reverse-Transcriptase Inhibitor-Based Therapy
by Miguel Goicoechea and Shanshan Liu and Brookie Best and Shelly Sun and Sonia Jain and Carol Kemper and Mallory Witt and Catherine Diamond and Richard Haubrich and Stan Louie and California Collaborative Treatment Group 578 Team
The Journal of infectious diseases, ISSN 0022-1899, 1/2008, Volume 197, Issue 1, pp. 102 - 108
T lymphocytes | HIV/AIDS | Renal function | RNA | HIV | Renal clearance | Drug interactions | Drug design | Modeling | Nephrotoxicity | HIV 1 | HIV Protease Inhibitors - adverse effects | Adenine - analogs & derivatives | Prospective Studies | Kidney Tubules - drug effects | Humans | Middle Aged | Organophosphonates - adverse effects | Male | Nucleosides - adverse effects | Time | Reverse Transcriptase Inhibitors - classification | Reverse Transcriptase Inhibitors - adverse effects | Tenofovir | Glomerular Filtration Rate - drug effects | HIV Protease Inhibitors - classification | Adenine - adverse effects | Kidney Diseases - chemically induced | Adult | Female | HIV Infections - drug therapy | Drug Therapy, Combination | Index Medicus | Abridged Index Medicus
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4. Full Text Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs
by Himmel, Daniel M and Myshakina, Nataliya S and Ilina, Tatiana and Van Ry, Alexander and Ho, William C and Parniak, Michael A and Arnold, Eddy and Brookhaven National Laboratory (BNL)
Journal of molecular biology, ISSN 0022-2836, 07/2014, Volume 426, Issue 14, pp. 2617 - 2631
structure-based drug design | RNase H inhibitors | dihydroxybenzopyrone derivatives | HIV ribonuclease H | protein–inhibitor complex | protein-inhibitor complex | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Catalytic Domain | HIV Reverse Transcriptase - antagonists & inhibitors | Models, Molecular | Reverse Transcriptase Inhibitors - pharmacology | Structure-Activity Relationship | Reverse Transcriptase Inhibitors - chemistry | HIV Reverse Transcriptase - metabolism | Umbelliferones - metabolism | Protein Conformation | Molecular Docking Simulation | Reverse Transcriptase Inhibitors - metabolism | HIV Reverse Transcriptase - chemistry | Ribonuclease H - metabolism | DNA polymerases | Ribonuclease | Proteases | Drug approval | Analysis | Index Medicus | RNase H Inhibitors
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5. Full Text An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission
by Ugaonkar, Shweta R and Clark, Justin T and English, Lexie B and Johnson, Todd J and Buckheit, Karen W and Bahde, Robert J and Appella, Daniel H and Buckheit, Robert W and Kiser, Patrick F
Journal of pharmaceutical sciences, ISSN 0022-3549, 10/2015, Volume 104, Issue 10, pp. 3426 - 3439
epithelial delivery/permeability | HIV/AIDS | controlled release | physicochemical properties | polymeric drug delivery system | biocompatibility | mucosal drug delivery | extrusion | stability | preformulation | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | HIV Infections - prevention & control | HIV-1 - drug effects | Anti-HIV Agents - adverse effects | Humans | Solubility | Administration, Intravaginal | HIV-1 - genetics | Reverse Transcriptase Inhibitors - administration & dosage | Chemistry, Pharmaceutical | Drug Delivery Systems | Anti-HIV Agents - administration & dosage | Benzamides - administration & dosage | Benzamides - therapeutic use | Differential Thermal Analysis | Anti-HIV Agents - therapeutic use | Female | HIV Infections - transmission | Pyrimidinones - pharmacology | Pyrimidinones - administration & dosage | Reverse Transcriptase Inhibitors - therapeutic use | Benzamides - adverse effects | Delayed-Action Preparations | Organ Culture Techniques | Drugs | Antiviral agents | Drug delivery systems | Analysis | Pharmacists | HIV (Viruses) | Drug therapy | Health aspects | Vehicles | Index Medicus | epithelial delivery | HIV | permeability | AIDS
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6. Full Text Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naïve volunteers infected with HIV-1: A Randomized, controlled equivalence trial
by Lennox, Jeffrey L and Landovitz, Raphael J and Ribaudo, Heather J and Ofotokun, Ighovwerha and Na, Lumine H and Godfrey, Catherine and Kuritzkes, Daniel R and Sagar, Manish and Brown, Todd T and Cohn, Susan E and McComsey, Grace A and Aweeka, Francesca and Fichtenbaum, Carl J and Presti, Rachel M and Koletar, Susan L and Haas, David W and Patterson, Kristine B and Benson, Constance A and Baugh, Bryan P and Leavitt, Randi Y and Rooney, James F and Seekins, Daniel and Currier, Judith S and ACTG A5257 Team
Annals of internal medicine, ISSN 0003-4819, 10/2014, Volume 161, Issue 7, pp. 461 - 471
Darunavir | Humans | Male | Viral Load | Oligopeptides - therapeutic use | Tenofovir | Deoxycytidine - therapeutic use | Adenine - therapeutic use | HIV-1 - isolation & purification | Atazanavir Sulfate | Adult | Female | Drug Therapy, Combination | RNA, Viral - isolation & purification | Pyridines - therapeutic use | Emtricitabine | HIV Protease Inhibitors - adverse effects | Adenine - analogs & derivatives | Organophosphonates - therapeutic use | HIV-1 - genetics | HIV Protease Inhibitors - therapeutic use | Sulfonamides - therapeutic use | HIV Infections - drug therapy | Reverse Transcriptase Inhibitors | Deoxycytidine - analogs & derivatives | Drug Combinations | Therapeutic Equivalency | Reverse transcriptase inhibitors | Dosage and administration | Research | Drug therapy | HIV infection | Clinical trials | Antiretroviral drugs | Inhibitor drugs | Human immunodeficiency virus--HIV | Index Medicus | Abridged Index Medicus
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7. Full Text Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy
by Cantrell, Leigh A and Zhou, Chunxiao and Mendivil, Alberto and Malloy, Kimberly M and Gehrig, Paola A and Bae-Jump, Victoria L
Gynecologic oncology, ISSN 0090-8258, 2009, Volume 116, Issue 1, pp. 92 - 98
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | mTOR | Metformin | Endometrial cancer | Telomerase | Protein Kinases - metabolism | Apoptosis - drug effects | Cell Growth Processes - drug effects | Humans | Metformin - pharmacology | RNA, Messenger - genetics | Endometrial Neoplasms - metabolism | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Dose-Response Relationship, Drug | Telomerase - biosynthesis | Telomerase - genetics | Endometrial Neoplasms - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Endometrial Neoplasms - drug therapy | Endometrial Neoplasms - pathology | Female | TOR Serine-Threonine Kinases | Cell Cycle - drug effects | Prevention | Care and treatment | Diabetes | Cancer | Diabetes therapy | Index Medicus
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8. Full Text Nucleoside reverse transcriptase inhibitor-sparing regimen (nonnucleoside reverse transcriptase inhibitor + protease inhibitor) was more likely associated with resistance comparing to nonnucleoside reverse transcriptase inhibitor or protease inhibitor + nucleoside reverse transcriptase inhibitor in the randomized ANRS 121 trial
by Soulié, Cathia and Assoumou, Lambert and Ghosn, Jade and Duvivier, Claudine and Peytavin, Gilles and Ait-Arkoub, Zaina and Molina, Jean-Michel and Costagliola, Dominique and Katlama, Christine and Calvez, Vincent and Marcelin, Anne-Geneviève
AIDS (London), ISSN 0269-9370, 07/2009, Volume 23, Issue 12, pp. 1605 - 1608
Antiviral agents | Infectious diseases | Pharmacology. Drug treatments | Viral diseases | Viral diseases of the lymphoid tissue and the blood. Aids | Biological and medical sciences | Medical sciences | Human viral diseases | Antibiotics. Antiinfectious agents. Antiparasitic agents | HIV-1 - drug effects | HIV Infections - virology | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Drug Resistance, Viral | HIV-1 - genetics | HIV Protease Inhibitors - therapeutic use | Viral Load | HIV-1 - isolation & purification | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | Mutation | Reverse Transcriptase Inhibitors - therapeutic use | Antiretroviral Therapy, Highly Active - methods | Index Medicus | AIDS/HIV
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9. Full Text Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation
by Zhang, Pingzhao and Wang, Dejie and Zhao, Yu and Ren, Shancheng and Gao, Kun and Ye, Zhenqing and Wang, Shangqian and Pan, Chun-Wu and Zhu, Yasheng and Yan, Yuqian and Yang, Yinhui and Wu, Di and He, Yundong and Zhang, Jun and Lu, Daru and Liu, Xiuping and Yu, Long and Zhao, Shimin and Li, Yao and Lin, Dong and Wang, Yuzhuo and Wang, Liguo and Chen, Yu and Sun, Yinghao and Wang, Chenji and Huang, Haojie
Nature medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1055 - 1062
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Prostatic Neoplasms - metabolism | Immunoprecipitation | TOR Serine-Threonine Kinases - metabolism | Humans | Drug Resistance, Neoplasm | Male | Gene Expression Profiling | Molecular Targeted Therapy | Mechanistic Target of Rapamycin Complex 1 | Transcription Factors - drug effects | Multiprotein Complexes - metabolism | Prostatic Neoplasms - genetics | Proteasome Endopeptidase Complex - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Nuclear Proteins - drug effects | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | TOR Serine-Threonine Kinases - drug effects | Multiprotein Complexes - drug effects | Prostatic Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Triazoles - therapeutic use | Cell Survival | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Azepines - therapeutic use | RNA-Binding Proteins - drug effects | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Nuclear Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mutation | RNA-Binding Proteins - metabolism | rac1 GTP-Binding Protein - metabolism | Proto-Oncogene Proteins c-akt - drug effects | rac1 GTP-Binding Protein - genetics | Gene mutations | Physiological aspects | Genetic aspects | Research | Drug resistance | Drug therapy | Prostate cancer | Ubiquitin | Inhibitor drugs | Stabilization | AKT protein | Biosynthesis | Degradation | Proteins | Ubiquitination | Transcription activation | Ubiquitin-protein ligase | Binding | Rac1 protein | Guanosine triphosphatases | Tumor cell lines | Gene expression | Cholesterol | Mutants | Inhibitors | Proteasomes | Biomarkers | Bet protein | Prostate | Cancer | Index Medicus
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10. Full Text Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients
by Wyen, Christoph and Hendra, Heidy and Vogel, Martin and Hoffmann, Christian and Knechten, Heribert and Brockmeyer, Norbert H and Bogner, Johannes R and Rockstroh, Jürgen and Esser, Stefan and Jaeger, Hans and Harrer, Thomas and Mauss, Stefan and van Lunzen, Jan and Skoetz, Nicole and Jetter, Alexander and Groneuer, Christiane and Fätkenheuer, Gerd and Khoo, Saye H and Egan, Deirdre and Back, David J and Owen, Andrew and German Competence Network HIVAIDS and German Competence Network for HIV/AIDS and on behalf of the German Competence Network for HIV/AIDS
Journal of antimicrobial chemotherapy, ISSN 0305-7453, 4/2008, Volume 61, Issue 4, pp. 914 - 918