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Journal of pharmaceutical sciences, ISSN 0022-3549, 06/2019
Many challenges limit the formulation of antibodies as high-concentration liquid dosage forms including elevated solution viscosity, decreased physical... 
Journal Article
Journal of Chromatography A, ISSN 0021-9673, 10/2014, Volume 1362, pp. 186 - 193
Some monoclonal antibodies (mAbs) are reported to display concentration-dependent reversible self-association (RSA). There are multiple studies that... 
Peak splitting | Monoclonal antibody (mAb) | Mobile-phase modifier | Cation exchange chromatography (CEX) | Reversible self-association (RSA) | CHEMISTRY, ANALYTICAL | STABILITY | BIOCHEMICAL RESEARCH METHODS | ARGININE | TRENDS | Monoclonal antibodies | Chromatography
Journal Article
Journal of pharmaceutical sciences, ISSN 0022-3549, 06/2019
In this work, we continue to examine excipient effects on the reversible self-association (RSA) of 2 different IgG1 monoclonal antibodies (mAb-J and mAb-C). We... 
Journal Article
mAbs, ISSN 1942-0862, 05/2015, Volume 7, Issue 3, pp. 525 - 539
There is a need for new analytical approaches to better characterize the nature of the concentration-dependent, reversible self-association (RSA) of monoclonal... 
flexibility | hydrogen exchange | reversible self-association | immunoglobulin G1 | mass spectrometry | aggregation | monoclonal antibody | high protein concentration | stability | protein-protein interactions | Aggregation | Reversible self-association | Stability | High protein concentration | Hydrogen exchange | Monoclonal antibody | Flexibility | Mass spectrometry | Protein-protein interactions | Immunoglobulin G1 | MEDICINE, RESEARCH & EXPERIMENTAL | HIGH-THROUGHPUT ANALYSIS | Fc, crystallizable fragment | mAb, monoclonal antibody | RSA, reversible self-association | IgG1, immunoglobulin G1 | SEC, size-exclusion chromatography | CONFORMATIONAL-CHANGES | BsAbs, bispecific antibodies | BSG, bis (sulfosuccinimidyl) 2,2,4,4 glutarate | ADCs, antibody-drug conjugates | IONIC-STRENGTH | SC, subcutaneous | FORMULATION DEVELOPMENT | BEHAVIOR | LIGHT-SCATTERING | V-H/V-L, variable domain of the heavy/light chain | VISCOSITY | HX-MS, hydrogen exchange mass spectrometry | DLS, dynamic light scattering | HPLC, high-performance liquid chromatography | HOFMEISTER SERIES | LC, light chain | C(H)1-C(H)3, constant domains 1-3 respectively of the heavy chain | HYDROGEN/DEUTERIUM-EXCHANGE | CDR, complementarity-determining regions | Fab, antigen binding fragment | BINDING | HC, heavy chain | CD, circular dichroism | Deuterium Exchange Measurement | Animals | Antibodies, Monoclonal, Murine-Derived - immunology | Complementarity Determining Regions - chemistry | Immunoglobulin G - immunology | Immunoglobulin G - chemistry | Mass Spectrometry | Antibodies, Monoclonal, Murine-Derived - chemistry | Complementarity Determining Regions - immunology | Mice | Molecular Dynamics Simulation
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 2005, Volume 3, Issue 4, pp. 561 - 569
pi Radical cations, which are highly reactive in general, can be made persistently stable by appropriate structural modification with heteroatoms,... 
WURSTERS BLUE PERCHLORATE | AROMATIC-HYDROCARBONS | ROOM-TEMPERATURE | ELECTRON-SPIN-RESONANCE | CRYSTAL-STRUCTURE | X-RAY-STRUCTURE | REVERSIBLE DIMERIZATION | CHEMISTRY, ORGANIC | LOW-TEMPERATURE MODIFICATIONS | ABSORPTION-SPECTRA | DIMER CATIONS
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2013, Volume 102, Issue 9, pp. 3089 - 3099
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2013, Volume 102, Issue 1, pp. 62 - 72
Journal Article
Journal of Chromatography A, ISSN 0021-9673, 07/2019, Volume 1597, pp. 100 - 108
Platform manufacturing processes are widely adopted to simplify and standardize the development and manufacturing of monoclonal antibodies (mAbs). However,... 
Aggregation | Reversible self-association | Scale-down | Automation | Monoclonal antibody purification | High throughput process development | Monoclonal antibodies | Evaluation | Biological products
Journal Article
Journal of Rheology, ISSN 0148-6055, 07/2016, Volume 60, Issue 4, pp. 531 - 540
Video-based particle tracking microrheology that requires ∼2 μl per sample is used to measure the viscosity of protein solutions of monoclonal antibodies.... 
SHEAR RHEOLOGY | REVERSIBLE SELF-ASSOCIATION | MECHANICS | ERRORS | CONCENTRATED MONOCLONAL-ANTIBODY | CHEMISTRY | VISCOSITY | DEPENDENCE
Journal Article