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Journal of Cell Science, ISSN 0021-9533, 02/2018, Volume 131, Issue 3
Journal Article
Oncogene, ISSN 0950-9232, 01/2010, Volume 29, Issue 3, pp. 380 - 391
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer and are attractive targets for anti-cancer drug discovery.... 
Isoprenylcysteine carboxyl methyltransferase (Icmt) | S-trans,trans-farnesylthiosalicylic acid (FTS) | Rheb | Ras converting enzyme 1(Rce1) | MTOR | Ras converting enzyme 1 (Rce1) | MAMMALIAN TARGET | FISSION YEAST | HUMAN-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | isoprenylcysteine carboxyl methyltransferase (Icmt) | FARNESYLTRANSFERASE INHIBITORS | CELL BIOLOGY | S-trans, trans-farnesylthiosalicylic acid (FTS) | BREAST-CANCER CELLS | TUBEROUS SCLEROSIS COMPLEX | ONCOLOGY | GENETICS & HEREDITY | mTOR | RHO GTPASES | MEMBRANE ASSOCIATION | FARNESYLTHIOSALICYLIC ACID | ACTIVE RAS | Prenylation | NIH 3T3 Cells | Farnesol - pharmacology | Humans | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Ras Homolog Enriched in Brain Protein | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Salicylates - pharmacology | Transfection | Neuropeptides - genetics | Phosphorylation - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Green Fluorescent Proteins - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Rats | Neuropeptides - metabolism | Binding Sites - genetics | Monomeric GTP-Binding Proteins - genetics | Blotting, Western | Animals | Monomeric GTP-Binding Proteins - metabolism | Cell Line, Tumor | Farnesol - analogs & derivatives | Golgi Apparatus - metabolism | Mice | Protein Processing, Post-Translational | TOR Serine-Threonine Kinases | Mutation | COS Cells | Microscopy, Fluorescence | Post-translational modification | Care and treatment | Genes | Physiological aspects | Research | Health aspects | Cancer | Signal transduction | Enzymes | Oncology | Amino acids | Genetics
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2008, Volume 412, Issue 2, pp. 179 - 190
TSC1 and TSC2 are the tumour-suppressor genes mutated in the tumour syndrome TSC (tuberous sclerosis complex). Their gene products form a complex that has... 
Cell growth control | Tuberous sclerosis complex (TSC) | Mammalian target of rapamycin complex 1 (mTORC1) | Hamartin (TSC1) | Tuberin (TSC2) | Ras homologue enriched in brain (Rheb) | MAMMALIAN TARGET | RHEB GTPASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | hamartin (TSC1) | TSC2 GENE | cell growth control | P70 S6 KINASE | tuberin (TSC2) | TUBEROUS SCLEROSIS COMPLEX | mammalian target of rapamycin complex 1 (mTORC1) | PULMONARY LYMPHANGIOLEIOMYOMATOSIS | TUMOR-SUPPRESSOR PROTEINS | AMINO-ACID SUFFICIENCY | GENE-PRODUCTS | tuberous sclerosis complex (TSC) | RAPAMYCIN ANALOG CCI-779 | Protein Kinases - metabolism | Protein Kinases - genetics | Ribosomal Protein S6 Kinases - metabolism | Humans | Molecular Sequence Data | Ras Homolog Enriched in Brain Protein | Insulin-Like Growth Factor I - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Tumor Suppressor Proteins - genetics | Neuropeptides - genetics | Genes, Tumor Suppressor | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Neuropeptides - metabolism | Monomeric GTP-Binding Proteins - genetics | Transcription Factors - genetics | Cell Growth Processes | Transcription Factors - metabolism | Insulin - metabolism | Sequence Alignment | Animals | Monomeric GTP-Binding Proteins - metabolism | Cell Cycle - physiology | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Ribosomal Protein S6 Kinases - genetics | Insulin-Like Growth Factor I - metabolism
Journal Article
Cellular Signalling, ISSN 0898-6568, 05/2016, Volume 28, Issue 5, pp. 412 - 424
Iron is an indispensable micronutrient that regulates many aspects of cell function, including growth and proliferation. These processes are critically... 
Rheb | TSC2 | 4E-BP1 | PP2A | Akt | Deferoxamine | S6K1
Journal Article
Journal of cell science, ISSN 0021-9533, 11/2018, Volume 131, Issue 22, p. jcs221457
The human TSC2 gene, mutations in which predispose individuals to the disease tuberous sclerosis complex (TSC), encodes a GTPase-activating protein for the... 
RHEB–mTOR | Transposon | Glucose/cAMP signaling | Autophagy | Nitrogen starvation | Tuberous sclerosis complex | RHEB-mTOR | PROTEIN-KINASE-A | FEEDBACK-CONTROL | TUBEROUS SCLEROSIS GENE | RETROTRANSPOSONS | HOMOLOG | RAPAMYCIN TOR | CELL BIOLOGY | ENDOGENOUS RETROVIRUSES | SCHIZOSACCHAROMYCES-POMBE
Journal Article
Cancer research, ISSN 0008-5472, 4/2010, Volume 70, Issue 8, pp. 3287 - 3298
Small GTPase RHEB binds and activates the key metabolic regulator mTORC1, which has an important role in cancer cells, but the role of RHEB in cancer... 
RHEB | mTORC1 | tumorigenesis
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 12/2011, Volume 7, Issue 12, pp. 942 - 949
Lipidated Rho and Rab GTP-binding proteins are transported between membranes in complex with solubilizing factors called 'guanine nucleotide dissociation... 
DELTA-SUBUNIT | PDE-DELTA | STRUCTURAL BASIS | RHEB | PRENYL-BINDING PROTEIN | DISSOCIATION INHIBITOR | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-GROWTH | GTPASE-ACTIVATING PROTEIN | RAB GTPASES
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2007, Volume 282, Issue 28, pp. 20534 - 20543
Tumors that form as a result of heightened mammalian target of rapamycin ( mTOR) signaling are highly vascularized. This process of angiogenesis is regulated... 
BINDING PARTNER | TRANSCRIPTIONAL ACTIVATION | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | PATHWAY | RHEB | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-PRODUCTS | TUBEROUS SCLEROSIS | IDENTIFICATION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR
Journal Article
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, ISSN 1096-4959, 08/2017, Volume 210, pp. 48 - 54
RHEB (Ras Homolog Enriched in Brain) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in... 
MAMMALIAN TARGET | RHEB GTPASE | RAPAMYCIN COMPLEX 1 | FISSION YEAST | ACTIVATION | EXPRESSION ANALYSIS | PROTEIN | NF-kappa B pathway | BIOCHEMISTRY & MOLECULAR BIOLOGY | Haliotis diversicolor | CELL-GROWTH | MTOR | ZOOLOGY | RHEB | Hypoxia | B SIGNALING PATHWAY | Thermal
Journal Article
European Journal of Medical Genetics, ISSN 1769-7212, 2018, p. 103571
Malformations of cortical development are a frequent cause of drug-resistant Epilepsy and developmental delay. Hemimegalencephaly is a Malformation of cortical... 
Somatic mutation | Hemimegalencephaly | RHEB gene | Drug resistant Epilepsy
Journal Article
BMC Cancer, ISSN 1471-2407, 01/2018, Volume 18, Issue 1, pp. 69 - 11
Background: RHEB is a unique member of the RAS superfamily of small GTPases expressed in all tissues and conserved from yeast to humans. Early studies on RHEB... 
RAF/MEK/ERK | Signaling | MEK | Transformation | RHEB | RAF | RHEB Y35N | Cancer | ERK | ACTIVATION | PROTEIN | MECHANISM | HETERODIMERIZATION | CELL-GROWTH | IDENTIFICATION | MTOR | B-RAF KINASE | ONCOLOGY | PATHWAY | GTPASE | Ras genes | Research | Gene mutations | Analysis | Cancer cells
Journal Article