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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Cancer Science, ISSN 1347-9032, 02/2011, Volume 102, Issue 2, pp. 393 - 399
Malignant gliomas are characterized by high invasive potential and strong angiogenic ability. Constitutive activation of Rho and its downstream target... 
FASUDIL HYDROCHLORIDE | CELLS | GLIOBLASTOMA | INVASION | GTPASES | ONCOLOGY | PHOSPHORYLATION | CEREBRAL VASOSPASM | RADIOTHERAPY | ENDOTHELIAL GROWTH-FACTOR | ADJUVANT TEMOZOLOMIDE | Enzyme-Linked Immunosorbent Assay | Gene Expression - drug effects | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Brain Neoplasms - blood supply | Extracellular Signal-Regulated MAP Kinases - metabolism | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - blood supply | Cell Movement - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Signal Transduction - drug effects | rho-Associated Kinases - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Gliomas | Analysis | Genetic research | Development and progression | Vascular endothelial growth factor | Protein kinases | Enzyme-linked immunosorbent assay | Endothelium | Protein binding | Cell culture | Animal models | Phosphorylation | Invasiveness | Brain tumors | Extracellular signal-regulated kinase | MAP kinase | Matrix metalloproteinase | Endothelial cells | Gelatinase B | Rho-associated kinase | Western blotting | Polymerase chain reaction | Angiogenesis | Glioma | Glioma cells | Tumors
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2005, Volume 386, Issue 2, pp. 201 - 214
The Rho GTPases are a family of molecular switches that are critical regulators of signal transduction pathways in eukaryotic cells. They are known principally... 
Rho | ROK (rho-kinase) | Rac | MLK (mixed-lineage kinase) | PAK (p21-activated kinase) | Cdc42 | BINDING PROTEIN-RHO | SERINE-THREONINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYOTONIC-DYSTROPHY KINASE | ACTIN STRESS FIBERS | P21-ACTIVATED KINASE | MIXED-LINEAGE KINASE | SMALL GTPASE RHO | ANCHORAGE-INDEPENDENT GROWTH | ROK (Rho-kinase) | CDC42-BINDING KINASE | MYOSIN LIGHT-CHAIN | p21-Activated Kinases | Amino Acid Sequence | Animals | Humans | rho-Associated Kinases | Intracellular Signaling Peptides and Proteins | Molecular Sequence Data | Genetic Variation - physiology | Protein-Serine-Threonine Kinases - metabolism | PBD, p21-binding domain | ROK, Rho-kinase | PDK1, 3-phosphoinositide-dependent kinase 1 | Review | ACC, anti-parallel coiled-coil | MEKK, MAPK | SH3, Src homology 3 | JNK, c-Jun N-terminal kinase | CRIB, Cdc42 and Rac interactive binding | KIM, KI motif | MRCK, myotonin-related Cdc42-binding kinase | MLK, mixed-lineage kinase | PKN, protein kinase novel | PKC, protein kinase C | PAK, p21-activated kinase | Crmp, collapsin response mediator protein | CRIK, citron kinase | R-MLC, regulatory myosin light chain | KI, kinase inhibitory | MKK, MAPK kinase | ERK (extracellular-signal-regulated kinase) kinase kinase | PH, pleckstrin homology | GEF, guanine nucleotide exchange factor | MBS, myosin-binding subunit | PP1, protein phosphatase type 1 | DMPK, myotonic dystrophy kinase | GIT1, G-protein-coupled receptor kinase-interacting target 1 | PIX, PAK-interacting exchange factor | Hsp90, heat shock protein 90 | MAPK, mitogen-activated protein kinase | LIMK, LIM domain kinase
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 05/2006, Volume 97, Issue 4, pp. 957 - 967
Rho family GTPases promote the survival of certain neuronal populations. However, pro‐survival and pro‐death signaling pathways regulated downstream of Rho... 
signal transducer and activator of transcription‐1 | apoptosis | Janus kinase | Rac1 | Clostridium difficile toxin B | Signal transducer and activator of transcription-1 | Apoptosis | CEREBELLAR GRANULE NEURONS | INDUCED APOPTOSIS | LETHAL TOXIN | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | CELL-DEATH | CLOSTRIDIUM-SORDELLII | ACTIN STRESS FIBERS | RAC | PATHWAY | GROWTH | signal transducer and activator of transcription-1 | MAP Kinase Signaling System - physiology | rho GTP-Binding Proteins - antagonists & inhibitors | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | STAT Transcription Factors - metabolism | Male | Neurons - cytology | Extracellular Signal-Regulated MAP Kinases - metabolism | STAT1 Transcription Factor - metabolism | Female | Cerebellar Cortex - enzymology | Neurons - drug effects | Cell Survival - physiology | Repressor Proteins - metabolism | Animals, Newborn | Cell Survival - drug effects | Cerebellar Cortex - cytology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Rats, Sprague-Dawley | Proto-Oncogene Proteins c-raf - metabolism | Janus Kinase 1 | Bacterial Proteins - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Bacterial Toxins - pharmacology | Neurons - enzymology | rho GTP-Binding Proteins - metabolism | Apoptosis - physiology | rac1 GTP-Binding Protein - metabolism | Proteins | Mutual fund industry | Gene expression | Neurons | Protein kinases | Gram-positive bacteria | Enzymes | Signal transduction
Journal Article
Neuron, ISSN 0896-6273, 01/2008, Volume 57, Issue 1, pp. 94 - 107
Neuronal activity augments maturation of mushroom-shaped spines to form excitatory synapses, thereby strengthening synaptic transmission. We have delineated a... 
CELLBIO | MOLNEURO | SIGNALING | DENDRITIC SPINE MORPHOGENESIS | POSTSYNAPTIC DENSITY PROTEINS | MENTAL-RETARDATION | NUCLEOTIDE EXCHANGE FACTOR | RESONANCE ENERGY-TRANSFER | LONG-TERM POTENTIATION | ACTIN-BASED PLASTICITY | RHO-GTPASES | SYNAPTIC PLASTICITY | NEUROSCIENCES | BETA-PIX
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e106725
Successful placentation depends on the proper invasion of extravillous trophoblast (EVT) cells into maternal tissues. Previous reports demonstrated that S1P... 
MIGRATION | APOPTOSIS | CANCER CELLS | PROTEIN-COUPLED RECEPTOR | EARLY HUMAN-PREGNANCY | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | HUMAN DECIDUA | EXPRESSION | SPHINGOSINE 1-PHOSPHATE | RHO/RHO-KINASE | RNA, Small Interfering - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Collagen - chemistry | Proteoglycans - chemistry | MAP Kinase Kinase 1 - genetics | Trophoblasts - drug effects | Mitogen-Activated Protein Kinase 1 - genetics | Lysophospholipids - pharmacology | Receptors, Lysosphingolipid - genetics | Biological Assay | Trophoblasts - cytology | Receptors, Lysosphingolipid - metabolism | MAP Kinase Kinase 2 - genetics | Cell Line | MAP Kinase Kinase 1 - antagonists & inhibitors | Trophoblasts - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Matrix Metalloproteinase 2 - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Sphingosine - pharmacology | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Sphingosine - analogs & derivatives | Diffusion Chambers, Culture | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 2 - antagonists & inhibitors | Receptors, Lysosphingolipid - agonists | Laminin - chemistry | Protein Kinase Inhibitors - pharmacology | Drug Combinations | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Phosphates | Enzymes | RNA | Sphingosine | Enzyme activity | Extracellular signal-regulated kinase | Activation | mRNA | siRNA | Kinases | Gene expression | Tissues | Sphingosine 1-phosphate | Cell adhesion & migration | Gelatinase A | Pregnancy | Proteins | Signaling | Receptors | Molecular modelling | Pathways | Enzymatic activity | Gelatin | Pharmacy | Receptor mechanisms | Cell migration | Cancer
Journal Article