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06/2010
Rationale: Vascular remodeling and right-ventricular (RV) dysfunction are features of refractory pulmonary hypertension (PHT) in human neonates. These features... 
Y-27632 | 0719 | rho-kinase inhibition | Pulmonary hypertension
Dissertation
07/2011
Schistosomiasis, classified by the World Health Organization as a neglected tropical disease, is an intravascular parasitic disease associated to a chronic... 
immune-vascular | nitric oxide | Rho kinase | schistosomiasis | 5-HT | vascular
Web Resource
Behavioural Brain Research, ISSN 0166-4328, 11/2019, Volume 373, p. 112083
Twenty-nine protein kinase inhibitors have been used to treat human diseases. Out of these, two are Rho-associated protein kinase (ROCK) 1 and 2 inhibitors.... 
Anxiety | Rho kinase | ROCK1 | ROCK2 | Fasudil
Journal Article
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 02/2012, Volume 23, Issue 2, pp. 252 - 265
Synthesis and deposition of extracellular matrix (ECM) within the glomerulus and interstitium characterizes renal fibrosis, but the mechanisms underlying this... 
EPITHELIAL-MESENCHYMAL TRANSITION | CANCER-CELLS | SALT-SENSITIVE RATS | GROWTH-FACTOR-BETA | RHO-KINASE | UROLOGY & NEPHROLOGY | DIABETIC-NEPHROPATHY | ANGIOTENSIN-II | E-CADHERIN | END-PRODUCTS RAGE | MIR-200 FAMILY
Journal Article
11/2013
Chronic neonatal pulmonary hypertension (PHT) frequently presents with rightventricular (RV) dysfunction. In neonatal rats exposed to chronic hypoxia, RV... 
Vascular Remodeling | Rat | Rho-kinase | Right-ventricular Dysfunction | Hypoxia | 0719 | Pulmonary Hypertension | Y27632 | Fasudil
Dissertation
Drug and Chemical Toxicology, ISSN 0148-0545, 2018, pp. 1 - 7
Acrylamide (ACR), a vinyl monomer that has multiple chemical and industrial applications, is a neurotoxic agent in human and animal. Fasudil is a potent... 
Acrylamide | apoptosis | neurotoxicity | rho-kinase inhibitor | Fasudil
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 06/2012, Volume 44, Issue 6, pp. 1031 - 1039
Accumulation of collagen I and III in the myocardium is a prominent feature of interstitial fibrosis. Prostaglandin F (PGF ) facilitates fibrosis by increasing... 
Rho kinase | Collagen | PKC | FP receptor | PGF
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 01/2008, Volume 14, Issue 1, pp. 45 - 54
Aberrant wound-healing responses to injury have been implicated in the development of pulmonary fibrosis, but the mediators directing these pathologic... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | BRONCHOALVEOLAR LAVAGE FLUID | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RHO-KINASE | IDENTIFICATION | CELL BIOLOGY | INFLAMMATION | EDG-FAMILY | FIBROCYTES | EXPRESSION | REQUIREMENT
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2016, Volume 7
Matrix stiffening is a prominent feature of pulmonary fibrosis. In this study, we demonstrate that matrix stiffness regulates the ability of fibrotic lung... 
MATRIX METALLOPROTEINASES | ALPHA-6-BETA-4 INTEGRIN | ACTIVATION | MULTIDISCIPLINARY SCIENCES | RHO-KINASE | P38 MAPK | EXTRACELLULAR-MATRIX | CELL MIGRATION | DIFFERENTIATION | EXPRESSION | PULMONARY-FIBROSIS
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 547 - 554
Emerging evidence suggests that the T helper 17 (T(H)17) subset of alpha beta T cells contributes to the development of allergic asthma. In this study, we... 
MEDICINE, RESEARCH & EXPERIMENTAL | ROR-GAMMA-T | BIOCHEMISTRY & MOLECULAR BIOLOGY | RHO-KINASE | RECEPTOR | GENE POLYMORPHISMS | CELL BIOLOGY | GROWTH-FACTOR-BETA | T(H)17 CELLS | INTERLEUKIN-17 | INFLAMMATION | ALLERGIC-ASTHMA | ASSOCIATION
Journal Article
Circulation Research, ISSN 0009-7330, 10/2008, Volume 103, Issue 9, pp. 1037 - 1046
Isoprostanes are endogenously formed end products of lipid peroxidation. Furthermore, they are markers of oxidative stress and independent risk markers of... 
Isoprostanes | Angiogenesis | Rho kinase | Migration | Thromboxane A2 receptor
Journal Article
Journal of Cell Science, ISSN 0021-9533, 04/2011, Volume 124, Issue 7, pp. 1077 - 1087
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 09/2009, Volume 158, Issue 1, pp. 41 - 49
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 23, pp. 10502 - 10518
Heptaheteroaryl compounds comprised of oxazole and pyridine units (TOxaPy) are quadruplex DNA (G4)-interactive compounds. Herein, we report on the synthesis of... 
MITOSIS | CHEMISTRY, MEDICINAL | SERIES | PHOSPHORYLATION | MYC | RHO-KINASE | TARGETS | BINDING | DISCOVERY
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 16, pp. 12995 - 13008
Doxorubicin is among the essential medicines with a wide antitumor spectrum, but its clinical application is limited by its cardiotoxicity. We recently... 
Cardiotoxicity | Rho kinase | Autophagy | Doxorubicin | Apoptosis
Journal Article
CURRENT OPINION IN CELL BIOLOGY, ISSN 0955-0674, 04/2008, Volume 20, Issue 2, pp. 242 - 248
ROCK kinases, which play central roles in the organization of the actin cytoskeleton, are tantalizing targets for the treatment of human diseases. Deletion of... 
FASUDIL HYDROCHLORIDE | STABLE ANGINA | APOPTOSIS | STEM-CELLS | ANEURYSMAL SUBARACHNOID HEMORRHAGE | PROTEIN-KINASE | RHO-KINASE | DOUBLE-BLIND | CEREBRAL VASOSPASM | VENTRAL BODY-WALL | CELL BIOLOGY
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2012, Volume 125, Issue 8, pp. 1855 - 1864
Journal Article
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