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Journal Article
Circulation Journal, ISSN 1346-9843, 2013, Volume 77, Issue 10, pp. 2619 - 2625
Background: We have previously demonstrated that long-term inhibition of Rho-kinase ameliorates pulmonary arterial hypertension (PAH) in animal models. In the... 
Signal transduction | Rho-kinase inhibitor | Pulmonary arterial hypertension | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN-KINASE | PROSTACYCLIN | RATS | CARDIOVASCULAR MEDICINE | FASUDIL | THERAPEUTIC TARGET | BINDING | GTPASE
Journal Article
by Xie, T and Luo, GY and Zhang, Y and Wang, X and Wang, XY and Wu, M and Li, GP
Clinical & Experimental Allergy, ISSN 0954-7894, 12/2015, Volume 45, Issue 12, pp. 1812 - 1822
Summary Background Airway mucus hypersecretion is a key pathophysiological feature in asthma. Fasudil, a selective Rho‐A/Rho kinase inhibitor, has been used in... 
mucus hypersecretion | STAT6 | NFκB | fasudil | MUC5AC | Rho‐kinase inhibitor | Rho-kinase inhibitor | Mucus hypersecretion | Fasudil | LUNG-FUNCTION | IMMUNOLOGY | CHILDREN | IN-VITRO | STATISTICAL LEARNING TECHNIQUES | GENE-CLUSTER | ALLERGY | ASTHMA | WHEEZE PHENOTYPES | BIRTH COHORT | CONFIRMED WHEEZE | NF kappa B | T-CELLS | Asthma - metabolism | Ovalbumin - immunology | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Hypersensitivity - immunology | Male | NF-kappa B - metabolism | Case-Control Studies | rho-Associated Kinases - antagonists & inhibitors | Respiratory Mucosa - pathology | Allergens - immunology | Hypersensitivity - metabolism | rho-Associated Kinases - metabolism | Respiratory Mucosa - immunology | Asthma - immunology | Female | Hypersensitivity - genetics | Mucus - metabolism | Disease Models, Animal | Cell Line | Gene Expression | Cytokines - metabolism | Down-Regulation | rho-Associated Kinases - genetics | STAT6 Transcription Factor - metabolism | Asthma - genetics | Animals | Signal Transduction - drug effects | Hypersensitivity - pathology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Mucin 5AC - genetics | Mucin 5AC - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Respiratory Mucosa - metabolism | Asthma - pathology | Pyroglyphidae - immunology
Journal Article
Journal Article
Journal Article
Inflammatory Bowel Diseases, ISSN 1078-0998, 01/2014, Volume 20, Issue 1, pp. 154 - 165
Background:Ras homolog gene family, member A (RhoA)/Rho-associated coiled-coil forming protein kinase signaling is a key pathway in multiple types of solid... 
Crohn's disease | MRTF-A | Rho/ROCK | Matrix stiffness | Fibrosis | TRANSCRIPTION FACTORS | ROCK | RHO-KINASE | matrix stiffness | ACTIN DYNAMICS | MECHANISMS | INTESTINAL FIBROSIS | IMPACT | Rho | fibrosis | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | EPIDEMIOLOGY | Oncogene Proteins, Fusion - metabolism | rho GTP-Binding Proteins - antagonists & inhibitors | Serum Response Factor - antagonists & inhibitors | Humans | Colon - drug effects | Extracellular Matrix - metabolism | Fibrosis - metabolism | DNA-Binding Proteins - metabolism | Myofibroblasts - metabolism | Cell Nucleus - metabolism | Benzamides - pharmacology | Fibrosis - prevention & control | Real-Time Polymerase Chain Reaction | Myofibroblasts - pathology | DNA-Binding Proteins - antagonists & inhibitors | Colon - pathology | Serum Response Factor - metabolism | Extracellular Matrix - drug effects | RNA, Messenger - genetics | Trans-Activators | Cells, Cultured | Cell Adhesion - drug effects | Myofibroblasts - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Colon - metabolism | Transforming Growth Factor beta - genetics | Signal Transduction - drug effects | rho GTP-Binding Proteins - metabolism | Anilides - pharmacology | Oncogene Proteins, Fusion - antagonists & inhibitors | Fibrosis - pathology | Cell Nucleus - drug effects | Transforming Growth Factor beta - metabolism | Crohn’s disease
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2013, Volume 54, Issue 4, pp. 2493 - 2502
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 03/2015, Volume 14, Issue 3, pp. 1574 - 1586
Solid supported probes have proven to be an efficient tool for chemical proteomics. The kinobeads technology features kinase inhibitors covalently attached to... 
chemical proteomics | kinase inhibitors | affinity matrix | drug profiling | kinobeads | PEPTIDE IDENTIFICATION | PROTEIN-KINASE | STRATEGY | DRUG DISCOVERY | BIOCHEMICAL RESEARCH METHODS | RHO-KINASE | CELL LINES | KINOME | IN-VIVO | kinase inhibitory | GROWTH-FACTOR | SELECTIVITY | Mass Spectrometry | Protein Kinase Inhibitors - pharmacology | Proteomics | Index Medicus
Journal Article
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 07/2014, Volume 143, Issue 1, pp. 87 - 110
The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an essential cellular pathway that is involved in diverse cell functions.... 
Farnesyl transferase inhibitors | Rho GTPase | Statins | Fibrosis | Geranylgeranyl transferase inhibitors | Asthma | C-REACTIVE PROTEIN | SMALL GTPASE RHOA | BRONCHIAL EPITHELIAL-CELLS | COENZYME-A REDUCTASE | GERANYLGERANYLTRANSFERASE-I INHIBITOR | HMG-COA REDUCTASE | RHO-KINASE INHIBITOR | RANDOMIZED CONTROLLED-TRIAL | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | rho-Associated Kinases - physiology | rho GTP-Binding Proteins - antagonists & inhibitors | Cardiovascular Diseases - drug therapy | Humans | Alkyl and Aryl Transferases - antagonists & inhibitors | Hydroxymethylglutaryl CoA Reductases - physiology | Lung Diseases - drug therapy | Mevalonic Acid - metabolism | rho GTP-Binding Proteins - physiology | rho-Associated Kinases - antagonists & inhibitors | Neoplasms - drug therapy | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Farnesyltranstransferase - antagonists & inhibitors | Pulmonary Disease, Chronic Obstructive - drug therapy | Enzymes | Hypercholesterolemia | Lung diseases | Physiological aspects | Cardiovascular diseases | Health aspects | Cancer | geranylgeranyl transferase inhibitors | farnesy transferase inhibtors | asthma | fibrosis | cancer | chronic obstructive pulmonary disease | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article