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The FEBS Journal, ISSN 1742-464X, 09/2016, Volume 283, Issue 18, pp. 3371 - 3388
ADP ‐ribosylation is a conserved post‐translational protein modification that plays a role in all major cellular processes, particularly DNA repair,... 
PAR | protein | ribosylation | poly | ribose | ENPP | mass spectrometry | PARP | phosphodiesterase | ADP | post‐translational modification | Post-translational modification | Protein ADP-ribosylation | PARP1 | Poly(ADP-ribose) | ENPP1 | Mass spectrometry | Phosphodiesterase | protein ADP-ribosylation | poly(ADP-ribose) | post-translational modification | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUDIX HYDROLASES | RIBOSE | BONE MINERALIZATION | SPINDLE STRUCTURE | NUCLEOTIDE PYROPHOSPHATASES/PHOSPHODIESTERASES | POLY(ADP-RIBOSE) GLYCOHYDROLASE | CELLULAR FUNCTIONS | PURIFICATION | EXPRESSION | Humans | Adenosine Diphosphate Ribose - metabolism | Pyrophosphatases - genetics | Proto-Oncogene Proteins - chemistry | Tandem Mass Spectrometry | Protein Domains | Poly(ADP-ribose) Polymerases - chemistry | Binding Sites | ADP Ribose Transferases - metabolism | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Phosphoric Diester Hydrolases - metabolism | Recombinant Proteins - chemistry | Poly (ADP-Ribose) Polymerase-1 - metabolism | Proto-Oncogene Proteins - genetics | Phosphoric Diester Hydrolases - genetics | Pyrophosphatases - chemistry | Recombinant Proteins - genetics | Phosphoric Diester Hydrolases - chemistry | Pyrophosphatases - metabolism | Sequence Homology, Amino Acid | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Poly (ADP-Ribose) Polymerase-1 - chemistry | Mice | Protein Processing, Post-Translational | In Vitro Techniques | Poly (ADP-Ribose) Polymerase-1 - genetics | Phosphates | Enzymes | Nervous system diseases | Physiological aspects | Sugars | Protein binding | Monosaccharides | Proteins | Molecular biology | Index Medicus | poly(ADP‐ribose) | protein ADP‐ribosylation | Original
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2006, Volume 14, Issue 5, pp. 1378 - 1390
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 645 - 652
PARylation [poly(ADP-ribosyl)ation] is involved in the maintenance of genomic methylation patterns through its control of Dram 1 [DNA... 
DNA methylation | Epigenetics | Poly(ADP-ribosyl)ation (PARylation) | DNA methyltranferase 1 (Dnmt1) | CCCTC-binding factor (Ctcf) | Poly(ADP-ribose) polymerase 1 (Parp1) | POLY(ADP-RIBOSYL)ATION REACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | poly(ADP-ribosyl)ation (PARylation) | epigenetics | HUMAN GENOME | GENE | EMBRYONIC STEM-CELLS | INSULATOR PROTEIN CTCF | UNMETHYLATED STATE | TUMOR-SUPPRESSOR | poly(ADP-ribose) polymerase 1 (Parp1) | CPG ISLANDS | BINDING | DNA (Cytosine-5-)-Methyltransferases - metabolism | Multiprotein Complexes - metabolism | DNA Methylation | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | CCCTC-Binding Factor | Epigenesis, Genetic | CpG Islands - physiology | Repressor Proteins - metabolism | Index Medicus | poly(ADP-ribose) polymerase 1 | DNMT1 protein | genomics | Promoters | ADP-ribosylation | CpG islands | Life Sciences | Poly(ADP-ribose) Polymerases | DNA (Cytosine-5-)-Methyltransferase | Multiprotein Complexes | Repressor Proteins | Biochemistry, Molecular Biology | CpG Islands | Poly Adenosine Diphosphate Ribose | Molecular biology | DMR1, differentially methylated region 1 | Ab, antibody | poly(ADPribosyl)ation (PARylation) | H2B, histone 2B | PARG, poly(ADP-ribose) glycohydrolase | Ctcf, CCCTC-binding factor | IP, immunoprecipitation | DTT, dithiothreitol | ChIP, chromatin immunoprecipitation | TBST, Tris-buffered saline plus 0.05% Tween 20 | Dnmt1, DNA (cytosine-5)-methyltransferase 1 | Parp1, poly(ADP-ribose) polymerase 1 | H1, histone 1 | CGI, CpG island | dsDNA, double-stranded DNA | PARylation, poly(ADP-ribosyl)ation | PARs, poly(ADP-ribose) polymers | RE-ChIP, sequential ChIP
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 12/2017, Volume 232, Issue 12, pp. 3744 - 3761
The study findings imply that activation of either PARP‐1 or ‐2 is likely to play a relevant role in muscle protein catabolism via oxidative stress, NF‐κB... 
| Parp‐1 | and Parp‐2 | muscle atrophy and myosin loss | muscle anabolism and catabolism and mitochondrial content | PARP activity | mice | cancer‐induced cachexia | Parp-1 | cancer-induced cachexia | and Parp-2 | POLY(ADP-RIBOSE) POLYMERASE | PHYSIOLOGY | LIMB MUSCLES | ADP-RIBOSE-POLYMERASE | THORACIC-SURGERY | CELL BIOLOGY | SKELETAL-MUSCLE | INHIBITION | EXPERIMENTAL-MODEL | MITOCHONDRIAL DYSFUNCTION | EXPRESSION | Diaphragm - pathology | Oxidative Stress | Mitochondria, Muscle - metabolism | Lung Neoplasms - pathology | NF-kappa B - metabolism | Mice, 129 Strain | Ubiquitination | Time Factors | Proteolysis | Cachexia - etiology | Muscle Proteins - metabolism | Poly (ADP-Ribose) Polymerase-1 - deficiency | Female | Biomarkers - metabolism | Lung Neoplasms - genetics | Muscle, Skeletal - enzymology | Cachexia - genetics | Lung Neoplasms - enzymology | Signal Transduction | Mitochondria, Muscle - pathology | Mice, Inbred C57BL | Organ Size | Genotype | Poly (ADP-Ribose) Polymerase-1 - metabolism | Diaphragm - enzymology | Lung Neoplasms - complications | Mice, Knockout | Phenotype | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cachexia - enzymology | Cachexia - pathology | Muscle Fibers, Skeletal - pathology | Cell Line, Tumor | Poly(ADP-ribose) Polymerases - deficiency | Mice, Inbred BALB C | Muscle, Skeletal - pathology | Proteasome Endopeptidase Complex - metabolism | Poly (ADP-Ribose) Polymerase-1 - genetics | Apoptosis | Muscle Fibers, Skeletal - enzymology | Ubiquitin | Tyrosine | Oxidative stress | Lung cancer | Cachexia | Mitochondrial DNA | Muscle proteins | Monosaccharides | Ligases | Myosin | Genetic aspects | Sugars | Adenocarcinoma | Chromatin | Poly(ADP-ribose) | AKT protein | ADP | Nuclei | Body composition | Fibers | Proteins | Degradation | Atrophy | Genotype & phenotype | Signal transduction | Protein composition | Body composition (biology) | Ribose | Rodents | Diaphragm (anatomy) | Oxidation | Polymers | Deoxyribonucleic acid--DNA | NF-κB protein | Markers | Contractility | Muscles | Poly(ADP-ribose) polymerase | Inflammation | Metabolism | Muscle contraction | Chronic conditions | Poly(ADP-ribose) Polymerase 1 | Proteasomes | Catabolism | Nuclei (cytology) | Mice | Diaphragm | Cancer | Index Medicus | 62D05 Sampling theory, sample surveys | 92D Genetics and population dynamics | 62H Multivariate analysis | 92 Biology and other natural sciences | Anàlisi multivariable | Matemàtica aplicada a les ciències | Classificació AMS | Multivariate analysis | Parp-1-/- and Parp-2-/- mice | Anàlisi numèrica | Genètica | Sampling (Statistics) | Mostreig (Estadística) | Matemàtiques i estadística | Genetics | Probabilitat | 62 Statistics | Àrees temàtiques de la UPC
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, pp. e46927 - e46927
Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA... 
GENOMIC METHYLATION PATTERNS | DNMT1 | BASE EXCISION-REPAIR | CPG ISLAND METHYLATION | MULTIDISCIPLINARY SCIENCES | PREIMPLANTATION DEVELOPMENT | ACTIVATES PARP-1 | METHYLTRANSFERASE EXPRESSION | DE-NOVO METHYLATION | MAMMALIAN-CELLS | ADP-RIBOSE POLYMERS | Male | Embryo, Mammalian - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | DNA Methylation | Time Factors | Gene Expression Regulation, Developmental | Female | Germ Cells - metabolism | Proto-Oncogene Proteins - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | DNA (Cytosine-5-)-Methyltransferases - genetics | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Analysis of Variance | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Mice | DNA Damage | Poly (ADP-Ribose) Polymerase-1 | Chromatin | Germ cells | DNA damage | Genomes | ADP | DNA repair | Proteins | Demethylation | Ribose | DNA methylation | Public health | Deoxyribonucleic acid--DNA | ADP-ribosylation | Medical research | Enzymes | Hematology | Developmental biology | DNMT1 protein | Poly(ADP-ribose) polymerase | Gene expression | Studies | Poly(ADP-ribose) Polymerase 1 | Structural damage | Epigenetics | Methylation | Cancer | Index Medicus | Poly(ADP-ribose) Polymerases | Embryo, Mammalian | Biochemistry, Molecular Biology | Germ Cells | Poly Adenosine Diphosphate Ribose | Cellular Biology | Life Sciences | DNA (Cytosine-5-)-Methyltransferase | Proto-Oncogene Proteins | Molecular biology | DNA-Binding Proteins | Deoxyribonucleic acid | DNA
Journal Article
DNA Repair, ISSN 1568-7864, 11/2014, Volume 23, pp. 4 - 16
Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in regulation of many cellular pathways. Poly(ADP-ribose) (PAR) consists of... 
Macrodomain | PARP | PARG | DNA damage response | Poly(ADP-ribose) | MACRO DOMAINS | DNA-DAMAGE RESPONSE | CRYSTAL-STRUCTURE | SULFOLOBUS-SOLFATARICUS | MONO-ADP-RIBOSYLTRANSFERASE | FINGER ANTIVIRAL PROTEIN | STRUCTURAL BASIS | GENETICS & HEREDITY | VIRAL MESSENGER-RNAS | TOXICOLOGY | POLYMERASE-ACTIVITY | IONIZING-RADIATION | Viruses - genetics | Humans | Eukaryotic Cells - metabolism | Proto-Oncogene Proteins - chemistry | Phylogeny | Tankyrases - metabolism | Plant Proteins - chemistry | Fishes | DNA Repair Enzymes - metabolism | Archaeal Proteins - genetics | Plant Proteins - metabolism | Poly(ADP-ribose) Polymerases - chemistry | Insect Proteins - metabolism | DNA Repair Enzymes - chemistry | Archaeal Proteins - metabolism | Hydrolases - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Catalytic Domain | Signal Transduction | Viruses - metabolism | Tankyrases - chemistry | Poly Adenosine Diphosphate Ribose - chemistry | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Prokaryotic Cells - metabolism | DNA Repair | Insect Proteins - chemistry | Hydrolases - chemistry | Evolution, Molecular | Index Medicus | TARG1, terminal ADP-ribose protein glycohydrolase | ARH, ADP-ribosylhydrolase | PARG, poly(ADP-ribose) glycohydrolase | PAR, poly(ADP-ribose) | PARP, poly(ADP-ribose) polymerase | ADPr, ADP-ribose
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2018, Volume 128, Issue 5, pp. 2116 - 2126
BACKGROUND. Poly(ADP-ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | POLY(ADP-RIBOSE) POLYMERASE | DNA-REPAIR DEFECT | DIPHOSPHATE-RIBOSE) POLYMERASE EXPRESSION | PHASE-3 TRIAL | DOUBLE-BLIND | BRCA MUTANT-CELLS | RIBOSE POLYMERASE | CARCINOMA | MAINTENANCE THERAPY | Neoplasm Transplantation | Humans | Middle Aged | Drug Resistance, Neoplasm | Poly (ADP-Ribose) Polymerase-1 - metabolism | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Ovarian Neoplasms - diagnostic imaging | Ovarian Neoplasms - genetics | Positron Emission Tomography Computed Tomography | Animals | Heterografts | Contrast Media - administration & dosage | Neoplasm Proteins | Cell Line, Tumor | Adult | Female | Aged | Mice | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - drug therapy | Poly (ADP-Ribose) Polymerase-1 - genetics | Usage | Care and treatment | Enzyme inhibitors | PET imaging | Development and progression | Genetic aspects | Gene expression | Health aspects | Ovarian cancer | Immunohistochemistry | Animal models | Poly(ADP-ribose) | Clinical trials | Metastasis | Cancer therapies | DNA repair | Metastases | Clonal deletion | Ribose | Cell cycle | Xenografts | Deoxyribonucleic acid--DNA | CRISPR | Enzymes | Translation | Medical imaging | Poly(ADP-ribose) polymerase | Breast cancer | FDA approval | Tumor cell lines | Patients | Poly(ADP-ribose) Polymerase 1 | Cell lines | Biomarkers | Clinical medicine | Mutation | Prostate cancer | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2013, Volume 449, Issue 3, pp. 623 - 630
Ctcf (CCCTC-binding factor) directly induces Parp [poly(ADP-ribose) polymerase] 1 activity and its PARylation [poly(ADP-ribosyl)ation] in the absence of DNA... 
Poly(ADP-ribose) glycohydrolase (Parg) | Poly(ADP-ribosyl) ation (PARylation) | CCCTC-binding factor (Ctcf) | Chromatin structure | Poly(ADP-ribose) polymerase 1 (Parp1) | DNA METHYLATION | INSULATOR | PROTEIN CTCF | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | poly(ADP-ribosyl)ation (PARylation) | poly(ADP-ribose) polymerase 1 (Parp 1) | GENOME | CCCTC-BINDING FACTOR | GENE PROMOTER | SITES | POLY(ADP-RIBOSE) POLYMERASE-1 | TUMOR-SUPPRESSOR | poly(ADP-ribose) glycohydrolase (Parg) | chromatin structure | Glycoside Hydrolases - genetics | Adenosine Diphosphate Ribose - metabolism | Recombinant Fusion Proteins - metabolism | Repressor Proteins - antagonists & inhibitors | Gene Knockdown Techniques | DNA Methylation | Cell Nucleus - metabolism | Lamins - metabolism | Active Transport, Cell Nucleus | Repressor Proteins - metabolism | Cell Line | Mutagenesis, Site-Directed | Mutant Proteins - genetics | Chromatin Assembly and Disassembly | Repressor Proteins - genetics | Mutant Proteins - metabolism | Poly(ADP-ribose) Polymerase Inhibitors | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | CCCTC-Binding Factor | Recombinant Fusion Proteins - genetics | Mice | Glycoside Hydrolases - metabolism | Poly (ADP-Ribose) Polymerase-1 | Amino Acid Substitution | Index Medicus | Poly(ADP-ribose) Polymerases | Adenosine Diphosphate Ribose | Repressor Proteins | Biochemistry, Molecular Biology | Lamins | Recombinant Fusion Proteins | Mutant Proteins | Life Sciences | Glycoside Hydrolases | Cell Nucleus
Journal Article
Journal Article