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The FEBS Journal, ISSN 1742-464X, 09/2016, Volume 283, Issue 18, pp. 3371 - 3388
ADP‐ribosylation is a conserved post‐translational protein modification that plays a role in all major cellular processes, particularly DNA repair,... 
PAR | poly(ADP‐ribose) | PARP1 | protein ADP‐ribosylation | ENPP1 | mass spectrometry | phosphodiesterase | post‐translational modification | Post-translational modification | Protein ADP-ribosylation | Poly(ADP-ribose) | Mass spectrometry | Phosphodiesterase | protein ADP-ribosylation | poly(ADP-ribose) | post-translational modification | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUDIX HYDROLASES | RIBOSE | BONE MINERALIZATION | SPINDLE STRUCTURE | NUCLEOTIDE PYROPHOSPHATASES/PHOSPHODIESTERASES | POLY(ADP-RIBOSE) GLYCOHYDROLASE | CELLULAR FUNCTIONS | PURIFICATION | EXPRESSION | Humans | Adenosine Diphosphate Ribose - metabolism | Pyrophosphatases - genetics | Proto-Oncogene Proteins - chemistry | Tandem Mass Spectrometry | Protein Domains | Poly(ADP-ribose) Polymerases - chemistry | Binding Sites | ADP Ribose Transferases - metabolism | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Phosphoric Diester Hydrolases - metabolism | Recombinant Proteins - chemistry | Poly (ADP-Ribose) Polymerase-1 - metabolism | Proto-Oncogene Proteins - genetics | Phosphoric Diester Hydrolases - genetics | Pyrophosphatases - chemistry | Recombinant Proteins - genetics | Phosphoric Diester Hydrolases - chemistry | Pyrophosphatases - metabolism | Sequence Homology, Amino Acid | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Poly (ADP-Ribose) Polymerase-1 - chemistry | Mice | Protein Processing, Post-Translational | In Vitro Techniques | Poly (ADP-Ribose) Polymerase-1 - genetics | Phosphates | Enzymes | Nervous system diseases | Physiological aspects | Sugars | Protein binding | Monosaccharides | Proteins | Molecular biology | Original
Journal Article
PloS one, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46927
Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA... 
GENOMIC METHYLATION PATTERNS | DNMT1 | BASE EXCISION-REPAIR | CPG ISLAND METHYLATION | MULTIDISCIPLINARY SCIENCES | PREIMPLANTATION DEVELOPMENT | ACTIVATES PARP-1 | METHYLTRANSFERASE EXPRESSION | DE-NOVO METHYLATION | MAMMALIAN-CELLS | ADP-RIBOSE POLYMERS | Male | Embryo, Mammalian - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | DNA Methylation | Time Factors | Gene Expression Regulation, Developmental | Female | Germ Cells - metabolism | Proto-Oncogene Proteins - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | DNA (Cytosine-5-)-Methyltransferases - genetics | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Analysis of Variance | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Mice | DNA Damage | Poly (ADP-Ribose) Polymerase-1 | Chromatin | Germ cells | DNA damage | Genomes | DNA repair | Proteins | Demethylation | Ribose | DNA methylation | Public health | Deoxyribonucleic acid--DNA | ADP-ribosylation | Medical research | Enzymes | Hematology | Developmental biology | DNMT1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Gene expression | Studies | Poly(ADP-ribose) Polymerase 1 | Structural damage | Epigenetics | Methylation | Cancer | Poly(ADP-ribose) Polymerases | Embryo, Mammalian | Biochemistry, Molecular Biology | Germ Cells | Poly Adenosine Diphosphate Ribose | Cellular Biology | Life Sciences | DNA (Cytosine-5-)-Methyltransferase | Proto-Oncogene Proteins | Molecular biology | DNA-Binding Proteins | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 2019, Volume 116, Issue 29, pp. 201908547 - 14582
Androgen receptor (AR) is a ligand-activated transcription factor and a key driver of prostate cancer (PCa) growth and progression. Understanding the factors... 
FOXA1 | prostate cancer | androgen receptor | ROLES | MULTIDISCIPLINARY SCIENCES | PARP inhibitor | PARP-2 | CELL-CYCLE | INCREASED SURVIVAL | DNA-REPAIR | EXPRESSION | POLY(ADP-RIBOSE) POLYMERASE-2 PARP-2 | Tissue Array Analysis | Humans | Receptors, Androgen - metabolism | Male | Hepatocyte Nuclear Factor 3-alpha - antagonists & inhibitors | Prostatic Neoplasms, Castration-Resistant - genetics | Prostatic Neoplasms, Castration-Resistant - pathology | Prostate - pathology | Gene Expression Regulation, Neoplastic - drug effects | Benzimidazoles - therapeutic use | Datasets as Topic | Kaplan-Meier Estimate | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - therapeutic use | Signal Transduction - genetics | Prostatic Neoplasms, Castration-Resistant - drug therapy | Gene Knockout Techniques | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Xenograft Model Antitumor Assays | Disease-Free Survival | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Phthalazines - therapeutic use | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Signal Transduction - drug effects | RNA-Seq | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Prostatic Neoplasms, Castration-Resistant - mortality | Poly (ADP-Ribose) Polymerase-1 - genetics | RNA, Small Interfering - metabolism | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Catalytic activity | Lethality | DNA repair | Critical components | Proteins | Castration | Ribose | Catalysis | Inhibition | Repair | Deoxyribonucleic acid--DNA | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Pharmacology | Gene expression | Chemical compounds | Augmented reality | Poly(ADP-ribose) Polymerase 1 | Androgens | Antiandrogens | Ligands | Disruption | Prostate cancer | Prostate | Tumors | Cancer | Biological Sciences | PNAS Plus
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 12/2017, Volume 232, Issue 12, pp. 3744 - 3761
Strategies to treat cachexia are still at its infancy. Enhanced muscle protein breakdown and ubiquitin‐proteasome system are common features of cachexia... 
muscle atrophy and myosin loss | muscle anabolism and catabolism and mitochondrial content | PARP activity | Parp‐1−/− and Parp‐2−/− mice | cancer‐induced cachexia | Parp-1 | cancer-induced cachexia | and Parp-2 | mice | POLY(ADP-RIBOSE) POLYMERASE | PHYSIOLOGY | LIMB MUSCLES | ADP-RIBOSE-POLYMERASE | THORACIC-SURGERY | CELL BIOLOGY | SKELETAL-MUSCLE | INHIBITION | EXPERIMENTAL-MODEL | MITOCHONDRIAL DYSFUNCTION | EXPRESSION | Diaphragm - pathology | Oxidative Stress | Mitochondria, Muscle - metabolism | Lung Neoplasms - pathology | NF-kappa B - metabolism | Mice, 129 Strain | Ubiquitination | Time Factors | Proteolysis | Cachexia - etiology | Muscle Proteins - metabolism | Poly (ADP-Ribose) Polymerase-1 - deficiency | Female | Biomarkers - metabolism | Lung Neoplasms - genetics | Muscle, Skeletal - enzymology | Cachexia - genetics | Lung Neoplasms - enzymology | Signal Transduction | Mitochondria, Muscle - pathology | Mice, Inbred C57BL | Organ Size | Genotype | Poly (ADP-Ribose) Polymerase-1 - metabolism | Diaphragm - enzymology | Lung Neoplasms - complications | Mice, Knockout | Phenotype | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cachexia - enzymology | Cachexia - pathology | Muscle Fibers, Skeletal - pathology | Cell Line, Tumor | Poly(ADP-ribose) Polymerases - deficiency | Mice, Inbred BALB C | Muscle, Skeletal - pathology | Proteasome Endopeptidase Complex - metabolism | Poly (ADP-Ribose) Polymerase-1 - genetics | Apoptosis | Muscle Fibers, Skeletal - enzymology | Ubiquitin | Tyrosine | Oxidative stress | Lung cancer | Cachexia | Mitochondrial DNA | Muscle proteins | Monosaccharides | Ligases | Myosin | Genetic aspects | Sugars | Adenocarcinoma | Chromatin | Poly(ADP-ribose) | AKT protein | Nuclei | Body composition | Fibers | Proteins | Degradation | Atrophy | Genotype & phenotype | Signal transduction | Protein composition | Body composition (biology) | Ribose | Rodents | Diaphragm (anatomy) | Oxidation | Polymers | Deoxyribonucleic acid--DNA | NF-κB protein | Markers | Muscles | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Inflammation | Metabolism | Muscle contraction | Chronic conditions | Poly(ADP-ribose) Polymerase 1 | Proteasomes | Catabolism | Nuclei (cytology) | Mice | Diaphragm | Cancer | 62D05 Sampling theory, sample surveys | 92D Genetics and population dynamics | 62H Multivariate analysis | 92 Biology and other natural sciences | Anàlisi multivariable | Matemàtica aplicada a les ciències | Classificació AMS | Multivariate analysis | Parp-1-/- and Parp-2-/- mice | Anàlisi numèrica | Genètica | Sampling (Statistics) | Mostreig (Estadística) | Matemàtiques i estadística | Genetics | Probabilitat | 62 Statistics | Àrees temàtiques de la UPC
Journal Article
DNA repair, ISSN 1568-7864, 2014, Volume 23, pp. 4 - 16
•PARPs are present in representatives from all six major eukaryotic supergroups.•Reversible PAR metabolism was established early in eukaryotic evolution.•The... 
Macrodomain | PARP | PARG | DNA damage response | Poly(ADP-ribose) | MACRO DOMAINS | DNA-DAMAGE RESPONSE | CRYSTAL-STRUCTURE | SULFOLOBUS-SOLFATARICUS | MONO-ADP-RIBOSYLTRANSFERASE | FINGER ANTIVIRAL PROTEIN | STRUCTURAL BASIS | GENETICS & HEREDITY | VIRAL MESSENGER-RNAS | TOXICOLOGY | POLYMERASE-ACTIVITY | IONIZING-RADIATION | Viruses - genetics | Humans | Eukaryotic Cells - metabolism | Proto-Oncogene Proteins - chemistry | Phylogeny | Tankyrases - metabolism | Plant Proteins - chemistry | Fishes | DNA Repair Enzymes - metabolism | Archaeal Proteins - genetics | Plant Proteins - metabolism | Poly(ADP-ribose) Polymerases - chemistry | Insect Proteins - metabolism | DNA Repair Enzymes - chemistry | Archaeal Proteins - metabolism | Hydrolases - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Catalytic Domain | Signal Transduction | Viruses - metabolism | Tankyrases - chemistry | Poly Adenosine Diphosphate Ribose - chemistry | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Prokaryotic Cells - metabolism | DNA Repair | Insect Proteins - chemistry | Hydrolases - chemistry | Evolution, Molecular | TARG1, terminal ADP-ribose protein glycohydrolase | ARH, ADP-ribosylhydrolase | PARG, poly(ADP-ribose) glycohydrolase | PAR, poly(ADP-ribose) | PARP, poly(ADP-ribose) polymerase | ADPr, ADP-ribose
Journal Article