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Dermatologic Surgery, ISSN 1076-0512, 09/2014, Volume 40, Issue 9, pp. 948 - 963
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 45 - 57
We show that in melanoma cells oncogenic BRAF, acting through MEK and the transcription factor BRN2, downregulates the cGMP-specific phosphodiesterase PDE5A... 
APOPTOSIS | SMOOTH-MUSCLE | ACTIVATION | CYCLIC-GMP | CANCER CELLS | GENE | ONCOLOGY | INHIBITS GROWTH | PROLIFERATION | B-RAF | EXPRESSION | CELL BIOLOGY | Cyclic GMP - pharmacology | RNA, Small Interfering - genetics | Protein Binding - genetics | Cell Proliferation | Gene Expression - drug effects | Calcium - metabolism | Gene Expression - genetics | Homeodomain Proteins - metabolism | Humans | Neoplasm Invasiveness - prevention & control | Lung Neoplasms - pathology | Promoter Regions, Genetic - genetics | Cell Movement - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Calcium - antagonists & inhibitors | Myosin Light Chains - antagonists & inhibitors | Cyclic GMP - analogs & derivatives | Lung Neoplasms - secondary | Neoplasm Invasiveness - pathology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Phosphodiesterase 5 Inhibitors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Gene Expression Regulation, Neoplastic - physiology | Cardiac Myosins - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Cardiac Myosins - antagonists & inhibitors | POU Domain Factors - metabolism | Melanoma - metabolism | Melanoma - pathology | Calcimycin - pharmacology | Down-Regulation - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Animals | Cyclic GMP - metabolism | Lung Neoplasms - prevention & control | Mice, Nude | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Transplantation, Heterologous - pathology | Mice | Myosin Light Chains - metabolism | Protein Kinase Inhibitors - pharmacology
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 48, pp. 79557 - 79571
.... Our previous results demonstrated that TRAF6 is overexpressed in melanoma and that TRAF6 knockdown dramatically attenuates tumor cell growth and metastasis... 
Ubiquitination | EGCG | TRAF6 | Melanoma | GALLATE EGCG | WILD-TYPE | UBIQUITIN LIGASE | melanoma | RECEPTOR | CELL BIOLOGY | GREEN TEA CATECHINS | ubiquitination | RING DOMAIN | IKK ACTIVATION | NF-KAPPA-B | CANCER CHEMOPREVENTION | SKIN-CANCER | Skin Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | NF-kappa B - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - metabolism | TNF Receptor-Associated Factor 6 - genetics | Catechin - metabolism | Signal Transduction | Enzyme Inhibitors - pharmacology | Ubiquitin-Protein Ligases - metabolism | MAP Kinase Kinase Kinases - metabolism | Ubiquitin-Protein Ligases - chemistry | Cell Movement - drug effects | Lung Neoplasms - prevention & control | Ubiquitin-Conjugating Enzymes - metabolism | NF-KappaB Inhibitor alpha - metabolism | Cell Line, Tumor | Protein Conformation | Mice, Inbred BALB C | Molecular Docking Simulation | Ubiquitin-Protein Ligases - genetics | Catechin - chemistry | Phosphorylation | Gene Expression Regulation, Neoplastic | Ubiquitin-Protein Ligases - antagonists & inhibitors | Structure-Activity Relationship | Transfection | Lung Neoplasms - secondary | Melanoma - genetics | HEK293 Cells | Catechin - pharmacology | Lung Neoplasms - genetics | Melanoma - metabolism | Skin Neoplasms - pathology | Neoplasm Invasiveness | Antineoplastic Agents, Phytogenic - chemistry | Melanoma - secondary | Skin Neoplasms - metabolism | Animals | Tumor Burden - drug effects | Melanoma - drug therapy | Skin Neoplasms - genetics | TNF Receptor-Associated Factor 6 - chemistry | TNF Receptor-Associated Factor 6 - metabolism | Protein Binding | Catechin - analogs & derivatives | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology
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Journal Article
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