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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2019, Volume 116, Issue 20, pp. 10162 - 10167
During development or under stress, chloroplasts generate signals that regulate the expression of a large number of nuclear genes, a process called retrograde... 
RNA editing | ORGANELLAR | DOMAIN | MULTIDISCIPLINARY SCIENCES | CHLOROPLASTS | MOTIF | GUN1 | PENTATRICOPEPTIDE REPEAT PROTEINS | MUTANTS | retrograde signaling | PPR | MORF2/RIP2 | GENE-EXPRESSION | ARABIDOPSIS | REVEALS | Phenotypes | Transcription | Editing | Genomes | Retrograde transport | Gene expression | Ribonucleic acid--RNA | Mutants | Seedlings | Genotype & phenotype | Signaling | Chloroplasts | Mutation | Plastids | Biological Sciences | MORF2 | RIP2
Journal Article
Oncotarget, ISSN 1949-2553, 06/2018, Volume 9, Issue 44, pp. 27319 - 27320
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 12/2019, Volume 101, p. 103455
An octamer consisting of two copies of histones H2A, H2B, H3 and H4 is the nucleosome core. It is well established that histone derived antimicrobial peptides... 
Bacterial infection | Zebrafish histone H2A | Antibacterial genes | MHC-Related genes | RIP2
Journal Article
Circulation, ISSN 0009-7322, 3/2015, Volume 131, Issue 13, pp. 1160 - 1170
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 06/2019, Volume 60, Issue 7, pp. 2641 - 2649
To investigate expression and role of nucleotide-binding oligomerization domain 2 (NOD2) in the ocular surface of experimental dry eye (EDE), which is a... 
APOPTOSIS | ACTIVATION | KAPPA-B | dry eye | HYPEROSMOLARITY | NF-kappa B | nucleotide-binding oligomerization domain 2 (NOD2) | INFLAMMATION | DISEASE | UVEITIS | OPHTHALMOLOGY | INFLAMMASOMES | RECEPTORS | PROTEINS | RIP2
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2007, Volume 404, Issue 2, pp. 179 - 190
MDP (muramyl dipeptide), a component of peptidoglycan, interacts with NOD2 (nucleotide-binding oligomerization domain 2) stimulating the NOD2-RIP2... 
Pro-inflammatory cytokines | Nucleotide-binding oligomerization domain 2 (NOD2) | Muramyl dipeptide (MDP) | Receptor-interacting protein 2 (RIP2) | Transforming-growth-factor-β-activated kinase-1 (TAK1) | ACTIVATION | CROHNS-DISEASE | muramyl dipeptide (MDP) | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOD2 | P38 MAP KINASE | nucleotide-binding oligomerization domain 2 (NOD2) | TAK1 | pro-inflammatory cytokines | transforming-growth-factor-beta-activated kinase-1 (TAK1) | IN-VIVO | receptor-interacting protein 2 (RIP2) | FRAMESHIFT MUTATION | NF-KAPPA-B | ADAPTIVE IMMUNE-RESPONSES | PROTEIN-KINASE INHIBITORS | Cell Line | Signal Transduction | Humans | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | MAP Kinase Kinase Kinases - metabolism | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | DNA Primers | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Nod2 Signaling Adaptor Protein - metabolism | Base Sequence | Interleukin-1beta - biosynthesis | Pyridines - pharmacology | Catalysis | Enzyme Activation | Tumor Necrosis Factor-alpha - biosynthesis | Cytokines - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Interleukin-1beta - antagonists & inhibitors | KI, kinase inactive | CK1, ‘casein kinase 1’ | TLR, Toll-like receptor | WT, wild-type | TNF, tumour necrosis factor | HEK-293, human embryonic kidney 293 cells | JNK, c-Jun N-terminal kinase | MDP, muramyl dipeptide | TAK1, transforming-growth-factor-β-activated kinase-1 | transforming-growth-factor-β-activated kinase-1 (TAK1) | ERK, extracellular-signal-regulated kinase | K63-pUb, Lys63-linked polyubiquitin | RIP2, receptor-interacting protein 2 | MKK1, MAPK kinase-1 | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | GAK, cyclin G-associated kinase | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | IKKβ, inhibitor of nuclear factor κB kinase β | GST, glutathione S-transferase | NF-κB, nuclear factor κB | NEMO, nuclear factor κB essential modifier | HA, haemagglutinin | NOD, nucleotide-binding oligomerization domain | TRAF6, TNF-receptor-associated factor 6 | M-TriDAP, muramyl-N-acetyl-L-Ala-D-Glu-m-diaminopimelic acid | IL, interleukin | LPS, lipopolysaccharide | shRNA, short hairpin RNA | VSV-G, vesicular-stomatitis-virus envelope glycoprotein | PBMCs, peripheral-blood mononuclear cells | Tpl2, tumour progression locus 2 | FCS, foetal-calf serum | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2018, Volume 497, Issue 1, pp. 115 - 121
Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune... 
RIP2 (Receptor-interacting serine-threonine kinase-2) | NF-κB (Nuclear Factor κ-light-chain-enhancer of activated B cells) | TNBC (Triple negative breast cancer) | Apoptosis
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 06/2019, Volume 294, Issue 26, pp. 10365 - 10378
Receptor-interacting protein 2 (RIP2) is a kinase that mediates signaling downstream of the bacterial peptidoglycan sensors NOD1 and NOD2. Genetic loss or... 
ACTIVATION | PROTEIN | Src | signal transduction | Fc-gamma receptor | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | INNATE | NOD1 | reactive oxygen species (ROS) | IDENTIFICATION | Fc receptor | inflammation | HOST RECOGNITION | IMMUNE-RESPONSES | receptor interacting protein 2 (RIP2) | RECEPTORS | ASSOCIATION
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2014, Volume 588, Issue 18, pp. 3382 - 3389
Understanding how single nucleotide polymorphisms (SNPs) lead to disease at a molecular level provides a starting point for improved therapeutic intervention.... 
Nucleotide-binding, leucine-rich repeat containing receptor | Nucleotide oligomerisation domain containing 2 | Innate immunity | Single nucleotide polymorphisms | NACHT | Blau syndrome | NOD | single nucleotide polymorphism | cryopyrin-associated periodic syndromes | receptor interacting protein 2 | nuclear factor kappa B | EOS | helical domain | nucleotide oligomerisation domain | nucleotide-binding, leucine-rich repeat containing receptor | found in NAIP, CIITA, HET-E and TP-1 | early onset sarcoidosis | NF-κB | SNP | NLR | CAPS | RIP2 | Nucleotide oligomerisation domain | containing 2 | KAPPA-B ACTIVATION | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHENOTYPE | CARD15 MUTATIONS | EARLY-ONSET SARCOIDOSIS | PLASMA-MEMBRANE | CELL BIOLOGY | BIOPHYSICS | GENE | MURAMYL DIPEPTIDE | DISEASE | Cranial Nerve Diseases - enzymology | Uveitis - enzymology | Cranial Nerve Diseases - genetics | Humans | Molecular Sequence Data | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Arthritis | HEK293 Cells | Synovitis - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Genetic Predisposition to Disease | Nod1 Signaling Adaptor Protein - physiology | Genetic Association Studies | Protein Structure, Secondary | Signal Transduction | Models, Molecular | Protein Transport | Hydrolysis | Nod2 Signaling Adaptor Protein - metabolism | Synovitis - enzymology | Polymorphism, Single Nucleotide | Uveitis - genetics | Amino Acid Substitution | Genetic aspects | EOS, early onset sarcoidosis | BS, Blau syndrome | NLR, nucleotide-binding, leucine-rich repeat containing receptor | CAPS, cryopyrin-associated periodic syndromes | NACHT, found in NAIP, CIITA, HET-E and TP-1 | RIP2, receptor interacting protein 2 | SNP, single nucleotide polymorphism | NOD, nucleotide oligomerisation domain | NF-κB, nuclear factor kappa B | HD, helical domain
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2018, Volume 69, Issue 4, pp. 551 - 565.e7
Inflammatory responses mediated by NOD2 rely on RIP2 kinase and ubiquitin ligase XIAP for the activation of nuclear factor κB (NF-κB), mitogen-activated... 
kinase inhibitor | inflammatory signaling | RIPK2 | IAP antagonist | XIAP | NOD2 | ubiquitin | RIP2 | KINASE-ACTIVITY | KAPPA-B ACTIVATION | NOD-LIKE RECEPTORS | CROHNS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-DEPENDENT APOPTOSIS | HOST-DEFENSE | IAP ANTAGONISTS | CELL-DEATH | INNATE IMMUNITY | BOWEL-DISEASE | CELL BIOLOGY | Ubiquitin | Lysine | Ligases | Mitogens | Protein kinases | Apoptosis
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 02/2018, Volume 497, Issue 1, pp. 115 - 121
Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune... 
RIP2 (Receptor-interacting serine-threonine kinase-2) | KINASE-ACTIVITY | BIOPHYSICS | TNBC (Triple negative breast cancer) | IMMUNE-RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | Apoptosis | NF-kappa B (Nuclear Factor kappa-light-chain-enhancer of activated B cells)
Journal Article
FEBS Letters, ISSN 0014-5793, 08/2014, Volume 588, Issue 17, pp. 2830 - 2836
NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38... 
Crohn’s Disease | Caspase activation and recruitment domain | Stress kinase pathway | Signal transduction | Innate immunity | Nucleotide-binding leucine-rich repeat containing receptor | NOD | single nucleotide polymorphism | receptor interacting protein 2 | nuclear factor kappa B | nucleotide oligomerisation domain | CARD | NF-κB | caspase activation and recruitment domain | Crohn's Disease | SNP | NLR | MBP | nucleotide-binding leucine-rich repeat containing receptor | maltose binding protein | RIP2 | CELLS | ACTIVATION | ADAPTER PROTEIN CARD9 | CROHNS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | PLASMA-MEMBRANE | CELL BIOLOGY | INFLAMMATORY-BOWEL-DISEASE | BIOPHYSICS | MURAMYL DIPEPTIDE RECOGNITION | NF-KAPPA-B | Adaptor Proteins, Signal Transducing - chemistry | Protein Structure, Tertiary | Animals | Nod2 Signaling Adaptor Protein - metabolism | CARD Signaling Adaptor Proteins | Humans | Nod2 Signaling Adaptor Protein - chemistry | Models, Molecular | Protein Binding | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cellular signal transduction | Single nucleotide polymorphisms | Sugars | Protein binding | NLR, nucleotide-binding leucine-rich repeat containing receptor | CARD, caspase activation and recruitment domain | RIP2, receptor interacting protein 2 | SNP, single nucleotide polymorphism | NOD, nucleotide oligomerisation domain | NF-κB, nuclear factor kappa B | MBP, maltose binding protein
Journal Article
Neuroscience Letters, ISSN 0304-3940, 04/2018, Volume 671, pp. 43 - 49
The objectives of this study were to investigate the role of the NOD2-RIP2 pathway in host responses to the gram-positive bacteria and to evaluate the effect... 
Gram-positive bacteria | Meningitis | NOD2 | Cytokines | RIP2 | INHIBITION | INNATE IMMUNE-RESPONSES | PNEUMOCOCCAL MENINGITIS | EXPRESSION | NEUROSCIENCES | Yuan (China) | Pneumonia | Analysis | Bacterial pneumonia | Brain damage | Bacteria | Streptococcus pneumoniae
Journal Article
The Journal of Immunology, ISSN 0022-1767, 02/2007, Volume 178, Issue 4, pp. 2380 - 2386
Journal Article
Immunity, ISSN 1074-7613, 06/2009, Volume 30, Issue 6, pp. 789 - 801
Cellular inhibitor of apoptosis proteins (cIAPs) block apoptosis, but their physiological functions are still under investigation. Here, we report that cIAP1... 
MOLIMMUNO | CELLS | ACTIVATION | C-IAP1 | PROTEIN | DROSOPHILA IMD PATHWAY | IN-VIVO | KINASE | IMMUNOLOGY | POLYUBIQUITINATION | NF-KAPPA-B | RIP2 | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Receptors, Pattern Recognition - immunology | Inhibitor of Apoptosis Proteins - genetics | Nod1 Signaling Adaptor Protein - agonists | Colitis - pathology | Baculoviral IAP Repeat-Containing 3 Protein | Nod1 Signaling Adaptor Protein - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Receptors, Pattern Recognition - agonists | Nod2 Signaling Adaptor Protein - agonists | Inhibitor of Apoptosis Proteins - metabolism | Colitis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Cytokines - immunology | Cytokines - metabolism | Mice, Inbred C57BL | Nod2 Signaling Adaptor Protein - immunology | Ubiquitination - immunology | Nod1 Signaling Adaptor Protein - immunology | Immunity, Innate | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Ubiquitin-Protein Ligases | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Apoptosis - immunology | Colitis - enzymology | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Inhibitor of Apoptosis Proteins - immunology | Mice | Ubiquitin | Oligomers | Ligases | Physiological aspects | Crohn's disease | Colitis | Apoptosis | Medical research | Enzymes | Statistical analysis | Cytokines | Kinases | Proteins | Inflammatory bowel disease | Genotype & phenotype | Insects | Bacteria | Gram-negative bacteria | Chemokines | Immune system
Journal Article